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4AU1
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CRYSTAL STRUCTURE OF COBH (PRECORRIN-8X METHYL MUTASE) COMPLEXED WITH C5 DESMETHYL-HBA
Descriptor:PRECORRIN-8X METHYLMUTASE, DESMETHYL-HBA, SULFATE ION
Authors:Deery, E., Lawrence, A.D., Schroeder, S., Taylor, S.L., Seyedarabi, A., Vevodova, J., Wilson, K.S., Brown, D., Geeves, M.A., Howard, M.J., Pickersgill, R.W., Warren, M.J.
Deposit date:2012-05-11
Release date:2012-09-19
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:An Enzyme-Trap Approach Allows Isolation of Intermediates in Cobalamin Biosynthesis
Nat.Chem.Biol., 8, 2012
4FDV
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COBH FROM RHODOBACTER CAPSULATUS (SB1003) IN COMPLEX WITH HBA
Descriptor:Precorrin-8X methylmutase, 3-[(1R,2R,3R,5R,6S,7R,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-hydroxy-2-oxoethyl)-3,12,17-tris(3-hydroxy-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-1,2,5,6,7,12,17,22-octahydrocorrin-7-yl]propanoic acid, GLYCEROL
Authors:Pickersgill, R.W., Schroeder, S., Deery, E., Warren, M.J.
Deposit date:2012-05-29
Release date:2012-10-17
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.
Nat.Chem.Biol., 8, 2012
2W6K
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THE CRYSTAL STRUCTURE AT 1.7 A RESOLUTION OF COBE, A PROTEIN FROM THE COBALAMIN (VITAMIN B12) BIOSYNTHETIC PATHWAY
Descriptor:COBE, SULFATE ION, GLYCEROL
Authors:Vevodova, J., Smith, D., McGoldrick, H., Deery, E., Murzin, A.G., Warren, M.J., Wilson, K.S.
Deposit date:2008-12-18
Release date:2008-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure at 1.7 A Resolution of Cobe, a Protein from the Cobalamin (Vitamin B12) Biosynthetic Pathway
To be Published
2W6L
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THE CRYSTAL STRUCTURE AT 1.7 A RESOLUTION OF COBE, A PROTEIN FROM THE COBALAMIN (VITAMIN B12) BIOSYNTHETIC PATHWAY
Descriptor:COBE, SULFATE ION, GLYCEROL
Authors:Vevodova, J., Smith, D., McGoldrick, H., Deery, E., Murzin, A.G., Warren, M.J., Wilson, K.S.
Deposit date:2008-12-18
Release date:2008-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:The Crystal Structure at 1.7 A Resolution of Cobe, a Protein from the Cobalamin (Vitamin B12) Biosynthetic Pathway
To be Published
2XWP
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ANAEROBIC COBALT CHELATASE (CBIK) FROM SALMONELLA TYPHIMURIUM IN COMPLEX WITH METALATED TETRAPYRROLE
Descriptor:SIROHYDROCHLORIN COBALTOCHELATASE, COBALT SIROHYDROCHLORIN, GLYCEROL
Authors:Ladakis, D., Brindley, A.A., Deery, E., Warren, M.J., Pickersgill, R.W.
Deposit date:2010-11-04
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evolution in a Family of Chelatases Facilitated by the Introduction of Active Site Asymmetry and Protein Oligomerization.
Proc.Natl.Acad.Sci.USA, 108, 2011
2XWQ
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ANAEROBIC COBALT CHELATASE FROM ARCHEAOGLOBUS FULGIDUS (CBIX) IN COMPLEX WITH METALATED SIROHYDROCHLORIN PRODUCT
Descriptor:SIROHYDROCHLORIN COBALTOCHELATASE, COBALT SIROHYDROCHLORIN
Authors:Ladakis, D., Brindley, A.A., Deery, E., Warren, M.J., Pickersgill, R.W.
Deposit date:2010-11-04
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Evolution in a Family of Chelatases Facilitated by the Introduction of Active Site Asymmetry and Protein Oligomerization.
