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2TNF
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1.4 A RESOLUTION STRUCTURE OF MOUSE TUMOR NECROSIS FACTOR, TOWARDS MODULATION OF ITS SELECTIVITY AND TRIMERISATION
Descriptor:PROTEIN (TUMOR NECROSIS FACTOR ALPHA), 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ISOPROPYL ALCOHOL
Authors:Baeyens, K.J., De Bondt, H.L., Raeymaekers, A., Fiers, W., De Ranter, C.J.
Deposit date:1998-10-12
Release date:1999-10-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The structure of mouse tumour-necrosis factor at 1.4 A resolution: towards modulation of its selectivity and trimerization.
Acta Crystallogr.,Sect.D, 55, 1999
1HCK
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HUMAN CYCLIN-DEPENDENT KINASE 2
Descriptor:HUMAN CYCLIN-DEPENDENT KINASE 2, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Schulze-Gahmen, U., De Bondt, H.L., Kim, S.-H.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.
J.Med.Chem., 39, 1996
1HCL
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HUMAN CYCLIN-DEPENDENT KINASE 2
Descriptor:HUMAN CYCLIN-DEPENDENT KINASE 2
Authors:Schulze-Gahmen, U., De Bondt, H.L., Kim, S.-H.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.
J.Med.Chem., 39, 1996
2SAK
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STAPHYLOKINASE (SAKSTAR VARIANT)
Descriptor:STAPHYLOKINASE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Rabijns, A., De Bondt, H.L., De Maeyer, M., Lasters, I., De Ranter, C.
Deposit date:1997-02-20
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential.
Nat.Struct.Biol., 4, 1997
9PAI
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CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor:PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 19-364, PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 365-397
Authors:Aertgeerts, K., De Bondt, H.L., De Ranter, C.J., Declerck, P.J.
Deposit date:1999-03-11
Release date:1999-03-19
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1.
Nat.Struct.Biol., 2, 1995
205D
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STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP
Descriptor:RNA (5'-R(*GP*GP*AP*CP*UP*UP*UP*GP*GP*UP*CP*C)-3')
Authors:Baeyens, K.J., De Bondt, H.L., Holbrook, S.R.
Deposit date:1995-04-14
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structure of an RNA double helix including uracil-uracil base pairs in an internal loop.
Nat.Struct.Biol., 2, 1995
283D
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A CURVED RNA HELIX INCORPORATING AN INTERNAL LOOP WITH G-A AND A-A NON-WATSON-CRICK BASE PAIRING
Descriptor:RNA (5'-R(*GP*GP*CP*CP*GP*AP*AP*AP*GP*GP*CP*C)-3'), MANGANESE (II) ION
Authors:Baeyens, K.J., De Bondt, H.L., Pardi, A., Holbrook, S.R.
Deposit date:1996-09-03
Release date:1996-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A curved RNA helix incorporating an internal loop with G.A and A.A non-Watson-Crick base pairing.
Proc.Natl.Acad.Sci.USA, 93, 1996
3HKW
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HCV NS5B GENOTYPE 1A IN COMPLEX WITH 1,5 BENZODIAZEPINE INHIBITOR 6
Descriptor:NS5B RNA-dependent RNA polymerase, (11S)-10-[(2,5-dimethyl-1,3-oxazol-4-yl)carbonyl]-11-{2-fluoro-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}-3,3-dimethyl-2,3,4,5,10,11-hexahydrothiopyrano[3,2-b][1,5]benzodiazepin-6-ol 1,1-dioxide, SULFATE ION, ...
Authors:Nyanguile, O., De Bondt, H.L.
Deposit date:2009-05-26
Release date:2010-05-26
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus
J.Virol., 84, 2010
3HKY
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HCV NS5B POLYMERASE GENOTYPE 1B IN COMPLEX WITH 1,5 BENZODIAZEPINE 6
Descriptor:RNA-directed RNA polymerase, (11S)-10-[(2,5-dimethyl-1,3-oxazol-4-yl)carbonyl]-11-{2-fluoro-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}-3,3-dimethyl-2,3,4,5,10,11-hexahydrothiopyrano[3,2-b][1,5]benzodiazepin-6-ol 1,1-dioxide, SULFATE ION, ...
Authors:Nyanguile, O., De Bondt, H.L.
Deposit date:2009-05-26
Release date:2010-05-26
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus
J.Virol., 84, 2010
3KPE
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SOLUTION STRUCTURE OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)SIX-HELIX BUNDLE COMPLEXED WITH TMC353121, A SMALL-MOLEUCULE INHIBITOR OF RSV
Descriptor:Fusion glycoprotein F0, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, TETRAETHYLENE GLYCOL
Authors:Roymans, D., De Bondt, H., Arnoult, E., Cummings, M.D., Van Vlijmen, H., Andries, K.
Deposit date:2009-11-16
Release date:2009-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
2A4L
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HUMAN CYCLIN-DEPENDENT KINASE 2 IN COMPLEX WITH ROSCOVITINE
Descriptor:Homo sapiens cyclin-dependent kinase 2, R-ROSCOVITINE
Authors:De Azevedo Jr., W.F., Kim, S.H.
Deposit date:2005-06-29
Release date:2006-10-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
Eur.J.Biochem., 243, 1997
1CKP
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR PURVALANOL B
Descriptor:PROTEIN (CYCLIN-DEPENDENT PROTEIN KINASE 2), PURVALANOL B, 1,2-ETHANEDIOL
Authors:Gray, N.S., Thunnissen, A.M.W.H., Schultz, P.G., Kim, S.H.
Deposit date:1998-07-14
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Science, 281, 1998
1DM2
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HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE
Descriptor:CYCLIN-DEPENDENT KINASE 2, 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO-4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN-8-ONE, 1,2-ETHANEDIOL
Authors:Thunnissen, A.M., Kim, S.-H.
Deposit date:1999-12-13
Release date:2000-05-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Chem.Biol., 7, 2000
1AQ1
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Descriptor:CYCLIN-DEPENDENT PROTEIN KINASE 2, STAUROSPORINE
Authors:Endicott, J.A., Noble, M.E.M., Johnson, L.N., Lawrie, A., Tunnah, P., Brown, N.R.
Deposit date:1997-08-05
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nat.Struct.Biol., 4, 1997