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2WFU
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CRYSTAL STRUCTURE OF DILP5 VARIANT DB
Descriptor:PROBABLE INSULIN-LIKE PEPTIDE 5 A CHAIN, PROBABLE INSULIN-LIKE PEPTIDE 5 B CHAIN
Authors:Kulahin, N., Schluckebier, G., Sajid, W., De Meyts, P.
Deposit date:2009-04-15
Release date:2010-05-26
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biological Properties of the Drosophila Insulin-Like Peptide 5 Show Evolutionary Conservation.
J.Biol.Chem., 286, 2011
2WFV
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CRYSTAL STRUCTURE OF DILP5 VARIANT C4
Descriptor:PROBABLE INSULIN-LIKE PEPTIDE 5 A CHAIN, PROBABLE INSULIN-LIKE PEPTIDE 5 B CHAIN
Authors:Kulahin, N., Schluckebier, G., Sajid, W., De Meyts, P.
Deposit date:2009-04-15
Release date:2010-05-26
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biological Properties of the Drosophila Insulin-Like Peptide 5 Show Evolutionary Conservation.
J.Biol.Chem., 286, 2011
1T1K
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ALA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1P
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:insulin, Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1Q
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ABA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:insulin, Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2012-03-28
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
2JUM
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THRA3-DKP-INSULIN
Descriptor:Insulin A chain, Insulin B chain
Authors:Huang, K., Chan, S., Hua, Q., Chu, Y., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S.H., Steiner, D.F., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2007-08-31
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUU
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ALLO-THRA3 DKP-INSULIN
Descriptor:Insulin A chain, Insulin B chain
Authors:Huang, K., Chan, S., Hua, Q., Chu, Y., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S.H., Steiner, D.F., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2007-09-03
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUV
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ABAA3-DKP-INSULIN
Descriptor:Insulin A chain, Insulin B chain
Authors:Huang, K., Chan, S., Hua, Q., Chu, Y., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S.H., Steiner, D.F., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2007-09-05
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
6FEY
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CRYSTAL STRUCTURE OF DROSOPHILA NEURAL ECTODERMAL DEVELOPMENT FACTOR IMP-L2 WITH DROSOPHILA DILP5 INSULIN
Descriptor:Neural/ectodermal development factor IMP-L2, Probable insulin-like peptide 5
Authors:Brzozowski, A.M., Kulahin, N., Kristensen, O., Schluckebier, G., Meyts, P.D.
Deposit date:2018-01-03
Release date:2018-09-26
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
Nat Commun, 9, 2018
6FF3
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CRYSTAL STRUCTURE OF DROSOPHILA NEURAL ECTODERMAL DEVELOPMENT FACTOR IMP-L1 WITH HUMAN IGF-I
Descriptor:Neural/ectodermal development factor IMP-L2, Insulin-like growth factor I
Authors:Brzozowski, A.M., Kulahin, N., Kristensen, O., Schluckebier, G., Meyts, P.D., Viola, C.M.
Deposit date:2018-01-03
Release date:2018-09-26
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
Nat Commun, 9, 2018
3GKY
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THE STRUCTURAL BASIS OF AN ER STRESS-ASSOCIATED BOTTLENECK IN A PROTEIN FOLDING LANDSCAPE
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Liu, M., Wan, Z.L., Chu, Y.C., Alddin, H., Klaproth, B., Weiss, M.A.
Deposit date:2009-03-11
Release date:2009-03-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
5U8Q
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STRUCTURE OF THE ECTODOMAIN OF THE HUMAN TYPE 1 INSULIN-LIKE GROWTH FACTOR RECEPTOR IN COMPLEX WITH IGF-I
Descriptor:Insulin-like growth factor 1 receptor, Insulin-like growth factor I, Fv 24-60 heavy chain, ...
Authors:Lawrence, M., Xu, Y.
Deposit date:2016-12-14
Release date:2018-02-28
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (3.27104 Å)
Cite:How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
5U8R
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STRUCTURE OF THE ECTODOMAIN OF THE HUMAN TYPE 1 INSULIN-LIKE GROWTH FACTOR RECEPTOR
Descriptor:Insulin-like growth factor 1 receptor, Fv 24-60 heavy chain, Fv 24-60 light chain, ...
Authors:Lawrence, M., Xu, Y.
Deposit date:2016-12-14
Release date:2018-02-28
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (3.000016 Å)
Cite:How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018