Author results

1ZS6
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STRUCTURE OF HUMAN NUCLEOSIDE-DIPHOSPHATE KINASE 3
Descriptor:Nucleoside diphosphate kinase 3, ADENOSINE-5'-DIPHOSPHATE
Authors:Choe, J., Dimov, S., Arrowsmith, C., Edwards, A., Sundstrom, M., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2005-05-23
Release date:2005-06-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human nucleoside-diphosphate kinase 3
To be Published
2AJP
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CRYSTAL STRUCTURE OF A HUMAN PYRIDOXAL KINASE
Descriptor:Pyridoxal kinase, MAGNESIUM ION, UNKNOWN ATOM OR ION, ...
Authors:Ismail, S., Dimov, S., Atanassova, A., Tempel, W., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2005-08-02
Release date:2005-08-09
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a human pyridoxal kinase
To be Published
2AL7
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STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 10C
Descriptor:ADP-ribosylation factor-like 10C, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Ismail, S., Dimov, S., Atanassova, A., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2005-08-04
Release date:2005-08-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:GTP-like conformation of GDP-bound ARL10C GTPase
To be Published
3GQY
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, L(+)-TARTARIC ACID, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-03-24
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
3GR4
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, L(+)-TARTARIC ACID, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-03-24
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
3H6O
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, UNKNOWN ATOM OR ION, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-04-23
Release date:2009-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
3ME3
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline, BETA-FRUCTOSE-1,6-DIPHOSPHATE, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
3U2Z
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, UNKNOWN ATOM OR ION, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-10-04
Release date:2012-09-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
2B6H
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STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR 5
Descriptor:ADP-ribosylation factor 5, CHLORIDE ION, SULFATE ION, ...
Authors:Tempel, W., Atanassova, A., Sundarajan, E., Dimov, S., Shehab, I., Lew, J., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2005-10-01
Release date:2005-10-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.764 Å)
Cite:Structure of human ADP-ribosylation factor 5
To be Published
2GAO
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CRYSTAL STRUCTURE OF HUMAN SAR1A IN COMPLEX WITH GDP
Descriptor:GTP-binding protein SAR1a, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION
Authors:Wang, J., Dimov, S., Tempel, W., Yaniw, D., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-03-09
Release date:2006-03-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Human SAR1a in Complex With GDP
To be Published
2H18
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STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 10B (ARL10B)
Descriptor:ADP-ribosylation factor-like protein 8A, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION
Authors:Atanassova, A., Tempel, W., Dimov, S., Yaniw, D., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-05-16
Release date:2006-06-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:Structure of human ADP-ribosylation factor-like 10B (ARL10B)
To be Published
2IQJ
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CRYSTAL STRUCTURE OF THE GAP DOMAIN OF SMAP1L (LOC64744) STROMAL MEMBRANE-ASSOCIATED PROTEIN 1-LIKE
Descriptor:Stromal membrane-associated protein 1-like, ZINC ION, BETA-MERCAPTOETHANOL, ...
Authors:Tong, Y., Dimov, S., Shen, L., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-10-13
Release date:2006-10-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the GAP domain of SMAP1L (LOC64744) stromal membrane-associated protein 1-like
To be Published
2OLM
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ARFGAP DOMAIN OF HIV-1 REV BINDING PROTEIN
Descriptor:Nucleoporin-like protein RIP, ZINC ION, SULFATE ION, ...
Authors:Tong, Y., Tempel, W., Shen, L., Dimov, S., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-01-19
Release date:2007-01-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:ArfGap domain of HIV-1 Rev binding protein
To be Published
2P57
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GAP DOMAIN OF ZNF289, AN ID1-REGULATED ZINC FINGER PROTEIN
Descriptor:GTPase-activating protein ZNF289, ZINC ION, UNKNOWN ATOM OR ION
Authors:Tong, Y., Dimov, S., Shen, L., Zhu, H., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-03-14
Release date:2007-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:GAP domain of ZNF289, an ID1-regulated zinc finger protein
To be Published
2QFZ
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CRYSTAL STRUCTURE OF HUMAN TBC1 DOMAIN FAMILY MEMBER 22A
Descriptor:TBC1 domain family member 22A, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Dimov, S., Dong, A., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human TBC1 domain family member 22A.
