Author results

2PI2
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FULL-LENGTH REPLICATION PROTEIN A SUBUNITS RPA14 AND RPA32
Descriptor:Replication protein A 32 kDa subunit, Replication protein A 14 kDa subunit, 1,4-DIETHYLENE DIOXIDE
Authors:Deng, X., Borgstahl, G.E.
Deposit date:2007-04-12
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Full-length Human RPA14/32 Complex Gives Insights into the Mechanism of DNA Binding and Complex Formation.
J.Mol.Biol., 374, 2007
2PQA
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CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN RPA 14/32 HETERODIMER
Descriptor:Replication protein A 32 kDa subunit, Replication protein A 14 kDa subunit
Authors:Deng, X., Borgstahl, G.E.
Deposit date:2007-05-01
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the full-length human RPA14/32 complex gives insights into the mechanism of DNA binding and complex formation.
J.Mol.Biol., 374, 2007
2Z6K
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CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN RPA14/32 HETERODIMER
Descriptor:Replication protein A 32 kDa subunit, Replication protein A 14 kDa subunit
Authors:Deng, X., Habel, J.E., Kabaleeswaran, V., Borgstahl, G.E.
Deposit date:2007-08-03
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Full-length Human RPA14/32 Complex Gives Insights into the Mechanism of DNA Binding and Complex Formation
J.Mol.Biol., 374, 2007
3I65
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH TRIAZOLOPYRIMIDINE-BASED INHIBITOR DSM1
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial, 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2009-07-06
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3I68
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH TRIAZOLOPYRIMIDINE-BASED INHIBITOR DSM2
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial, N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2009-07-06
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3I6R
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH TRIAZOLOPYRIMIDINE-BASED INHIBITOR DSM74
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial, 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2009-07-07
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3N29
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CRYSTAL STRUCTURE OF CARBOXYNORSPERMIDINE DECARBOXYLASE COMPLEXED WITH NORSPERMIDINE FROM CAMPYLOBACTER JEJUNI
Descriptor:Carboxynorspermidine decarboxylase, PYRIDOXAL-5'-PHOSPHATE, N-(3-aminopropyl)propane-1,3-diamine, ...
Authors:Deng, X., Lee, J., Michael, A.J., Tomchick, D.R., Goldsmith, E.J., Phillips, M.A.
Deposit date:2010-05-17
Release date:2010-06-09
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
J.Biol.Chem., 285, 2010
3N2O
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X-RAY CRYSTAL STRUCTURE OF ARGININE DECARBOXYLASE COMPLEXED WITH ARGININE FROM VIBRIO VULNIFICUS
Descriptor:Biosynthetic arginine decarboxylase, PYRIDOXAL-5'-PHOSPHATE, AGMATINE
Authors:Deng, X., Lee, J., Michael, A.J., Tomchick, D.R., Goldsmith, E.J., Phillips, M.A.
Deposit date:2010-05-18
Release date:2010-06-09
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
J.Biol.Chem., 285, 2010
3S84
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DIMERIC APOA-IV
Descriptor:Apolipoprotein A-IV, SULFATE ION
Authors:Deng, X., Davidson, W.S., Thompson, T.B.
Deposit date:2011-05-27
Release date:2012-05-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of Dimeric Apolipoprotein A-IV and Its Mechanism of Self-Association.
Structure, 20, 2012
4OQV
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE BOUND WITH DSM338 (N-[3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PHENYL]-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2014-02-10
Release date:2014-06-04
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4ORI
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RAT DIHYDROOROTATE DEHYDROGENASE BOUND WITH DSM338 (N-[3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PHENYL]-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2014-02-11
Release date:2014-06-04
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4ORM
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM338 (N-[3,5-DIFLUORO-4-(TRIFLUOROMETHYL)PHENYL]-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE)
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M.A.
Deposit date:2014-02-11
Release date:2014-06-04
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
5DV0
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STRUCTURE OF S. PNEUMONIAE D39 SORTASE A
Descriptor:Sortase SrtA
Authors:Deng, X.
Deposit date:2015-09-21
Release date:2016-10-12
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:Structure of S. pneumoniae D39 Sortase A
To Be Published
5O09
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BTUBABC MINI MICROTUBULE
Descriptor:Tubulin, Tubulin BtubB, Bacterial kinesin light chain, ...
