Author results

1U4A
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SOLUTION STRUCTURE OF HUMAN SUMO-3 C47S
分子名称:Ubiquitin-like protein SMT3A
著者Ding, H., Xu, Y., Dai, H., Tang, Y., Wu, J., Shi, Y.
登録日2004-07-23
公開日2005-03-08
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structure of Human SUMO-3 C47S and Its Binding Surface for Ubc9
Biochemistry, 44, 2005
2FQM
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CRYSTAL STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE PHOSPHOPROTEIN OF VESICULAR STOMATITIS VIRUS
分子名称:Phosphoprotein
著者Ding, H., Green, T.J., Lu, S., Luo, M.
登録日2006-01-18
公開日2006-02-07
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus
J.Virol., 80, 2006
5YDH
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CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE CATALYTIC SUBUNITS OF THE MALARIA VECTOR ANOPHELES GAMBIAE, 3.2 A
分子名称:Acetylcholinesterase, SULFATE ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Han, Q., Guan, H., Robinson, H., Ding, H., Liao, C., Li, J.
登録日2017-09-13
公開日2018-03-07
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications
To Be Published
5YDI
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CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE CATALYTIC SUBUNITS OF THE MALARIA VECTOR ANOPHELES GAMBIAE, NEW CRYSTAL PACKING
分子名称:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
著者Han, Q., Guan, H., Ding, H., Liao, C., Robinson, H., Li, J.
登録日2017-09-13
公開日2018-03-07
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications
To Be Published
5YDJ
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CRYSTAL STRUCTURE OF ANOPHELES GAMBIAE ACETYLCHOLINESTERASE IN COMPLEX WITH PMSF
分子名称:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
著者Han, Q., Guan, H., Ding, H., Liao, C., Robinson, H., Li, J.
登録日2017-09-13
公開日2018-03-07
実験手法X-RAY DIFFRACTION (3.04 Å)
主引用文献Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications
To Be Published
1TMW
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SOLUTION STRUCTURE OF HUMAN COACTOSIN LIKE PROTEIN D123N
分子名称:Coactosin-like protein
著者Dai, H., Wu, J., Xu, Y., Tang, Y., Ding, H., Shi, Y.
登録日2004-06-11
公開日2005-06-28
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Study on Solution Structure and Its binding function to F-actin
To be Published
1YIY
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AEDES AEGYPTI KYNURENINE AMINOTRANSFERASE
分子名称:kynurenine aminotransferase; glutamine transaminase K, BROMIDE ION, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE
著者Han, Q., Gao, Y.G., Robinson, H., Ding, H., Wilson, S., Li, J.
登録日2005-01-13
公開日2005-05-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of Aedes aegypti kynurenine aminotransferase.
FEBS J., 272, 2005
1YIZ
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AEDES AEGYPTI KYNURENINE AMINOTRASFERASE
分子名称:kynurenine aminotransferase; glutamine transaminase, BROMIDE ION
著者Han, Q., Gao, Y.G., Robinson, H., Ding, H., Wilson, S., Li, J.
登録日2005-01-13
公開日2005-05-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal structures of Aedes aegypti kynurenine aminotransferase.
FEBS J., 272, 2005
2O1Y
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-X, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-29
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O21
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-2, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-29
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O22
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-2, N-[(4-{[1,1-dimethyl-2-(phenylthio)ethyl]amino}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-29
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2F
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-2, 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-29
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2M
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-X, 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-30
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2N
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-X, 4-[4-(BIPHENYL-2-YLMETHYL)PIPERAZIN-1-YL]-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-30
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
3K40
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CRYSTAL STRUCTURE OF DROSOPHILA 3,4-DIHYDROXYPHENYLALANINE DECARBOXYLASE
分子名称:Aromatic-L-amino-acid decarboxylase, GLYCEROL
著者Han, Q., Ding, H., Robinson, H., Christensen, B.M., Li, J.
