Author results

2FSL
  • Download 2fsl
  • View 2fsl
Molmil generated image of 2fsl
MITOGEN ACTIVATED PROTEIN KINASE P38ALPHA (D176A+F327S) ACTIVATING MUTANT FORM-A
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Livnah, O.
Deposit date:2006-01-23
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2FSM
  • Download 2fsm
  • View 2fsm
Molmil generated image of 2fsm
MITOGEN ACTIVATED PROTEIN KINASE P38ALPHA (D176A+F327S) ACTIVATING MUTANT FORM-B
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Livnah, O.
Deposit date:2006-01-23
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2FSO
  • Download 2fso
  • View 2fso
Molmil generated image of 2fso
MITOGEN ACTIVATED PROTEIN KINASE P38ALPHA (D176A) ACTIVATING MUTANT
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Livnah, O.
Deposit date:2006-01-23
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2FST
  • Download 2fst
  • View 2fst
Molmil generated image of 2fst
MITOGEN ACTIVATED PROTEIN KINASE P38ALPHA (D176A+F327L) ACTIVATING MUTANT
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Livnah, O.
Deposit date:2006-01-23
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structures of p38alpha Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
J.Mol.Biol., 365, 2007
2NPQ
  • Download 2npq
  • View 2npq
Molmil generated image of 2npq
A NOVEL LIPID BINDING SITE IN THE P38 ALPHA MAP KINASE
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Diskin, R., Engelberg, D., Livnah, O.
Deposit date:2006-10-29
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel lipid binding site formed by the MAP kinase insert in p38 alpha.
J.Mol.Biol., 375, 2008
3LMJ
  • Download 3lmj
  • View 3lmj
Molmil generated image of 3lmj
STRUCTURE OF HUMAN ANTI HIV 21C FAB
Descriptor:Heavy chain of anti HIV Fab from human 21c antibody, Light chain of anti HIV Fab from human 21c antibody, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Diskin, R., Marcovecchio, P.M., Bjorkman, P.J.
Deposit date:2010-01-30
Release date:2010-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.
Nat.Struct.Mol.Biol., 17, 2010
3LQA
  • Download 3lqa
  • View 3lqa
Molmil generated image of 3lqa
CRYSTAL STRUCTURE OF CLADE C GP120 IN COMPLEX WITH SCD4 AND 21C FAB
Descriptor:T-cell surface glycoprotein CD4, Envelope glycoprotein gp160, Heavy chain of anti HIV Fab from human 21c antibody, ...
Authors:Diskin, R., Marcovecchio, P.M., Bjorkman, P.J.
Deposit date:2010-02-08
Release date:2010-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.
Nat.Struct.Mol.Biol., 17, 2010
3U7W
  • Download 3u7w
  • View 3u7w
Molmil generated image of 3u7w
CRYSTAL STRUCTURE OF NIH45-46 FAB
Descriptor:Heavy chain, Ig gamma-1 chain C region, Light chain, ...
Authors:Diskin, R., Bjorkman, P.J.
Deposit date:2011-10-14
Release date:2011-11-16
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design.
Science, 334, 2011
3U7Y
  • Download 3u7y
  • View 3u7y
Molmil generated image of 3u7y
STRUCTURE OF NIH45-46 FAB IN COMPLEX WITH GP120 OF 93TH057 HIV
Descriptor:NIH45-46 heavy chain, Ig gamma-1 chain C region, Envelope glycoprotein gp160, ...
Authors:Diskin, R., Bjorkman, P.J.
Deposit date:2011-10-14
Release date:2011-11-16
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.4478 Å)
Cite:Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design.
Science, 334, 2011
4JKP
  • Download 4jkp
  • View 4jkp
Molmil generated image of 4jkp
RESTRICTING HIV-1 PATHWAYS FOR ESCAPE USING RATIONALLY-DESIGNED ANTI-HIV-1 ANTIBODIES
Descriptor:gp120, Heavy chain of antibody 45-46M2, Light chain of antibody 45-46M2, ...
