Author results

1U4A
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SOLUTION STRUCTURE OF HUMAN SUMO-3 C47S
Descriptor:Ubiquitin-like protein SMT3A
Authors:Ding, H., Xu, Y., Dai, H., Tang, Y., Wu, J., Shi, Y.
Deposit date:2004-07-23
Release date:2005-03-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of Human SUMO-3 C47S and Its Binding Surface for Ubc9
Biochemistry, 44, 2005
2FQM
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CRYSTAL STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE PHOSPHOPROTEIN OF VESICULAR STOMATITIS VIRUS
Descriptor:Phosphoprotein
Authors:Ding, H., Green, T.J., Lu, S., Luo, M.
Deposit date:2006-01-18
Release date:2006-02-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus
J.Virol., 80, 2006
5YDH
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CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE CATALYTIC SUBUNITS OF THE MALARIA VECTOR ANOPHELES GAMBIAE, 3.2 A
Descriptor:Acetylcholinesterase, SULFATE ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Han, Q., Guan, H., Robinson, H., Ding, H., Liao, C., Li, J.
Deposit date:2017-09-13
Release date:2018-03-07
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications
To Be Published
5YDI
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CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE CATALYTIC SUBUNITS OF THE MALARIA VECTOR ANOPHELES GAMBIAE, NEW CRYSTAL PACKING
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
Authors:Han, Q., Guan, H., Ding, H., Liao, C., Robinson, H., Li, J.
Deposit date:2017-09-13
Release date:2018-03-07
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications
To Be Published
5YDJ
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CRYSTAL STRUCTURE OF ANOPHELES GAMBIAE ACETYLCHOLINESTERASE IN COMPLEX WITH PMSF
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
Authors:Han, Q., Guan, H., Ding, H., Liao, C., Robinson, H., Li, J.
Deposit date:2017-09-13
Release date:2018-03-07
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications
To Be Published
1TMW
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SOLUTION STRUCTURE OF HUMAN COACTOSIN LIKE PROTEIN D123N
Descriptor:Coactosin-like protein
Authors:Dai, H., Wu, J., Xu, Y., Tang, Y., Ding, H., Shi, Y.
Deposit date:2004-06-11
Release date:2005-06-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Study on Solution Structure and Its binding function to F-actin
To be Published
1YIY
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AEDES AEGYPTI KYNURENINE AMINOTRANSFERASE
Descriptor:kynurenine aminotransferase; glutamine transaminase K, BROMIDE ION, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE
Authors:Han, Q., Gao, Y.G., Robinson, H., Ding, H., Wilson, S., Li, J.
Deposit date:2005-01-13
Release date:2005-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of Aedes aegypti kynurenine aminotransferase.
FEBS J., 272, 2005
1YIZ
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AEDES AEGYPTI KYNURENINE AMINOTRASFERASE
Descriptor:kynurenine aminotransferase; glutamine transaminase, BROMIDE ION
Authors:Han, Q., Gao, Y.G., Robinson, H., Ding, H., Wilson, S., Li, J.
Deposit date:2005-01-13
Release date:2005-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of Aedes aegypti kynurenine aminotransferase.
FEBS J., 272, 2005
2O1Y
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-29
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O21
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-2, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-29
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O22
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-2, N-[(4-{[1,1-dimethyl-2-(phenylthio)ethyl]amino}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-29
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2F
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-2, 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-29
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2M
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X, 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-30
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2N
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X, 4-[4-(BIPHENYL-2-YLMETHYL)PIPERAZIN-1-YL]-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-30
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
3K40
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CRYSTAL STRUCTURE OF DROSOPHILA 3,4-DIHYDROXYPHENYLALANINE DECARBOXYLASE
Descriptor:Aromatic-L-amino-acid decarboxylase, GLYCEROL
Authors:Han, Q., Ding, H., Robinson, H., Christensen, B.M., Li, J.