To be Published
2QQ8
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CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OF HUMAN TBC1 DOMAIN FAMILY MEMBER 14
Descriptor:TBC1 domain family member 14, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Dimov, S., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-07-26
Release date:2007-08-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14.
To be Published
3G2G
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S437Y MUTANT OF HUMAN MUSCLE PYRUVATE KINASE, ISOFORM M2
Descriptor:Pyruvate kinase isozymes M1/M2, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Hong, B., Dimov, S., Allali-Hassani, A., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, c., Weigelt, J., Bochkarev, A., Vedadi, M., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-01-31
Release date:2009-03-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:S437Y Mutant of human muscle pyruvate kinase, isoform M2
To be Published
3R90
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CRYSTAL STRUCTURE OF MALIGNANT T CELL-AMPLIFIED SEQUENCE 1 PROTEIN
Descriptor:Malignant T cell-amplified sequence 1, SULFATE ION, UNKNOWN ATOM OR ION, ...
Authors:Hong, B., Dimov, S., Tempel, W., Tong, Y., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-03-24
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Malignant T cell-amplified sequence 1 protein
to be published
4FK7
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CRYSTAL STRUCTURE OF CERTHRAX CATALYTIC DOMAIN
Descriptor:Putative ADP-ribosyltransferase Certhrax, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, CHLORIDE ION, ...
Authors:Hong, B.S., Dimov, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2012-06-12
Release date:2012-09-26
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
4FXQ
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FULL-LENGTH CERTHRAX TOXIN FROM BACILLUS CEREUS IN COMPLEX WITH INHIBITOR P6
Descriptor:Putative ADP-ribosyltransferase Certhrax, 8-fluoro-2-(3-piperidin-1-ylpropanoyl)-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one, CHLORIDE ION, ...
Authors:Visschedyk, D.D., Dimov, S., Kimber, M.S., Park, H.W., Merrill, A.R.
Deposit date:2012-07-03
Release date:2012-09-26
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (1.9599 Å)
Cite:Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
4GF1
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CRYSTAL STRUCTURE OF CERTHRAX
Descriptor:Putative ADP-ribosyltransferase Certhrax, UNKNOWN ATOM OR ION
Authors:Hong, B.S., Dimov, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2012-08-02
Release date:2012-09-26
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
3BOR
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CRYSTAL STRUCTURE OF THE DEADC DOMAIN OF HUMAN TRANSLATION INITIATION FACTOR 4A-2
Descriptor:Human initiation factor 4A-II
Authors:Dimov, S., Hong, B., Tempel, W., MacKenzie, F., Karlberg, T., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-12-17
Release date:2008-01-01
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Comparative Structural Analysis of Human DEAD-Box RNA Helicases.
Plos One, 5, 2010
2PZ9
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CRYSTAL STRUCTURE OF PUTATIVE TRANSCRIPTIONAL REGULATOR SCO4942 FROM STREPTOMYCES COELICOLOR
Descriptor:Putative regulatory protein, SULFATE ION
Authors:Filippova, E.V., Chruszcz, M., Xu, X., Zheng, H., Cymborowski, M., Savchenko, A., Edwards, A., Joachimiak, A., Minor, W., Midwest Center for Structural Genomics (MCSG)
Deposit date:2007-05-17
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:In situ proteolysis for protein crystallization and structure determination.
Nat.Methods, 4, 2007
3FEG
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CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE BETA IN COMPLEX WITH PHOSPHORYLATED HEMICHOLINIUM-3 AND ADENOSINE NUCLEOTIDE
Descriptor:Choline/ethanolamine kinase, (2S)-2-[4'-({dimethyl[2-(phosphonooxy)ethyl]ammonio}acetyl)biphenyl-4-yl]-2-hydroxy-4,4-dimethylmorpholin-4-ium, SULFATE ION, ...
Authors:Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2008-11-29
Release date:2008-12-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.302 Å)
Cite:Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
3G15
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CRYSTAL STRUCTURE OF HUMAN CHOLINE KINASE ALPHA IN COMPLEX WITH HEMICHOLINIUM-3 AND ADP
Descriptor:Choline kinase alpha, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Hong, B.S., Tempel, W., Rabeh, W.M., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2009-01-29
Release date:2009-02-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
J.Biol.Chem., 285, 2010
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