Author results

4APP
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4 IN COMPLEX WITH (S)-N-(5-(3-BENZYL-1-METHYLPIPERAZINE-4-CARBONYL)-6,6-DIMETHYL-1,4,5, 6-TETRAHYDROPYRROLO(3,4-C)PYRAZOL-3-YL)-3-PHENOXYBENZAMIDE
Descriptor:SERINE/THREONINE-PROTEIN KINASE PAK 4, N-[6,6-dimethyl-5-[(2S)-4-methyl-2-(phenylmethyl)piperazin-1-yl]carbonyl-2,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-phenoxy-benzamide, GLYCEROL
Authors:Knighton, D.D., Deng, Y.L., Wang, C., Guo, C., McAlpine, I., Zhang, J., Kephart, S., Johnson, M.C., Li, H., Bouzida, D., Yang, A., Dong, L., Marakovits, J., Tikhe, J., Richardson, P., Guo, L.C., Kania, R., Edwards, M.P., Kraynov, E., Christensen, J., Piraino, J., Lee, J., Dagostino, E., Del-Carmen, C., Smeal, T., Murray, B.W.
Deposit date:2012-04-04
Release date:2012-06-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of Pyrroloaminopyrazoles as Novel Pak Inhibitors.
J.Med.Chem., 55, 2012
4CLI
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STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF- 06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL-15-OXO-10,15,16, 17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE).
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-14
Release date:2014-05-28
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CLJ
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STRUCTURE OF L1196M MUTANT HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH PF-06463922 ((10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL- 15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE).
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-14
Release date:2014-05-28
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CMO
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STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 2-((1R)-1-((3-AMINO-6-(2-METHOXYPYRIDIN-3-YL)PYRAZIN-2-YL) OXY)ETHYL)-4-FLUORO-N-METHYLBENZAMIDE
Descriptor:ALK TYROSINE KINASE RECEPTOR, 2-[(1R)-1-{[3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl]oxy}ethyl]-4-fluoro-N-methylbenzamide
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-16
Release date:2014-05-28
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CMT
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STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL)ETHOXY)- 5-(3-(METHYLSULFONYL)PHENYL)PYRIDIN-2-AMINE
Descriptor:ALK TYROSINE KINASE RECEPTOR, 3-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}-5-[3-(methylsulfonyl)phenyl]pyridin-2-amine
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-17
Release date:2014-05-28
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CMU
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STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR (10R)-7-AMINO-12-FLUORO-1,3,10,16-TETRAMETHYL-16,17-DIHYDRO- 1H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11)BENZOXADIAZACYCLOTETRADECIN-15(10H)-ONE
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-17
Release date:2014-05-28
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CNH
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STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 3-((1R)-1-(5-FLUORO-2-METHOXYPHENYL)ETHOXY)-5-(1-METHYL-1H- 1,2,3-TRIAZOL-5-YL)PYRIDIN-2-AMINE
Descriptor:ALK TYROSINE KINASE RECEPTOR, 3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-methyl-1H-1,2,3-triazol-5-yl)pyridin-2-amine
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-01-22
Release date:2014-05-28
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CTB
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STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR (5R)-8-AMINO-3-FLUORO-5,19-DIMETHYL-20-OXO-5,18,19,20- TETRAHYDRO-7,11-(AZENO)PYRIDO(2',1':2,3)IMIDAZO(4,5-H)(2,5,11) BENZOXADIAZACYCLOTETRADECINE-14-CARBONITRILE
Descriptor:ALK TYROSINE KINASE RECEPTOR, (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20-tetrahydro-11,7-(azeno)pyrido[2',1':2,3]imidazo[4,5-h][2,5,11]benzoxadiazacyclotetradecine-14-carbonitrile
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-03-12
Release date:2014-05-28
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
4CTC
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STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH THE INHIBITOR 7-AMINO-3-CYCLOPROPYL-12-FLUORO-1,10,16-TRIMETHYL-16,17- DIHYDRO-1H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11) BENZOXADIAZACYCLOTETRADECIN-15(10H)-ONE
Descriptor:ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one
Authors:McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.
Deposit date:2014-03-12
Release date:2014-05-28
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
J.Med.Chem., 57, 2014
5KZ0
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STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH 2-[(1R)-1-{[2-AMINO-5-(1,3-DIMETHYL-1H-PYRAZOL-4-YL)PYRIDIN-3-YL]OXY}ETHYL]-4-FLUORO-N,N-DIMETHYLBENZAMIDE
Descriptor:ALK tyrosine kinase receptor, 2-[(1~{R})-1-[2-azanyl-5-(1,3-dimethylpyrazol-4-yl)pyridin-3-yl]oxyethyl]-4-fluoranyl-~{N},~{N}-dimethyl-benzamide
Authors:McTigue, M., Deng, Y.L., Liu, W., Brooun, A.
Deposit date:2016-07-22
Release date:2016-08-17
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.
J. Med. Chem., 57, 2014
1K6L
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PHOTOSYNETHETIC REACTION CENTER FROM RHODOBACTER SPHAEROIDES
Descriptor:PHOTOSYNTHETIC REACTION CENTER L SUBUNIT, PHOTOSYNTHETIC REACTION CENTER M SUBUNIT, PHOTOSYNTHETIC REACTION CENTER H SUBUNIT, ...
Authors:Pokkuluri, P.R., Laible, P.D., Deng, Y.-L., Wong, T.N., Hanson, D.K., Schiffer, M.
