Author results

1T7V
  • Download 1t7v
  • View 1t7v
Molmil generated image of 1t7v
ZN-ALPHA-2-GLYCOPROTEIN; BACULO-ZAG PEG 200
Descriptor:Zinc-alpha-2-glycoprotein, N-ACETYL-D-GLUCOSAMINE, HEXAETHYLENE GLYCOL
Authors:Delker, S.L., West Jr., A.P., McDermott, L., Kennedy, M.W., Bjorkman, P.J.
Deposit date:2004-05-11
Release date:2004-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.
J.Struct.Biol., 148, 2004
1T7W
  • Download 1t7w
  • View 1t7w
Molmil generated image of 1t7w
ZN-ALPHA-2-GLYCOPROTEIN; CHO-ZAG PEG 400
Descriptor:Zinc-alpha-2-glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Delker, S.L., West Jr., A.P., McDermott, L., Kennedy, M.W., Bjorkman, P.J.
Deposit date:2004-05-11
Release date:2004-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.
J.Struct.Biol., 148, 2004
1T7X
  • Download 1t7x
  • View 1t7x
Molmil generated image of 1t7x
ZN-ALPHA-2-GLYCOPROTEIN; REFOLDED CHO-ZAG PEG 400
Descriptor:Zinc-alpha-2-glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Delker, S.L., West Jr., A.P., McDermott, L., Kennedy, M.W., Bjorkman, P.J.
Deposit date:2004-05-11
Release date:2004-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.
J.Struct.Biol., 148, 2004
1T7Y
  • Download 1t7y
  • View 1t7y
Molmil generated image of 1t7y
ZN-ALPHA-2-GLYCOPROTEIN; BACULO-ZAG PEG 200, NO GLYCEROL
Descriptor:Zinc-alpha-2-glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Delker, S.L., West Jr., A.P., McDermott, L., Kennedy, M.W., Bjorkman, P.J.
Deposit date:2004-05-11
Release date:2004-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.
J.Struct.Biol., 148, 2004
1T7Z
  • Download 1t7z
  • View 1t7z
Molmil generated image of 1t7z
ZN-ALPHA-2-GLYCOPROTEIN; BACULO-ZAG NO PEG, NO GLYCEROL
Descriptor:Zinc-alpha-2-glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Delker, S.L., West Jr., A.P., McDermott, L., Kennedy, M.W., Bjorkman, P.J.
Deposit date:2004-05-11
Release date:2004-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.
J.Struct.Biol., 148, 2004
1T80
  • Download 1t80
  • View 1t80
Molmil generated image of 1t80
ZN-ALPHA-2-GLYCOPROTEIN; CHO-ZAG PEG 200
Descriptor:Zinc-alpha-2-glycoprotein, N-ACETYL-D-GLUCOSAMINE
Authors:Delker, S.L., West Jr., A.P., McDermott, L., Kennedy, M.W., Bjorkman, P.J.
Deposit date:2004-05-11
Release date:2004-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein.
J.Struct.Biol., 148, 2004
3JWS
  • Download 3jws
  • View 3jws
Molmil generated image of 3jws
STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE R349A MUTANT HEME DOMAIN COMPLEXED WITH N1-[(3' S,4'S)-4'-((6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL)PYRROLIDIN-3'-YL]-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE TETRAHYDROCHLORIDE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JWT
  • Download 3jwt
  • View 3jwt
Molmil generated image of 3jwt
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE R349A MUTANT HEME DOMAIN IN COMPLEX WITH N1-{(3'R,4'R)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JWU
  • Download 3jwu
  • View 3jwu
Molmil generated image of 3jwu
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE R349A MUTANT HEME DOMAIN IN COMPLEX WITH N1-{(3'R,4'S)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE TETRAHYDROCHLORIDE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JWV
  • Download 3jwv
  • View 3jwv
Molmil generated image of 3jwv
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE R349A MUTANT HEME DOMAIN IN COMPLEX WITH N1-{(3'S,4'R)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JWW
  • Download 3jww
  • View 3jww
Molmil generated image of 3jww
STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N1-[(3'S,4'S)-4'-((6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL)PYRROLIDIN-3'-YL]-N2- (3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE TETRAHYDROCHLORIDE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JWX
  • Download 3jwx
  • View 3jwx
Molmil generated image of 3jwx
STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N1-[(3'R,4'R)-4'-((6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL)PYRROLIDIN-3'-YL]-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE TETRAHYDROCHLORIDE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JWY
  • Download 3jwy
  • View 3jwy
Molmil generated image of 3jwy
STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N1-{(3'R,4'S)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE TETRAHYDROCHLORIDE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JWZ
  • Download 3jwz
  • View 3jwz
Molmil generated image of 3jwz
STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N1-[(3' S,4' R)-4'-((6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL)PYRROLIDIN-3'-YL]-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE TETRAHYDROCHLORIDE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JX0
  • Download 3jx0
  • View 3jx0
Molmil generated image of 3jx0
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE D597N MUTANT HEME DOMAIN IN COMPLEX WITH N1-{(3'S,4'S)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JX1
  • Download 3jx1
  • View 3jx1
Molmil generated image of 3jx1
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE D597N MUTANT HEME DOMAIN IN COMPLEX WITH N1-{(3'R,4'R)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JX2
  • Download 3jx2
  • View 3jx2
Molmil generated image of 3jx2
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE D597N/M336V MUTANT HEME DOMAIN IN COMPLEX WITH N1-{(3'S,4'S)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JX3
  • Download 3jx3
  • View 3jx3
Molmil generated image of 3jx3
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE D597N/M336V MUTANT HEME DOMAIN IN COMPLEX WITH N1-{(3'R,4'R)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JX4
  • Download 3jx4
  • View 3jx4
Molmil generated image of 3jx4
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE D597N/M336V MUTANT HEME DOMAIN IN COMPLEX WITH N1-{(3'R,4'S)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JX5
  • Download 3jx5
  • View 3jx5
Molmil generated image of 3jx5
STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE D597N/M336V MUTANT HEME DOMAIN IN COMPLEX WITH N1-{(3'S,4'R)-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3JX6
  • Download 3jx6
  • View 3jx6
Molmil generated image of 3jx6
STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE D597N/M336V/Y706A MUTANT HEME DOMAIN COMPLEXED WITH N1-[(3' R,4' R)-4'-((6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL)PYRROLIDIN-3'-YL]-N2-(3'-FLUOROPHENETHYL)ETHANE-1,2-DIAMINE TETRAHYDROCHLORIDE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2009-09-18
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
3N5P
  • Download 3n5p
  • View 3n5p
Molmil generated image of 3n5p
STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 4-(2-(6-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-2-YL)ETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5Q
  • Download 3n5q
  • View 3n5q
Molmil generated image of 3n5q
STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, CACODYLIC ACID, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5R
  • Download 3n5r
  • View 3n5r
Molmil generated image of 3n5r
STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 4-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5S
  • Download 3n5s
  • View 3n5s
Molmil generated image of 3n5s
STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 4-(2-(5-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)ETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010