Authors:Deng, X., Bharat, T.A.M., Lowe, J.
Deposit date:2017-05-16
Release date:2017-07-19
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Four-stranded mini microtubules formed by Prosthecobacter BtubAB show dynamic instability.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4Q2V
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CRYSTAL STRUCTURE OF RICIN A CHAIN COMPLEXED WITH BAICALIN INHIBITOR
Descriptor:Ricin, 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid
Authors:Deng, X., Li, X., Dong, J., Chen, Y.
Deposit date:2014-04-10
Release date:2015-04-15
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Baicalin Inhibits the Lethality of Ricin in Mice by Inducing Protein Oligomerization
J.Biol.Chem., 2015
4QEI
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TWO DISTINCT CONFORMATIONAL STATES OF GLYRS CAPTURED IN CRYSTAL LATTICE
Descriptor:Glycine--tRNA ligase, tRNA-Gly-CCC-2-2, ADENOSINE MONOPHOSPHATE
Authors:Xie, W., Qin, X., Deng, X., Zhang, Q., Li, Q.
Deposit date:2014-05-16
Release date:2015-05-20
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.875 Å)
Cite:Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis
J.Biol.Chem., 291, 2016
4RX0
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM265
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M., Tomchick, D.
Deposit date:2014-12-08
Release date:2015-07-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Sci Transl Med, 7, 2015
3O8A
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH NOVEL INHIBITOR GENZ667348
Descriptor:Dihydroorotate dehydrogenase homolog, mitochondrial, N-cyclopropyl-5-[2-methyl-5-(trifluoromethoxy)-1H-benzimidazol-1-yl]thiophene-2-carboxamide, ...
Authors:Deng, X., Booker, M.L., Phillips, M.A.
Deposit date:2010-08-02
Release date:2010-08-18
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
J.Biol.Chem., 285, 2010
3SFK
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM267
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-(1,1-difluoroethyl)-5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Deng, X., Phillips, M.
Deposit date:2011-06-13
Release date:2011-07-06
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential.
J.Med.Chem., 54, 2011
4IGH
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE BOUND WITH 4-QUINOLINE CARBOXYLIC ACID ANALOG
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X., Das, P., Fontoura, B.M.A., Phillips, M.A., De Brabander, J.K.
Deposit date:2012-12-17
Release date:2013-08-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.
ACS MED.CHEM.LETT., 4, 2013
4JPH
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CRYSTAL STRUCTURE OF PROTEIN RELATED TO DAN AND CERBERUS (PRDC)
Descriptor:Gremlin-2, GLYCEROL, GLUTATHIONE, ...
Authors:Deng, X., Nolan, K.T., Kattamuri, C., Thompson, T.B.
Deposit date:2013-03-19
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of protein related to dan and cerberus: insights into the mechanism of bone morphogenetic protein antagonism.
Structure, 21, 2013
5D1Q
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ISDB NEAT2 BOUND BY CLONE D2-06
Descriptor:D2-06 Light Chain, D2-06 Heavy Chain, P5 Heavy Chain, ...
Authors:Deng, X.
Deposit date:2015-08-04
Release date:2016-08-10
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire.
Nat Commun, 7, 2016
5D1X
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ISDB NEAT2 BOUND BY D4-30
Descriptor:D4-30 Light Chain, D4-30 Heavy Chain, P5 Heavy Chain, ...
Authors:Deng, X.
Deposit date:2015-08-04
Release date:2016-08-10
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire.
Nat Commun, 7, 2016
5D1Z
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ISDB NEAT1 BOUND BY CLONE D4-10
Descriptor:Y10 Light Chain, Y10 Heavy Chain, D4-10 Light Chain, ...
Authors:Deng, X.
Deposit date:2015-08-04
Release date:2016-09-14
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire.
Nat Commun, 7, 2016
5DEL
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE BOUND WITH INHIBITOR DSM59
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Phillips, M., Deng, X.
Deposit date:2015-08-25
Release date:2015-10-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions.
Acta Crystallogr.,Sect.F, 71, 2015