Deposit date:2001-10-16
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structure of a mutant photosynthetic reaction center shows unexpected changes in main chain orientations and quinone position.
Biochemistry, 41, 2002
1K6N
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E(L212)A,D(L213)A DOUBLE MUTANT STRUCTURE OF PHOTOSYNTHETIC REACTION CENTER FROM RHODOBACTER SPHAEROIDES
Descriptor:PHOTOSYNTHETIC REACTION CENTER L SUBUNIT, PHOTOSYNTHETIC REACTION CENTER M SUBUNIT, PHOTOSYNTHETIC REACTION CENTER H SUBUNIT, ...
Authors:Pokkuluri, P.R., Laible, P.D., Deng, Y.-L., Wong, T.N., Hanson, D.K., Schiffer, M.
Deposit date:2001-10-16
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structure of a mutant photosynthetic reaction center shows unexpected changes in main chain orientations and quinone position.
Biochemistry, 41, 2002
4H6J
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IDENTIFICATION OF CYS 255 IN HIF-1 AS A NOVEL SITE FOR DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 /ARNT PASB DOMAIN PROTEIN-PROTEIN INTERACTION.
Descriptor:HYPOXIA INDUCIBLE FACTOR 1-ALPHA, ARYL HYDROCARBON NUCLEAR TRANSLOCATOR
Authors:Cardoso, R., Love, R.A., Nilsson, C., Bergqvist, S., Nowlin, D., Yan, J., Liu, K., Zhu, J., Chen, P., Deng, Y.-L., Dyson, H.J., Greig, M.J., Brooun, A.
Deposit date:2012-09-19
Release date:2012-12-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Protein Sci., 21, 2012
4TUU
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ISOLATED P110A SUBUNIT OF PI3KA PROVIDES A PLATFORM FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Chen, P., Deng, Y.-L., Bergqvist, S., Falk, M., Liu, W., Timofeevski, S.
Deposit date:2014-06-24
Release date:2014-08-06
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23, 2014
4TV3
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ISOLATED P110A SUBUNIT OF PI3KA PROVIDES A PLATFORM FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Authors:Chen, P., Deng, Y.-L., Bergqvist, S., Falk, M., Liu, W., Timofeevski, S.
Deposit date:2014-06-25
Release date:2014-08-06
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23, 2014
4W2R
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STRUCTURE OF HS/ACPRC2 IN COMPLEX WITH 5,8-DICHLORO-2-[(4-METHOXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL]-7-[(R)-METHOXY(OXETAN-3-YL)METHYL]-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE
Descriptor:Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Gajiwala, K.S., Brooun, A., Liu, W., Deng, Y., Stewart, A.E.
Deposit date:2017-09-25
Release date:2017-12-27
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J. Med. Chem., 61, 2018
5IJ7
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STRUCTURE OF HS/ACPRC2 IN COMPLEX WITH A PYRIDONE INHIBITOR
Descriptor:Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Gajiwala, K.S., Brooun, A., Deng, Y.-L., Liu, W.
Deposit date:2016-03-01
Release date:2016-05-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun, 7, 2016
5IJ8
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STRUCTURE OF THE PRIMARY ONCOGENIC MUTANT Y641N HS/ACPRC2 IN COMPLEX WITH A PYRIDONE INHIBITOR
Descriptor:Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Gajiwala, K.S., Brooun, A., Deng, Y.-L., Liu, W.
Deposit date:2016-03-01
Release date:2016-05-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun, 7, 2016
6B3W
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STRUCTURE OF HS/ACPRC2 IN COMPLEX WITH 5,8-DICHLORO-7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-[(4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL]-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE
Descriptor:Enhancer of zeste 2 polycomb repressive complex 2 subunit,Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Gajiwala, K.S., Brooun, A., Liu, W., Deng, Y., Stewart, A.E.
Deposit date:2017-09-25
Release date:2017-12-27
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J. Med. Chem., 61, 2018
3JVR
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CHARACTERIZATION OF THE CHK1 ALLOSTERIC INHIBITOR BINDING SITE
Descriptor:Serine/threonine-protein kinase Chk1, (1S)-1-(1H-benzimidazol-2-yl)ethyl (3,4-dichlorophenyl)carbamate
Authors:Chen, P.
Deposit date:2009-09-17
Release date:2009-10-06
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Characterization of the CHK1 allosteric inhibitor binding site.
Biochemistry, 48, 2009
3JVS
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CHARACTERIZATION OF THE CHK1 ALLOSTERIC INHIBITOR BINDING SITE
Descriptor:Serine/threonine-protein kinase Chk1, 2-[(4-tert-butyl-3-nitrophenyl)carbonyl]-N-naphthalen-1-ylhydrazinecarboxamide
Authors:Chen, P.
Deposit date:2009-09-17
Release date:2009-10-06
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of the CHK1 allosteric inhibitor binding site.
Biochemistry, 48, 2009
6CDT
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STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE DOMAIN
Descriptor:ALK tyrosine kinase receptor
Authors:McTigue, M., Deng, Y.L., Liu, W., Brooun, A.
Deposit date:2018-02-09
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.
ACS Med Chem Lett, 9, 2018
1LVE
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STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN
Descriptor:LEN, A VARIABLE DOMAIN FROM KAPPA-4 TYPE
Authors:Schiffer, M., Huang, D.-B., Chang, C.-H.
Deposit date:1996-07-17
Release date:1998-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Variable domain structure of kappaIV human light chain Len: high homology to the murine light chain McPC603.
Mol.Immunol., 34, 1997