Author results

2JRP
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SOLUTION NMR STRUCTURE OF YFGJ FROM SALMONELLA TYPHIMURIUM MODELED WITH TWO ZN+2 BOUND, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET STR86
Descriptor:Putative cytoplasmic protein, ZINC ION
Authors:Ding, K., Ramelot, T.A., Cort, J.R., Wang, H., Nwosu, C., Cunningham, K., Owens, L., Ma, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR Structure of YfgJ from Salmonella typhimurium Modeled with Two Zn+2 Bound.
To be Published
2JOE
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NMR STRUCTURE OF E. COLI YEHR PROTEIN. NORTHEAST STRUCTURAL GENOMICS TARGET ER538.
Descriptor:Hypothetical lipoprotein yehR
Authors:Ding, K., Ramelot, T.A., Cort, J.R., Chen, C.X., Jiang, M., Cunningham, K., Ma, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-03-08
Release date:2007-04-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR Structure of E. Coli YehR Protein
To be Published
2JOV
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NMR STRUCTURE OF CLOSTRIDIUM PERFRINGENS PROTEIN CPE0013. NORTHEAST STRUCTURAL GENOMICS TARGET CPR31.
Descriptor:Hypothetical protein CPE0013
Authors:Ding, K., Ramelot, T.A., Anklin, C.G., Wang, H., Nwosu, C., Cunningham, K., Ma, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-04-04
Release date:2007-05-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of Clostridium perfringens protein CPE0013.
To be Published
2JUZ
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SOLUTION NMR STRUCTURE OF HI0947 FROM HAEMOPHILUS INFLUENZAE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET IR123
Descriptor:UPF0352 protein HI0840
Authors:Ding, K., Ramelot, T.A., Cort, J.R., Wang, D., Nwosu, C., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-09-09
Release date:2007-10-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR Structure of HI0947 from Haemophilus influenzae.
To be Published
2JZ8
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SOLUTION NMR STRUCTURE OF BH09830 FROM BARTONELLA HENSELAE MODELED WITH ONE ZN+2 BOUND. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET BNR55
Descriptor:Uncharacterized protein BH09830, ZINC ION
Authors:Ding, K., Cort, J.R., Wang, D., Janjua, H., Owens, L., Xiao, R., Liu, J., Baran, M.C., Swapna, G.V.T., Acton, T.B., Rost, B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-12-30
Release date:2008-01-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of BH09830 from Bartonella henselae modeled with one Zn+2 bound.
To be Published
6BP7
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RECOMBINANT MAJOR VAULT PROTEIN [RATTUS NORVEGICUS] STRUCTURE IN SOLUTION: CONFORMATION 2
Descriptor:Major vault protein
Authors:Ding, K., Zhang, X., Mrazek, J., Kickhoefer, V.A., Lai, M., Ng, H.L., Yang, O.O., Rome, L.H., Zhou, Z.H.
Deposit date:2017-11-22
Release date:2018-04-04
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Solution Structures of Engineered Vault Particles.
Structure, 26, 2018
6BP8
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RECOMBINANT MAJOR VAULT PROTEIN [RATTUS NORVEGICUS] STRUCTURE IN SOLUTION: CONFORMATION 1
Descriptor:Major vault protein
Authors:Ding, K., Zhang, X., Mrazek, J., Kickhoefer, V.A., Lai, M., Ng, H.L., Yang, O.O., Rome, L.H., Zhou, Z.H.
Deposit date:2017-11-22
Release date:2018-04-04
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Solution Structures of Engineered Vault Particles.
Structure, 26, 2018
6M99
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IN SITU STRUCTURE OF TRANSCRIPTIONAL ENZYME COMPLEX AND ASYMMETRIC INNER CAPSID PROTEIN OF AQUAREOVIRUS AT PRIMED STATE
Descriptor:VP2, Putative core protein NTPase/VP5, VP3, ...
Authors:Ding, K., Zhou, Z.H.
Deposit date:2018-08-23
Release date:2018-09-05
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:In SituStructures of the Polymerase Complex and RNA Genome Show How Aquareovirus Transcription Machineries Respond to Uncoating.
J. Virol., 92, 2018
6BQG
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH ERGOTAMINE
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
6BQH
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH RITANSERIN
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
5XR8
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CRYSTAL STRUCTURE OF THE HUMAN CB1 IN COMPLEX WITH AGONIST AM841
Descriptor:Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6aR,9R,10aR)-3-(8-azanyl-2-methyl-octan-2-yl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol, ...
