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1K6L
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PHOTOSYNETHETIC REACTION CENTER FROM RHODOBACTER SPHAEROIDES
Descriptor:PHOTOSYNTHETIC REACTION CENTER L SUBUNIT, PHOTOSYNTHETIC REACTION CENTER M SUBUNIT, PHOTOSYNTHETIC REACTION CENTER H SUBUNIT, ...
Authors:Pokkuluri, P.R., Laible, P.D., Deng, Y.-L., Wong, T.N., Hanson, D.K., Schiffer, M.
Deposit date:2001-10-16
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structure of a mutant photosynthetic reaction center shows unexpected changes in main chain orientations and quinone position.
Biochemistry, 41, 2002
1K6N
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E(L212)A,D(L213)A DOUBLE MUTANT STRUCTURE OF PHOTOSYNTHETIC REACTION CENTER FROM RHODOBACTER SPHAEROIDES
Descriptor:PHOTOSYNTHETIC REACTION CENTER L SUBUNIT, PHOTOSYNTHETIC REACTION CENTER M SUBUNIT, PHOTOSYNTHETIC REACTION CENTER H SUBUNIT, ...
Authors:Pokkuluri, P.R., Laible, P.D., Deng, Y.-L., Wong, T.N., Hanson, D.K., Schiffer, M.
Deposit date:2001-10-16
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structure of a mutant photosynthetic reaction center shows unexpected changes in main chain orientations and quinone position.
Biochemistry, 41, 2002
4H6J
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IDENTIFICATION OF CYS 255 IN HIF-1 AS A NOVEL SITE FOR DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 /ARNT PASB DOMAIN PROTEIN-PROTEIN INTERACTION.
Descriptor:HYPOXIA INDUCIBLE FACTOR 1-ALPHA, ARYL HYDROCARBON NUCLEAR TRANSLOCATOR
Authors:Cardoso, R., Love, R.A., Nilsson, C., Bergqvist, S., Nowlin, D., Yan, J., Liu, K., Zhu, J., Chen, P., Deng, Y.-L., Dyson, H.J., Greig, M.J., Brooun, A.
Deposit date:2012-09-19
Release date:2012-12-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Protein Sci., 21, 2012
4TUU
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ISOLATED P110A SUBUNIT OF PI3KA PROVIDES A PLATFORM FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Chen, P., Deng, Y.-L., Bergqvist, S., Falk, M., Liu, W., Timofeevski, S.
Deposit date:2014-06-24
Release date:2014-08-06
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23, 2014
4TV3
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ISOLATED P110A SUBUNIT OF PI3KA PROVIDES A PLATFORM FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Authors:Chen, P., Deng, Y.-L., Bergqvist, S., Falk, M., Liu, W., Timofeevski, S.
Deposit date:2014-06-25
Release date:2014-08-06
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23, 2014
5A9U
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STRUCTURE OF C1156Y MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL- 15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE).
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Authors:McTigue, M., Deng, Y.-L., Liu, W., Brooun, A., Stewart, A.
Deposit date:2015-07-22
Release date:2016-06-08
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F.
N.Engl.J.Med., 374, 2016
5AA8
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STRUCTURE OF C1156Y,L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL- 15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE).
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Authors:McTigue, M., Deng, Y.-L., Liu, W., Brooun, A., Stewart, A.
Deposit date:2015-07-23
Release date:2016-06-08
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F.
N.Engl.J.Med., 374, 2016
5AA9
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STRUCTURE OF L1198F MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL- 15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE).
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Authors:McTigue, M., Deng, Y.-L., Liu, W., Brooun, A., Stewart, A.
Deposit date:2015-07-23
Release date:2016-06-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F.
N.Engl.J.Med., 374, 2016
5IJ7
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STRUCTURE OF HS/ACPRC2 IN COMPLEX WITH A PYRIDONE INHIBITOR
Descriptor:Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Gajiwala, K.S., Brooun, A., Deng, Y.-L., Liu, W.
Deposit date:2016-03-01
Release date:2016-05-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun, 7, 2016
5IJ8
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STRUCTURE OF THE PRIMARY ONCOGENIC MUTANT Y641N HS/ACPRC2 IN COMPLEX WITH A PYRIDONE INHIBITOR
Descriptor:Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Gajiwala, K.S., Brooun, A., Deng, Y.-L., Liu, W.
Deposit date:2016-03-01
Release date:2016-05-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun, 7, 2016
1EK3
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KAPPA-4 IMMUNOGLOBULIN VL, REC
Descriptor:KAPPA-4 IMMUNOGLOBULIN LIGHT CHAIN VL, CHLORIDE ION, CALCIUM ION
Authors:Pokkuluri, P.R., Huang, D.-B., Raffen, R., Stevens, F.J., Schiffer, M.
Deposit date:2000-03-06
Release date:2001-03-06
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Structure of Amyloidogenic Kappa-4 Immunoglobulin VL, REC
To be Published