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1HGA
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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
Descriptor:HEMOGLOBIN (DEOXY) (ALPHA CHAIN), HEMOGLOBIN (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE
Authors:Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., Dodson, G.
Deposit date:1991-10-31
Release date:1994-01-31
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin.
J.Mol.Biol., 228, 1992
1HGB
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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
Descriptor:HEMOGLOBIN (AQUO MET) (ALPHA CHAIN), HEMOGLOBIN (AQUO MET) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE
Authors:Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., Dodson, G.
Deposit date:1991-10-31
Release date:1994-01-31
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin.
J.Mol.Biol., 228, 1992
1HGC
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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
Descriptor:HEMOGLOBIN (OXY) (ALPHA CHAIN), HEMOGLOBIN (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., Dodson, G.
Deposit date:1991-10-31
Release date:1994-01-31
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin.
J.Mol.Biol., 228, 1992
2V25
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STRUCTURE OF THE CAMPYLOBACTER JEJUNI ANTIGEN PEB1A, AN ASPARTATE AND GLUTAMATE RECEPTOR WITH BOUND ASPARTATE
Descriptor:MAJOR CELL-BINDING FACTOR, ASPARTIC ACID, ZINC ION
Authors:Muller, A., Dodson, E., del Rocio Leon-Kempis, M., Kelly, D.J., Wilkinson, A.J., Wilson, K.S.
Deposit date:2007-06-01
Release date:2007-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:A Bacterial Virulence Factor with a Dual Role as an Adhesin and a Solute Binding-Protein: The Crystal Structure at 1.5 A Resolution of the Peb1A Protein from the Food-Borne Human Pathogen Campylobacter Jejuni
J.Mol.Biol., 372, 2007
2WV7
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INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII
Descriptor:INTRACELLULAR SUBTILISIN PROTEASE, SODIUM ION
Authors:Vevodova, J., Gamble, M., Ariza, A., Dodson, E., Jones, D.D., Wilson, K.S.
Deposit date:2009-10-15
Release date:2010-09-08
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to This Subtilisin Family.
Structure, 18, 2010
2WWT
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INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII
Descriptor:INTRACELLULAR SUBTILISIN PROTEASE, SODIUM ION
Authors:Vevodova, J., Gamble, M., Ariza, A., Dodson, E., Jones, D.D., Wilson, K.S.
Deposit date:2009-10-27
Release date:2010-09-08
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to This Subtilisin Family.
Structure, 18, 2010
2X8J
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INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII
Descriptor:INTRACELLULAR SUBTILISIN PROTEASE, SODIUM ION, PENTAETHYLENE GLYCOL, ...
Authors:Vedodova, J., Gamble, M., Ariza, A., Dodson, E., Jones, D.D., Wilson, K.S.
Deposit date:2010-03-09
Release date:2010-08-11
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal structure of an intracellular subtilisin reveals novel structural features unique to this subtilisin family.
Structure, 18, 2010
3K3W
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THERMOSTABLE PENICILLIN G ACYLASE FROM ALCALIGENES FAECALIS IN ORTHORHOMBIC FORM
Descriptor:Penicillin G acylase, CALCIUM ION
Authors:Varshney, N.K., Kumar, R.S., Ignatova, Z., Dodson, E., Suresh, C.G.
Deposit date:2009-10-05
Release date:2009-11-10
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystallization and X-ray structure analysis of a thermostable penicillin G acylase from Alcaligenes faecalis
Acta Crystallogr.,Sect.F, 68, 2012
3ML0
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THERMOSTABLE PENICILLIN G ACYLASE FROM ALCALIGENES FAECALIS IN TETRAGONAL FORM
Descriptor:Penicillin G acylase, alpha subunit, beta subunit, ...
Authors:Varshney, N.K., Kumar, R.S., Ignatova, Z., Dodson, E., Suresh, C.G.
Deposit date:2010-04-16
Release date:2010-05-05
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystallization and X-ray structure analysis of a thermostable penicillin G acylase from Alcaligenes faecalis
Acta Crystallogr.,Sect.F, 68, 2012
1ZNI
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INSULIN
Descriptor:INSULIN, ZINC ION, CHLORIDE ION
Authors:Turkenburg, M.G.W., Whittingham, J.L., Dodson, G.G., Dodson, E.J., Xiao, B., Bentley, G.A.
Deposit date:1997-09-23
Release date:1998-01-28
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.498 Å)
Cite:Structure of insulin in 4-zinc insulin.
