Author results

1VHR
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HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE
Descriptor:HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE VHR, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION
Authors:Yuvaniyama, J., Denu, J.M., Dixon, J.E., Saper, M.A.
Deposit date:1996-02-20
Release date:1996-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the dual specificity protein phosphatase VHR.
Science, 272, 1996
3C9B
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CRYSTAL STRUCTURE OF SEMET VPS75
Descriptor:Vacuolar protein sorting-associated protein 75
Authors:Keck, J.L., Berndsen, C.E., Tsubota, T., Lindner, S.E., Lee, S., Holton, J.M., Kaufman, P.D., Denu, J.M.
Deposit date:2008-02-15
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75
Nat.Struct.Mol.Biol., 15, 2008
3C9D
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CRYSTAL STRUCTURE OF VPS75
Descriptor:Vacuolar protein sorting-associated protein 75
Authors:Berndsen, C.E., Tsubota, T., Lindner, S.E., Lee, S., Holton, J.M., Kaufman, P.D., Keck, J.L., Denu, J.M.
Deposit date:2008-02-15
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75
Nat.Struct.Mol.Biol., 15, 2008
1J4X
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HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE C124S MUTANT-PEPTIDE COMPLEX
Descriptor:DUAL SPECIFICITY PROTEIN PHOSPHATASE 3, DDE(AHP)(TPO)G(PTR)VATR
Authors:Schumacher, M.A., Todd, J.L., Tanner, K.G., Denu, J.M.
Deposit date:2001-12-13
Release date:2001-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase.
Biochemistry, 41, 2002
3V8E
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CRYSTAL STRUCTURE OF THE YEAST NICOTINAMIDASE PNC1P BOUND TO THE INHIBITOR NICOTINALDEHYDE
Descriptor:Nicotinamidase, ZINC ION, MAGNESIUM ION
Authors:Hoadley, K.A., Smith, B.C., Denu, J.M., Keck, J.L.
Deposit date:2011-12-22
Release date:2012-01-25
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural and Kinetic Isotope Effect Studies of Nicotinamidase (Pnc1) from Saccharomyces cerevisiae.
Biochemistry, 51, 2012
4UC4
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CRYSTAL STRUCTURE OF HYBRID TUDOR DOMAIN OF HUMAN LYSINE DEMETHYLASE KDM4B
Descriptor:Lysine-specific demethylase 4B
Authors:Wang, F., Su, Z., Denu, J.M., Phillips Jr., G.N.
Deposit date:2014-08-13
Release date:2016-03-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.5612 Å)
Cite:Reader domain specificity and lysine demethylase-4 family function.
Nat Commun, 7, 2016
5D6W
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CRYSTAL STRUCTURE OF DOUBLE TUDOR DOMAIN OF HUMAN LYSINE DEMETHYLASE KDM4A
Descriptor:Lysine-specific demethylase 4A, S,R MESO-TARTARIC ACID
Authors:Wang, F., Su, Z., Denu, J.M., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-08-13
Release date:2015-11-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.992 Å)
Cite:Reader domain specificity and lysine demethylase-4 family function.
Nat Commun, 7, 2016
5D6X
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CRYSTAL STRUCTURE OF DOUBLE TUDOR DOMAIN OF HUMAN LYSINE DEMETHYLASE KDM4A
Descriptor:Lysine-specific demethylase 4A, SULFATE ION
Authors:Wang, F., Su, Z., Denu, J.M., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-08-13
Release date:2015-11-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Reader domain specificity and lysine demethylase-4 family function.
Nat Commun, 7, 2016
5D6Y
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CRYSTAL STRUCTURE OF DOUBLE TUDOR DOMAIN OF HUMAN LYSINE DEMETHYLASE KDM4A COMPLEXED WITH HISTONE H3K23ME3
Descriptor:Lysine-specific demethylase 4A, peptide H3K23me3 (19-28)
Authors:Wang, F., Su, Z., Miller, M.D., Denu, J.M., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-08-13
Release date:2016-02-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.287 Å)
Cite:Reader domain specificity and lysine demethylase-4 family function.
