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7INS
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STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z
分子名称:INSULIN (CHAIN A), INSULIN (CHAIN B), GENERAL PROTAMINE CHAIN, ...
著者Balschmidt, P., Hansen, F.B., Dodson, E., Dodson, G., Korber, F.
登録日1991-09-03
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of porcine insulin cocrystallized with clupeine Z.
Acta Crystallogr.,Sect.B, 47, 1991
6INS
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X-RAY ANALYSIS OF THE SINGLE CHAIN B29-A1 PEPTIDE-LINKED INSULIN MOLECULE. A COMPLETELY INACTIVE ANALOGUE
分子名称:INSULIN, ZINC ION
著者Derewenda, U., Derewenda, Z., Dodson, E.J., Dodson, G.G., Bing, X., Markussen, J.
登録日1992-11-25
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.
J.Mol.Biol., 220, 1991
6B6Z
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CRYSTAL STRUCTURE OF THE APO ANTIBODY FRAGMENT (FAB) RAISED AGAINST C-TERMINAL DOMAIN OF EBOLA NUCLEOPROTEIN (EBOV, TAFV, BDBV STRAINS)
分子名称:Apo Fab Light Chain, Apo Fab Heavy Chain, ZINC ION
著者Radwanska, M.J., Derewenda, U., Kossiakoff, A.A., Derewenda, Z.S.
登録日2017-10-03
公開日2018-12-19
実験手法X-RAY DIFFRACTION (2.112 Å)
主引用文献Crystal structure of the Apo Antibody fragment (Fab) raised against C-terminal domain of Ebola nucleoprotein (EBOV, TAFV, BDBV strains)
To Be Published
5W2B
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CRYSTAL STRUCTURE OF C-TERMINAL DOMAIN OF EBOLA (RESTON) NUCLEOPROTEIN IN COMPLEX WITH FAB FRAGMENT
分子名称:Fab Heavy Chain, Fab Light Chain, Nucleoprotein
著者Radwanska, M.J., Derewenda, U., Kossiakoff, A.A., Derewenda, Z.S.
登録日2017-06-06
公開日2018-06-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of C-terminal domain of Ebola (Reston) nucleoprotein in complex with Fab fragment
To Be Published
5VZ1
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CRYSTAL STRUCTURE OF THE APO ANTIBODY FRAGMENT (FAB) RAISED AGAINST C-TERMINAL DOMAIN OF EBOLA NUCLEOPROTEIN (EBOV, TAFV, BDBV STRAINS)
分子名称:Apo Antibody Fab Light Chain, Apo Antibody Fab Heavy Chain, ZINC ION
著者Radwanska, M.J., Derewenda, U., Kossiakoff, A., Derewenda, Z.S.
登録日2017-05-26
公開日2018-06-27
実験手法X-RAY DIFFRACTION (2.112 Å)
主引用文献Crystal structure of the Apo Antibody fragment (Fab) raised against C-terminal domain of Ebola nucleoprotein (EBOV, TAFV, BDBV strains)
To Be Published
5VKD
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CRYSTAL STRUCTURE OF C-TERMINAL DOMAIN OF EBOLA (BUNDIBUGYO) NUCLEOPROTEIN IN COMPLEX WITH FAB FRAGMENT
分子名称:Nucleoprotein, Fab Heavy Chain, Fab light chain
著者Radwanska, M.J., Derewenda, U., Kossiakoff, A., Derewenda, Z.S.
登録日2017-04-21
公開日2018-04-25
実験手法X-RAY DIFFRACTION (1.749 Å)
主引用文献Crystal structure of C-terminal domain of Ebola (Bundibugyo) nucleoprotein in complex with Fab fragment
To Be Published
5VIM
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CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS5 METHYLTRANSFERASE.
分子名称:Methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION
著者Bukrejewska, M., Derewenda, Z.S., Derewenda, U.
登録日2017-04-17
公開日2017-09-06
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of the methyltransferase and helicase from the ZIKA 1947 MR766 Uganda strain.
