Author results

2BO4
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DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, CITRATE ANION
Authors:Flint, J., Taylor, E., Yang, M., Bolam, D.N., Tailford, L.E., Martinez-Fleites, C., Dodson, E.J., Davis, B.G., Gilbert, H.J., Davies, G.J.
Deposit date:2005-04-07
Release date:2005-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Dissection and High-Throughput Screening of Mannosylglyceerate Synthase
Nat.Struct.Mol.Biol., 12, 2005
2BO6
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DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, (2R)-2,3-DIHYDROXYPROPANOIC ACID, MANGANESE (II) ION
Authors:Flint, J., Taylor, E., Yang, M., Bolam, D.N., Tailford, L.E., Martinez-Fleites, C., Dodson, E.J., Davis, B.G., Gilbert, H.J., Davies, G.J.
Deposit date:2005-04-08
Release date:2005-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Dissection and High-Throughput Screening of Mannosylglyceerate Synthase
Nat.Struct.Mol.Biol., 12, 2005
2BO7
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DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, GUANOSINE-5'-DIPHOSPHATE, COBALT (II) ION
Authors:Flint, J., Taylor, E., Yang, M., Bolam, D.N., Tailford, L.E., Martinez-Fleites, C., Dodson, E.J., Davis, B.G., Gilbert, H.J., Davies, G.J.
Deposit date:2005-04-08
Release date:2005-06-06
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural dissection and high-throughput screening of mannosylglycerate synthase.
Nat. Struct. Mol. Biol., 12, 2005
2BO8
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DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, GUANOSINE 5'-(TRIHYDROGEN DIPHOSPHATE), P'-D-MANNOPYRANOSYL ESTER, ...
Authors:Flint, J., Taylor, E., Yang, M., Bolam, D.N., Tailford, L.E., Martinez-Fleites, C., Dodson, E.J., Davis, B.G., Gilbert, H.J., Davies, G.J.
Deposit date:2005-04-08
Release date:2005-06-06
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural dissection and high-throughput screening of mannosylglycerate synthase.
Nat. Struct. Mol. Biol., 12, 2005
2C1X
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STRUCTURE AND ACTIVITY OF A FLAVONOID 3-O GLUCOSYLTRANSFERASE REVEALS THE BASIS FOR PLANT NATURAL PRODUCT MODIFICATION
Descriptor:UDP-GLUCOSE FLAVONOID 3-O GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Offen, W., Martinez-Fleites, C., Kiat-Lim, E., Yang, M., Davis, B.G., Tarling, C.A., Ford, C.M., Bowles, D.J., Davies, G.J.
Deposit date:2005-09-22
Release date:2006-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Flavonoid Glucosyltransferase Reveals the Basis for Plant Natural Product Modification.
Embo J., 25, 2006
2C1Z
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STRUCTURE AND ACTIVITY OF A FLAVONOID 3-O GLUCOSYLTRANSFERASE REVEALS THE BASIS FOR PLANT NATURAL PRODUCT MODIFICATION
Descriptor:UDP-GLUCOSE FLAVONOID 3-O GLYCOSYLTRANSFERASE, 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
Authors:Offen, W., Martinez-Fleites, C., Kiat-Lim, E., Yang, M., Davis, B.G., Tarling, C.A., Ford, C.M., Bowles, D.J., Davies, G.J.
Deposit date:2005-09-22
Release date:2006-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Flavonoid Glucosyltransferase Reveals the Basis for Plant Natural Product Modification.
Embo J., 25, 2006
2C9Z
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STRUCTURE AND ACTIVITY OF A FLAVONOID 3-0 GLUCOSYLTRANSFERASE REVEALS THE BASIS FOR PLANT NATURAL PRODUCT MODIFICATION
Descriptor:UDP GLUCOSE\:FLAVONOID 3-O-GLUCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, 3,5,7,3',4'-PENTAHYDROXYFLAVONE
Authors:Offen, W., Martinez-Fleites, C., Kiat-Lim, E., Yang, M., Davis, B.G., Tarling, C.A., Ford, C.M., Bowles, D.J., Davies, G.J.
Deposit date:2005-12-15
Release date:2006-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of a Flavonoid Glucosyltransferase Reveals the Basis for Plant Natural Product Modification.
