Author results

5GM8
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ, SINEFUNGIN
Authors:Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2016-07-13
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5GMB
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
Authors:Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2016-07-13
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5GMC
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
Authors:Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2016-07-13
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5WRP
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T-STATE CRYSTAL STRUCTURE OF PYRUVATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Pyruvate kinase, PHOSPHATE ION
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-02
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WS8
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PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE
Descriptor:Pyruvate kinase, MAGNESIUM ION, OXALATE ION
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WS9
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PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE, ATP AND ALLOSTERIC ACTIVATOR AMP
Descriptor:Pyruvate kinase, MAGNESIUM ION, OXALATE ION, ...
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WSA
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PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE AND ALLOSTERIC ACTIVATOR GLUCOSE 6-PHOSPHATE
Descriptor:Pyruvate kinase, ALPHA-D-GLUCOSE-6-PHOSPHATE, MAGNESIUM ION, ...
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WSB
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PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE, ALLOSTERIC ACTIVATORS AMP AND GLUCOSE 6-PHOSPHATE
Descriptor:Pyruvate kinase, ADENOSINE MONOPHOSPHATE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WSC
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CRYSTAL OF PYRUVATE KINASE (PYK) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH OXALATE, SOAKED WITH ALLOSTERIC ACTIVATORS AMP AND GLUCOSE 6-PHOSPHATE
Descriptor:Pyruvate kinase, ADENOSINE MONOPHOSPHATE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Zhong, W., Cai, Q., El Sahili, A., Lescar, J., Dedon, P.C.
Deposit date:2016-12-06
Release date:2017-11-15
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.
Nat Commun, 8, 2017
5WYQ
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W., McBee, M.E., Maenpuen, S., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M., Chaiyen, P.
Deposit date:2017-01-15
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystal Structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa
To Be Published
5WYR
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, SINEFUNGIN
Authors:Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W.H., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2017-01-15
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure and catalytic mechanism of TrmD from Pseudomonas aeruginosa, a m1G37 tRNA methyltransferase essential for bacterial survival
To Be Published
5ZHI
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APO CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:tRNA (guanine-N(1)-)-methyltransferase
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Apo crystal structure of TrmD from Mycobacterium tuberculosis
To Be Published
5ZHJ
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH S-ADENOSYL HOMOCYSTEINE (SAH)
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of TrmD from Mycobacterium tuberculosis in complex with S-adenosyl homocysteine (SAH)
To Be Published
5ZHK
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-[(4-{[cyclohexyl(ethyl)amino]methyl}phenyl)methyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor
To Be Published
5ZHL
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of TrmD from Mycobacterium tuberculosis in complex with active-site inhibitor
To Be Published
5ZHM
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(diethylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide, S-ADENOSYLMETHIONINE
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor
To Be Published
5ZHN
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor
To Be Published
5ZQK
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DENGUE VIRUS NON STRUCTURAL PROTEIN 5
Descriptor:Non Structural Protein 5, S-ADENOSYLMETHIONINE, GLYCEROL, ...
Authors:El Sahili, A., Soh, T.S., Schiltz, J., Gharbi-Ayachi, A., Goh, B.C., Seh, C.C., Dedon, P.C., Shi, P.Y., Lim, S.P., Lescar, J.
Deposit date:2018-04-19
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A conformation of Dengue virus serotype 2 NS5 akin to its ZIKV and JEV homologues.
To Be Published
5XAJ
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STRUCTURAL MIMICRY OF THE DENGUE VIRUS ENVELOPE GLYCOPROTEIN REVEALED BY THE CRYSTALLOGRAPHIC STUDY OF AN IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX.
Descriptor:FabHM14c10 heavy chain, FabHM14c10 light chain, Fab E1 light chain, ...
Authors:Wong, Y.H., Goh, B.C., Lescar, J.
Deposit date:2017-03-13
Release date:2017-06-14
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex
J. Virol., 2017
1PIK
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ESPERAMICIN A1-DNA COMPLEX, NMR, 4 STRUCTURES
Descriptor:DNA (5'-D(C*GP*GP*AP*TP*CP*CP*GP)-3'), 2,4-DIDEOXY-4-[2-(PROPYL)AMINO]-3-O-METHYL ALPHA-L-THREO-PENTOPYRANOSIDE, 4,5-DIMETHOXY-N-(2'-METHOXYPROPENOYL ANTHRANILATE), ...
Authors:Kumar, R.A., Ikemoto, N., Patel, D.J.
Deposit date:1996-12-11
Release date:1997-03-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Esperamicin A1-DNA Complex
J.Mol.Biol., 265, 1997