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5HUQ
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A TETHERED NIACIN-DERIVED PINCER COMPLEX WITH A NICKEL-CARBON BOND IN LACTATE RACEMASE
Descriptor:Lactate racemization operon protein LarA, 1-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]-5-methanethioyl-pyridine-3-carbothioic S-acid, SULFATE ION, ...
Authors:Desguin, B., Zhang, T., Soumillion, P., Hols, P., Hu, J., Hausinger, R.P.
Deposit date:2016-01-27
Release date:2016-02-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase.
Science, 349, 2015
2YJG
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STRUCTURE OF THE LACTATE RACEMASE APOPROTEIN FROM THERMOANAEROBACTERIUM THERMOSACCHAROLYTICUM
Descriptor:LACTATE RACEMASE APOPROTEIN, MAGNESIUM ION, SULFATE ION, ...
Authors:Declercq, J.P., Desguin, B., Soumillion, P., Hols, P.
Deposit date:2011-05-19
Release date:2012-05-30
Last modified:2014-07-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Lactate Racemase is a Nickel-Dependent Enzyme Activated by a Widespread Maturation System.
Nat.Commun., 5, 2014
6BWO
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LARC2, THE C-TERMINAL DOMAIN OF A CYCLOMETALLASE INVOLVED IN THE SYNTHESIS OF THE NPN COFACTOR OF LACTATE RACEMASE, APO FORM
Descriptor:Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2017-12-15
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.
J. Biol. Chem., 293, 2018
5UDQ
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE, APO FORM
Descriptor:Lactate racemization operon protein LarE, SULFATE ION, PHOSPHATE ION
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDR
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE IN COMPLEX WITH NICOTINAMIDE MONONUCLEOTID NMN
Descriptor:ATP-utilizing enzyme of the PP-loopsuperfamily, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, MANGANESE (II) ION
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDS
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE, IN COMPLEX WITH MGATP
Descriptor:Lactate racemization operon protein LarE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDT
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE, IN COMPLEX WITH AMP
Descriptor:Lactate racemization operon protein LarE, ADENOSINE MONOPHOSPHATE, PHOSPHATE ION
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.188 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDU
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE, IN COMPLEX WITH MANGANESE
Descriptor:Lactate racemization operon protein LarE, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.792 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDV
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE, IN COMPLEX WITH IRON
Descriptor:Lactate racemization operon protein LarE, FE (III) ION, PHOSPHATE ION, ...
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.621 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDW
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE, IN COMPLEX WITH NICKEL
Descriptor:Lactate racemization operon protein LarE, PHOSPHATE ION, NICKEL (II) ION, ...
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UDX
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE, IN COMPLEX WITH ZINC
Descriptor:Lactate racemization operon protein LarE, ZINC ION, PHOSPHATE ION, ...
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2016-12-28
Release date:2017-08-23
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.784 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UNM
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE, SUBSTRATE FREE FORM WITH FLEXIBLE LOOP
Descriptor:ATP-utilizing enzyme of the PP-loopsuperfamily, PHOSPHATE ION
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2017-01-31
Release date:2017-08-23
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6C1W
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A TETHERED NIACIN-DERIVED PINCER COMPLEX WITH A NICKEL-CARBON OR SULFITE-CARBON BOND IN LACTATE RACEMASE
Descriptor:Lactate racemase, (4S)-5-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-4-sulfo-1,4-dihydropyridine-3-carbothioic S-acid, NICKEL (II) ION, ...
Authors:Fellner, M., Desguin, B., Hausinger, R.P., Hu, J.
Deposit date:2018-01-05
Release date:2018-03-14
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Lactate Racemase Nickel-Pincer Cofactor Operates by a Proton-Coupled Hydride Transfer Mechanism.
Biochemistry, 57, 2018
6BWQ
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LARC2, THE C-TERMINAL DOMAIN OF A CYCLOMETALLASE INVOLVED IN THE SYNTHESIS OF THE NPN COFACTOR OF LACTATE RACEMASE, IN COMPLEX WITH MNCTP
Descriptor:Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein, MANGANESE (II) ION, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Fellner, M., Hausinger, R.P., Hu, J.
Deposit date:2017-12-15
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.
J. Biol. Chem., 293, 2018
6BWR
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LARC2, THE C-TERMINAL DOMAIN OF A CYCLOMETALLASE INVOLVED IN THE SYNTHESIS OF THE NPN COFACTOR OF LACTATE RACEMASE, IN COMPLEX WITH NICKEL
Descriptor:Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein, NICKEL (II) ION
Authors:Fellner, M., Hausinger, R.P., Hu, J.
Deposit date:2017-12-15
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.
J. Biol. Chem., 293, 2018
6B2M
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE IN COMPLEX WITH COENZYME A
Descriptor:ATP-utilizing enzyme of the PP-loopsuperfamily, COENZYME A, PHOSPHATE ION
Authors:Fellner, M., Hausinger, R.P., Hu, J.
Deposit date:2017-09-20
Release date:2018-09-05
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.088 Å)
Cite:Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum.
Biochemistry, 57, 2018
6B2O
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LARE, A SULFUR TRANSFERASE INVOLVED IN SYNTHESIS OF THE COFACTOR FOR LACTATE RACEMASE, C176A VARIANT
Descriptor:ATP-utilizing enzyme of the PP-loopsuperfamily, PHOSPHATE ION, SULFATE ION
Authors:Fellner, M., Hausinger, R.P., Hu, J.
Deposit date:2017-09-20
Release date:2018-09-05
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum.
Biochemistry, 57, 2018