Author results

1EKG
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MATURE HUMAN FRATAXIN
Descriptor:FRATAXIN
Authors:Dhe-Paganon, S., Shigeta, R., Chi, Y.I., Ristow, M., Shoelson, S.E.
Deposit date:2000-03-08
Release date:2000-11-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human frataxin.
J.Biol.Chem., 275, 2000
1IFR
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STRUCTURE OF LAMIN A/C GLOBULAR DOMAIN
Descriptor:Lamin A/C, GLYCEROL
Authors:Dhe-Paganon, S., Werner, E.D., Shoelson, S.E.
Deposit date:2001-04-13
Release date:2002-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the globular tail of nuclear lamin.
J.Biol.Chem., 277, 2002
1M7W
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HNF4A LIGAND BINDING DOMAIN WITH BOUND FATTY ACID
Descriptor:Hepatocyte nuclear factor 4-alpha, LAURIC ACID
Authors:Dhe-Paganon, S., Duda, K., Iwamoto, M., Chi, Y.I., Shoelson, S.E.
Deposit date:2002-07-22
Release date:2003-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
J.Biol.Chem., 277, 2002
1Q2H
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PHENYLALANINE ZIPPER MEDIATES APS DIMERIZATION
Descriptor:adaptor protein with pleckstrin homology and src homology 2 domains
Authors:Dhe-Paganon, S., Werner, E.D., Nishi, M., Chi, Y.-I., Shoelson, S.E.
Deposit date:2003-07-24
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A phenylalanine zipper mediates APS dimerization.
Nat.Struct.Mol.Biol., 11, 2004
1QQG
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CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
Descriptor:INSULIN RECEPTOR SUBSTRATE 1
Authors:Dhe-Paganon, S., Shoelson, S.E.
Deposit date:1999-06-04
Release date:1999-08-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
3N3K
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THE CATALYTIC DOMAIN OF USP8 IN COMPLEX WITH A USP8 SPECIFIC INHIBITOR
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8, Ubiquitin, ZINC ION
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Li, Y., Allali-Hassani, A., Lam, R., Ernst, A., Sidhu, S., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2010-05-20
Release date:2010-06-23
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
2F4W
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HUMAN UBIQUITIN-CONJUGATING ENZYME E2 J2
Descriptor:ubiquitin-conjugating enzyme E2, J2
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Finerty Jr., P.J., Newman, E.M., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-11-24
Release date:2005-12-27
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012
2JUF
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NMR SOLUTION STRUCTURE OF PARC CPH DOMAIN. NESG TARGET HR3443B/SGC-TORONTO
Descriptor:p53-associated parkin-like cytoplasmic protein
Authors:Kaustov, L., Liao, J.C.C., Lemak, S., Duan, S., Muhandiram, R., Karra, M., Srisailam, S.H., Sundstrom, M., Weigelt, J., Edwards, A.M., Dhe-Paganon, S., Arrowsmith, C.H., Structural Genomics Consortium (SGC), Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-08-23
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR Solution Structure of PARC CPH Domain.
To be Published
2KLC
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NMR SOLUTION STRUCTURE OF HUMAN UBIQUITIN-LIKE DOMAIN OF UBIQUILIN 1, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HT5A
Descriptor:Ubiquilin-1
Authors:Doherty, R.S., Dhe-Paganon, S., Fares, C., Lemak, S., Gutmanas, A., Garcia, M., Yee, A., Montelione, G.T., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC), Ontario Centre for Structural Proteomics (OCSP)
Deposit date:2009-06-30
Release date:2009-07-14
Last modified:2012-01-18
Method:SOLUTION NMR
Cite:Solution structure of ubiquitin-like domain of ubiquilin 1
To be Published
2KVR
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SOLUTION NMR STRUCTURE OF HUMAN UBIQUITIN SPECIFIC PROTEASE USP7 UBL DOMAIN (RESIDUES 537-664). NESG TARGET HR4395C/ SGC-TORONTO
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7
Authors:Bezsonova, I., Lemak, A., Avvakumov, G., Xue, S., Dhe-Paganon, S., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
Deposit date:2010-03-25
Release date:2010-04-21
Last modified:2012-05-23
Method:SOLUTION NMR
Cite:solution structure of the ubiquitin specific protease Usp7 ubiquitin-like domain
To be Published
2L76
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SOLUTION NMR STRUCTURE OF HUMAN NFATC2IP UBIQUITIN-LIKE DOMAIN, NFATC2IP_244_338, NESG TARGET HT65A/OCSP TARGET HS00387_244_338/SGC-TORONTO
Descriptor:NFATC2-interacting protein
Authors:Wu, B., Yee, A., Houliston, S., Doherty, R., Semesi, A., Dhe-Paganon, S., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG), Ontario Centre for Structural Proteomics (OCSP)
Deposit date:2010-12-03
Release date:2010-12-22
Last modified:2012-02-22
Method:SOLUTION NMR
Cite:Human NFATC2IP ubiquitin-like domains
To be Published
2LFE
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SOLUTION NMR STRUCTURE OF N-TERMINAL DOMAIN OF HUMAN E3 UBIQUITIN-PROTEIN LIGASE HECW2, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HT6306A
Descriptor:E3 ubiquitin-protein ligase HECW2
Authors:Lemak, A., Yee, A., Houliston, S., Garcia, M., Chitayat, S., Dhe-Paganon, S., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
Deposit date:2011-06-29
Release date:2011-07-27
Method:SOLUTION NMR
Cite:NMR solution structure of N-terminal domain of E3 ligase HECW2
To be Published
2NQ3