Embo J., 25, 2006
2IYA
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THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING
Descriptor:OLEANDOMYCIN GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE
Authors:Bolam, D.N., Roberts, S.M., Proctor, M.R., Turkenburg, J.P., Dodson, E.J., Martinez-Fleites, C., Yang, M., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2006-07-13
Release date:2007-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
Proc.Natl.Acad.Sci.USA, 104, 2007
2IYF
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THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING
Descriptor:OLEANDOMYCIN GLYCOSYLTRANSFERASE, ERYTHROMYCIN A, URIDINE-5'-DIPHOSPHATE, ...
Authors:Bolam, D.N., Roberts, S.M., Proctor, M.R., Turkenburg, J.P., Dodson, E.J., Martinez-Fleites, C., Yang, M., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2006-07-17
Release date:2007-03-27
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
Proc.Natl.Acad.Sci.USA, 104, 2007
2WTX
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INSIGHT INTO THE MECHANISM OF ENZYMATIC GLYCOSYLTRANSFER WITH RETENTION THROUGH THE SYNTHESIS AND ANALYSIS OF BISUBSTRATE GLYCOMIMETICS OF TREHALOSE-6-PHOSPHATE SYNTHASE
Descriptor:ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING], 1,2-ETHANEDIOL, ...
Authors:Errey, J.C., Lee, S.S., Gibson, R.P., Martinez-Fleites, C., Barry, C.S., Jung, P.M.J., OSullivan, A., Davis, B.G., Davies, G.J.
Deposit date:2009-09-25
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic Insight Into Enzymatic Glycosyl Transfer with Retention of Configuration Through Analysis of Glycomimetic Inhibitors.
Angew.Chem.Int.Ed.Engl., 49, 2010
2Y4J
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MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH LACTATE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, LACTIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Nielsen, M.M., Suits, M.D.L., Yang, M., Barry, C.S., Martinez-Fleites, C., Tailford, L.E., Flint, J.E., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2011-01-07
Release date:2011-02-02
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase.
J.Biol.Chem., 286, 2011
2Y4K
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MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH MG-GDP
Descriptor:MANNOSYLGLYCERATE SYNTHASE, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Nielsen, M.M., Suits, M.D.L., Yang, M., Barry, C.S., Martinez-Fleites, C., Tailford, L.E., Flint, J.E., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2011-01-07
Release date:2011-02-02
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase.
J.Biol.Chem., 286, 2011
2Y4L
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MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH MANGANESE AND GDP
Descriptor:MANNOSYLGLYCERATE SYNTHASE, MANGANESE (II) ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Nielsen, M.M., Suits, M.D.L., Yang, M., Barry, C.S., Martinez-Fleites, C., Tailford, L.E., Flint, J.E., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2011-01-07
Release date:2011-02-02
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase.
J.Biol.Chem., 286, 2011
2Y4M
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MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH GDP-MANNOSE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, MAGNESIUM ION, GUANOSINE 5'-(TRIHYDROGEN DIPHOSPHATE), ...
Authors:Nielsen, M.M., Suits, M.D.L., Yang, M., Barry, C.S., Martinez-Fleites, C., Tailford, L.E., Flint, J.E., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2011-01-07
Release date:2011-02-02
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase.
J.Biol.Chem., 286, 2011
3OAY
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A NON-SELF SUGAR MIMIC OF THE HIV GLYCAN SHIELD SHOWS ENHANCED ANTIGENICITY
Descriptor:Fab 2G12, light chain, heavy chain, ...
Authors:Doores, K.J., Fulton, Z., Hong, V., Patel, M.K., Scanlan, C.N., Wormald, M.R., Finn, M.G., Burton, D.R., Wilson, I.A., Davis, B.G.
Deposit date:2010-08-05
Release date:2011-01-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Proc.Natl.Acad.Sci.USA, 107, 2010
3OAZ
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A NON-SELF SUGAR MIMIC OF THE HIV GLYCAN SHIELD SHOWS ENHANCED ANTIGENICITY
Descriptor:Fab 2G12, heavy chain, light chain, ...
