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1G6V
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BU of 1g6v by Molmil
Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase
Descriptor: ANTIBODY HEAVY CHAIN, CARBONIC ANHYDRASE, ZINC ION
Authors:Desmyter, A, Decanniere, K, Muyldermans, S, Wyns, L.
Deposit date:2000-11-08
Release date:2000-11-22
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody.
J.Biol.Chem., 276, 2001
4GRW
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BU of 4grw by Molmil
Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)
Descriptor: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, Nanobody 124C4, ...
Authors:Desmyter, A, Spinelli, S, Button, C, Saunders, M, de Haard, H, Rommelaere, H, Union, A, Cambillau, C.
Deposit date:2012-08-27
Release date:2014-02-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex.
Front Immunol, 8, 2017
4HEP
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BU of 4hep by Molmil
Complex of lactococcal phage TP901-1 with a llama vHH (vHH17) binder (nanobody)
Descriptor: BPP, SULFATE ION, vHH17 domain
Authors:Desmyter, A, Spinelli, S, Farenc, C, Blangy, S, Bebeacua, C, van Sinderen, D, Mahony, J, Cambillau, C.
Deposit date:2012-10-04
Release date:2013-03-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Viral infection modulation and neutralization by camelid nanobodies
Proc.Natl.Acad.Sci.USA, 110, 2013
4HEM
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BU of 4hem by Molmil
Llama vHH-02 binder of ORF49 (RBP) from lactococcal phage TP901-1
Descriptor: Anti-baseplate TP901-1 Llama vHH 02, BPP
Authors:Desmyter, A, Spinelli, S, Farenc, C, Blangy, S, Bebeacua, C, van Sinderen, D, Mahony, J, Cambillau, C.
Deposit date:2012-10-04
Release date:2013-03-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Viral infection modulation and neutralization by camelid nanobodies
Proc.Natl.Acad.Sci.USA, 110, 2013
4IOS
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BU of 4ios by Molmil
Structure of phage TP901-1 RBP (ORF49) in complex with nanobody 11.
Descriptor: BPP, GLYCEROL, Llama nanobody 11
Authors:Desmyter, A, Farenc, C, Mahony, J, Spinelli, S, Bebeacua, C, Blangy, S, Veesler, D, van Sinderen, D, Cambillau, C.
Deposit date:2013-01-08
Release date:2013-03-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Viral infection modulation and neutralization by camelid nanobodies
Proc.Natl.Acad.Sci.USA, 110, 2013
1KXT
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BU of 1kxt by Molmil
Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase
Descriptor: ALPHA-AMYLASE, PANCREATIC, CALCIUM ION, ...
Authors:Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1KXQ
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BU of 1kxq by Molmil
Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase
Descriptor: CALCIUM ION, CHLORIDE ION, alpha-amylase, ...
Authors:Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1KXV
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BU of 1kxv by Molmil
Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase
Descriptor: ALPHA-AMYLASE, PANCREATIC, CAMELID VHH DOMAIN CAB10
Authors:Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1MEL
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BU of 1mel by Molmil
CRYSTAL STRUCTURE OF A CAMEL SINGLE-DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME
Descriptor: LYSOZYME, VH SINGLE-DOMAIN ANTIBODY
Authors:Desmyter, A, Transue, T.R, Arbabi Gharoudi, M, Dao Thi, M, Poortmans, F, Hamers, R, Muyldermans, S, Wyns, L.
Deposit date:1996-06-06
Release date:1997-06-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme.
Nat.Struct.Biol., 3, 1996
1BZQ
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BU of 1bzq by Molmil
COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A
Descriptor: PHOSPHATE ION, PROTEIN (ANTIBODY CAB-RN05), PROTEIN (RNASE A)
Authors:Decanniere, K, Desmyter, A, Gahroudhi, M, Lauwereys, M, Muyldermans, S, Wyns, L.
Deposit date:1998-11-03
Release date:1998-11-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops.
Structure Fold.Des., 7, 1999
4O9H
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BU of 4o9h by Molmil
Structure of Interleukin-6 in complex with a Camelid Fab fragment
Descriptor: Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7
Authors:Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C.
Deposit date:2014-01-02
Release date:2015-04-15
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies
To be Published
4R90
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BU of 4r90 by Molmil
Anti CD70 Llama glama Fab 27B3
Descriptor: Anti CD70 Llama glama Fab 27B3 Heavy chain, Anti CD70 Llama glama Fab 27B3 Light chain, CALCIUM ION, ...
Authors:Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.746 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
4R96
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BU of 4r96 by Molmil
Structure of a Llama Glama Fab 48A2 against human cMet
Descriptor: Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain
Authors:Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
1OP9
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BU of 1op9 by Molmil
Complex of human lysozyme with camelid VHH HL6 antibody fragment
Descriptor: HL6 camel VHH fragment, Lysozyme C
Authors:Dumoulin, M, Last, A.M, Desmyter, A, Decanniere, K, Canet, D, Larsson, G, Spencer, A, Archer, D.B, Sasse, J, Muyldermans, S, Wyns, L, Redfield, C, Matagne, A, Robinson, C.V, Dobson, C.M.
