Author results

1OBS
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STRUCTURE OF RICIN A CHAIN MUTANT
分子名称:RICIN A CHAIN
著者Day, P.J., Ernst, S.R., Frankel, A.E., Monzingo, A.F., Pascal, J.M., Svinth, M., Robertus, J.D.
登録日1996-06-25
公開日1997-06-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and activity of an active site substitution of ricin A chain.
Biochemistry, 35, 1996
1OBT
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STRUCTURE OF RICIN A CHAIN MUTANT, COMPLEX WITH AMP
分子名称:RICIN A CHAIN, ADENOSINE MONOPHOSPHATE
著者Day, P.J., Ernst, S.R., Frankel, A.E., Monzingo, A.F., Pascal, J.M., Svinth, M., Robertus, J.D.
登録日1996-06-22
公開日1997-06-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure and activity of an active site substitution of ricin A chain.
Biochemistry, 35, 1996
2W96
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CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
分子名称:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4, GLYCEROL
著者Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., McMenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
登録日2009-01-21
公開日2009-03-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W99
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CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
分子名称:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4
著者Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., McMenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
登録日2009-01-22
公開日2009-03-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W9F
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CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
分子名称:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4
著者Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., McMenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
登録日2009-01-23
公開日2009-03-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W9Z
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CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
分子名称:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4
著者Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., McMenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
登録日2009-01-30
公開日2009-03-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
5JAD
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COMPOUND BINDING TO HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2)DISCOVERED THROUGH FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, MAGNESIUM ION, CHLORIDE ION, ...
著者Day, P.J., Woolford, A.J.-A.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-12-14
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5JAH
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EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-RAY FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, CHLORIDE ION, 1,5,5-trimethylimidazolidine-2,4-dione
著者Day, P.J.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5JAL
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EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-RAY FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, MAGNESIUM ION, CHLORIDE ION, ...
著者Day, P.J.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5JAN
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EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-RAY FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, CHLORIDE ION, CALCIUM ION, ...
著者Day, P.J.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5JAO
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EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-RAY FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, CALCIUM ION, CHLORIDE ION, ...
著者Day, P.J.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5JAP
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EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-RAY FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, CALCIUM ION, CHLORIDE ION, ...
著者Day, P.J.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5JAR
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EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-RAY FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, DIMETHYL SULFOXIDE, CHLORIDE ION, ...
著者Day, P.J.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5JAS
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EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-RAY FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Day, P.J.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5JAT
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EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-RAY FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Day, P.J.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5JAU
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EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-RAY FRAGMENT SCREENING
分子名称:Platelet-activating factor acetylhydrolase, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Day, P.J.
登録日2016-04-12
公開日2016-05-25
最終更新日2016-06-22
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J.Med.Chem., 59, 2016
5C0K
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FRAGMENT-BASED DRUG DISCOVERY TARGETING INHIBITOR OF APOPTOSIS PROTEINS: COMPOUND 3
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, 1,2-ETHANEDIOL, ...
著者Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.
登録日2015-06-12
公開日2015-08-12
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
5C0L
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FRAGMENT-BASED DRUG DISCOVERY TARGETING INHIBITOR OF APOPTOSIS PROTEINS: COMPOUND 2
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, 4-(4-bromo-1H-pyrazol-1-yl)piperidinium
著者Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.
登録日2015-06-12
公開日2015-08-12
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
5C3H
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FRAGMENT-BASED DRUG DISCOVERY TARGETING INHIBITOR OF APOPTOSIS PROTEINS: COMPOUND 1
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, 4-[2-oxo-2-(piperidin-1-yl)ethyl]piperazin-1-ium
著者Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.
登録日2015-06-17
公開日2015-08-12
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
5C3K
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FRAGMENT-BASED DRUG DISCOVERY TARGETING INHIBITOR OF APOPTOSIS PROTEINS: COMPOUND 4
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, (2S)-1-[(6-aminopyridin-2-yl)amino]-1-oxopropan-2-aminium
著者Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.
登録日2015-06-17
公開日2015-08-12
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
5C7A
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FRAGMENT-BASED DRUG DISCOVERY TARGETING INHIBITOR OF APOPTOSIS PROTEINS: COMPOUND 7
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, (2R)-4-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium
著者Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.
登録日2015-06-24
公開日2015-08-12
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
5C7B
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FRAGMENT-BASED DRUG DISCOVERY TARGETING INHIBITOR OF APOPTOSIS PROTEINS: COMPOUND 5
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, (2R)-2-methyl-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-ium
著者Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.
登録日2015-06-24
公開日2015-08-12
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
5C7C
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FRAGMENT-BASED DRUG DISCOVERY TARGETING INHIBITOR OF APOPTOSIS PROTEINS: COMPOUND 18
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, (2R)-4-[2-(6-chloro-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium
著者Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.
登録日2015-06-24
公開日2015-08-12
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
5C7D
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FRAGMENT-BASED DRUG DISCOVERY TARGETING INHIBITOR OF APOPTOSIS PROTEINS: COMPOUND 17
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, (2R)-4-[2-(6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium
著者Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.
登録日2015-06-24
公開日2015-08-12
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
5C83
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FRAGMENT-BASED DRUG DISCOVERY TARGETING INHIBITOR OF APOPTOSIS PROTEINS: COMPOUND 21
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, (2R,5R)-4-[2-(6-benzyl-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-5-(methoxymethyl)-2-methylpiperazin-1-ium
著者Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.
登録日2015-06-25
公開日2015-08-12
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
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