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1SMR
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THE 3-D STRUCTURE OF MOUSE SUBMAXILLARY RENIN COMPLEXED WITH A DECAPEPTIDE INHIBITOR CH-66 BASED ON THE 4-16 FRAGMENT OF RAT ANGIOTENSINOGEN
分子名称:RENIN, INHIBITOR CH-66
著者Dealwis, C.G., Blundell, T.L.
登録日1992-03-11
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
J.Mol.Biol., 236, 1994
1AJA
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THREE-DIMENSIONAL STRUCTURE OF THE D153G MUTANT OF E. COLI ALKALINE PHOSPHATASE: A MUTANT WITH WEAKER MAGNESIUM BINDING AND INCREASED CATALYTIC ACTIVITY
分子名称:ALKALINE PHOSPHATASE
著者Dealwis, C.G., Chen, L., Abad-Zapatero, C.
登録日1995-08-19
公開日1995-11-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
Biochemistry, 34, 1995
1AJB
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THREE-DIMENSIONAL STRUCTURE OF THE D153G MUTANT OF E. COLI ALKALINE PHOSPHATASE: A MUTANT WITH WEAKER MAGNESIUM BINDING AND INCREASED CATALYTIC ACTIVITY
分子名称:ALKALINE PHOSPHATASE, ZINC ION, MAGNESIUM ION, ...
著者Dealwis, C.G., Chen, L., Abad-Zapatero, C.
登録日1995-08-19
公開日1995-11-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity.
Protein Eng., 8, 1995
1AJC
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THREE-DIMENSIONAL STRUCTURE OF THE D153G MUTANT OF E. COLI ALKALINE PHOSPHATASE: A MUTANT WITH WEAKER MAGNESIUM BINDING AND INCREASED CATALYTIC ACTIVITY
分子名称:ALKALINE PHOSPHATASE, ZINC ION, MAGNESIUM ION
著者Dealwis, C.G., Chen, L., Abad-Zapatero, C.
登録日1995-07-18
公開日1995-11-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
Biochemistry, 34, 1995
1AJD
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THREE-DIMENSIONAL STRUCTURE OF THE D153G MUTANT OF E. COLI ALKALINE PHOSPHATASE: A MUTANT WITH WEAKER MAGNESIUM BINDING AND INCREASED CATALYTIC ACTIVITY
分子名称:ALKALINE PHOSPHATASE INTERMEDIATE II OF HOLO ENZYME, ZINC ION, MAGNESIUM ION
著者Dealwis, C.G., Chen, L., Abad-Zapatero, C.
登録日1995-08-18
公開日1995-11-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
Biochemistry, 34, 1995
4X3V
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CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE 1 BOUND TO INHIBITOR
分子名称:Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine
著者Dealwis, C.G., Ahmad, M.F., Alam, I.
登録日2014-12-01
公開日2015-11-11
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.
J.Med.Chem., 58, 2015
2ERC
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CRYSTAL STRUCTURE OF ERMC' A RRNA-METHYL TRANSFERASE
分子名称:RRNA METHYL TRANSFERASE
著者Bussiere, D.E., Muchmore, S.W., Dealwis, C.G., Schluckebier, G., Abad-Zapatero, C.
登録日1998-03-13
公開日1999-03-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria.
Biochemistry, 37, 1998
2INQ
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NEUTRON CRYSTAL STRUCTURE OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BOUND TO THE ANTI-CANCER DRUG, METHOTREXATE
分子名称:Dihydrofolate reductase, N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID
著者Bennett, B.C., Langan, P.A., Coates, L., Schoenborn, B., Dealwis, C.G.
登録日2006-10-08
公開日2007-02-06
最終更新日2011-07-13
実験手法NEUTRON DIFFRACTION (2.2 Å)
主引用文献Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2QK8
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CRYSTAL STRUCTURE OF THE ANTHRAX DRUG TARGET, BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE
分子名称:Dihydrofolate reductase, METHOTREXATE
著者Bennett, B.C., Xu, H., Simmerman, R.F., Lee, R.E., Dealwis, C.G.
登録日2007-07-10
公開日2007-08-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase.
J.Med.Chem., 50, 2007
3DAT
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CRYSTAL STRUCTURE OF THE TERNARY MTX NADPH COMPLEX OF BACILLUS ANTHRACIS DIHYDROFOLATE REDUCTASE
分子名称:Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Bennett, B.C., Dealwis, C.G.
登録日2008-05-30
公開日2009-04-14
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design.
J.Struct.Biol., 166, 2009
3DAU
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CRYSTAL STRUCTURE OF THE TERNARY MTX NADPH COMPLEX OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE
分子名称:Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Bennett, B.C., Dealwis, C.G.
登録日2008-05-30
公開日2009-04-14
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design.
J.Struct.Biol., 166, 2009
3HNC
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CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE 1 BOUND TO THE EFFECTOR TTP
分子名称:Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ...
著者Fairman, J.W., Wijerathna, S.R., Xu, H., Dealwis, C.G.
