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5HUQ
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BU of 5huq by Molmil
A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase
Descriptor: 1-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]-5-methanethioyl-pyridine-3-carbothioic S-acid, Lactate racemization operon protein LarA, NICKEL (II) ION, ...
Authors:Desguin, B, Zhang, T, Soumillion, P, Hols, P, Hu, J, Hausinger, R.P.
Deposit date:2016-01-27
Release date:2016-02-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase.
Science, 349, 2015
2YJG
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BU of 2yjg by Molmil
Structure of the lactate racemase apoprotein from Thermoanaerobacterium thermosaccharolyticum
Descriptor: 1,2-ETHANEDIOL, LACTATE RACEMASE APOPROTEIN, MAGNESIUM ION, ...
Authors:Declercq, J.P, Desguin, B, Soumillion, P, Hols, P.
Deposit date:2011-05-19
Release date:2012-05-30
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Lactate Racemase is a Nickel-Dependent Enzyme Activated by a Widespread Maturation System.
Nat.Commun., 5, 2014
6BWO
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BU of 6bwo by Molmil
LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, apo form
Descriptor: Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2017-12-15
Release date:2018-06-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.
J. Biol. Chem., 293, 2018
6C1W
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BU of 6c1w by Molmil
A tethered niacin-derived pincer complex with a nickel-carbon or sulfite-carbon bond in lactate racemase
Descriptor: (4S)-5-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-4-sulfo-1,4-dihydropyridine-3-carbothioic S-acid, 1-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]-5-methanethioyl-pyridine-3-carbothioic S-acid, Lactate racemase, ...
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2018-01-05
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Lactate Racemase Nickel-Pincer Cofactor Operates by a Proton-Coupled Hydride Transfer Mechanism.
Biochemistry, 57, 2018
5UDW
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BU of 5udw by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with nickel
Descriptor: Lactate racemization operon protein LarE, NICKEL (II) ION, PHOSPHATE ION, ...
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDT
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BU of 5udt by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Lactate racemization operon protein LarE, PHOSPHATE ION
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.188 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDX
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BU of 5udx by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with zinc
Descriptor: Lactate racemization operon protein LarE, PHOSPHATE ION, SULFATE ION, ...
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.784 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDQ
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BU of 5udq by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, apo form
Descriptor: Lactate racemization operon protein LarE, PHOSPHATE ION, SULFATE ION
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDV
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BU of 5udv by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with iron
Descriptor: FE (III) ION, Lactate racemization operon protein LarE, PHOSPHATE ION, ...
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.621 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDR
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BU of 5udr by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with nicotinamide mononucleotid NMN
Descriptor: ATP-utilizing enzyme of the PP-loopsuperfamily, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, MANGANESE (II) ION
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDU
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BU of 5udu by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with manganese
Descriptor: Lactate racemization operon protein LarE, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.792 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDS
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BU of 5uds by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with MgATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Lactate racemization operon protein LarE, MAGNESIUM ION, ...
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UNM
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BU of 5unm by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, substrate free form with flexible loop
Descriptor: ATP-utilizing enzyme of the PP-loopsuperfamily, PHOSPHATE ION
Authors:Fellner, M, Desguin, B, Hausinger, R.P, Hu, J.
Deposit date:2017-01-31
Release date:2017-08-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6BWR
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BU of 6bwr by Molmil
LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with nickel
Descriptor: NICKEL (II) ION, Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Authors:Fellner, M, Hausinger, R.P, Hu, J.
Deposit date:2017-12-15
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.
J. Biol. Chem., 293, 2018
6BWQ
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BU of 6bwq by Molmil
LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with MnCTP
Descriptor: CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Fellner, M, Hausinger, R.P, Hu, J.
Deposit date:2017-12-15
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.
J. Biol. Chem., 293, 2018
6D6Z
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BU of 6d6z by Molmil
Structure of the malate racemase apoprotein from Thermoanaerobacterium thermosaccharolyticum
Descriptor: Malate racemase Mar2
Authors:Fellner, M, Hausinger, R.P, Hu, J.
Deposit date:2018-04-23
Release date:2019-04-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases.
Sci Rep, 10, 2020
7S91
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BU of 7s91 by Molmil
Structure of the malate racemase mar2 apoprotein from Thermoanaerobacterium thermosaccharolyticum at 2.25 angstroms resolution
Descriptor: CHLORIDE ION, Malate racemase Mar2
Authors:Gatreddi, S, Hausinger, R.P, Hu, J.
Deposit date:2021-09-20
Release date:2021-10-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and mutational characterization of a malate racemase from the LarA superfamily.
Biometals, 36, 2023
6B2O
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BU of 6b2o by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, C176A variant
Descriptor: ATP-utilizing enzyme of the PP-loopsuperfamily, PHOSPHATE ION, SULFATE ION
Authors:Fellner, M, Hausinger, R.P, Hu, J.
Deposit date:2017-09-20
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum.
Biochemistry, 57, 2018
6B2M
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BU of 6b2m by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with coenzyme A
Descriptor: ATP-utilizing enzyme of the PP-loopsuperfamily, COENZYME A, PHOSPHATE ION
Authors:Fellner, M, Hausinger, R.P, Hu, J.
Deposit date:2017-09-20
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.088 Å)
Cite:Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum.
Biochemistry, 57, 2018
7MJ2
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BU of 7mj2 by Molmil
LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with Zn
Descriptor: MAGNESIUM ION, Pyridinium-3,5-biscarboxylic acid mononucleotide synthase, ZINC ION
Authors:Chatterjee, S, Rankin, J.A, Lagishetty, S, Hu, J, Hausinger, R.P.
Deposit date:2021-04-19
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJ0
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BU of 7mj0 by Molmil
LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with adenosine monophosphate AMP
Descriptor: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, Pyridinium-3,5-biscarboxylic acid mononucleotide synthase
Authors:Chatterjee, S, Rankin, J.A, Lagishetty, S, Hu, J, Hausinger, R.P.
Deposit date:2021-04-19
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJ1
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BU of 7mj1 by Molmil
LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with NAD
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Chatterjee, S, Rankin, J.A, Lagishetty, S, Hu, J, Hausinger, R.P.
Deposit date:2021-04-19
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.402 Å)
Cite:The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021

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PDB entries from 2024-03-27

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