Authors:Doores, K.J., Fulton, Z., Hong, V., Patel, M.K., Scanlan, C.N., Wormald, M.R., Finn, M.G., Burton, D.R., Wilson, I.A., Davis, B.G.
Deposit date:2010-08-06
Release date:2011-01-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Proc.Natl.Acad.Sci.USA, 107, 2010
3OB0
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A NON-SELF SUGAR MIMIC OF THE HIV GLYCAN SHIELD SHOWS ENHANCED ANTIGENICITY
Descriptor:Fab 2G12, light chain, heavy chain, ...
Authors:Doores, K.J., Fulton, Z., Hong, V., Patel, M.K., Scanlan, C.N., Wormald, M.R., Finn, M.G., Burton, D.R., Wilson, I.A., Davis, B.G.
Deposit date:2010-08-06
Release date:2011-01-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Proc.Natl.Acad.Sci.USA, 107, 2010
3VPS
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STRUCTURE OF A NOVEL NAD DEPENDENT-NDP-HEXOSAMINE 5,6-DEHYDRATASE, TUNA, INVOLVED IN TUNICAMYCIN BIOSYNTHESIS
Descriptor:NAD-dependent epimerase/dehydratase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Wyszynski, F.J., Lee, S.S., Yabe, T., Wang, H., Gomez-Escribano, J.P., Bibb, M.J., Lee, S.J., Davies, G.J., Davis, B.G.
Deposit date:2012-03-12
Release date:2012-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Biosynthesis of nucleoside antibiotic tunicamycin proceeds via unique exo-glycal intermediates
To be published
4YR7
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STRUCTURE OF LUXP IN COMPLEX WITH 1-DEOXY-ALPHA-L-XYLULOFURANOSE-1,2-BORATE
Descriptor:Autoinducer 2-binding periplasmic protein LuxP, 1-deoxy-alpha-L-xylulofuranose-1,2-borate
Authors:McDonough, M.A., Sattin, S., Davis, B.G.
Deposit date:2015-03-14
Release date:2016-03-23
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.533 Å)
Cite:Discovery of Glycomimetic Agonists from a Protocell Metabolism, Proto-natural Product Libraries
To Be Published
5AQE
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COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, (4-VINYLPHENYL)METHANESULFONIC ACID, SULFATE ION, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-22
Release date:2015-10-07
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Bisubstrate Localisation by a Tailored Serine Protease Allows Creation of a Heck-Ase
To be Published
5ARB
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COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, CALCIUM ION, GLYCEROL, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-24
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase
To be Published
5ARC
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COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, CALCIUM ION, 5-methyl-2-(5-methylpyridin-2-yl)pyridine, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-24
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase
To be Published
5ARD
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COOPERATIVE BIO-METALLIC SELECTIVITY IN A TAILORED PROTEASE ENABLES CREATION OF A C-C CROSS-COUPLING HECKASE
Descriptor:SUBTILISIN SAVINASE, CALCIUM ION, GLYCEROL, ...
Authors:Sharma, M., Diaz-Rodriguez, A., Offen, W.A., Palm-Espling, M.E., Pordea, A., Wormald, M.R., Mcdonough, M., Davies, G.J., Davis, B.G.
Deposit date:2015-09-24
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Cooperative Bio-Metallic Selectivity in a Tailored Protease Enables Creation of a C-C Cross-Coupling Heckase
To be Published
6EQJ
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) TYR195PIPHE MUTANT, APO FORM
Descriptor:Glycogenin-1, 1,2-ETHANEDIOL
Authors:Bailey, H.J., Kopec, J., Bilyard, M.K., Bezerra, G.A., Seo Lee, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Davis, B.G., Yue, W.W.
Deposit date:2017-10-13
Release date:2017-12-20
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis.
Nature, 563, 2018
6EQL
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-1 (GYG1) TYR195PIPHE MUTANT COMPLEXED WITH MANGANESE AND UDP
Descriptor:Glycogenin-1, URIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Bailey, H.J., Kopec, J., Bilyard, M.K., Bezerra, G.A., Seo Lee, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Davis, B.G., Yue, W.W.
Deposit date:2017-10-13
Release date:2017-12-20
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis.
Nature, 563, 2018
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