Authors:Diskin, R., Bjorkman, P.J.
Deposit date:2013-03-11
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies.
J.Exp.Med., 210, 2013
3RPI
  • Download 3rpi
  • View 3rpi
Molmil generated image of 3rpi
CRYSTAL STRUCTURE OF FAB FROM 3BNC60, HIGHLY POTENT ANTI-HIV ANTIBODY
Descriptor:Light chain from highly potent anti-HIV neutralizing antibody, Heavy chain from highly potent anti-HIV neutralizing antibody, N-ACETYL-D-GLUCOSAMINE
Authors:Diskin, R., Bjorkman, P.J.
Deposit date:2011-04-26
Release date:2011-07-20
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.648 Å)
Cite:Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Science, 333, 2011
4GW4
  • Download 4gw4
  • View 4gw4
Molmil generated image of 4gw4
CRYSTAL STRUCTURE OF 3BNC60 FAB WITH P61A MUTATION
Descriptor:3BNC60 Fab Light-chain, 3BNC60 Fab Heavy-chain, N-ACETYL-D-GLUCOSAMINE
Authors:Diskin, R., Fu, B.Z., Bjorkman, P.J.
Deposit date:2012-08-31
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization.
Cell(Cambridge,Mass.), 153, 2013
4JDV
  • Download 4jdv
  • View 4jdv
Molmil generated image of 4jdv
CRYSTAL STRUCTURE OF GERM-LINE PRECURSOR OF NIH45-46 FAB
Descriptor:Fab heavy chain, Fab light chain, SULFATE ION, ...
Authors:Diskin, R., Scharf, L., Bjorkman, P.J.
Deposit date:2013-02-25
Release date:2013-03-20
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JDT
  • Download 4jdt
  • View 4jdt
Molmil generated image of 4jdt
CRYSTAL STRUCTURE OF CHIMERIC GERM-LINE PRECURSOR OF NIH45-46 FAB IN COMPLEX WITH GP120 OF 93TH057 HIV-1
Descriptor:gp120, Fab heavy chain, Fab light chain, ...
Authors:Scharf, L., Diskin, R., Bjorkman, P.J.
Deposit date:2013-02-25
Release date:2013-03-20
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody.
Proc.Natl.Acad.Sci.USA, 110, 2013
4ZJF
  • Download 4zjf
  • View 4zjf
Molmil generated image of 4zjf
CRYSTAL STRUCTURE OF GP1 - THE RECEPTOR BINDING DOMAIN OF LASSA VIRUS
Descriptor:Glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Cohen-Dvashi, H., Cohen, N., Israeli, H., Diskin, R.
Deposit date:2015-04-29
Release date:2015-05-27
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Molecular Mechanism for LAMP1 Recognition by Lassa Virus.
J.Virol., 89, 2015
5NFF
  • Download 5nff
  • View 5nff
Molmil generated image of 5nff
CRYSTAL STRUCTURE OF GP1 RECEPTOR BINDING DOMAIN FROM MOROGORO VIRUS
Descriptor:Glycoprotein, N-ACETYL-D-GLUCOSAMINE, CITRIC ACID, ...
Authors:Israeli, H., Cohen-Dvashi, H., Shulman, A., Shimon, A., Diskin, R.
Deposit date:2017-03-14
Release date:2017-04-19
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.615 Å)
Cite:Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses.
PLoS Pathog., 13, 2017
5NSJ
  • Download 5nsj
  • View 5nsj
Molmil generated image of 5nsj
GP1 RECEPTOR-BINDING DOMAIN FROM WHITEWATER ARROYO MAMMARENAVIRUS
Descriptor:Pre-glycoprotein polyprotein GP complex, N-ACETYL-D-GLUCOSAMINE, SAMARIUM (III) ION, ...
Authors:Shimon, A., Shani, O., Diskin, R.
