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2CHN
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BACTEROIDES THETAIOTAOMICRON HEXOSAMINIDASE WITH O-GLCNACASE ACTIVITY- NAG-THIAZOLINE COMPLEX
Descriptor:GLUCOSAMINIDASE, CALCIUM ION, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, ...
Authors:Dennis, R.J., Taylor, E.J., Macauley, M.S., Stubbs, K.A., Turkenburg, J.P., Hart, S.J., Black, G.N., Vocadlo, D.J., Davies, G.J.
Deposit date:2006-03-15
Release date:2006-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and Mechanism of a Bacterial B-Glucosaminidase Having O-Glcnacase Activity
Nat.Struct.Mol.Biol., 13, 2006
2CHO
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BACTEROIDES THETAIOTAOMICRON HEXOSAMINIDASE WITH O-GLCNACASE ACTIVITY
Descriptor:GLUCOSAMINIDASE, CALCIUM ION, ACETATE ION, ...
Authors:Dennis, R.J., Taylor, E.J., Macauley, M.S., Stubbs, K.A., Turkenburg, J.P., Hart, S.J., Black, G.N., Vocadlo, D.J., Davies, G.J.
Deposit date:2006-03-16
Release date:2006-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and Mechanism of a Bacterial B-Glucosaminidase Having O-Glcnacase Activity
Nat.Struct.Mol.Biol., 13, 2006
2J47
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR
Descriptor:GLUCOSAMINIDASE, (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE, GLYCEROL
Authors:Dennis, R.J., Davies, G.J.
Deposit date:2006-08-25
Release date:2006-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Inhibition of O-Glcnacase by a Gluco-Configured Nagstatin and a Pugnac-Imidazole Hybrid Inhibitor
Chem. Commun., 42, 2006
2J4G
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH N-BUTYL- THIAZOLINE INHIBITOR
Descriptor:HYALURONOGLUCOSAMINIDASE, (3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-PROPYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL, ACETATE ION, ...
Authors:Dennis, R.J., Davies, G.J.
Deposit date:2006-08-31
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Analysis of Pugnac and Nag-Thiazoline as Transition State Analogues for Human O-Glcnacase: Mechanistic and Structural Insights Into Inhibitor Selectivity and Transition State Poise.
J.Am.Chem.Soc., 129, 2007
2JIW
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH 2- ACETYLAMINO-2-DEOXY-1-EPIVALIENAMINE
Descriptor:O-GLCNACASE BT_4395, N-[(1S,2R,5R,6R)-2-AMINO-5,6-DIHYDROXY-4-(HYDROXYMETHYL)CYCLOHEX-3-EN-1-YL]ACETAMIDE
Authors:Dennis, R.J., Davies, G.J.
Deposit date:2007-07-02
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A 1-Acetamido Derivative of 6-Epi-Valienamine: An Inhibitor of a Diverse Group of Beta-N-Acetylglucosaminidases.
Org.Biomol.Chem., 5, 2007
2WK2
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CHITINASE A FROM SERRATIA MARCESCENS ATCC990 IN COMPLEX WITH CHITOTRIO-THIAZOLINE DITHIOAMIDE.
Descriptor:CHITINASE A, 2-deoxy-2-(ethanethioylamino)-beta-D-glucopyranose, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, ...
Authors:Taylor, E.J., Dennis, R.J., Macdonald, J.M., Tarling, C.A., Knapp, S., Withers, S.G., Davies, G.J.
Deposit date:2009-06-04
Release date:2010-03-16
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines.
Angew.Chem.Int.Ed.Engl., 49, 2010
2WLY
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CHITINASE A FROM SERRATIA MARCESCENS ATCC990 IN COMPLEX WITH CHITOTRIO-THIAZOLINE.
Descriptor:Chitinase, 1,4-DIETHYLENE DIOXIDE, DI(HYDROXYETHYL)ETHER, ...