登録日2009-10-05
公開日2010-02-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase
Plos One, 5, 2010
4HU8
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CRYSTAL STRUCTURE OF A BACTERIAL IG-LIKE DOMAIN CONTAINING GH10 XYLANASE FROM TERMITE GUT
分子名称:GH10 Xylanase, SULFATE ION, GLYCEROL
著者Han, Q., Liu, N., Robinson, H., Cao, L., Qian, C., Wang, Q., Xie, L., Ding, H., Wang, Q., Huang, Y., Li, J., Zhou, Z.
登録日2012-11-02
公開日2013-09-18
最終更新日2013-11-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Biochemical characterization and crystal structure of a GH10 xylanase from termite gut bacteria reveal a novel structural feature and significance of its bacterial Ig-like domain.
Biotechnol.Bioeng., 110, 2013
5X61
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CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE CATALYTIC SUBUNIT OF THE MALARIA VECTOR ANOPHELES GAMBIAE, 3.4 A
分子名称:Acetylcholinesterase, SULFATE ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Han, Q., Robinson, H., Ding, H., Wong, D.M., Lam, P.C.H., Totrov, M.M., Carlier, P.R., Li, J.
登録日2017-02-20
公開日2017-03-15
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae
Insect Sci., 2017
1R94
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CRYSTAL STRUCTURE OF ISCA (MERCURY DERIVATIVE)
分子名称:Protein yfhF, MERCURY (II) ION
著者Bilder, P.W., Ding, H., Newcomer, M.E.
登録日2003-10-28
公開日2003-12-23
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold.
Biochemistry, 43, 2004
1R95
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CRYSTAL STRUCTURE OF ISCA (NATIVE)
分子名称:Protein yfhF
著者Bilder, P.W., Ding, H., Newcomer, M.E.
登録日2003-10-28
公開日2003-12-23
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold.
Biochemistry, 43, 2004
3NSP
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CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD
分子名称:Retinoid X receptor, alpha
著者Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
登録日2010-07-02
公開日2010-11-17
最終更新日2012-04-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
3NSQ
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CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD COMPLEXED WITH ANTAGONIST DANTHRON
分子名称:Retinoid X receptor, alpha, 1,8-dihydroxyanthracene-9,10-dione
著者Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
登録日2010-07-02
公開日2010-11-17
最終更新日2012-04-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
5H21
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TRIMETHOXY-RING INHIBITOR IN COMPLEX WITH THE FIRST BROMODOMAIN OF BRD4
分子名称:Bromodomain-containing protein 4, 3,4,5-trimethoxy-~{N}-(2-thiophen-2-ylethyl)benzamide
著者Zhang, H., Luo, C.
登録日2016-10-13
公開日2017-07-05
実験手法X-RAY DIFFRACTION (1.591 Å)
主引用文献Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay.
Medchemcomm, 8, 2017
5WUU
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COMPLEX STRUCTURE OF THE FIRST BROMODOMAIN OF BRD4 WITH AN INHIBITOR THAT CONTAINING A 2H-CHROMEN-2-ONE RING
分子名称:Bromodomain-containing protein 4, ~{N}-methyl-~{N}-[3-[(2-oxidanylidenechromen-4-yl)amino]propyl]thiophene-2-carboxamide
著者Zhang, H., Sun, Z.Y.
登録日2016-12-21
公開日2017-04-12
最終更新日2017-06-14
実験手法X-RAY DIFFRACTION (1.724 Å)
主引用文献Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.
Bioorg. Med. Chem. Lett., 27, 2017
5Y1Y
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COMPLEX STRUCTURE OF NITROXOLINE WITH THE FIRST BROMODOMAIN OF BRD4
分子名称:Bromodomain-containing protein 4, 5-nitroquinolin-8-ol
著者Jiang, H., Luo, C.
登録日2017-07-21
公開日2017-11-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.912 Å)
主引用文献Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.
Org. Biomol. Chem., 15, 2017
5Z5T
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THE FIRST BROMODOMAIN OF BRD4 WITH COMPOUND BDF-2141
分子名称:Bromodomain-containing protein 4, 2-amino-4-(1H-imidazol-1-yl)quinolin-8-ol
著者Zhang, H., Luo, C.
登録日2018-01-20
公開日2019-01-23
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (1.991 Å)
主引用文献Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.
Oncogenesis, 7, 2018
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