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5MP7
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CRYSTAL STRUCTURE OF PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE FROM MYCOBACTERIUM SMEGMATIS
Descriptor:Ribose-phosphate pyrophosphokinase, ACETATE ION
Authors:Donini, S., Garavaglia, S., Ferraris, D.M., Miggiano, R., Mori, s., Shibayama, K., Rizzi, M.
Deposit date:2016-12-16
Release date:2017-04-26
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis.
PLoS ONE, 12, 2017
5HKF
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS H37RV OROTATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH 5-PHOSPHO-ALPHA-D-RIBOSYL 1-DIPHOSPHATE (PRPP)
Descriptor:Orotate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID
Authors:Donini, S., Ferraris, D.M., Bolognesi, G., Rizzi, M.
Deposit date:2016-01-14
Release date:2017-01-25
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.
Sci Rep, 7, 2017
5HKI
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS H37RV OROTATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH FE(III) DICITRATE
Descriptor:Orotate phosphoribosyltransferase, Iron(III) dicitrate
Authors:Donini, S., Ferraris, D.M., Bolognesi, G., Rizzi, M.
Deposit date:2016-01-14
Release date:2017-01-25
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.
Sci Rep, 7, 2017
5HKL
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS H37RV OROTATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH INORGANIC PHOSPHATE
Descriptor:Orotate phosphoribosyltransferase, PHOSPHATE ION
Authors:Donini, S., Bolognesi, G., Rizzi, M.
Deposit date:2016-01-14
Release date:2017-01-25
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.
Sci Rep, 7, 2017
6F6U
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN IN COMPLEX WITH GEBR-7B
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ZINC ION, ...
Authors:Prosdocimi, T., Donini, S., Parisini, E.
Deposit date:2017-12-06
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.828 Å)
Cite:Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry, 57, 2018
6F8R
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN IN COMPLEX WITH GEBR-54
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, (2~{S})-1-[3-(3-cyclopentyloxy-4-methoxy-phenyl)pyrazol-1-yl]-3-morpholin-4-yl-propan-2-ol, MAGNESIUM ION, ...
Authors:Prosdocimi, T., Donini, S., Parisini, E.
Deposit date:2017-12-13
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.826 Å)
Cite:Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry, 57, 2018
6F8T
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN IN COMPLEX WITH GEBR-4A
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Prosdocimi, T., Donini, S., Parisini, E.
Deposit date:2017-12-13
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry, 57, 2018
6F8U
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN IN COMPLEX WITH GEBR-20B
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Prosdocimi, T., Donini, S., Parisini, E.
Deposit date:2017-12-13
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry, 57, 2018
6F8V
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN IN COMPLEX WITH GEBR-18B
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Prosdocimi, T., Donini, S., Parisini, E.
Deposit date:2017-12-13
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry, 57, 2018
6F8W
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN IN COMPLEX WITH GEBR-18A
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Prosdocimi, T., Donini, S., Parisini, E.
Deposit date:2017-12-13
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry, 57, 2018
6F8X
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN IN COMPLEX WITH GEBR-26G
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Prosdocimi, T., Donini, S., Parisini, E.
Deposit date:2017-12-13
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry, 57, 2018
6FDC
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CRYSTAL STRUCTURE OF THE PDE4D CATALYTIC DOMAIN IN COMPLEX WITH GEBR-32A
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Prosdocimi, T., Donini, S., Parisini, E.
Deposit date:2017-12-22
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
Biochemistry, 57, 2018
4YBO
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STRUCTURE OF CITRATE SYNTHASE FROM THE THERMOACIDOPHILIC EURYARCHAEON THERMOLASMA ACIDOPHILUM
Descriptor:Citrate synthase, BICARBONATE ION
Authors:Murphy, J.R., Donini, S., Kappock, T.J.
Deposit date:2015-02-19
Release date:2015-09-02
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.179 Å)
Cite:An active site-tail interaction in the structure of hexahistidine-tagged Thermoplasma acidophilum citrate synthase.
Acta Crystallogr F Struct Biol Commun, 71, 2015
5OC2
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CRYSTAL STRUCTURE OF ASP295CYS/LYS303CYS AMADORIASE I MUTANT FROM ASPERGILLUS FUMIGATUS
Descriptor:Fructosyl amine:oxygen oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Rigoldi, F., Donini, S., Gautieri, A., Parisini, E.
Deposit date:2017-06-29
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Thermal stabilization of the deglycating enzyme Amadoriase I by rational design.
Sci Rep, 8, 2018
5OC3
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CRYSTAL STRUCTURE OF SER67CYS/PRO121CYS AMADORIASE I MUTANT FROM ASPERGILLUS FUMIGATUS
Descriptor:Fructosyl amine:oxygen oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Rigoldi, F., Donini, S., Gautieri, A., Parisini, E.
Deposit date:2017-06-29
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Thermal stabilization of the deglycating enzyme Amadoriase I by rational design.
Sci Rep, 8, 2018
5FHZ
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HUMAN ALDEHYDE DEHYDROGENASE 1A3 COMPLEXED WITH NAD(+) AND RETINOIC ACID
Descriptor:Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, RETINOIC ACID
Authors:Moretti, A., Rizzi, M., Garavaglia, S.
Deposit date:2015-12-22
Release date:2016-11-02
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid.
Sci Rep, 6, 2016
5J5R
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M. THERMORESISTIBLE GUAB2 DELTA-CBS IN COMPLEX WITH INHIBITOR VCC234718
Descriptor:Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, cyclohexyl{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}methanone, INOSINIC ACID
Authors:Pacitto, A., Ascher, D.B., Blundell, T.L.
Deposit date:2016-04-03
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.
ACS Infect Dis, 3, 2017
5K4X
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M. THERMORESISTIBLE IMPDH IN COMPLEX WITH IMP AND COMPOUND 1
Descriptor:Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, ~{N}-(2~{H}-indazol-6-yl)-3,5-dimethyl-1~{H}-pyrazole-4-sulfonamide, INOSINIC ACID
Authors:Pacitto, A., Ascher, D.B., Blundell, T.L.
Deposit date:2016-05-22
Release date:2016-10-19
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.
ACS Infect Dis, 3, 2017
5K4Z
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M. THERMORESISTIBLE IMPDH IN COMPLEX WITH IMP AND COMPOUND 6
Descriptor:Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, ~{N}-(4-fluorophenyl)-4-(2~{H}-indazol-6-ylsulfamoyl)-3,5-dimethyl-1~{H}-pyrrole-2-carboxamide
Authors:Pacitto, A., Ascher, D.B., Blundell, T.L.
Deposit date:2016-05-22
Release date:2016-10-19
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.
ACS Infect Dis, 3, 2017