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3KO1
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CYSTAL STRUCTURE OF THERMOSOME FROM ACIDIANUS TENGCHONGENSIS STRAIN S5
Descriptor:Chaperonin, ADENOSINE-5'-DIPHOSPHATE
Authors:Huo, Y., Zhang, K., Hu, Z., Wang, L., Zhai, Y., Zhou, Q., Lander, G., He, Y., Zhu, J., Xu, W., Dong, Z., Sun, F.
Deposit date:2009-11-12
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of group II chaperonin in the open state.
Structure, 18, 2010
3KYS
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CRYSTAL STRUCTURE OF HUMAN YAP AND TEAD COMPLEX
Descriptor:Transcriptional enhancer factor TEF-1, 65 kDa Yes-associated protein, BETA-MERCAPTOETHANOL
Authors:Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K.L., Xu, Y.
Deposit date:2009-12-07
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the YAP and TEAD complex
Genes Dev., 24, 2010
4GU1
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CRYSTAL STRUCTURE OF LSD2
Descriptor:Lysine-specific histone demethylase 1B, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ...
Authors:Chen, F., Dong, Z., Fang, J., Yang, Y., Li, Z., Xu, Y., Yang, H., Wang, P., Fang, R., Shi, Y., Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.939 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
4GUR
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CRYSTAL STRUCTURE OF LSD2-NPAC WITH H3 IN SPACE GROUP P21
Descriptor:Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, Histone H3.3, ...
Authors:Chen, F., Dong, Z., Fang, J., Yang, Y., Li, Z., Xu, Y., Yang, H., Wang, P., Fang, R., Shi, Y., Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
4GUS
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CRYSTAL STRUCTURE OF LSD2-NPAC WITH H3 IN SPACE GROUP P3221
Descriptor:Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, Histone H3.3, ...
Authors:Chen, F., Dong, Z., Fang, J., Yang, Y., Li, Z., Xu, Y., Yang, H., Wang, P., Fang, R., Shi, Y., Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
4GUT
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CRYSTAL STRUCTURE OF LSD2-NPAC
Descriptor:Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Chen, F., Dong, Z., Fang, J., Yang, Y., Li, Z., Xu, Y., Yang, H., Wang, P., Fang, R., Shi, Y., Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
4GUU
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CRYSTAL STRUCTURE OF LSD2-NPAC WITH TRANYLCYPROMINE
Descriptor:Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(3R,3aS,7aR)-10,11-dimethyl-1,4,6-trioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate, ...
Authors:Chen, F., Dong, Z., Fang, J., Yang, Y., Li, Z., Xu, Y., Yang, H., Wang, P., Xu, Y.
Deposit date:2012-08-29
Release date:2013-01-16
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
4GU0
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CRYSTAL STRUCTURE OF LSD2 WITH H3
Descriptor:Lysine-specific histone demethylase 1B, Histone H3.3, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Chen, F., Yang, H., Dong, Z., Fang, J., Zhu, T., Gong, W., Xu, Y.
Deposit date:2012-08-29
Release date:2013-02-13
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (3.103 Å)
Cite:Structural insight into substrate recognition by histone demethylase LSD2/KDM1b
Cell Res., 23, 2013
4HSU
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CRYSTAL STRUCTURE OF LSD2-NPAC WITH H3(1-26)IN SPACE GROUP P21
Descriptor:Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, Histone H3, ...
Authors:Chen, F., Dong, Z., Fang, J., Xu, Y.
Deposit date:2012-10-30
Release date:2013-02-13
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.988 Å)
Cite:Structural insight into substrate recognition by histone demethylase LSD2/KDM1b.
Cell Res., 23, 2013
2QR7
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2.0A X-RAY STRUCTURE OF C-TERMINAL KINASE DOMAIN OF P90 RIBOSOMAL S6 KINASE 2: SE-MET DERIVATIVE
Descriptor:Ribosomal protein S6 kinase alpha-3, SODIUM ION
Authors:Malakhova, M., Tereshko, V., Dong, Z.
Deposit date:2007-07-27
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nat.Struct.Mol.Biol., 15, 2008
2QR8
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2.0A X-RAY STRUCTURE OF C-TERMINAL KINASE DOMAIN OF P90 RIBOSOMAL S6 KINASE 2 (RSK2)
Descriptor:Ribosomal protein S6 kinase alpha-3, SODIUM ION
Authors:Tereshko, V., Malakhova, M., Dong, Z.
Deposit date:2007-07-27
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nat.Struct.Mol.Biol., 15, 2008
3KN5
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CRYSTAL STRUCTURE OF THE C-TERMINAL KINASE DOMAIN OF MSK1 IN COMPLEX WITH AMP-PNP
Descriptor:Ribosomal protein S6 kinase alpha-5, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:D'Angelo, I., Malakhova, M., Dong, Z.
Deposit date:2009-11-12
Release date:2010-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
J.Mol.Biol., 399, 2010
3KN6
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CRYSTAL STRUCTURE OF THE C-TERMINAL KINASE DOMAIN OF MSK1
Descriptor:Ribosomal protein S6 kinase alpha-5
Authors:D'Angelo, I., Malakhova, M., Dong, Z.
Deposit date:2009-11-12
Release date:2010-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
J.Mol.Biol., 399, 2010
3OOB
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STRUCTURAL AND FUNCTIONAL INSIGHTS OF DIRECTLY TARGETING PIN1 BY EPIGALLOCATECHIN-3-GALLATE
Descriptor:Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Urusova, D.V., Shim, J.-H., Kim, D.-J., Jung, S.K., Zykova, T.A., Bode, A.M., Dong, Z.
