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2FSL
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MITOGEN ACTIVATED PROTEIN KINASE P38ALPHA (D176A+F327S) ACTIVATING MUTANT FORM-A
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Livnah, O.
Deposit date:2006-01-23
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2FSM
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MITOGEN ACTIVATED PROTEIN KINASE P38ALPHA (D176A+F327S) ACTIVATING MUTANT FORM-B
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Livnah, O.
Deposit date:2006-01-23
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2FSO
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MITOGEN ACTIVATED PROTEIN KINASE P38ALPHA (D176A) ACTIVATING MUTANT
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Livnah, O.
Deposit date:2006-01-23
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2FST
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MITOGEN ACTIVATED PROTEIN KINASE P38ALPHA (D176A+F327L) ACTIVATING MUTANT
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Livnah, O.
Deposit date:2006-01-23
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2NPQ
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A NOVEL LIPID BINDING SITE IN THE P38 ALPHA MAP KINASE
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Engelberg, D., Livnah, O.
Deposit date:2006-10-29
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel lipid binding site formed by the MAP kinase insert in p38 alpha.
J.Mol.Biol., 375, 2008
3LMJ
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STRUCTURE OF HUMAN ANTI HIV 21C FAB
Descriptor:Heavy chain of anti HIV Fab from human 21c antibody, Light chain of anti HIV Fab from human 21c antibody, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Diskin, R., Marcovecchio, P.M., Bjorkman, P.J.
Deposit date:2010-01-30
Release date:2010-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.
Nat.Struct.Mol.Biol., 17, 2010
3LQA
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CRYSTAL STRUCTURE OF CLADE C GP120 IN COMPLEX WITH SCD4 AND 21C FAB
Descriptor:T-cell surface glycoprotein CD4, Envelope glycoprotein gp160, Heavy chain of anti HIV Fab from human 21c antibody, ...
Authors:Diskin, R., Marcovecchio, P.M., Bjorkman, P.J.
Deposit date:2010-02-08
Release date:2010-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.
Nat.Struct.Mol.Biol., 17, 2010
3U7W
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CRYSTAL STRUCTURE OF NIH45-46 FAB
Descriptor:Heavy chain, Ig gamma-1 chain C region, Light chain, ...
Authors:Diskin, R., Bjorkman, P.J.
Deposit date:2011-10-14
Release date:2011-11-16
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design.
Science, 334, 2011
3U7Y
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STRUCTURE OF NIH45-46 FAB IN COMPLEX WITH GP120 OF 93TH057 HIV
Descriptor:NIH45-46 heavy chain, Ig gamma-1 chain C region, Envelope glycoprotein gp160, ...
Authors:Diskin, R., Bjorkman, P.J.
Deposit date:2011-10-14
Release date:2011-11-16
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.4478 Å)
Cite:Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design.
Science, 334, 2011
4JKP
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RESTRICTING HIV-1 PATHWAYS FOR ESCAPE USING RATIONALLY-DESIGNED ANTI-HIV-1 ANTIBODIES
Descriptor:gp120, Heavy chain of antibody 45-46M2, Light chain of antibody 45-46M2, ...
Authors:Diskin, R., Bjorkman, P.J.
Deposit date:2013-03-11
Release date:2013-05-15
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies.
J.Exp.Med., 210, 2013
6QCU
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CRYSTAL STRUCTURE OF A FAB PORTION OF THE ANTI EBOV 3T0331 ANTIBODY
Descriptor:Light chain, Heavy chain, SULFATE ION
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2018-12-31
Release date:2019-10-02
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:rVSV-ZEBOV induces a polyclonal and convergent B cell response with potent Ebola virus-neutralizing antibodies
Nat.Med. (N.Y.), 2019
6QD8
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EM STRUCTURE OF A EBOV-GP BOUND TO 4M0368 NEUTRALIZING ANTIBODY
Descriptor:Light chain, Envelope glycoprotein,Virion spike glycoprotein,EBOV-GP1, Envelope glycoprotein, ...
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2019-01-01
Release date:2019-10-02
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:rVSV-ZEBOV induces a polyclonal and convergent B cell response with potent Ebola virus-neutralizing antibodies
Nat.Med. (N.Y.), 2019
6QD7
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EM STRUCTURE OF A EBOV-GP BOUND TO 3T0331 NEUTRALIZING ANTIBODY
Descriptor:Light chain, Heavy chain, Envelope glycoprotein,Virion spike glycoprotein,EBOV-GP1, ...
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2019-01-01
Release date:2019-10-02
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV.
Nat. Med., 25, 2019
6S9J
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CRYSTAL STRUCTURE OF TFR1 MIMICRY IN COMPLEX WITH GP1 FROM MACV
Descriptor:Pre-glycoprotein polyprotein GP complex, Transferrin receptor 1,Transferrin receptor 1, BETA-D-MANNOSE, ...
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2019-07-15
Release date:2020-01-15
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Rational design of universal immunotherapy for TfR1-tropic arenaviruses.
