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8YCM
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BU of 8ycm by Molmil
Monomeric Human STK19
Descriptor: Isoform 4 of Inactive serine/threonine-protein kinase 19, SULFATE ION
Authors:Li, J, Ma, X, Dong, Z.
Deposit date:2024-02-18
Release date:2024-03-06
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Monomeric human STK19
To Be Published
3KO1
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BU of 3ko1 by Molmil
Cystal structure of thermosome from Acidianus tengchongensis strain S5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperonin
Authors:Huo, Y, Zhang, K, Hu, Z, Wang, L, Zhai, Y, Zhou, Q, Lander, G, He, Y, Zhu, J, Xu, W, Dong, Z, Sun, F.
Deposit date:2009-11-12
Release date:2010-11-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of group II chaperonin in the open state.
Structure, 18, 2010
3KYS
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BU of 3kys by Molmil
Crystal structure of human YAP and TEAD complex
Descriptor: 65 kDa Yes-associated protein, Transcriptional enhancer factor TEF-1
Authors:Li, Z, Zhao, B, Wang, P, Chen, F, Dong, Z, Yang, H, Guan, K.L, Xu, Y.
Deposit date:2009-12-07
Release date:2010-02-23
Last modified:2020-10-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the YAP and TEAD complex
Genes Dev., 24, 2010
3V3V
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BU of 3v3v by Molmil
Structural and functional analysis of quercetagetin, a natural JNK1 inhibitor
Descriptor: 3,5,6,7-TETRAHYDROXY-2-(3,4-DIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, C-Jun-amino-terminal kinase-interacting protein 1, CHLORIDE ION, ...
Authors:Baek, S, Kang, N.J, Popowicz, G.M, Arciniega, M, Jung, S.K, Byun, S, Song, N.R, Heo, Y.S, Kim, B.Y, Lee, H.J, Holak, T.A, Augustin, M, Bode, A.M, Huber, R, Dong, Z, Lee, K.W.
Deposit date:2011-12-14
Release date:2012-12-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin.
J.Mol.Biol., 425, 2013
2QR8
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BU of 2qr8 by Molmil
2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)
Descriptor: Ribosomal protein S6 kinase alpha-3, SODIUM ION
Authors:Tereshko, V, Malakhova, M, Dong, Z.
Deposit date:2007-07-27
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nat.Struct.Mol.Biol., 15, 2008
2QR7
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BU of 2qr7 by Molmil
2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative
Descriptor: Ribosomal protein S6 kinase alpha-3, SODIUM ION
Authors:Malakhova, M, Tereshko, V, Dong, Z.
Deposit date:2007-07-27
Release date:2007-12-11
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nat.Struct.Mol.Biol., 15, 2008
4GUS
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BU of 4gus by Molmil
Crystal structure of LSD2-NPAC with H3 in space group P3221
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ...
Authors:Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
4GUR
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BU of 4gur by Molmil
Crystal structure of LSD2-NPAC with H3 in space group P21
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ...
Authors:Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
4GUT
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BU of 4gut by Molmil
Crystal structure of LSD2-NPAC
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1B, ...
Authors:Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
4GU1
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BU of 4gu1 by Molmil
Crystal structure of LSD2
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1B, ...
Authors:Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.939 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
4GUU
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BU of 4guu by Molmil
Crystal structure of LSD2-NPAC with tranylcypromine
Descriptor: Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, ZINC ION, ...
Authors:Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
3KN6
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BU of 3kn6 by Molmil
Crystal structure of the C-terminal kinase domain of MSK1
Descriptor: Ribosomal protein S6 kinase alpha-5
Authors:D'Angelo, I, Malakhova, M, Dong, Z.
Deposit date:2009-11-12
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
J.Mol.Biol., 399, 2010
3KN5
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BU of 3kn5 by Molmil
Crystal structure of the C-terminal kinase domain of msk1 in complex with AMP-PNP
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-5
Authors:D'Angelo, I, Malakhova, M, Dong, Z.
Deposit date:2009-11-12
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
J.Mol.Biol., 399, 2010
4GU0
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BU of 4gu0 by Molmil
Crystal structure of LSD2 with H3
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.3, Lysine-specific histone demethylase 1B, ...
Authors:Chen, F, Yang, H, Dong, Z, Fang, J, Zhu, T, Gong, W, Xu, Y.
Deposit date:2012-08-29
Release date:2013-02-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.103 Å)
Cite:Structural insight into substrate recognition by histone demethylase LSD2/KDM1b
Cell Res., 23, 2013
4HSU
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BU of 4hsu by Molmil
Crystal structure of LSD2-NPAC with H3(1-26)in space group P21
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3, Lysine-specific histone demethylase 1B, ...
