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1ES6
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CRYSTAL STRUCTURE OF THE MATRIX PROTEIN OF EBOLA VIRUS
Descriptor:MATRIX PROTEIN VP40
Authors:Dessen, A., Volchkov, V., Dolnik, O., Klenk, H.-D., Weissenhorn, W.
Deposit date:2000-04-07
Release date:2000-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the matrix protein VP40 from Ebola virus.
EMBO J., 19, 2000
1ENY
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CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS
Descriptor:ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Dessen, A., Quemard, A., Blanchard, J.S., Jacobs Jr., W.R., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:1995-01-27
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science, 267, 1995
1ENZ
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CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS
Descriptor:ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Dessen, A., Quemard, A., Blanchard, J.S., Jacobs Jr., W.R., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:1995-01-27
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science, 267, 1995
1CJY
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HUMAN CYTOSOLIC PHOSPHOLIPASE A2
Descriptor:PROTEIN (CYTOSOLIC PHOSPHOLIPASE A2), CALCIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Dessen, A., Tang, J., Schmidt, H., Stahl, M., Clark, J.D., Seehra, J., Somers, W.S.
Deposit date:1999-04-20
Release date:2000-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.
Cell(Cambridge,Mass.), 97, 1999
1K25
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PBP2X FROM A HIGHLY PENICILLIN-RESISTANT STREPTOCOCCUS PNEUMONIAE CLINICAL ISOLATE
Descriptor:low-affinity PENICILLIN-BINDING PROTEIN 2X
Authors:Dessen, A., Mouz, N., Hopkins, J., Dideberg, O.
Deposit date:2001-09-26
Release date:2001-10-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations.
J.Biol.Chem., 276, 2001
2SBA
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SOYBEAN AGGLUTININ COMPLEXED WITH 2,6-PENTASACCHARIDE
Descriptor:Lectin, N-ACETYL-D-GLUCOSAMINE, BETA-D-GALACTOSE, ...
Authors:Dessen, A., Gupta, D., Sabesan, S., Brewer, C.F., Sacchettini, J.C.
Deposit date:1998-12-03
Release date:1998-12-09
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-ray crystal structure of the soybean agglutinin cross-linked with a biantennary analog of the blood group I carbohydrate antigen.
Biochemistry, 34, 1995
2SEB
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X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II
Descriptor:HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ENTEROTOXIN TYPE B, PEPTIDE FROM COLLAGEN II, ...
Authors:Dessen, A., Lawrence, C.M., Cupo, S., Zaller, D.M., Wiley, D.C.
Deposit date:1997-10-16
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II.
Immunity, 7, 1997
1SBD
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SOYBEAN AGGLUTININ COMPLEXED WITH 2,4-PENTASACCHARIDE
Descriptor:SOYBEAN AGGLUTININ, N-ACETYL-D-GLUCOSAMINE, BETA-D-GALACTOSE, ...
Authors:Dessen, A., Olsen, L.R., Gupta, D., Sabesan, S., Brewer, C.F., Sacchettini, J.C.
Deposit date:1995-07-13
Release date:1998-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.
Biochemistry, 36, 1997
1SBE
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SOYBEAN AGGLUTININ FROM GLYCINE MAX
Descriptor:SOYBEAN AGGLUTININ, N-ACETYL-D-GLUCOSAMINE, BETA-D-GALACTOSE, ...
Authors:Dessen, A., Olsen, L.R., Gupta, D., Sabesan, S., Sacchettini, J.C., Brewer, C.F.
Deposit date:1995-07-13
Release date:1998-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.
Biochemistry, 36, 1997
1RP5
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PBP2X FROM STREPTOCOCCUS PNEUMONIAE STRAIN 5259 WITH REDUCED SUSCEPTIBILITY TO BETA-LACTAM ANTIBIOTICS
Descriptor:penicillin-binding protein 2x, SULFATE ION
Authors:Pernot, L., Chesnel, L., Legouellec, A., Croize, J., Vernet, T., Dideberg, O., Dessen, A.