Authors:Hua, T., Vemuri, K., Nikas, P.S., Laprairie, R.B., Wu, Y., Qu, L., Pu, M., Korde, A., Shan, J., Ho, J.H., Han, G.W., Ding, K., Li, X., Liu, H., Hanson, M.A., Zhao, S., Bohn, L.M., Makriyannis, A., Stevens, R.C., Liu, Z.J.
Deposit date:2017-06-07
Release date:2017-07-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature, 547, 2017
5XRA
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CRYSTAL STRUCTURE OF THE HUMAN CB1 IN COMPLEX WITH AGONIST AM11542
Descriptor:Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, ...
Authors:Hua, T., Vemuri, K., Nikas, P.S., Laprairie, R.B., Wu, Y., Qu, L., Pu, M., Korde, A., Shan, J., Ho, J.H., Han, G.W., Ding, K., Li, X., Liu, H., Hanson, M.A., Zhao, S., Bohn, L.M., Makriyannis, A., Stevens, R.C., Liu, Z.J.
Deposit date:2017-06-08
Release date:2017-07-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature, 547, 2017
4PW2
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5 EPIMERASE
Descriptor:D-glucuronyl C5 epimerase B, CITRIC ACID
Authors:Ke, J., Qin, Y., Gu, X., Brunzelle, J.S., Xu, H.E., Ding, K.
Deposit date:2014-03-18
Release date:2015-01-14
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
4PXQ
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5-EPIMERASE IN COMPLEX WITH HEPARIN HEXASACCHARIDE
Descriptor:D-glucuronyl C5 epimerase B, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Ke, J., Qin, Y., Gu, X., Tan, J., Brunzelle, J.S., Xu, H.E., Ding, K.
Deposit date:2014-03-24
Release date:2015-01-14
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
5FDP
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STRUCTURE OF DDR1 RECEPTOR TYROSINE KINASE IN COMPLEX WITH D2099 INHIBITOR AT 2.25 ANGSTROMS RESOLUTION.
Descriptor:Epithelial discoidin domain-containing receptor 1, (4~{S})-4-methyl-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1~{H}-isoquinoline-7-carboxamide, DI(HYDROXYETHYL)ETHER, ...
Authors:Bartual, S.G., Pinkas, D.M., Wang, Z., Ding, K., Mahajan, P., Kupinska, K., Mukhopadhyay, S., Strain-Damerell, C., Borkowska, O., Talon, R., Kopec, J., Williams, E., Tallant, C., Chaikuad, A., Sorell, F., Newman, J., Burgess-Brown, N., Arrowsmith, C.H., von Delft, F., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2015-12-16
Release date:2016-06-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.
J.Med.Chem., 59, 2016
5FDX
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STRUCTURE OF DDR1 RECEPTOR TYROSINE KINASE IN COMPLEX WITH D2164 INHIBITOR AT 2.65 ANGSTROMS RESOLUTION.
Descriptor:Epithelial discoidin domain-containing receptor 1, 3-[(4-methylpiperazin-1-yl)methyl]-~{N}-[(4~{R})-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1~{H}-isoquinolin-7-yl]-5-(trifluoromethyl)benzamide, 1,2-ETHANEDIOL, ...
Authors:Bartual, S.G., Pinkas, D.M., Wang, Z., Ding, K., Mahajan, P., Kupinska, K., Mukhopadhyay, S., Strain-Damerell, C., Chalk, R., Borkowska, O., Talon, R., Kopec, J., Williams, E., Tallant, C., Chaikuad, A., Sorell, F., Newman, J., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2015-12-16
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.
To Be Published
2K75
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SOLUTION NMR STRUCTURE OF THE OB DOMAIN OF TA0387 FROM THERMOPLASMA ACIDOPHILUM. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET TAR80B.
Descriptor:uncharacterized protein Ta0387
Authors:Ramelot, T.A., Ding, K., Lee, D., Jiang, M., Ciccosanti, C., Xiao, R., Nair, R., Everett, J.K., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-08-01
Release date:2008-08-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of the OB domain of Ta0387 from Thermoplasma acidophilum.