Proc.Natl.Acad.Sci.USA, 108, 2011
2XWS
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ANAEROBIC COBALT CHELATASE (CBIX) FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:SIROHYDROCHLORIN COBALTOCHELATASE
Authors:Romao, C.V., Ladakis, D., Lobo, S.A.L., Carrondo, M.A., Brindley, A.A., Deery, E., Matias, P.M., Pickersgill, R.W., Saraiva, L.M., Warren, M.J.
Deposit date:2010-11-04
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Evolution in a Family of Chelatases Facilitated by the Introduction of Active Site Asymmetry and Protein Oligomerization.
Proc.Natl.Acad.Sci.USA, 108, 2011
4CCS
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THE STRUCTURE OF CBIX, THE TERMINAL ENZYME FOR BIOSYNTHESIS OF SIROHEME IN DENITRIFYING BACTERIA
Descriptor:CBIX, D-MALATE, SODIUM ION, ...
Authors:Bali, S., Rollauer, S.E., Roversi, P., Raux-Deery, E., Lea, S.M., Warren, M.J., Ferguson, S.J.
Deposit date:2013-10-25
Release date:2014-04-09
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification and Characterization of the 'Missing' Terminal Enzyme for Siroheme Biosynthesis in Alpha-Proteobacteria.
Mol.Microbiol., 92, 2014
4MLQ
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CRYSTAL STRUCTURE OF BACILLUS MEGATERIUM PORPHOBILINOGEN DEAMINASE
Descriptor:Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, 3-[(5S)-5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]propanoic acid, ...
Authors:Azim, N., Deery, E., Warren, M.J., Erskine, P., Cooper, J.B., Coker, A., Wood, S.P., Akhtar, M.
Deposit date:2013-09-06
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Bacillus megaterium enzyme at near-atomic resolution.
Acta Crystallogr.,Sect.D, 70, 2014
4MLV
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CRYSTAL STRUCTURE OF BACILLUS MEGATERIUM PORPHOBILINOGEN DEAMINASE
Descriptor:Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, 3-[(5S)-5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]propanoic acid, ...
Authors:Azim, N., Deery, E., Warren, M.J., Erskine, P., Cooper, J.B., Coker, A., Wood, S.P., Akhtar, M.
Deposit date:2013-09-06
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.455 Å)
Cite:Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Bacillus megaterium enzyme at near-atomic resolution.
Acta Crystallogr.,Sect.D, 70, 2014
4X7G
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COBK PRECORRIN-6A REDUCTASE
Descriptor:Precorrin-6A reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[(1R,2S,3S,7S,11S,16S,17R,18R,19R)-2,7,12,18-tetrakis(2-hydroxy-2-oxoethyl)-3,13-bis(3-hydroxy-3-oxopropyl)-1,2,5,7,11,17-hexamethyl-17-(3-oxidanyl-3-oxidanylidene-prop-1-enyl)-3,6,8,10,15,16,18,19,21,24-decahydrocorrin-8-yl]propanoic acid
Authors:Gu, S., Deery, E., Warren, M.J., Pickersgill, R.W.
Deposit date:2014-12-09
Release date:2016-01-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Crystal structure of CobK reveals strand-swapping between Rossmann-fold domains and molecular basis of the reduced precorrin product trap.
Sci Rep, 5, 2015
3NJR
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CRYSTAL STRUCTURE OF C-TERMINAL DOMAIN OF PRECORRIN-6Y C5,15-METHYLTRANSFERASE FROM RHODOBACTER CAPSULATUS
Descriptor:Precorrin-6y methylase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL, ...
Authors:Seyedarabi, A., Pickersgill, R.W.
Deposit date:2010-06-17
Release date:2011-06-08
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.
Nat.Chem.Biol., 8, 2012
2DJ5
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CRYSTAL STRUCTURE OF THE VITAMIN B12 BIOSYNTHETIC COBALTOCHELATASE, CBIXS, FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:Sirohydrochlorin cobaltochelatase, PHOSPHATE ION, GLYCEROL
Authors:Yin, J., Cherney, M.M., James, M.N.G.
