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1LW0
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CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-30
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LW2
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CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-30
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LWC
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CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-31
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LWE
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CRYSTAL STRUCTURE OF M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-31
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LWF
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CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Chamberlain, P.P., Nichols, C.E., Douglas, L., Stuart, D.I., Stammers, D.K.
Deposit date:2002-05-31
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
5OQF
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CRYSTAL STRUCTURE OF A SINGLE CHAIN TRIMER COMPOSED OF THE MHC 1 HEAVY CHAIN H2-KB WT, BETA-2MICROGLOBULIN, AND OVALBUMIN DERIVED PEPTIDE
Descriptor:Beta-2-microglobulin,H-2 class I histocompatibility antigen, K-B alpha chain
Authors:Mikolajek, H., Werner, J.M.
Deposit date:2017-08-11
Release date:2018-04-11
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
J. Biol. Chem., 293, 2018
5OQG
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CRYSTAL STRUCTURE OF A SINGLE CHAIN TRIMER COMPOSED OF THE MHC I HEAVY CHAIN H-2KB W167A, BETA-2MICROGLOBULIN, AND AND OVALBUMIN-DERIVED PEPTIDE.
Descriptor:Beta-2-microglobulin,H-2 class I histocompatibility antigen, K-B alpha chain
Authors:Mikolajek, H., Werner, J.M.
Deposit date:2017-08-11
Release date:2018-04-11
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
J. Biol. Chem., 293, 2018
5OQH
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CRYSTAL STRUCTURE OF A DISULFIDE TRAPPED SINGLE CHAIN TRIMER COMPOSED OF THE MHC I HEAVY CHAIN H-2KB Y84C K66A MUTANT, BETA-2MICROGLOBULIN, AND OVALBUMIN-DERIVED PEPTIDE
Descriptor:Beta-2-microglobulin,H-2 class I histocompatibility antigen, K-B alpha chain
Authors:Mikolajek, H., Werner, J.M., Beton, M.E.
Deposit date:2017-08-11
Release date:2018-04-18
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
J. Biol. Chem., 293, 2018
5OQI
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CRYSTAL STRUCTURE OF A DISULFIDE TRAPPED SINGLE CHAIN TRIMER COMPOSED OF THE MHC I HEAVY CHAIN H-2KB Y84C E63A MUTANT, BETA-2MICROGLOBULIN, AND OVALBUMIN-DERIVED PEPTIDE
Descriptor:Beta-2-microglobulin,H-2 class I histocompatibility antigen, K-B alpha chain
Authors:Mikolajek, H., Werner, J.M., Beton, M.E.
Deposit date:2017-08-11
Release date:2018-04-11
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
J. Biol. Chem., 293, 2018
1S1T
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
Descriptor:Reverse transcriptase, PHOSPHATE ION, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1U
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:Reverse transcriptase, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1V
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651
Descriptor:Reverse transcriptase, 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1W
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CRYSTAL STRUCTURE OF V106A MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
Descriptor:Reverse transcriptase, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1X
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CRYSTAL STRUCTURE OF V108I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:Reverse transcriptase, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1TKT
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318
Descriptor:Pol polyproteins [Reverse transcriptase], Chain A, Chain B, ...
Authors:Hopkins, A.L., Ren, J., Stuart, D.I., Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J.Med.Chem., 47, 2004
1TKX
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745
Descriptor:Pol polyprotein, Reverse transcriptase, Chain A, ...
Authors:Ren, J., Hopkins, A.L., Stuart, D.I., Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
J.Med.Chem., 47, 2004
1TKZ
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW429576
Descriptor:Pol polyprotein, Reverse transcriptase, Chain A, ...
Authors:Hopkins, A.L., Ren, J., Stuart, D.I., Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J.Med.Chem., 47, 2004
1TL1
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW451211
Descriptor:Pol polyprotein, Reverse transcriptase, Chain A, ...
Authors:Hopkins, A.L., Ren, J., Stuart, D.I., Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J.Med.Chem., 47, 2004
1TL3
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW450557
Descriptor:Pol polyprotein, Reverse transcriptase, Chain A, ...
Authors:Hopkins, A.L., Ren, J., Stuart, D.I., Stammers, D.K.
Deposit date:2004-06-09
Release date:2004-12-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J.Med.Chem., 47, 2004