登録日2009-05-31
公開日2011-02-23
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
3HND
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CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE 1 BOUND TO THE EFFECTOR TTP AND SUBSTRATE GDP
分子名称:Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ...
著者Fairman, J.W., Wijerathna, S.R., Xu, H., Dealwis, C.G.
登録日2009-05-31
公開日2011-02-23
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
3HNE
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CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE 1 BOUND TO THE EFFECTORS TTP AND ATP
分子名称:Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Fairman, J.W., Wijerathna, S.R., Xu, H., Dealwis, C.G.
登録日2009-05-31
公開日2011-02-23
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
3HNF
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CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE 1 BOUND TO THE EFFECTORS TTP AND DATP
分子名称:Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ...
著者Fairman, J.W., Wijerathna, S.R., Xu, H., Dealwis, C.G.
登録日2009-05-31
公開日2011-02-23
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (3.16 Å)
主引用文献Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
3PAW
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LOW RESOLUTION X-RAY CRYSTAL STRUCTURE OF YEAST RNR1P WITH DATP BOUND IN THE A-SITE
分子名称:Ribonucleoside-diphosphate reductase large chain 1
著者Fairman, J.W., Wijerathna, S.R., Dealwis, C.G.
登録日2010-10-19
公開日2011-02-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (6.61 Å)
主引用文献Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nat.Struct.Mol.Biol., 18, 2011
5TUS
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POTENT COMPETITIVE INHIBITION OF HUMAN RIBONUCLEOTIDE REDUCTASE BY A NOVEL NON-NUCLEOSIDE SMALL MOLECULE
分子名称:Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Mohammed, F.A., Alam, I., Dealwis, C.G.
登録日2016-11-07
公開日2017-08-02
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1A15
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SDF-1ALPHA
分子名称:STROMAL DERIVED FACTOR-1ALPHA, SULFATE ION
著者Dealwis, C.G., Fernandez, E.J., Lolis, E.
登録日1997-12-22
公開日1998-08-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor.
Proc.Natl.Acad.Sci.USA, 95, 1998
3EYS
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PFA1 FAB FRAGMENT COMPLEXED WITH PYRO-GLU3-A-BETA (3-8)
分子名称:If kappa light chain, PFA1 Fab Heavy Chain, pyro-Glu3-A-Beta (3-8) peptide, ...
著者Gardberg, A.S., Dealwis, C.G.
登録日2008-10-21
公開日2009-05-12
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structures of Abeta-related peptide--monoclonal antibody complexes.
Biochemistry, 48, 2009
3EYU
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PFA1 FAB FRAGMENT COMPLEXED WITH ROR2(518-525)
分子名称:If kappa light chain, PFA1 Fab Heavy Chain, ROR2(518-525) peptide
著者Gardberg, A.S., Dealwis, C.G.
登録日2008-10-21
公開日2009-05-12
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structures of Abeta-related peptide--monoclonal antibody complexes.
Biochemistry, 48, 2009
3RSR
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CRYSTAL STRUCTURE OF 5-NITP INHIBITION OF YEAST RIBONUCLEOTIDE REDUCTASE
分子名称:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO-1H-INDOLE
著者Wan, Q., Mohammed, F., Jha, S., Motea, E., Berdis, A., Dealwis, C.G.
登録日2011-05-02
公開日2012-11-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase.
Mol.Cancer Ther., 11, 2012
3TB9
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STRUCTURE OF YEAST RIBONUCLEOTIDE REDUCTASE 1 Q288A WITH AMPPNP AND CDP
分子名称:Ribonucleoside-diphosphate reductase large chain 1, CYTIDINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ahmad, M.F., Kaushal, P.S., Wan, Q., Wijeratna, S.R., Huang, M., Dealwis, C.D.
登録日2011-08-05
公開日2012-04-04
最終更新日2012-06-06
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase.
J.Mol.Biol., 419, 2012
3TBA
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STRUCTURE OF YEAST RIBONUCLEOTIDE REDUCTASE 1 Q288A WITH DGTP AND ADP
分子名称:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
著者Ahmad, M.F., Kaushal, P.S., Wan, Q., Wijeratna, S.R., Huang, M., Dealwis, C.
登録日2011-08-05
公開日2012-04-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase.
J.Mol.Biol., 419, 2012
1BBS
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X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS
分子名称:RENIN
著者Dhanaraj, V., Blundell, T.L.
登録日1992-05-21
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.
Nature, 357, 1992
1ENT
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X-RAY ANALYSES OF ASPARTIC PROTEINASES. THE THREE-DIMENSIONAL STRUCTURE AT 2.1 ANGSTROMS RESOLUTION OF ENDOTHIAPEPSIN
分子名称:ENDOTHIAPEPSIN, N-(tert-butoxycarbonyl)-L-phenylalanyl-N-{(1S)-1-[(R)-hydroxy(2-{[(2S)-2-methylbutyl]amino}-2-oxoethyl)phosphoryl]-3-methylbutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide, SULFATE ION
著者Blundell, T.L., Dealwis, C.G.
登録日1992-03-11
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin.
J.Mol.Biol., 211, 1990
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