Deposit date:2017-04-26
Release date:2017-08-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:Structural Basis for Receptor Selectivity by the Whitewater Arroyo Mammarenavirus.
J. Mol. Biol., 429, 2017
5OMI
  • Download 5omi
  • View 5omi
Molmil generated image of 5omi
CRYSTAL STRUCTURE OF GP2 FROM LASSA VIRUS IN A POST FUSION CONFORMATION
Descriptor:Pre-glycoprotein polyprotein GP complex, CHLORIDE ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Shulman, A., Diskin, R.
Deposit date:2017-07-31
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Crystal structure of GP2 from Lassa virus in a post fusion conformation
To Be Published
6GH8
  • Download 6gh8
  • View 6gh8
Molmil generated image of 6gh8
CRYSTAL STRUCTURE OF GP1 DOMAIN OF LUJO VIRUS IN COMPLEX WITH THE FIRST CUB DOMAIN OF NEUROPILIN-2
Descriptor:Glycoprotein, Neuropilin-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Cohen-Dvashi, H., Kilimnik, I., Diskin, R.
Deposit date:2018-05-06
Release date:2018-07-25
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural basis for receptor recognition by Lujo virus.
Nat Microbiol, 3, 2018
6GJC
  • Download 6gjc
  • View 6gjc
Molmil generated image of 6gjc
STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS FATTY ACID SYNTHASE - I
Descriptor:Fatty acid synthase, FLAVIN MONONUCLEOTIDE
Authors:Elad, N., Baron, S., Shakked, Z., Zimhony, O., Diskin, R.
Deposit date:2018-05-16
Release date:2018-09-05
Last modified:2018-10-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 angstrom resolution.
Nat Commun, 9, 2018
5T87
  • Download 5t87
  • View 5t87
Molmil generated image of 5t87
CRYSTAL STRUCTURE OF CDI COMPLEX FROM CUPRIAVIDUS TAIWANENSIS LMG 19424
Descriptor:CdiI immunity protein, CdiA toxin
Authors:Michalska, K., Joachimiak, G., Jedrzejczak, R., Hayes, C.S., Goulding, C.W., Joachimiak, A., Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI), Midwest Center for Structural Genomics (MCSG)
Deposit date:2016-09-06
Release date:2017-09-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).
Proteins, 86 Suppl 1, 2018
2VSD
  • Download 2vsd
  • View 2vsd
Molmil generated image of 2vsd
CRYSTAL STRUCTURE OF CHIR-AB1
Descriptor:CHIR AB1, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Arnon, T.I., Kaiser, J.T., Bjorkman, P.J.
Deposit date:2008-04-22
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The Crystal Structure of Chir-Ab1: A Primordial Avian Classical Fc Receptor.
J.Mol.Biol., 381, 2008
3OD6
  • Download 3od6
  • View 3od6
Molmil generated image of 3od6
CRYSTAL STRUCTURE OF P38ALPHA Y323T ACTIVE MUTANT
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Livnah, O., Tzarum, N.
Deposit date:2010-08-11
Release date:2011-01-12
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.682 Å)
Cite:Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation.
J.Mol.Biol., 405, 2011
3ODY
  • Download 3ody
  • View 3ody
Molmil generated image of 3ody
CRYSTAL STRUCTURE OF P38ALPHA Y323Q ACTIVE MUTANT
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Livnah, O., Tzarum, N.
Deposit date:2010-08-12
Release date:2011-01-12
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation.
J.Mol.Biol., 405, 2011
3ODZ
  • Download 3odz
  • View 3odz
Molmil generated image of 3odz
CRYSTAL STRUCTURE OF P38ALPHA Y323R ACTIVE MUTANT
Descriptor:Mitogen-activated protein kinase 14, B-OCTYLGLUCOSIDE
Authors:Livnah, O., Tzarum, N.
Deposit date:2010-08-12
Release date:2011-01-12
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation.
J.Mol.Biol., 405, 2011
<12>