Author results

6HB5
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CRYSTAL STRUCTURE OF E. COLI TYRRS IN COMPLEX WITH 5'-O-(N-L-TYROSYL)SULFAMOYL-CYTIDINE
Descriptor:Tyrosine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate, 1,2-ETHANEDIOL, ...
Authors:De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-09
Release date:2019-04-17
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6HB6
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CRYSTAL STRUCTURE OF E. COLI TYRRS IN COMPLEX WITH 5'-O-(N-L-TYROSYL)SULFAMOYL-URIDINE
Descriptor:Tyrosine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate, 1,2-ETHANEDIOL, ...
Authors:De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-09
Release date:2019-04-17
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6HB7
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CRYSTAL STRUCTURE OF E. COLI TYRRS IN COMPLEX WITH 5'-O-(N-L-TYROSYL)SULFAMOYL-N3-METHYLURIDINE
Descriptor:Tyrosine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-[3-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate, 1,2-ETHANEDIOL, ...
Authors:De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-09
Release date:2019-04-17
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6HHV
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STRUCTURE OF T. THERMOPHILUS ASPRS IN COMPLEX WITH 5'-O-(N-(L-ASPARTYL)-SULFAMOYL)N3-METHYLURIDINE
Descriptor:Aspartate--tRNA(Asp) ligase, 5'-O-(N-(L-aspartyl)-sulfamoyl)N3-methyluridine
Authors:De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-29
Release date:2019-12-18
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HHW
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STRUCTURE OF T. THERMOPHILUS ASPRS IN COMPLEX WITH 5'-O-(N-(L-ASPARTYL)-SULFAMOYL)URIDINE
Descriptor:Aspartate--tRNA(Asp) ligase, 5'-O-(N-(L-aspartyl)-sulfamoyl)uridine
Authors:De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-29
Release date:2019-12-18
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HHX
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STRUCTURE OF T. THERMOPHILUS ASPRS IN COMPLEX WITH 5'-O-(N-(L-ASPARTYL)-SULFAMOYL)CYTIDINE
Descriptor:Aspartate--tRNA(Asp) ligase, 5'-O-(N-(L-aspartyl)-sulfamoyl)cytidine
Authors:De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-29
Release date:2019-12-18
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6I5Y
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CRYSTAL STRUCTURE OF E. COLI TYRRS IN COMPLEX WITH 5'-O-(N-L-TYROSYL)SULFAMOYL-ADENOSINE
Descriptor:Tyrosine--tRNA ligase, 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, 1,2-ETHANEDIOL
Authors:De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-11-15
Release date:2019-04-17
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6SJC
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STRUCTURE OF T. THERMOPHILUS ASPRS IN COMPLEX WITH 5'-O-(N-(L-ASPARTYL)-SULFAMOYL)ADENOSINE
Descriptor:Aspartate--tRNA(Asp) ligase, 5'-O-(L-alpha-aspartylsulfamoyl)adenosine
Authors:De Graef, S., Pang, L., Strelkov, S.V., Weeks, S.D.
Deposit date:2019-08-13
Release date:2020-01-08
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6H9X
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KLEBSIELLA PNEUMONIAE SERYL-TRNA SYNTHETASE IN COMPLEX WITH THE INTERMEDIATE ANALOG 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
Descriptor:Serine--tRNA ligase, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, 1,2-ETHANEDIOL, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-06
Release date:2019-05-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily.
Eur.J.Med.Chem., 174, 2019
6HDZ
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PSEUDOMONAS AERUGINOSA SERYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-SERYL)-SULFAMOYL)URIDINE
Descriptor:Serine--tRNA ligase, 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-Sulfamoyl)uridine, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-20
Release date:2019-12-04
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HE1
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PSEUDOMONAS AERUGINOSA SERYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-SERYL)-SULFAMOYL)N3-METHYLURIDINE
Descriptor:Serine--tRNA ligase, 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-20
Release date:2019-12-04
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HE3
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PSEUDOMONAS AERUGINOSA SERYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-SERYL)-SULFAMOYL)CYTIDINE
Descriptor:Serine--tRNA ligase, 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-sulfamoyl)cytidine, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-08-20
Release date:2019-12-04
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HHY
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KLEBSIELLA PNEUMONIAE SERYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-SERYL)-SULFAMOYL)N3-METHYLURIDINE
Descriptor:Serine--tRNA ligase, 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, ...