Deposit date:2003-12-03
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics.
J.Biol.Chem., 279, 2004
1H2C
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EBOLA VIRUS MATRIX PROTEIN VP40 N-TERMINAL DOMAIN IN COMPLEX WITH RNA (HIGH-RESOLUTION VP40[55-194] VARIANT).
Descriptor:MATRIX PROTEIN VP40, 5'-R(*UP*GP*AP)-3'
Authors:Gomis-Ruth, F.X., Dessen, A., Bracher, A., Klenk, H.D., Weissenhorn, W.
Deposit date:2002-08-05
Release date:2003-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Matrix Protein Vp40 from Ebola Virus Octamerizes Into Pore-Like Structures with Specific RNA Binding Properties
Structure, 11, 2003
1H2D
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EBOLA VIRUS MATRIX PROTEIN VP40 N-TERMINAL DOMAIN IN COMPLEX WITH RNA (LOW-RESOLUTION VP40[31-212] VARIANT).
Descriptor:MATRIX PROTEIN VP40, 5'-R(*UP*GP*AP)-3', CHLORIDE ION
Authors:Gomis-Ruth, F.X., Dessen, A., Bracher, A., Klenk, H.D., Weissenhorn, W.
Deposit date:2002-08-06
Release date:2003-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Matrix Protein Vp40 from Ebola Virus Octamerizes Into Pore-Like Structures with Specific RNA Binding Properties
Structure, 11, 2003
2UWJ
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STRUCTURE OF THE HETEROTRIMERIC COMPLEX WHICH REGULATES TYPE III SECRETION NEEDLE FORMATION
Descriptor:TYPE III EXPORT PROTEIN PSCE, TYPE III EXPORT PROTEIN PSCF, TYPE III EXPORT PROTEIN PSCG, ...
Authors:Quinaud, M., Ple, S., Job, V., Contreras-Martel, C., Simorre, J.P., Attree, I., Dessen, A.
Deposit date:2007-03-22
Release date:2007-05-15
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the heterotrimeric complex that regulates type III secretion needle formation.
Proc. Natl. Acad. Sci. U.S.A., 104, 2007
2XD5
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STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM AND THE ROLE OF STREPTOCOCCUS PNEUMONIAE PBP1B
Descriptor:PENICILLIN-BINDING PROTEIN 1B, SULFATE ION, N-BENZOYL-D-ALANINE, ...
Authors:Macheboeuf, P., Lemaire, D., Jamin, M., Dideberg, O., Dessen, A.
Deposit date:2010-04-29
Release date:2010-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights Into the Catalytic Mechanism and the Role of Streptococcus Pneumoniae Pbp1B
To be Published
1SBF
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SOYBEAN AGGLUTININ
Descriptor:SOYBEAN AGGLUTININ, N-ACETYL-D-GLUCOSAMINE, BETA-D-GALACTOSE, ...
Authors:Olsen, L.R., Dessen, A., Gupta, D., Sabesan, S., Brewer, C.F., Sacchettini, J.C.
Deposit date:1997-10-21
Release date:1998-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.
Biochemistry, 36, 1997
2C5W
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PENICILLIN-BINDING PROTEIN 1A (PBP-1A) ACYL-ENZYME COMPLEX (CEFOTAXIME) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:PENICILLIN-BINDING PROTEIN 1A, ZINC ION, CHLORIDE ION, ...
Authors:Contreras-Martel, C., Job, V., Di Guilmi, A.-M., Vernet, T., Dideberg, O., Dessen, A.
Deposit date:2005-11-02
Release date:2005-12-07
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal Structure of Penicillin-Binding Protein 1A (Pbp1A) Reveals a Mutational Hotspot Implicated in Beta-Lactam Resistance in Streptococcus Pneumoniae.
J.Mol.Biol., 355, 2006
2C6W
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PENICILLIN-BINDING PROTEIN 1A (PBP-1A) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:PENICILLIN-BINDING PROTEIN 1A, ZINC ION, CHLORIDE ION
Authors:Contreras-Martel, C., Job, V., Di Guilmi, A.-M., Vernet, T., Dideberg, O., Dessen, A.