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CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN ITCHY HOMOLOG E3 UBIQUITIN PROTEIN LIGASE
Descriptor:Itchy homolog E3 ubiquitin protein ligase, CHLORIDE ION
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Butler-Cole, C., Finerty Jr., P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-10-30
Release date:2006-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase
To be Published
2NSQ
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CRYSTAL STRUCTURE OF THE C2 DOMAIN OF THE HUMAN E3 UBIQUITIN-PROTEIN LIGASE NEDD4-LIKE PROTEIN
Descriptor:E3 ubiquitin-protein ligase NEDD4-like protein, 1,2-ETHANEDIOL, GLYCEROL
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Butler-Cole, C., Finerty Jr., P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-11-06
Release date:2006-12-19
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein
To be Published
2P82
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CYSTEINE PROTEASE ATG4A
Descriptor:Cysteine protease ATG4A, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Walker, J.R., Davis, T., Mujib, S., Butler-Cole, C., Finerty Jr., P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-21
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human cysteine protease ATG4A
To be Published
3BI7
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CRYSTAL STRUCTURE OF THE SRA DOMAIN OF E3 UBIQUITIN-PROTEIN LIGASE UHRF1
Descriptor:E3 ubiquitin-protein ligase UHRF1, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Li, Y., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-11-30
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
Nature, 455, 2008
3CLZ
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THE SET AND RING ASSOCIATED (SRA) DOMAIN OF UHRF1 BOUND TO METHYLATED DNA
Descriptor:E3 ubiquitin-protein ligase UHRF1, 5'-D(*DGP*DGP*DGP*DCP*DCP*(5CM)P*DGP*DCP*DAP*DGP*DGP*DG)-3', 5'-D(*DCP*DCP*DCP*DTP*DGP*DCP*DGP*DGP*DGP*DCP*DCP*DC)-3'
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Dong, A., Li, Y., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-03-20
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
Nature, 455, 2008
3DB3
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CRYSTAL STRUCTURE OF THE TANDEM TUDOR DOMAINS OF THE E3 UBIQUITIN-PROTEIN LIGASE UHRF1 IN COMPLEX WITH TRIMETHYLATED HISTONE H3-K9 PEPTIDE
Descriptor:E3 ubiquitin-protein ligase UHRF1, Trimethylated histone H3-K9 peptide
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Dong, A., Li, Y., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-05-30
Release date:2008-09-16
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
J.Biol.Chem., 286, 2011
3DB4
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CRYSTAL STRUCTURE OF THE TANDEM TUDOR DOMAINS OF THE E3 UBIQUITIN-PROTEIN LIGASE UHRF1
Descriptor:E3 ubiquitin-protein ligase UHRF1, SULFATE ION
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Dong, A., Li, Y., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-05-30
Release date:2008-09-16
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
J.Biol.Chem., 286, 2011
1Y6L
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HUMAN UBIQUITIN CONJUGATING ENZYME E2E2
Descriptor:Ubiquitin-conjugating enzyme E2E2
Authors:Walker, J.R., Avvakumov, G.V., Newman, E.M., Mackenzie, F., Kozieradzki, I., Bochkarev, A., Sundstrom, M., Arrowsmith, C., Edwards, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2004-12-06
Release date:2005-01-11
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012
1YH2
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UBIQUITIN-CONJUGATING ENZYME HSPC150
Descriptor:HSPC150 protein similar to ubiquitin-conjugating enzyme
Authors:Walker, J.R., Avvakumov, G.V., Newman, E.M., Mackenzie, F., Kozieradzki, I., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-01-06
Release date:2005-02-15
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012
1YLA
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UBIQUITIN-CONJUGATING ENZYME E2-25 KDA (HUNTINGTON INTERACTING PROTEIN 2)
Descriptor:Ubiquitin-conjugating enzyme E2-25 kDa
Authors:Choe, J., Avvakumov, G.V., Newman, E.M., Mackenzie, F., Kozieradzki, I., Bochkarev, A., Sundstrom, M., Arrowsmith, C., Edwards, A., Dhe-paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-01-19
Release date:2005-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity
J.Biol.Chem., 285, 2010
1YQB
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HUMAN UBIQUILIN 3
Descriptor:Ubiquilin 3
Authors:Walker, J.R., Xue, S., Avvakumov, G.V., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-02-01
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Ubiquitin-like domain of Human Ubiquilin 3
To be Published
1YRV
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NOVEL UBIQUITIN-CONJUGATING ENZYME
Descriptor:ubiquitin-conjugating ligase MGC351130
Authors:Walker, J.R., Choe, J., Avvakumov, G.V., Newman, E.M., MacKenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-02-04
Release date:2005-03-22
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012
1Z6U
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NP95-LIKE RING FINGER PROTEIN ISOFORM B [HOMO SAPIENS]
Descriptor:Np95-like ring finger protein isoform b, ZINC ION
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-03-23
Release date:2005-05-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:2.1 Angstrom Crystal Structure of the Human Ubiquitin Liagse NIRF
To be Published