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5O8I
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BU of 5o8i by Molmil
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) crystallized at P212121 space group, and refined to 1.27 A
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Seda, A, Nawrot, B.C.
Deposit date:2017-06-13
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Differences in crystal packing as the key factor for stabilization of the N-terminal fragment of hHINT1 protein
To Be Published
8CLM
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BU of 8clm by Molmil
1.80 A crystal structure of RNA/2'-O-methyl-RNA heteroduplex
Descriptor: POTASSIUM ION, RNA (5'-R(*(UZL)*(OMU)P*(A2M)P*(OMG)P*(OMG)P*(A2M)P*(OMG)P*(A2M)P*(OMC)P*)-3'), RNA (5'-R(*G*UP*CP*UP*CP*CP*UP*AP*GP*)-3'), ...
Authors:Dolot, R.M, Maciaszek, A, Nawrot, B.C.
Deposit date:2023-02-16
Release date:2023-03-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of RNA/2'-O-methyl-RNA heteroduplex
To Be Published
8OFD
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BU of 8ofd by Molmil
Crystal structure of beta-conglutin from Lupinus albus refined to 2.81 A
Descriptor: ACETATE ION, Conglutin beta 1, POTASSIUM ION, ...
Authors:Dolot, R.M, O'Sullivan, C.K, Jauset-Rubio, M.
Deposit date:2023-03-15
Release date:2023-06-14
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:First crystal structure of beta-conglutin, a major lupin allergen from Lupinus albus seeds
To Be Published
6G9Z
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BU of 6g9z by Molmil
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) crystallized at P212121 space group, with visible extended fragment of N-terminus
Descriptor: (2S)-2-hydroxybutanedioic acid, Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Seda, A, Nawrot, B.C.
Deposit date:2018-04-11
Release date:2018-04-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Differences in crystal packing as the key factor for stabilization of the N-terminal fragment of hHINT1 protein
To Be Published
8CKS
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BU of 8cks by Molmil
Crystal structure of Human Serum Albumin in complex with FESAN
Descriptor: 3,3'-commo-bis(1,2-dicarba-3-ferra-closo-dodecaborane), DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Dolot, R.M, Kaniowski, D, Ebenryter-Olbinska, K, Szczupak, P, Suwara, J, Nawrot, B.C.
Deposit date:2023-02-16
Release date:2023-03-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Human Serum Albumin in complex with FESAN
To Be Published
7Q2U
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BU of 7q2u by Molmil
The crystal structure of the HINT1 Q62A mutant.
Descriptor: CACODYLATE ION, HEXAETHYLENE GLYCOL, Histidine triad nucleotide-binding protein 1, ...
Authors:Dolot, R.M, Strom, A.M, Wagner, C.R.
Deposit date:2021-10-26
Release date:2021-11-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Dynamic Long-Range Interactions Influence Substrate Binding and Catalysis by Human Histidine Triad Nucleotide-Binding Proteins (HINTs), Key Regulators of Multiple Cellular Processes and Activators of Antiviral ProTides.
Biochemistry, 61, 2022
3TW2
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BU of 3tw2 by Molmil
High resolution structure of human histidine triad nucleotide-binding protein 1 (hHINT1)/AMP complex in a monoclinic space group
Descriptor: ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Wlodarczyk, A, Ozga, M, Krakowiak, A, Nawrot, B.
Deposit date:2011-09-21
Release date:2011-11-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 A resolution.
Acta Crystallogr.,Sect.F, 68, 2012
7OW0
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BU of 7ow0 by Molmil
1.55 A crystal structure of DNA/2'-O-methyl-RNA heteroduplex with overhangs solved by Zn-SAD.
Descriptor: DNA (5'-D(*TP*CP*TP*CP*CP*TP*AP*GP*G)-3'), RNA (5'-R(*(OMC)P*(OMU)P*(A2M)P*(OMG)P*(OMG)P*(A2M)P*(OMG)P*(A2M)P*(OMC))-3'), ZINC ION
Authors:Dolot, R.M, Maciaszek, A, Nawrot, B.C.
Deposit date:2021-06-15
Release date:2021-07-14
Last modified:2022-06-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:First High-Resolution Crystal Structures of DNA:2'-O-Methyl-RNA Heteroduplexes
Crystals, 2022
7OXS
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BU of 7oxs by Molmil
1.91 A crystal structure of DNA/2'-O-methyl-RNA heteroduplex
Descriptor: DNA (5'-D(*GP*TP*CP*TP*CP*CP*TP*AP*G)-3'), RNA (5'-R(*(OMC)P*(OMU)P*(A2M)P*(OMG)P*(OMG)P*(A2M)P*(OMG)P*(A2M)P*(OMC))-3'), SULFATE ION
Authors:Dolot, R.M, Maciaszek, A, Nawrot, B.C.
Deposit date:2021-06-23
Release date:2021-07-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:First High-Resolution Crystal Structures of DNA:2'-O-Methyl-RNA Heteroduplexes
Crystals, 2022
4ZKV
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BU of 4zkv by Molmil
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) refined to 1.92A at P21 space group
Descriptor: Histidine triad nucleotide-binding protein 1, SULFATE ION
Authors:Dolot, R.M, Seda, A, Nawrot, B.