Authors:Pang, L., De Graef, S., Weeks, S.D., Strelkov, S.V.
Deposit date:2018-08-29
Release date:2019-12-18
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HHZ
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KLEBSIELLA PNEUMONIAE SERYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-SERYL)-SULFAMOYL)CYTIDINE
Descriptor:Serine--tRNA ligase, 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-sulfamoyl)cytidine, ...
Authors:Pang, L., De Graef, S., Weeks, S.D., Strelkov, S.V.
Deposit date:2018-08-29
Release date:2019-12-18
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HI0
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KLEBSIELLA PNEUMONIAE SERYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-SERYL)-SULFAMOYL)URIDINE
Descriptor:Serine--tRNA ligase, 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-Sulfamoyl)uridine, ...
Authors:Pang, L., De Graef, S., Weeks, S.D., Strelkov, S.V.
Deposit date:2018-08-29
Release date:2019-12-18
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6Q89
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NEISSERIA GONORRHOEAE LEUCYL-TRNA SYNTHETASE IN COMPLEX WITH THE INTERMEDIATE ANALOG 5'-O-(N-(L-LEUCYL)-SULFAMOYL)ADENOSINE
Descriptor:Leucine--tRNA ligase, 5'-O-(L-leucylsulfamoyl)adenosine, 1,2-ETHANEDIOL, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-12-14
Release date:2019-04-17
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6Q8A
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NEISSERIA GONORRHOEAE LEUCYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-LEUCYL)-SULFAMOYL)CYTIDINE
Descriptor:Leucine--tRNA ligase, 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine, ZINC ION, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-12-14
Release date:2019-04-17
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6Q8B
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NEISSERIA GONORRHOEAE LEUCYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-LEUCYL)-SULFAMOYL)N3-METHYLURIDINE
Descriptor:Leucine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-[3-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-4-methyl-pentanoyl]sulfamate, ZINC ION, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-12-14
Release date:2019-04-17
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6Q8C
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NEISSERIA GONORRHOEAE LEUCYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-LEUCYL)-SULFAMOYL)URIDINE
Descriptor:Leucine--tRNA ligase, 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine, ZINC ION, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2018-12-14
Release date:2019-04-17
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173, 2019
6RLT
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TRYPANOSOMA BRUCEI SERYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-SERYL)-SULFAMOYL)URIDINE
Descriptor:Seryl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2019-05-02
Release date:2020-01-08
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6RLU
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TRYPANOSOMA BRUCEI SERYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-SERYL)-SULFAMOYL)CYTIDINE
Descriptor:Seryl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2019-05-02
Release date:2020-01-08
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6RLV
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TRYPANOSOMA BRUCEI SERYL-TRNA SYNTHETASE IN COMPLEX WITH 5'-O-(N-(L-SERYL)-SULFAMOYL)N3-METHYLURIDINE
Descriptor:Seryl-tRNA synthetase, putative, GLYCEROL, ...
Authors:Pang, L., De Graef, S., Strelkov, S.V., Weeks, S.D.
Deposit date:2019-05-02
Release date:2020-01-08
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6S30
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CRYSTAL STRUCTURE OF SERYL-TRNA SYNTHETASE FROM KLEBSIELLA PNEUMONIAE
Descriptor:Serine--tRNA ligase, 1,2-ETHANEDIOL, CALCIUM ION
Authors:Pang, L., De Graef, S., Weeks, S.D., Strelkov, S.V.
Deposit date:2019-06-23
Release date:2020-01-08
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6Z4U
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X-RAY CRYSTALLOGRAPHIC STRUCTURE OF ORF9B FROM SARS-COV-2
Descriptor:Protein 9b, POLYETHYLENE GLYCOL (N=34)
Authors:Weeks, S.D., De Graef, S., Munawar, A.
Deposit date:2020-05-25
Release date:2020-06-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:X-ray Crystallographic Structure of Orf9b from SARS-CoV-2
To Be Published
170172
PDB entries from 2020-10-21