Deposit date:2006-03-31
Release date:2006-09-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal Structure of the Vitamin B(12) Biosynthetic Cobaltochelatase, CbiX (S), from Archaeoglobus Fulgidus
J.STRUCT.FUNCT.GENOM., 7, 2006
2QBU
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CRYSTAL STRUCTURE OF METHANOTHERMOBACTER THERMAUTOTROPHICUS CBIL
Descriptor:Precorrin-2 methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Frank, S., Warren, M.J., Pickersgill, R.W.
Deposit date:2007-06-18
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Elucidation of substrate specificity in the cobalamin (vitamin B12) biosynthetic methyltransferases. Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicus.
J.Biol.Chem., 282, 2007
2XVX
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COBALT CHELATASE CBIK (PERIPLASMATIC) FROM DESULVOBRIO VULGARIS HILDENBOROUGH (NATIVE)
Descriptor:CHELATASE, PUTATIVE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Romao, C.V., Lobo, S.A.L., Carrondo, M.A., Saraiva, L.M., Matias, P.M.
Deposit date:2010-10-28
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evolution in a Family of Chelatases Facilitated by the Introduction of Active Site Asymmetry and Protein Oligomerization.
Proc.Natl.Acad.Sci.USA, 108, 2011
2XVZ
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COBALT CHELATASE CBIK (PERIPLASMATIC) FROM DESULVOBRIO VULGARIS HILDENBOROUGH (CO-CRYSTALLIZED WITH COBALT)
Descriptor:CHELATASE, PUTATIVE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Romao, C.V., Lobo, S.A.L., Carrondo, M.A., Saraiva, L.M., Matias, P.M.
Deposit date:2010-10-28
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Evolution in a Family of Chelatases Facilitated by the Introduction of Active Site Asymmetry and Protein Oligomerization.
Proc.Natl.Acad.Sci.USA, 108, 2011
3CB0
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COBR
Descriptor:4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE, FLAVIN MONONUCLEOTIDE
Authors:Lawrence, A.D., Warren, M.J., Pickersgill, R.W.
Deposit date:2008-02-21
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification, characterization, and structure/function analysis of a corrin reductase involved in adenosylcobalamin biosynthesis
J.Biol.Chem., 283, 2008
4CZD
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SIROHAEM DECARBOXYLASE AHBA/B - AN ENZYME WITH STRUCTURAL HOMOLOGY TO THE LRP/ASNC TRANSCRIPTION FACTOR FAMILY THAT IS PART OF THE ALTERNATIVE HAEM BIOSYNTHESIS PATHWAY.
Descriptor:PUTATIVE TRANSCRIPTIONAL REGULATOR, ASNC FAMILY
Authors:Palmer, D.J., Brown, D.G., Warren, M.J.
Deposit date:2014-04-17
Release date:2014-06-11
Last modified:2014-07-30
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:The Structure, Function and Properties of Sirohaem Decarboxylase - an Enzyme with Structural Homology to a Transcription Factor Family that is Part of the Alternative Haem Biosynthesis Pathway.
Mol.Microbiol., 93, 2014
4UN1
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SIROHAEM DECARBOXYLASE AHBA/B - AN ENZYME WITH STRUCTURAL HOMOLOGY TO THE LRP/ASNC TRANSCRIPTION FACTOR FAMILY THAT IS PART OF THE ALTERNATIVE HAEM BIOSYNTHESIS PATHWAY.
Descriptor:PUTATIVE TRANSCRIPTIONAL REGULATOR, ASNC FAMILY, 12,18-DIDECARBOXY-SIROHEME
Authors:Palmer, D.J., Brown, D.G., Warren, M.J., Pickersgill, R.W.
Deposit date:2014-05-23
Release date:2014-06-11
Last modified:2014-07-30
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The Structure, Function and Properties of Sirohaem Decarboxylase - an Enzyme with Structural Homology to a Transcription Factor Family that is Part of the Alternative Haem Biosynthesis Pathway.
Mol.Microbiol., 93, 2014
5C4R
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COBK PRECORRIN-6A REDUCTASE
Descriptor:Precorrin-6A reductase
Authors:Gu, S., Pickersgill, R.W.
Deposit date:2015-06-18
Release date:2016-11-16
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Crystal structure of CobK reveals strand-swapping between Rossmann-fold domains and molecular basis of the reduced precorrin product trap.
Sci Rep, 5, 2015