Deposit date:2003-03-05
Release date:2003-10-14
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme
Nature, 424, 2003
4ZS7
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BU of 4zs7 by Molmil
Structural mimicry of receptor interaction by antagonistic IL-6 antibodies
Descriptor: Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain
Authors:Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
4QGY
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BU of 4qgy by Molmil
Camelid (llama) nanobody n25 (VHH) against type 6 secretion system TssM protein
Descriptor: nanobody n25, VH domain
Authors:Nguyen, V.S, Desmyter, A, Le, T.T.H, Durand, E, Kellenberger, C, Douzi, B, Spinelli, S, Cascales, E, Cambillau, C, Roussel, A.
Deposit date:2014-05-26
Release date:2015-04-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody.
Plos One, 10, 2015
4QLR
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BU of 4qlr by Molmil
Llama nanobody n02 raised against EAEC T6SS TssM
Descriptor: Llama nanobody n02 VH domain
Authors:Nguyen, V.S, Desmyter, A, Le, T.T.H, Durand, E, Kellenberger, C, Douzi, B, Spinelli, S, Cascales, E, Cambillau, C, Roussel, A.
Deposit date:2014-06-13
Release date:2015-04-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody.
Plos One, 10, 2015
4PIR
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BU of 4pir by Molmil
X-ray structure of the mouse serotonin 5-HT3 receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ...
Authors:Hassaine, G, Deluz, C, Grasso, L, Wyss, R, Tol, M.B, Hovius, R, Graff, A, Stahlberg, H, Tomizaki, T, Desmyter, A, Moreau, C, Li, X.-D, Poitevin, F, Vogel, H, Nury, H.
Deposit date:2014-05-09
Release date:2014-08-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:X-ray structure of the mouse serotonin 5-HT3 receptor.
Nature, 512, 2014
1ZRU
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BU of 1zru by Molmil
structure of the lactophage p2 receptor binding protein in complex with glycerol
Descriptor: GLYCEROL, lactophage p2 receptor binding protein
Authors:Spinelli, S, Tremblay, D.M, Tegoni, M, Blangy, S, Huyghe, C, Desmyter, A, Labrie, S, de Haard, H, Moineau, S, Cambillau, C, Structural Proteomics in Europe (SPINE)
Deposit date:2005-05-22
Release date:2006-03-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Receptor-binding protein of Lactococcus lactis phages: identification and characterization of the saccharide receptor-binding site.
J.Bacteriol., 188, 2006
1SJV
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BU of 1sjv by Molmil
Three-Dimensional Structure of a Llama VHH Domain Swapping
Descriptor: r9
Authors:Spinelli, S, Desmyter, A, Frenken, L, Verrips, T, Cambillau, C.
Deposit date:2004-03-04
Release date:2004-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Domain swapping of a llama VHH domain builds a crystal-wide beta-sheet structure.
Febs Lett., 564, 2004
1U0Q
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BU of 1u0q by Molmil
Structure of a Llama VHH domain raised against a carbazole molecule
Descriptor: immunoglobulin heavy chain variable domain
Authors:Cambillau, C, Spinelli, S, Desmyter, A, Verrips, T.
Deposit date:2004-07-14
Release date:2005-06-28
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of a Llama VHH Domain Raised Against a Carbazole Hapten
TO BE PUBLISHED
2BSE
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BU of 2bse by Molmil
Structure of Lactococcal Bacteriophage p2 Receptor Binding Protein in complex with a llama VHH domain
Descriptor: LLAMA IMMUNOGLOBULIN, RECEPTOR BINDING PROTEIN
Authors:Spinelli, S, Desmyter, A, Verrips, C.T, de Haard, H.J.W, Moineau, S, Cambillau, C.
Deposit date:2005-05-20
Release date:2005-11-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Lactococcal Bacteriophage P2 Receptor Binding Protein Structure Suggests a Common Ancestor Gene with Bacterial and Mammalian Viruses.
Nat.Struct.Mol.Biol., 13, 2006
2BSD
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BU of 2bsd by Molmil
Structure of Lactococcal Bacteriophage p2 Receptor Binding Protein
Descriptor: RECEPTOR BINDING PROTEIN
Authors:Spinelli, S, Desmyter, A, Verrips, C.T, Dehaard, H.J.W, Moineau, S, Cambillau, C.
Deposit date:2005-05-20
Release date:2005-11-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Lactococcal Bacteriophage P2 Receptor-Binding Protein Structure Suggests a Common Ancestor Gene with Bacterial and Mammalian Viruses.
Nat.Struct.Mol.Biol., 13, 2006
5E7F
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BU of 5e7f by Molmil
Complex between lactococcal phage Tuc2009 RBP head domain and a nanobody (L06)
Descriptor: Major structural protein 1, nanobody L06
Authors:Legrand, P, Collins, B, Blangy, S, Murphy, J, Spinelli, S, Gutierrez, C, Richet, N, Kellenberger, C, Desmyter, A, Mahony, J, van Sinderen, D, Cambillau, C.
Deposit date:2015-10-12
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules.
Mbio, 7, 2016
5E7T
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BU of 5e7t by Molmil
Structure of the tripod (BppUct-A-L) from the baseplate of bacteriophage Tuc2009
Descriptor: CALCIUM ION, Major structural protein 1, Minor structural protein 4, ...
Authors:Legrand, P, Collins, B, Blangy, S, Murphy, J, Spinelli, S, Gutierrez, C, Richet, N, Kellenberger, C, Desmyter, A, Mahony, J, van Sinderen, D, Cambillau, C.
Deposit date:2015-10-13
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules.
Mbio, 7, 2016

 

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