Acta Crystallogr D Struct Biol, 73, 2017
5VI7
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CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS3 HELICASE
分子名称:helicase, SULFATE ION
著者Bukrejewska, M., Derewenda, U., Derewenda, Z.S.
登録日2017-04-14
公開日2017-09-06
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献Crystal structures of the methyltransferase and helicase from the ZIKA 1947 MR766 Uganda strain.
Acta Crystallogr D Struct Biol, 73, 2017
5TGL
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A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX
分子名称:LIPASE, N-HEXYLPHOSPHONATE ETHYL ESTER
著者Brzozowski, A.M., Derewenda, U., Derewenda, Z.S., Dodson, G.G., Lawson, D., Turkenburg, J.P., Bjorkling, F., Huge-Jensen, B., Patkar, S.R., Thim, L.
登録日1991-10-30
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex.
Nature, 351, 1991
5IRC
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P190A GAP DOMAIN COMPLEX WITH RHOA
分子名称:Rho GTPase-activating protein 35, Transforming protein RhoA, CHLORIDE ION, ...
著者Derewenda, U., Derewenda, Z.
登録日2016-03-12
公開日2016-08-17
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.
J.Biol.Chem., 291, 2016
5E2X
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THE CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF EBOLA (TAI FOREST) NUCLEOPROTEIN
分子名称:NP, NONAETHYLENE GLYCOL
著者Baker, L.E., Handing, K.B., Derewenda, U., Utepbergenov, D., Derewenda, Z.S.
登録日2015-10-01
公開日2015-10-21
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses.
Acta Crystallogr D Struct Biol, 72, 2016
5DSD
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THE CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF EBOLA (BUNDIBUGYO) NUCLEOPROTEIN
分子名称:Nucleoprotein, GLYCEROL, CHLORIDE ION
著者Baker, L., Handing, K.B., Utepbergenov, D., Derewenda, U., Derewenda, Z.S.
登録日2015-09-17
公開日2015-09-30
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses.
Acta Crystallogr D Struct Biol, 72, 2016
4TGL
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CATALYSIS AT THE INTERFACE: THE ANATOMY OF A CONFORMATIONAL CHANGE IN A TRIGLYCERIDE LIPASE
分子名称:TRIACYL-GLYCEROL ACYLHYDROLASE, DIETHYL PHOSPHONATE
著者Derewenda, U., Brzozowski, A.M., Lawson, D., Derewenda, Z.S.
登録日1991-07-29
公開日1993-07-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase.
Biochemistry, 31, 1992
4QB0
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THE CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF EBOLA (ZAIRE) NUCLEOPROTEIN
分子名称:Nucleoprotein
著者Derewenda, U., Dziubanska, P.J., Derewenda, Z.S.
登録日2014-05-06
公開日2014-09-10
最終更新日2014-09-24
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein.
Acta Crystallogr.,Sect.D, 70, 2014
4QAZ
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THE CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF EBOLA (ZAIRE) NUCLEOPROTEIN
分子名称:Nucleoprotein
著者Derewenda, U., Dziubanska, P.J., Derewenda, Z.S.
登録日2014-05-06
公開日2014-09-10
最終更新日2014-09-24
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein.
Acta Crystallogr.,Sect.D, 70, 2014
4GUE
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STRUCTURE OF N-TERMINAL KINASE DOMAIN OF RSK2 WITH FLAVONOID GLYCOSIDE QUERCITRIN
分子名称:Ribosomal protein S6 kinase alpha-3, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, MAGNESIUM ION, ...
著者Derewenda, U., Utepbergenov, D., Szukalska, G., Derewenda, Z.S.
登録日2012-08-29
公開日2013-01-30
最終更新日2013-03-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 A resolution.
Acta Crystallogr.,Sect.D, 69, 2013
4EL9
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STRUCTURE OF N-TERMINAL KINASE DOMAIN OF RSK2 WITH AFZELIN
分子名称:Ribosomal protein S6 kinase alpha-3, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside
著者Utepbergenov, D., Derewenda, U., Derewenda, Z.S.