Nature, 261, 1976
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
7INS
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STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z
Descriptor:INSULIN (CHAIN A), INSULIN (CHAIN B), GENERAL PROTAMINE CHAIN, ...
Authors:Balschmidt, P., Hansen, F.B., Dodson, E., Dodson, G., Korber, F.
Deposit date:1991-09-03
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of porcine insulin cocrystallized with clupeine Z.
Acta Crystallogr.,Sect.B, 47, 1991
2INS
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THE STRUCTURE OF DES-PHE B1 BOVINE INSULIN
Descriptor:DES-PHE B1 INSULIN (CHAIN A), DES-PHE B1 INSULIN (CHAIN B), ZINC ION
Authors:Smith, G.D., Duax, W.L., Dodson, E.J., Dodson, G.G., Degraaf, R.A.G., Reynolds, C.D.
Deposit date:1982-05-10
Release date:1982-08-05
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structure of Des-Phe B1 Bovine Insulin
Acta Crystallogr.,Sect.B, 38, 1982
4INS
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THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION
Descriptor:INSULIN (CHAIN A), INSULIN (CHAIN B), ZINC ION
Authors:Dodson, G.G., Dodson, E.J., Hodgkin, D.C., Isaacs, N.W., Vijayan, M.
Deposit date:1989-07-10
Release date:1990-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure of 2Zn pig insulin crystals at 1.5 A resolution.
Philos.Trans.R.Soc.London,Ser.B, 319, 1988
1TGL
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A SERINE PROTEASE TRIAD FORMS THE CATALYTIC CENTRE OF A TRIACYLGLYCEROL LIPASE
Descriptor:TRIACYL-GLYCEROL ACYLHYDROLASE
Authors:Brady, L., Brzozowski, A.M., Derewenda, Z.S., Dodson, E.J., Dodson, G.G., Tolley, S.P., Turkenburg, J.P., Christiansen, L., Huge-Jensen, B., Norskov, L., Thim, L.
Deposit date:1990-02-05
Release date:1990-10-15
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A serine protease triad forms the catalytic centre of a triacylglycerol lipase.
Nature, 343, 1990
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3TGL
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STRUCTURE AND MOLECULAR MODEL REFINEMENT OF RHIZOMUCOR MIEHEI TRIACYLGLYCERIDE LIPASE: A CASE STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT
Descriptor:TRIACYL-GLYCEROL ACYLHYDROLASE
Authors:Brady, L., Brzozowski, A.M., Derewenda, Z.S., Dodson, E.J., Dodson, G.G., Tolley, S.P., Turkenburg, J.P., Christiansen, L., Huge-Jensen, B., Norskov, L., Thim, L.
Deposit date:1991-07-29
Release date:1993-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:STRUCTURE AND MOLECULAR-MODEL REFINEMENT OF RHIZOMUCOR-MIEHEI TRIACYLGLYCERIDE LIPASE - A CASE-STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT.
Acta Crystallogr.,Sect.B, 48, 1992
1G7A
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1.2 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K
Descriptor:INSULIN A-CHAIN, INSULIN B-CHAIN, ZINC ION, ...
Authors:Smith, G.D., Pangborn, W.A., Blessing, R.H.
Deposit date:2000-11-09
Release date:2001-08-03
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced?
Acta Crystallogr.,Sect.D, 57, 2001
1G7B
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1.3 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K
Descriptor:INSULIN A-CHAIN, INSULIN B-CHAIN, ZINC ION, ...
Authors:Smith, G.D., Pangborn, W.A., Blessing, R.H.
Deposit date:2000-11-09
Release date:2001-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced?
Acta Crystallogr.,Sect.D, 57, 2001
3BXQ
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THE STRUCTURE OF A MUTANT INSULIN UNCOUPLES RECEPTOR BINDING FROM PROTEIN ALLOSTERY. AN ELECTROSTATIC BLOCK TO THE TR TRANSITION
Descriptor:insulin A chain, insulin B chain, ZINC ION
Authors:Wan, Z.L., Huang, K., Hu, S.Q., Whittaker, J., Weiss, M.A.
Deposit date:2008-01-14
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
3GKY
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THE STRUCTURAL BASIS OF AN ER STRESS-ASSOCIATED BOTTLENECK IN A PROTEIN FOLDING LANDSCAPE
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Liu, M., Wan, Z.L., Chu, Y.C., Alddin, H., Klaproth, B., Weiss, M.A.
Deposit date:2009-03-11
Release date:2009-03-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
3KQ6
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ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
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