Deposit date:2009-10-05
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase
Plos One, 5, 2010
4HU8
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CRYSTAL STRUCTURE OF A BACTERIAL IG-LIKE DOMAIN CONTAINING GH10 XYLANASE FROM TERMITE GUT
Descriptor:GH10 Xylanase, SULFATE ION, GLYCEROL
Authors:Han, Q., Liu, N., Robinson, H., Cao, L., Qian, C., Wang, Q., Xie, L., Ding, H., Wang, Q., Huang, Y., Li, J., Zhou, Z.
Deposit date:2012-11-02
Release date:2013-09-18
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biochemical characterization and crystal structure of a GH10 xylanase from termite gut bacteria reveal a novel structural feature and significance of its bacterial Ig-like domain.
Biotechnol.Bioeng., 110, 2013
5X61
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CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE CATALYTIC SUBUNIT OF THE MALARIA VECTOR ANOPHELES GAMBIAE, 3.4 A
Descriptor:Acetylcholinesterase, SULFATE ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Han, Q., Robinson, H., Ding, H., Wong, D.M., Lam, P.C.H., Totrov, M.M., Carlier, P.R., Li, J.
Deposit date:2017-02-20
Release date:2017-03-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae
Insect Sci., 2017
1R94
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CRYSTAL STRUCTURE OF ISCA (MERCURY DERIVATIVE)
Descriptor:Protein yfhF, MERCURY (II) ION
Authors:Bilder, P.W., Ding, H., Newcomer, M.E.
Deposit date:2003-10-28
Release date:2003-12-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold.
Biochemistry, 43, 2004
1R95
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CRYSTAL STRUCTURE OF ISCA (NATIVE)
Descriptor:Protein yfhF
Authors:Bilder, P.W., Ding, H., Newcomer, M.E.
Deposit date:2003-10-28
Release date:2003-12-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold.
Biochemistry, 43, 2004
3NSP
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CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD
Descriptor:Retinoid X receptor, alpha
Authors:Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
Deposit date:2010-07-02
Release date:2010-11-17
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
3NSQ
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CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD COMPLEXED WITH ANTAGONIST DANTHRON
Descriptor:Retinoid X receptor, alpha, 1,8-dihydroxyanthracene-9,10-dione
Authors:Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
Deposit date:2010-07-02
Release date:2010-11-17
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
5H21
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TRIMETHOXY-RING INHIBITOR IN COMPLEX WITH THE FIRST BROMODOMAIN OF BRD4
Descriptor:Bromodomain-containing protein 4, 3,4,5-trimethoxy-~{N}-(2-thiophen-2-ylethyl)benzamide
Authors:Zhang, H., Luo, C.
Deposit date:2016-10-13
Release date:2017-07-05
Method:X-RAY DIFFRACTION (1.591 Å)
Cite:Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay.
Medchemcomm, 8, 2017
5WUU
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COMPLEX STRUCTURE OF THE FIRST BROMODOMAIN OF BRD4 WITH AN INHIBITOR THAT CONTAINING A 2H-CHROMEN-2-ONE RING
Descriptor:Bromodomain-containing protein 4, ~{N}-methyl-~{N}-[3-[(2-oxidanylidenechromen-4-yl)amino]propyl]thiophene-2-carboxamide
Authors:Zhang, H., Sun, Z.Y.
Deposit date:2016-12-21
Release date:2017-04-12
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.724 Å)
Cite:Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.
Bioorg. Med. Chem. Lett., 27, 2017
5Y1Y
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COMPLEX STRUCTURE OF NITROXOLINE WITH THE FIRST BROMODOMAIN OF BRD4
Descriptor:Bromodomain-containing protein 4, 5-nitroquinolin-8-ol
Authors:Jiang, H., Luo, C.
Deposit date:2017-07-21
Release date:2017-11-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.912 Å)
Cite:Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.
Org. Biomol. Chem., 15, 2017
5Z5T
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THE FIRST BROMODOMAIN OF BRD4 WITH COMPOUND BDF-2141
Descriptor:Bromodomain-containing protein 4, 2-amino-4-(1H-imidazol-1-yl)quinolin-8-ol
Authors:Zhang, H., Luo, C.
Deposit date:2018-01-20
Release date:2019-01-23
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.
Oncogenesis, 7, 2018
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