登録日2012-04-10
公開日2012-09-05
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Insights into the Inhibition of the p90 Ribosomal S6 Kinase (RSK) by the Flavonol Glycoside SL0101 from the 1.5 A Crystal Structure of the N-Terminal Domain of RSK2 with Bound Inhibitor.
Biochemistry, 51, 2012
3ZQD
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B. SUBTILIS L,D-TRANSPEPTIDASE
分子名称:L, D-TRANSPEPTIDASE YKUD
著者Lecoq, L., Simorre, J.-P., Bougault, C., Arthur, M., Hugonnet, J.-E., Veckerle, C., Pessey, O.
登録日2011-06-09
公開日2012-05-23
最終更新日2018-01-24
実験手法SOLUTION NMR
主引用文献Dynamics Induced by Beta-Lactam Antibiotics in the Active Site of Bacillus subtilis L,D-Transpeptidase.
Structure, 20, 2012
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, PHENOL, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
登録日2011-12-09
公開日2012-12-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3UBD
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STRUCTURE OF N-TERMINAL DOMAIN OF RSK2 KINASE IN COMPLEX WITH FLAVONOID GLYCOSIDE SL0101
分子名称:Ribosomal protein S6 kinase alpha-3, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 3,4-di-O-acetyl-6-deoxy-alpha-L-mannopyranoside
著者Utepbergenov, D., Derewenda, U., Derewenda, Z.S.
登録日2011-10-24
公開日2012-09-05
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Insights into the Inhibition of the p90 Ribosomal S6 Kinase (RSK) by the Flavonol Glycoside SL0101 from the 1.5 A Crystal Structure of the N-Terminal Domain of RSK2 with Bound Inhibitor.
Biochemistry, 51, 2012
3TV0
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STRUCTURE OF DYNACTIN P27 SUBUNIT
分子名称:Dynactin subunit 6
著者Derewenda, Z.S., Derewenda, U., Kowalska, A.
登録日2011-09-19
公開日2012-10-03
実験手法X-RAY DIFFRACTION (2.1492 Å)
主引用文献Dynactin targets Polo-like kinase 1 to kinetochores
To be Published
3TGL
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STRUCTURE AND MOLECULAR MODEL REFINEMENT OF RHIZOMUCOR MIEHEI TRIACYLGLYCERIDE LIPASE: A CASE STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT
分子名称:TRIACYL-GLYCEROL ACYLHYDROLASE
著者Brady, L., Brzozowski, A.M., Derewenda, Z.S., Dodson, E.J., Dodson, G.G., Tolley, S.P., Turkenburg, J.P., Christiansen, L., Huge-Jensen, B., Norskov, L., Thim, L.
登録日1991-07-29
公開日1993-07-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献STRUCTURE AND MOLECULAR-MODEL REFINEMENT OF RHIZOMUCOR-MIEHEI TRIACYLGLYCERIDE LIPASE - A CASE-STUDY OF THE USE OF SIMULATED ANNEALING IN PARTIAL MODEL REFINEMENT.
Acta Crystallogr.,Sect.B, 48, 1992
3T06
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CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF PDZRHOGEF WITH N-TERMINAL REGULATORY ELEMENTS IN COMPLEX WITH HUMAN RHOA
分子名称:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA
著者Bielnicki, J.A., Derewenda, U., Derewenda, Z.S.
登録日2011-07-19
公開日2011-08-03
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF.
J.Biol.Chem., 286, 2011
3SXZ
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METAL-FREE FCD DOMAIN OF TM0439 A PUTATIVE TRANSCRIPTIONAL REGULATOR
分子名称:Transcriptional regulator, GntR family
著者Czelakowski, G.P., Derewenda, Z.S., Integrated Center for Structure and Function Innovation (ISFI)
登録日2011-07-15
公開日2011-11-16
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.322 Å)
主引用文献Metal-free FCD domain of TM0439 a putative transcriptional regulator
To be Published