To be Published
2KBN
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SOLUTION NMR STRUCTURE OF THE OB DOMAIN (RESIDUES 67-166) OF MM0293 FROM METHANOSARCINA MAZEI. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET MAR214A.
Descriptor:Conserved protein
Authors:Ramelot, T.A., Ding, K., Magliqui, M., Jiang, M., Ciccosanti, C., Xiao, R., Lui, J., Everett, J.K., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-12-03
Release date:2009-07-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of the OB domain of mm0293 from the archea methanosarcina mazei
To be Published
2KCD
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SOLUTION NMR STRUCTURE OF SSP0047 FROM STAPHYLOCOCCUS SAPROPHYTICUS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SYR6.
Descriptor:Uncharacterized protein SSP0047
Authors:Ramelot, T.A., Ding, K., Chen, C.X., Jiang, M., Ciccosanti, C., Xiao, R., Liu, J., Baran, M.C., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-12-19
Release date:2009-02-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of SSP0047 from Staphylococcus saprophyticus. Northeast Structural Genomics Consortium Target SyR6.
To be Published
2KEN
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SOLUTION NMR STRUCTURE OF THE OB DOMAIN (RESIDUES 67-166) OF MM0293 FROM METHANOSARCINA MAZEI. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET MAR214A.
Descriptor:Conserved protein
Authors:Ramelot, T.A., Ding, K., Magliqui, M., Jiang, M., Ciccosanti, C., Xiao, R., Lui, J., Everett, J.K., Swapna, G., Acton, T.B., Rost, B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2009-01-30
Release date:2009-02-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of the OB domain of MM0293 from the archea Methanosarcina mazei
To be Published
3JB6
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IN SITU STRUCTURES OF THE SEGMENTED GENOME AND RNA POLYMERASE COMPLEX INSIDE A DSRNA VIRUS
Descriptor:RNA-dependent RNA polymerase, Viral structural protein 4, VP1 CSP, ...
Authors:Zhang, X., Ding, K., Yu, X.K., Chang, W., Sun, J.C., Zhou, Z.H.
Deposit date:2015-08-02
Release date:2015-10-28
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus.
Nature, 527, 2015
3JB7
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IN SITU STRUCTURES OF THE SEGMENTED GENOME AND RNA POLYMERASE COMPLEX INSIDE A DSRNA VIRUS
Descriptor:CPV RNA-dependent RNA polymerase, Viral structural protein 4, VP1 CSP, ...
Authors:Zhang, X., Ding, K., Yu, X.K., Chang, W., Sun, J.C., Zhou, Z.H.
Deposit date:2015-08-03
Release date:2015-10-28
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.001 Å)
Cite:In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus.
Nature, 527, 2015
3TZR
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STRUCTURE OF A RIBOSWITCH-LIKE RNA-LIGAND COMPLEX FROM THE HEPATITIS C VIRUS INTERNAL RIBOSOME ENTRY SITE
Descriptor:5'-R(*CP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*CP*C)-3', 5'-R(*GP*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*UP*CP*GP*G)-3', MAGNESIUM ION, ...
Authors:Dibrov, S.M., Ding, K., Brunn, N., Parker, M.A., Bergdahl, B.M., Wyles, D.L., Hermann, T.
Deposit date:2011-09-27
Release date:2012-03-21
Method:X-RAY DIFFRACTION (2.212 Å)
Cite:Structure of a Riboswitch in the Hepatitis C Virus Internal Ribosome Entry Site
To be Published
5V56
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2.9A XFEL STRUCTURE OF THE MULTI-DOMAIN HUMAN SMOOTHENED RECEPTOR (WITH E194M MUTATION) IN COMPLEX WITH TC114
Descriptor:Smoothened homolog,Flavodoxin,Smoothened homolog, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P.R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.A., Cherezov, V., Stevens, R.C., Tan, W., Tao, H., Xu, F.
Deposit date:2017-03-13
Release date:2017-05-24
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
5V57
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3.0A SYN STRUCTURE OF THE MULTI-DOMAIN HUMAN SMOOTHENED RECEPTOR IN COMPLEX WITH TC114
Descriptor:Smoothened homolog,Flavodoxin,Smoothened homolog, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P.R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.A., Cherezov, V., Stevens, R.C., Tan, W., Tao, H., Xu, F.
Deposit date:2017-03-13
Release date:2017-05-24
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
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