Authors:Taylor, E.J., Dennis, R.J., Macdonald, J.M., Tarling, C.A., Knapp, S., Withers, S.G., Davies, G.J.
Deposit date:2009-06-29
Release date:2010-03-16
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Chitinase inhibition by chitobiose and chitotriose thiazolines.
Angew. Chem. Int. Ed. Engl., 49, 2010
2WLZ
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CHITINASE A FROM SERRATIA MARCESCENS ATCC990 IN COMPLEX WITH CHITOBIO- THIAZOLINE.
Descriptor:CHITINASE A, 1,4-DIETHYLENE DIOXIDE, DI(HYDROXYETHYL)ETHER, ...
Authors:Taylor, E.J., Dennis, R.J., Macdonald, J.M., Tarling, C.A., Knapp, S., Withers, S.G., Davies, G.J.
Deposit date:2009-06-29
Release date:2010-03-16
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines.
Angew.Chem.Int.Ed.Engl., 49, 2010
2WM0
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CHITINASE A FROM SERRATIA MARCESCENS ATCC990 IN COMPLEX WITH CHITOBIO- THIAZOLINE THIOAMIDE.
Descriptor:CHITINASE A, N-ACETYL-D-GLUCOSAMINE, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, ...
Authors:Taylor, E.J., Dennis, R.J., Macdonald, J.M., Tarling, C.A., Knapp, S., Withers, S.G., Davies, G.J.
Deposit date:2009-06-29
Release date:2010-03-16
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines.
Angew.Chem.Int.Ed.Engl., 49, 2010
2CDY
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MANGANESE SUPEROXIDE DISMUTASE (MN-SOD) FROM DEINOCOCCUS RADIODURANS
Descriptor:SUPEROXIDE DISMUTASE [MN], MANGANESE (II) ION
Authors:Dennis, R., Micossi, E., McCarthy, J., Moe, E., Gordon, E., Leonard, G., McSweeney, S.
Deposit date:2006-01-31
Release date:2006-02-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 62, 2006
2CE4
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MANGANESE SUPEROXIDE DISMUTASE (MN-SOD) FROM DEINOCOCCUS RADIODURANS
Descriptor:SUPEROXIDE DISMUTASE [MN], MANGANESE (II) ION
Authors:Dennis, R., Micossi, E., McCarthy, J., Moe, E., Gordon, E., Leonard, G., McSweeney, S.
Deposit date:2006-02-03
Release date:2006-02-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 62, 2006
1AWF
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NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT
Descriptor:ALPHA THROMBIN, HIRUGEN, R3-ACETOXY-17-(1-FORMYL-5-METHYL-3-OXO-HEX-4-ENYL)-12,16-DIHYDROXY-14-HYDROXYMETHYL-4,10,13-TRIMETHYL-2,3,4,5,6,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-4-CARBOXYLIC ACID IDOPYRANOSYL ESTER
Authors:Jhoti, H., Cleasby, A., Wonacott, A.
Deposit date:1997-10-02
Release date:1998-10-28
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.
Biochemistry, 37, 1998
1AWH
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NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT
Descriptor:ALPHA THROMBIN, 3-ACETOXY-17-(1-FORMYL-5-METHYL-3-OXO-HEX-4-ENYL)-16-HYDROXY-4,10,13,14-TETRAMETHYL-2,3,4,5,6,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-4-CARBOXYLIC ACID
Authors:Jhoti, H., Cleasby, A., Wonacott, A.
Deposit date:1997-10-02
Release date:1998-10-28
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.
Biochemistry, 37, 1998
2VVN
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BTGH84 IN COMPLEX WITH NH-BUTYLTHIAZOLINE
Descriptor:O-GLCNACASE BT_4395, GLYCEROL, AMMONIUM ION, ...
Authors:He, Y., Davies, G.J.
Deposit date:2008-06-10
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Potent Mechanism-Inspired O-Glcnacase Inhibitor that Blocks Phosphorylation of Tau in Vivo.
Nat.Chem.Biol., 4, 2008