Nat Commun, 11, 2020
3RPI
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CRYSTAL STRUCTURE OF FAB FROM 3BNC60, HIGHLY POTENT ANTI-HIV ANTIBODY
Descriptor:Light chain from highly potent anti-HIV neutralizing antibody, Heavy chain from highly potent anti-HIV neutralizing antibody, N-ACETYL-D-GLUCOSAMINE
Authors:Diskin, R., Bjorkman, P.J.
Deposit date:2011-04-26
Release date:2011-07-20
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.648 Å)
Cite:Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Science, 333, 2011
4GW4
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CRYSTAL STRUCTURE OF 3BNC60 FAB WITH P61A MUTATION
Descriptor:3BNC60 Fab Light-chain, 3BNC60 Fab Heavy-chain, N-ACETYL-D-GLUCOSAMINE
Authors:Diskin, R., Fu, B.Z., Bjorkman, P.J.
Deposit date:2012-08-31
Release date:2013-04-17
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization.
Cell(Cambridge,Mass.), 153, 2013
4JDV
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CRYSTAL STRUCTURE OF GERM-LINE PRECURSOR OF NIH45-46 FAB
Descriptor:Fab heavy chain, Fab light chain, SULFATE ION, ...
Authors:Diskin, R., Scharf, L., Bjorkman, P.J.
Deposit date:2013-02-25
Release date:2013-03-20
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody.
Proc.Natl.Acad.Sci.USA, 110, 2013
6S8D
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STRUCTURE OF ZEBOV GP IN COMPLEX WITH 1T0227 ANTIBODY
Descriptor:Light chain, Heavy chain, Envelope glycoprotein, ...
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2019-07-09
Release date:2020-02-12
Last modified:2020-03-25
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Structural Basis for a Convergent Immune Response against Ebola Virus.
Cell Host Microbe, 27, 2020
6S8I
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STRUCTURE OF ZEBOV GP IN COMPLEX WITH 3T0265 ANTIBODY
Descriptor:Light Chain, Heavy Chain, Enveloped Glycoprotein 1, ...
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2019-07-10
Release date:2020-02-12
Last modified:2020-03-25
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Structural Basis for a Convergent Immune Response against Ebola Virus.
Cell Host Microbe, 27, 2020
6S8J
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STRUCTURE OF ZEBOV GP IN COMPLEX WITH 5T0180 ANTIBODY
Descriptor:Light Chain, Heavy Chain, Envelope Glycoprotein 1, ...
Authors:Diskin, R., Cohen-Dvashi, H.
Deposit date:2019-07-10
Release date:2020-02-12
Last modified:2020-03-25
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Structural Basis for a Convergent Immune Response against Ebola Virus.
Cell Host Microbe, 27, 2020
6GC2
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ABLIFT: ANTIBODY STABILITY AND AFFINITY OPTIMIZATION BY COMPUTATIONAL DESIGN OF THE VARIABLE LIGHT-HEAVY CHAIN INTERFACE
Descriptor:Light Chain, Heavy chain
Authors:Warszawski, S., Katz, A., Khmelnitsky, L., Ben Nissan, G., Javitt, G., Dym, O., Unger, T., Knop, O., Diskin, R., Albeck, S., Fass, D., Sharon, M., Fleishman, S.J.
Deposit date:2018-04-17
Release date:2019-05-01
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
Plos Comput.Biol., 15, 2019
4JDT
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CRYSTAL STRUCTURE OF CHIMERIC GERM-LINE PRECURSOR OF NIH45-46 FAB IN COMPLEX WITH GP120 OF 93TH057 HIV-1
Descriptor:gp120, Fab heavy chain, Fab light chain, ...
Authors:Scharf, L., Diskin, R., Bjorkman, P.J.
Deposit date:2013-02-25
Release date:2013-03-20
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody.
Proc.Natl.Acad.Sci.USA, 110, 2013
4ZJF
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CRYSTAL STRUCTURE OF GP1 - THE RECEPTOR BINDING DOMAIN OF LASSA VIRUS
Descriptor:Glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Cohen-Dvashi, H., Cohen, N., Israeli, H., Diskin, R.
Deposit date:2015-04-29
Release date:2015-05-27
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Molecular Mechanism for LAMP1 Recognition by Lassa Virus.
J.Virol., 89, 2015
5NFF
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CRYSTAL STRUCTURE OF GP1 RECEPTOR BINDING DOMAIN FROM MOROGORO VIRUS
Descriptor:Glycoprotein, N-ACETYL-D-GLUCOSAMINE, CITRIC ACID, ...
Authors:Israeli, H., Cohen-Dvashi, H., Shulman, A., Shimon, A., Diskin, R.
Deposit date:2017-03-14
Release date:2017-04-19
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.615 Å)
Cite:Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses.
PLoS Pathog., 13, 2017
5NSJ
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GP1 RECEPTOR-BINDING DOMAIN FROM WHITEWATER ARROYO MAMMARENAVIRUS
Descriptor:Pre-glycoprotein polyprotein GP complex, N-ACETYL-D-GLUCOSAMINE, SAMARIUM (III) ION, ...
Authors:Shimon, A., Shani, O., Diskin, R.
Deposit date:2017-04-26
Release date:2017-08-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:Structural Basis for Receptor Selectivity by the Whitewater Arroyo Mammarenavirus.
J. Mol. Biol., 429, 2017
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