Deposit date:2010-08-30
Release date:2011-08-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1.
Cancer Prev Res (Phila), 4, 2011
3V3V
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF QUERCETAGETIN, A NATURAL JNK1 INHIBITOR
Descriptor:Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, 3,5,6,7-TETRAHYDROXY-2-(3,4-DIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, ...
Authors:Baek, S., Kang, N.J., Popowicz, G.M., Arciniega, M., Jung, S.K., Byun, S., Song, N.R., Heo, Y.S., Kim, B.Y., Lee, H.J., Holak, T.A., Augustin, M., Bode, A.M., Huber, R., Dong, Z., Lee, K.W.
Deposit date:2011-12-14
Release date:2012-12-05
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin.
J.Mol.Biol., 425, 2013
4N0S
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COMPLEX OF ERK2 WITH CAFFEIC ACID
Descriptor:Mitogen-activated protein kinase 1, CAFFEIC ACID, SULFATE ION, ...
Authors:Kurinov, I., Malakhova, M.
Deposit date:2013-10-02
Release date:2014-08-27
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.7992 Å)
Cite:Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis.
Cancer Prev Res (Phila), 7, 2014
4ZXT
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COMPLEX OF ERK2 WITH CATECHOL
Descriptor:Mitogen-activated protein kinase 1, CATECHOL, SULFATE ION, ...
Authors:Kurinov, I., Malakhova, M.
Deposit date:2015-05-20
Release date:2016-05-25
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer.
Oncotarget, 7, 2016
3J1B
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CRYO-EM STRUCTURE OF 8-FOLD SYMMETRIC RATCPN-ALPHA IN APO STATE
Descriptor:Chaperonin alpha subunit
Authors:Zhang, K., Wang, L., Liu, Y.X., Wang, X., Gao, B., Hu, Z.J., Ji, G., Chan, K.Y., Schulten, K., Dong, Z.Y., Sun, F.
Deposit date:2012-02-06
Release date:2013-08-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Flexible interwoven termini determine the thermal stability of thermosomes.
Protein Cell, 4, 2013
3J1C
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CRYO-EM STRUCTURE OF 9-FOLD SYMMETRIC RATCPN-ALPHA IN APO STATE
Descriptor:Chaperonin alpha subunit
Authors:Zhang, K., Wang, L., Liu, Y.X., Wang, X., Gao, B., Hu, Z.J., Ji, G., Chan, K.Y., Schulten, K., Dong, Z.Y., Sun, F.
Deposit date:2012-02-06
Release date:2013-08-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:Flexible interwoven termini determine the thermal stability of thermosomes.
Protein Cell, 4, 2013
3J1E
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CRYO-EM STRUCTURE OF 9-FOLD SYMMETRIC RATCPN-BETA IN APO STATE
Descriptor:Chaperonin beta subunit
Authors:Zhang, K., Wang, L., Liu, Y.X., Wang, X., Gao, B., Hu, Z.J., Ji, G., Chan, K.Y., Schulten, K., Dong, Z.Y., Sun, F.
Deposit date:2012-02-06
Release date:2013-08-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (8.3 Å)
Cite:Flexible interwoven termini determine the thermal stability of thermosomes.
Protein Cell, 4, 2013
3J1F
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CRYO-EM STRUCTURE OF 9-FOLD SYMMETRIC RATCPN-BETA IN ATP-BINDING STATE
Descriptor:Chaperonin beta subunit, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Zhang, K., Wang, L., Liu, Y.X., Wang, X., Gao, B., Hu, Z.J., Ji, G., Chan, K.Y., Schulten, K., Dong, Z.Y., Sun, F.
Deposit date:2012-02-06
Release date:2013-08-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Flexible interwoven termini determine the thermal stability of thermosomes.
Protein Cell, 4, 2013
4NXL
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DIBENZOTHIOPHENE MONOOXYGENASE (DSZC) FROM RHODOCOCCUS ERYTHROPOLIS
Descriptor:DszC
Authors:Zhang, L., Duan, X., Li, X., Rao, Z.
Deposit date:2013-12-09
Release date:2014-07-23
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the stabilization of active, tetrameric DszC by its C-terminus.
Proteins, 82, 2014
5TP0
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HUMAN MESOTRYPSIN IN COMPLEX WITH DIMINAZENE
Descriptor:Trypsin-3, CALCIUM ION, SULFATE ION, ...
Authors:Kayode, O., Soares, A., Radisky, E.S.
Deposit date:2016-10-19
Release date:2017-05-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Small molecule inhibitors of mesotrypsin from a structure-based docking screen.
PLoS ONE, 12, 2017
3G51
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STRUCTURAL DIVERSITY OF THE ACTIVE CONFORMATION OF THE N-TERMINAL KINASE DOMAIN OF P90 RIBOSOMAL S6 KINASE 2
Descriptor:Ribosomal protein S6 kinase alpha-3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Kurinov, I.
Deposit date:2009-02-04
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2
Plos One, 4, 2009
3SA0
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COMPLEX OF ERK2 WITH NORATHYRIOL
Descriptor:Mitogen-activated protein kinase 1, norathyriol, SULFATE ION
Authors:Kurinov, I., Malakhova, M.
Deposit date:2011-06-02
Release date:2011-12-14
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.5947 Å)
Cite:Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases.
Cancer Res., 72, 2012
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