Nat Commun, 7, 2016
1XMT
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X-RAY STRUCTURE OF GENE PRODUCT FROM ARABIDOPSIS THALIANA AT1G77540
Descriptor:putative acetyltransferase, BROMIDE ION
Authors:Wesenberg, G.E., Smith, D.W., Phillips Jr., G.N., Bitto, E., Bingman, C.A., Allard, S.T.M., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2004-10-04
Release date:2004-10-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure of Arabidopsis thaliana At1g77540 Protein, a Minimal Acetyltransferase from the COG2388 Family.
Biochemistry, 45, 2006
2EVN
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NMR SOLUTION STRUCTURES OF AT1G77540
Descriptor:Protein At1g77540
Authors:Tyler, R.C., Singh, S., Tonelli, M., Min, M.S., Markley, J.L., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2005-10-31
Release date:2005-11-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of Arabidopsis thaliana At1g77540 Protein, a Minimal Acetyltransferase from the COG2388 Family.
Biochemistry, 45, 2006
2IL4
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CRYSTAL STRUCTURE OF AT1G77540-COENZYME A COMPLEX
Descriptor:Protein At1g77540, COENZYME A
Authors:Bitto, E., Wesenberg, G.E., Phillips Jr., G.N., Bingman, C.A., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2006-10-02
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Structure of Arabidopsis thaliana At1g77540 Protein, a Minimal Acetyltransferase from the COG2388 Family.
Biochemistry, 45, 2006
2L5U
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STRUCTURE OF THE FIRST PHD FINGER (PHD1) FROM CHD4 (MI2B)
Descriptor:Chromodomain-helicase-DNA-binding protein 4, ZINC ION
Authors:Mansfield, R.E., Kwan, A.H., Mackay, J.P.
Deposit date:2010-11-08
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9
J.Biol.Chem., 286, 2011
2L75
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SOLUTION STRUCTURE OF CHD4-PHD2 IN COMPLEX WITH H3K9ME3
Descriptor:Chromodomain-helicase-DNA-binding protein 4, 14-meric peptide from 1Histone H3.1, ZINC ION
Authors:Mansfield, R.E., Kwan, A.H., Mackay, J.P.
Deposit date:2010-12-02
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9
J.Biol.Chem., 286, 2011
2L8R
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SOLUTION STRUCTURE OF HUMAN PROTEIN C6ORF130 IN COMPLEX WITH ADP-RIBOSE
Descriptor:Uncharacterized protein C6orf130, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Lytle, B.L., Peterson, F.C., Volkman, B.F., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2011-01-22
Release date:2011-02-23
Last modified:2011-10-26
Method:SOLUTION NMR
Cite:Orphan Macrodomain Protein (Human C6orf130) Is an O-Acyl-ADP-ribose Deacylase: SOLUTION STRUCTURE AND CATALYTIC PROPERTIES.
J.Biol.Chem., 286, 2011
2LGR
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SOLUTION STRUCTURE OF HUMAN PROTEIN C6ORF130, A PUTATIVE MACRO DOMAIN
Descriptor:Uncharacterized protein C6orf130
Authors:Volkman, B.F., Lytle, B.L., Peterson, F.C., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2011-08-01
Release date:2011-08-17
Last modified:2011-10-26
Method:SOLUTION NMR
Cite:Orphan Macrodomain Protein (Human C6orf130) Is an O-Acyl-ADP-ribose Deacylase: SOLUTION STRUCTURE AND CATALYTIC PROPERTIES.
J.Biol.Chem., 286, 2011
2X47
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CRYSTAL STRUCTURE OF HUMAN MACROD1
Descriptor:MACRO DOMAIN-CONTAINING PROTEIN 1, SULFATE ION
Authors:Vollmar, M., Phillips, C., Mehrotra, P.V., Ahel, I., Krojer, T., Yue, W., Ugochukwu, E., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Gileadi, O.
Deposit date:2010-01-28
Release date:2010-03-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification of Macro Domain Proteins as Novel O-Acetyl-Adp-Ribose Deacetylases.