Deposit date:2005-11-14
Release date:2005-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal Structure of Penicillin-Binding Protein 1A (Pbp1A) Reveals a Mutational Hotspot Implicated in Beta-Lactam Resistance in Streptococcus Pneumoniae.
J.Mol.Biol., 355, 2006
2Y2G
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (A01)
Descriptor:PENICILLIN-BINDING PROTEIN 1B, [(2,6-DIMETHOXYPHENYL)CARBONYLAMINO]METHYL-TRIHYDROXY-BORON, SULFATE ION, ...
Authors:Contreras-Martel, C., Amoroso, A., Woon, E.C., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A., Job, V., Luxen, A., Joris, B., Schofield, C.J., Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol., 6, 2011
2Y2H
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (ZA2)
Descriptor:PENICILLIN-BINDING PROTEIN 1B, [(2-CHLOROPHENYL)CARBONYLAMINO]METHYL-TRIHYDROXY-BORON, SULFATE ION, ...
Authors:Contreras-Martel, C., Amoroso, A., Woon, E.C., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A., Job, V., Luxen, A., Joris, B., Schofield, C.J., Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol., 6, 2011
2Y2I
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (ZA3)
Descriptor:PENICILLIN-BINDING PROTEIN 1B, TRIHYDROXY-[[(2-NITROPHENYL)CARBONYLAMINO]METHYL]BORON, SULFATE ION, ...
Authors:Contreras-Martel, C., Amoroso, A., Woon, E.C., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A., Job, V., Luxen, A., Joris, B., Schofield, C.J., Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol., 6, 2011
2Y2J
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (ZA4)
Descriptor:PENICILLIN-BINDING PROTEIN 1B, [(2-FLUOROPHENYL)CARBONYLAMINO]METHYL-TRIHYDROXY-BORON, SULFATE ION, ...
Authors:Contreras-Martel, C., Amoroso, A., Woon, E.C., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A., Job, V., Luxen, A., Joris, B., Schofield, C.J., Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol, 6, 2011
2Y2K
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (ZA5)
Descriptor:PENICILLIN-BINDING PROTEIN 1B, [(2,6-DIFLUOROPHENYL)CARBONYLAMINO]METHYL-TRIHYDROXY-BORON, SULFATE ION, ...
Authors:Contreras-Martel, C., Amoroso, A., Woon, E., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A., Job, V., Luxen, A., Joris, B., Schofield, C., Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol, 6, 2011
2Y2L
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (E06)
Descriptor:PENICILLIN-BINDING PROTEIN 1B, [(1R)-1-[(2,6-difluorophenyl)carbonylamino]ethyl]-trihydroxy-boron, SULFATE ION, ...
Authors:Contreras-Martel, C., Amoroso, A., Woon, E.C., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A., Job, V., Luxen, A., Joris, B., Schofield, C.J., Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol., 6, 2011
2Y2M
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (E08)
Descriptor:PENICILLIN-BINDING PROTEIN 1B, TRIHYDROXY-[(1S)-1-[(2-PROPAN-2-YLPHENYL)CARBONYLAMINO]ETHYL]BORON, CHLORIDE ION, ...
Authors:Contreras-Martel, C., Amoroso, A., Woon, E.C., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A., Job, V., Luxen, A., Joris, B., Schofield, C.J., Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol., 6, 2011
2Y2N
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PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (E07)
Descriptor:PENICILLIN-BINDING PROTEIN 1B, TRIHYDROXY-[(1S)-1-[[2-(PHENYLMETHYL)PHENYL]CARBONYLAMINO]ETHYL]BORON, CHLORIDE ION, ...
Authors:Contreras-Martel, C., Amoroso, A., Woon, E.C., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A., Job, V., Luxen, A., Joris, B., Schofield, C.J., Dessen, A.
Deposit date:2010-12-15
Release date:2011-08-03
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).
Acs Chem.Biol., 6, 2011