Authors:Chen, F, Dong, Z, Fang, J, Xu, Y.
Deposit date:2012-10-30
Release date:2013-02-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.988 Å)
Cite:Structural insight into substrate recognition by histone demethylase LSD2/KDM1b.
Cell Res., 23, 2013
3OOB
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BU of 3oob by Molmil
Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate
Descriptor: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
Authors:Urusova, D.V, Shim, J.-H, Kim, D.-J, Jung, S.K, Zykova, T.A, Bode, A.M, Dong, Z.
Deposit date:2010-08-30
Release date:2011-08-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1.
Cancer Prev Res (Phila), 4, 2011
6WLG
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BU of 6wlg by Molmil
Ints3 C-terminal Domain
Descriptor: Integrator complex subunit 3
Authors:Li, J, Ma, X.L, Banerjee, S, Dong, Z.G.
Deposit date:2020-04-20
Release date:2020-12-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.111 Å)
Cite:Structural basis for multifunctional roles of human Ints3 C-terminal domain.
J.Biol.Chem., 296, 2020
6WQX
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BU of 6wqx by Molmil
Human PRPK-TPRKB complex
Descriptor: EKC/KEOPS complex subunit TP53RK, EKC/KEOPS complex subunit TPRKB, MAGNESIUM ION, ...
Authors:Li, J, Ma, X.L, Banerjee, S, Dong, Z.G.
Deposit date:2020-04-29
Release date:2021-02-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal structure of the human PRPK-TPRKB complex.
Commun Biol, 4, 2021
4ZXT
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BU of 4zxt by Molmil
Complex of ERK2 with catechol
Descriptor: AMMONIUM ION, CATECHOL, Mitogen-activated protein kinase 1, ...
Authors:Kurinov, I, Malakhova, M.
Deposit date:2015-05-20
Release date:2016-05-25
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer.
Oncotarget, 7, 2016
6SLG
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BU of 6slg by Molmil
HUMAN ERK2 WITH ERK1/2 INHIBITOR, AZD0364.
Descriptor: (6~{R})-7-[[3,4-bis(fluoranyl)phenyl]methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one, 1,2-ETHANEDIOL, ERK-tide, ...
Authors:Breed, J, Phillips, C.
Deposit date:2019-08-19
Release date:2019-11-20
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).
J.Med.Chem., 62, 2019
4N0S
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BU of 4n0s by Molmil
Complex of ERK2 with caffeic acid
Descriptor: CAFFEIC ACID, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Kurinov, I, Malakhova, M.
Deposit date:2013-10-02
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7992 Å)
Cite:Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis.
Cancer Prev Res (Phila), 7, 2014
8BI2
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BU of 8bi2 by Molmil
Syk kinase domain in complex with macrocyclic inhibitor 20a
Descriptor: 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one, Tyrosine-protein kinase SYK
Authors:Read, J.A, Patel, J.
Deposit date:2022-11-01
Release date:2023-06-14
Last modified:2023-06-21
Method:X-RAY DIFFRACTION (1.508 Å)
Cite:Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorg.Med.Chem.Lett., 91, 2023
5KUE
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BU of 5kue by Molmil
Human SeMet incorporated I141M/L146M mitochondrial calcium uniporter (residues 72-189) crystal structure with magnesium
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Calcium uniporter protein, ...
Authors:Mok, C.Y.M, Lee, S.K, Junop, M.S, Stathopulos, P.B.
Deposit date:2016-07-13
Release date:2016-09-07
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations.
Cell Chem Biol, 23, 2016
5KUI
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BU of 5kui by Molmil
Human mitochondrial calcium uniporter (residues 72-189) crystal structure with calcium.
Descriptor: Calcium uniporter protein, mitochondrial
Authors:Mok, M.C.Y, Lee, S.K, Junop, M.S, Stathopulos, P.B.
Deposit date:2016-07-13
Release date:2016-09-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations.
Cell Chem Biol, 23, 2016
5KUJ
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BU of 5kuj by Molmil
Human mitochondrial calcium uniporter (residues 72-189) crystal structure with magnesium.
Descriptor: Calcium uniporter protein, mitochondrial, MAGNESIUM ION
Authors:Mok, M.C.Y, Lee, S.K, Junop, M.S, Stathopulos, P.B.
Deposit date:2016-07-13
Release date:2016-09-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations.
Cell Chem Biol, 23, 2016

 

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