Deposit date:2015-04-30
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
Int.J.Biol.Macromol., 87, 2016
4ZKL
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BU of 4zkl by Molmil
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog)
Descriptor: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[2-[[(2S)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-sulfanyl-phosphoryl]oxyethyl]oxolane-3,4-diol, ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Kaczmarek, R, Seda, A, Krakowiak, A, Baraniak, J, Nawrot, B.
Deposit date:2015-04-30
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
Int.J.Biol.Macromol., 87, 2016
6EO6
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BU of 6eo6 by Molmil
X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(2-(1H-indol-3-yl)acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, GA63A - TBA MODIFIED APTAMER, ...
Authors:Dolot, R.M, Nawrot, B, Yang, X.
Deposit date:2017-10-09
Release date:2017-10-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Nucleic Acids Res., 46, 2018
6EO7
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BU of 6eo7 by Molmil
X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, GA68B2 - MODIFIED HUMAN THROMBIN BINDING APTAMER, ...
Authors:Dolot, R.M, Nawrot, B, Yang, X.
Deposit date:2017-10-09
Release date:2017-10-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Nucleic Acids Res., 46, 2018
8PA9
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BU of 8pa9 by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl N2-methyl-2-aminoethenoadenosine
Descriptor: 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl N2-methyl-2-aminoethenoadenosine, Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Dillenburg, M, Wagner, C.R.
Deposit date:2023-06-07
Release date:2023-06-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Novel inhibitors for hHINT1 protein
To Be Published
8PAI
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BU of 8pai by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] N2-methyl-2-aminoethenoadenosine
Descriptor: 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] N2-methyl-2-aminoethenoadenosine, Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Dillenburg, M, Wagner, C.R.
Deposit date:2023-06-07
Release date:2023-06-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Novel inhibitors for hHINT1 protein
To Be Published
8PA6
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BU of 8pa6 by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl 2-aminoethenoadenosine
Descriptor: 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl 2-aminoethenoadenosine, Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Dillenburg, M, Wagner, C.R.
Deposit date:2023-06-07
Release date:2023-06-14
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Novel inhibitors for hHINT1 protein
To Be Published
8P8P
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BU of 8p8p by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl Ethenoadenosine
Descriptor: Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-imidazo[2,1-f]purin-3-yl-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[2-(1~{H}-indol-3-yl)ethyl]carbamate
Authors:Dolot, R.M, Dillenburg, M, Wagner, C.R.
Deposit date:2023-06-02
Release date:2023-06-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Novel inhibitors for hHINT1 protein
To Be Published
8PAF
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BU of 8paf by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] 2-aminoethenoadenosine
Descriptor: 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] 2-aminoethenoadenosine, Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Dillenburg, M, Wagner, C.R.
Deposit date:2023-06-07
Release date:2023-06-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel inhibitors for hHINT1 protein
To Be Published
3O1C
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BU of 3o1c by Molmil
High resolution crystal structure of histidine triad nucleotide-binding protein 1 (Hint1) C38A mutant from rabbit complexed with Adenosine
Descriptor: ADENOSINE, Histidine triad nucleotide-binding protein 1, SODIUM ION
Authors:Dolot, R.M, Ozga, M, Krakowiak, A.K, Nawrot, B, Stec, W.J.
Deposit date:2010-07-21
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Histidine Triad Nucleotide-binding Protein 1 (HINT-1) Phosphoramidase Transforms Nucleoside 5'-O-Phosphorothioates to Nucleoside 5'-O-Phosphates.
J.Biol.Chem., 285, 2010
3O1X
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BU of 3o1x by Molmil
High resolution crystal structure of histidine triad nucleotide-binding protein 1 (Hint1) C84A mutant from rabbit complexed with adenosine
Descriptor: ADENOSINE, Histidine triad nucleotide-binding protein 1, SODIUM ION
Authors:Dolot, R.M, Ozga, M, Krakowiak, A.K, Nawrot, B, Stec, W.J.
Deposit date:2010-07-22
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Histidine Triad Nucleotide-binding Protein 1 (HINT-1) Phosphoramidase Transforms Nucleoside 5'-O-Phosphorothioates to Nucleoside 5'-O-Phosphates.
J.Biol.Chem., 285, 2010
3O1Z
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BU of 3o1z by Molmil
High resolution crystal structure of histidine triad nucleotide-binding protein 1 (Hint1) double cysteine mutant from rabbit
Descriptor: Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Ozga, M, Krakowiak, A.K, Nawrot, B, Stec, W.J.
Deposit date:2010-07-22
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Histidine Triad Nucleotide-binding Protein 1 (HINT-1) Phosphoramidase Transforms Nucleoside 5'-O-Phosphorothioates to Nucleoside 5'-O-Phosphates.
J.Biol.Chem., 285, 2010
3QGZ
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BU of 3qgz by Molmil
Re-investigated high resolution crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from rabbit complexed with adenosine
Descriptor: ADENOSINE, Histidine triad nucleotide-binding protein 1
Authors:Dolot, R.M, Ozga, M, Krakowiak, A, Nawrot, B, Stec, W.J.
Deposit date:2011-01-25
Release date:2011-02-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:High-resolution X-ray crystal structure of rabbit histidine triad nucleotide-binding protein 1 (rHINT1) - adenosine complex at 1.10A resolution
Acta Crystallogr.,Sect.D, 67, 2011

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