Author results

2X9E
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HUMAN MPS1 IN COMPLEX WITH NMS-P715
Descriptor:DUAL SPECIFICITY PROTEIN KINASE TTK, N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE
Authors:Colombo, R., Caldarelli, M., Mennecozzi, M., Giorgini, M.L., Sola, F., Cappella, P., Perrera, C., DePaolini, S.R., Rusconi, L., Cucchi, U., Avanzi, N., Bertrand, J.A., Bossi, R.T., Pesenti, E., Galvani, A., Isacchi, A., Colotta, F., Donati, D., Moll, J.
Deposit date:2010-03-17
Release date:2010-12-29
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Targeting the Mitotic Checkpoint for Cancer Therapy with Nms-P715, an Inhibitor of Mps1 Kinase.
Cancer Res., 70, 2010
5M5A
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
Descriptor:Maternal embryonic leucine zipper kinase, SODIUM ION, CHLORIDE ION, ...
Authors:Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
Deposit date:2016-10-21
Release date:2017-12-06
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The target landscape of clinical kinase drugs.
Science, 358, 2017
5MAF
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
Descriptor:Maternal embryonic leucine zipper kinase, DIMETHYL SULFOXIDE, CHLORIDE ION, ...
Authors:Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
Deposit date:2016-11-03
Release date:2017-12-06
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The target landscape of clinical kinase drugs.
Science, 358, 2017
5MAG
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
Descriptor:Maternal embryonic leucine zipper kinase, ~{N}-[(1~{S})-2-(dimethylamino)-1-phenyl-ethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide, DIMETHYL SULFOXIDE, ...
Authors:Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
Deposit date:2016-11-03
Release date:2017-12-06
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The target landscape of clinical kinase drugs.
Science, 358, 2017
5MAH
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
Descriptor:Maternal embryonic leucine zipper kinase, ~{N}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide, GLYCEROL, ...
Authors:Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
Deposit date:2016-11-03
Release date:2017-12-06
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The target landscape of clinical kinase drugs.
Science, 358, 2017
5MAI
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
Descriptor:Maternal embryonic leucine zipper kinase, DIMETHYL SULFOXIDE, 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide
Authors:Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
Deposit date:2016-11-03
Release date:2017-12-06
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The target landscape of clinical kinase drugs.
Science, 358, 2017
2YAC
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CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH NMS-P937
Descriptor:SERINE/THREONINE-PROTEIN KINASE PLK1, 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE, ZINC ION, ...
Authors:Bertrand, J.A., Bossi, R.T.
Deposit date:2011-02-18
Release date:2011-04-06
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Nms-P937, a 4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline Derivative as Potent and Selective Polo-Like Kinase 1 Inhibitor.
Bioorg.Med.Chem.Lett., 21, 2011
5LBW
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STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH VOLITINIB
Descriptor:Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Schneider, S., Medard, G., Kuester, B.
Deposit date:2016-06-17
Release date:2017-11-29
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The target landscape of clinical kinase drugs.
Science, 358, 2017
5LBY
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STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH CRENOLANIB
Descriptor:Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Schneider, S., Medard, G., Kuester, B.
Deposit date:2016-06-17
Release date:2017-11-29
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The target landscape of clinical kinase drugs.
Science, 358, 2017
5LBZ
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STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH PACRITINIB
Descriptor:Ribosyldihydronicotinamide dehydrogenase [quinone], FLAVIN-ADENINE DINUCLEOTIDE, 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene, ...
Authors:Schneider, S., Medard, G., Kuster, B.
Deposit date:2016-06-17
Release date:2017-11-29
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The target landscape of clinical kinase drugs.
Science, 358, 2017