J.Biol.Chem., 286, 2011
3K35
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CRYSTAL STRUCTURE OF HUMAN SIRT6
Descriptor:NAD-dependent deacetylase sirtuin-6, ZINC ION, ADENOSINE-5-DIPHOSPHORIBOSE, ...
Authors:Pan, P.W., Dong, A., Qiu, W., Loppnau, P., Wang, J., Ravichandran, M., Bochkarev, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Min, J., Edwards, A.M., Structural Genomics Consortium (SGC)
Deposit date:2009-10-01
Release date:2009-12-08
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and biochemical functions of SIRT6.
J.Biol.Chem., 286, 2011
3PKI
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HUMAN SIRT6 CRYSTAL STRUCTURE IN COMPLEX WITH ADP RIBOSE
Descriptor:NAD-dependent deacetylase sirtuin-6, UNKNOWN ATOM OR ION, ZINC ION, ...
Authors:Pan, P.W., Dong, A., Qiu, W., Loppnau, P., Wang, J., Ravichandran, M., Bochkarev, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Min, J., Edwards, A.M., Structural Genomics Consortium (SGC)
Deposit date:2010-11-11
Release date:2011-01-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structure and biochemical functions of SIRT6.
J.Biol.Chem., 286, 2011
3PKJ
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HUMAN SIRT6 CRYSTAL STRUCTURE IN COMPLEX WITH 2'-N-ACETYL ADP RIBOSE
Descriptor:NAD-dependent deacetylase sirtuin-6, [(2R,3S,4R,5R)-4-(acetylamino)-3,5-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ZINC ION, ...
Authors:Pan, P.W., Dong, A., Qiu, W., Loppnau, P., Wang, J., Ravichandran, M., Walker, J.R., Bountra, C., Weigelt, J., Arrowsmith, C.H., Min, J., Edwards, A.M., Structural Genomics Consortium (SGC)
Deposit date:2010-11-11
Release date:2011-01-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structure and biochemical functions of SIRT6.
J.Biol.Chem., 286, 2011
4Y6L
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HUMAN SIRT2 IN COMPLEX WITH MYRISTOYLATED PEPTIDE (H3K9MYR)
Descriptor:NAD-dependent protein deacetylase sirtuin-2, peptide THR-ALA-ARG-MYK-SER-THR-GLY, ZINC ION
Authors:Kudo, N., Ito, A., Yoshida, M.
Deposit date:2015-02-13
Release date:2016-01-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.
Biochemistry, 54, 2015
4Y6O
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HUMAN SIRT2 IN COMPLEX WITH MYRISTOYLATED PEPTIDE (TNF-ALPHAK20MYR)
Descriptor:NAD-dependent protein deacetylase sirtuin-2, peptide LEU-PRO-LYS-MYK-THR-GLY-GLY, ZINC ION
Authors:Kudo, N., Ito, A., Yoshida, M.
Deposit date:2015-02-13
Release date:2016-01-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.
Biochemistry, 54, 2015
4Y6Q
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HUMAN SIRT2 IN COMPLEX WITH 2-O-MYRISTOYL-ADP-RIBOSE
Descriptor:NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate
Authors:Kudo, N., Ito, A., Yoshida, M.
Deposit date:2015-02-13
Release date:2016-01-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.
Biochemistry, 54, 2015
5Z8L
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA EBS IN COMPLEX WITH AN H3K27ME3 PEPTIDE
Descriptor:Chromatin remodeling protein EBS, H3K27me3 peptide, ZINC ION
Authors:Yang, Z., Du, J.
Deposit date:2018-01-31
Release date:2018-07-25
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.
Nat. Genet., 50, 2018
5Z8N
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA EBS C-TERMINAL DELETION CONSTRUCT IN COMPLEX WITH AN H3K4ME2 PEPTIDE
Descriptor:Chromatin remodeling protein EBS, H3K4me2 peptide, ZINC ION
Authors:Yang, Z., Du, J.
Deposit date:2018-01-31
Release date:2018-07-25
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.
Nat. Genet., 50, 2018
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