Author results

3X2U
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MICHAELIS-LIKE INITIAL COMPLEX OF CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT.
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, Substrate Peptide, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Das, A., Langan, P., Gerlits, O., Kovalevsky, A.Y., Heller, W.T.
Deposit date:2015-01-02
Release date:2015-12-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation.
Structure, 23, 2015
3X2V
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MICHAELIS-LIKE COMPLEX OF CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, Substrate Peptide, MAGNESIUM ION, ...
Authors:Das, A., Langan, P., Gerlits, O., Kovalevsky, A.Y., Heller, W.T.
Deposit date:2015-01-02
Release date:2015-12-16
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation.
Structure, 23, 2015
3X2W
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MICHAELIS COMPLEX OF CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, Substrate Peptide, MAGNESIUM ION, ...
Authors:Das, A., Langan, P., Gerlits, O., Kovalevsky, A.Y., Heller, W.T.
Deposit date:2015-01-02
Release date:2015-12-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation.
Structure, 23, 2015
5DN7
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CRESCERIN USES A TOG DOMAIN ARRAY TO REGULATE MICROTUBULES IN THE PRIMARY CILIUM
Descriptor:Protein FAM179B
Authors:Das, A., Dickinson, D.J., Wood, C.C., Goldstein, B., Slep, K.C.
Deposit date:2015-09-09
Release date:2015-09-23
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.
Mol.Biol.Cell, 26, 2015
5YRS
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X-RAY SNAPSHOT OF HIV-1 PROTEASE IN ACTION: OBSERVATION OF TETRAHEDRAL INTERMEDIATE AND ITS SIHB WITH CATALYTIC ASPARTATE
Descriptor:PROTEASE, RT-RH oligopeprtide
Authors:Das, A., Mahale, S., Prashar, V., Bihani, S., Ferrer, J.-L., Hosur, M.V.
Deposit date:2017-11-10
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:X-ray snapshot of HIV-1 protease in action: observation of tetrahedral intermediate and short ionic hydrogen bond SIHB with catalytic aspartate.
J. Am. Chem. Soc., 132, 2010
2NPH
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CRYSTAL STRUCTURE OF HIV1 PROTEASE IN SITU PRODUCT COMPLEX
Descriptor:PROTEASE RETROPEPSIN, tetrapeptide fragment, pentapeptide fragment
Authors:Hosur, M.V., Das, A., Prashar, V.
Deposit date:2006-10-27
Release date:2006-12-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates
Proc.Natl.Acad.Sci.Usa, 103, 2006
4O21
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PRODUCT COMPLEX OF METAL-FREE PKAC, ATP-GAMMA-S AND SP20.
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, Thio-phosphorylated peptide pSP20, ADENOSINE-5'-DIPHOSPHATE
Authors:Das, A., Kovalevsky, A.Y., Gerlits, O., Langan, P., Heller, W.T., Keshwani, M., Taylor, S.
Deposit date:2013-12-16
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer.
Biochemistry, 53, 2014
4O22
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BINARY COMPLEX OF METAL-FREE PKAC WITH SP20.
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha., Phosphorylated peptide pSP20.
Authors:Das, A., Kovalevsky, A.Y., Gerlits, O., Langan, P., Heller, W.T., Keshwani, M., Taylor, S.S.
Deposit date:2013-12-16
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer.
Biochemistry, 53, 2014
3DOX
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X-RAY STRUCTURE OF HIV-1 PROTEASE IN SITU PRODUCT COMPLEX
Descriptor:HIV-1 PROTEASE, A PEPTIDE SUBSTRATE-SQNY, A PEPTIDE SUBSTRATE-PIV
Authors:Hosur, M.V., Ferrer, J.-L., Das, A., Prashar, V., Bihani, S.
Deposit date:2008-07-07
Release date:2008-09-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of HIV-1 protease in situ product complex
Proteins, 74, 2009
4XW4
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X-RAY STRUCTURE OF PKAC WITH AMPPNP, SP20, CALCIUM IONS
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, CALCIUM ION, ...
Authors:Gerlits, O., Tian, J., Das, A., Taylor, S., Langan, P., Heller, T.W., Kovalevsky, A.
Deposit date:2015-01-28
Release date:2015-05-06
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT.
J.Biol.Chem., 290, 2015
4XW5
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X-RAY STRUCTURE OF PKAC WITH ATP, CP20, CALCIUM IONS
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, CALCIUM ION, ...
Authors:Gerlits, O., Tian, J., Das, A., Taylor, S., Langan, P., Heller, T.W., Kovalevsky, A.
Deposit date:2015-01-28
Release date:2015-05-06
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT.
J.Biol.Chem., 290, 2015
4XW6
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X-RAY STRUCTURE OF PKAC WITH ADP, FREE PHOSPHATE ION, CP20, MAGNESIUM IONS
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, MAGNESIUM ION, ...
Authors:Gerlits, O., Tian, J., Das, A., Taylor, S., Langan, P., Heller, T.W., Kovalevsky, A.
Deposit date:2015-01-28
Release date:2015-05-06
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT.
J.Biol.Chem., 290, 2015
5E5K
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JOINT X-RAY/NEUTRON STRUCTURE OF HIV-1 PROTEASE TRIPLE MUTANT (V32I,I47V,V82I) WITH DARUNAVIR AT PH 4.3
Descriptor:HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
Authors:Kovalevsky, A.Y., Das, A.
Deposit date:2015-10-08
Release date:2016-05-04
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.75 Å), NEUTRON DIFFRACTION
Cite:Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site.
Angew.Chem.Int.Ed.Engl., 55, 2016
1JO1
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N7-GUANINE ADDUCT OF 2,7-DIAMINOMITOSENE WITH DNA
Descriptor:5'-D(*GP*TP*GP*(DAJ)GP*TP*AP*TP*AP*CP*CP*AP*C)-3', DECARBAMOYL-2,7-DIAMINOMITOSENE
Authors:Subramaniam, G., Paz, M.M., Kumar, G.S., Das, A., Palom, Y., Clement, C.C., Patel, D.J., Tomasz, M.
Deposit date:2001-07-26
Release date:2001-09-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.
Biochemistry, 40, 2001
1Y80
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STRUCTURE OF A CORRINOID (FACTOR IIIM)-BINDING PROTEIN FROM MOORELLA THERMOACETICA
Descriptor:Predicted cobalamin binding protein, CO-5-METHOXYBENZIMIDAZOLYLCOBAMIDE, UNKNOWN ATOM OR ION
Authors:Liu, Z.-J., Fu, Z.-Q., Tempel, W., Das, A., Habel, J., Zhou, W., Chang, J., Chen, L., Lee, D., Nguyen, D., Chang, S.-H., Ljungdahl, L., Rose, J.P., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2004-12-10
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of a corrinoid (factor IIIm)-binding protein from Moorella thermoacetica
To be published
2WHH
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HIV-1 PROTEASE TETHERED DIMER Q-PRODUCT COMPLEX ALONG WITH NUCLEOPHILIC WATER MOLECULE
Descriptor:POL PROTEIN, PARA-NITROPHENYLALANINE, GLUTAMIC ACID
Authors:Prashar, V., Bihani, S., Das, A., Ferrer, J.L., Hosur, M.V.
Deposit date:2009-05-05
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Catalytic Water Co-Existing with a Product Peptide in the Active Site of HIV-1 Protease Revealed by X- Ray Structure Analysis.
Plos One, 4, 2009
3H4C
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STRUCTURE OF THE C-TERMINAL DOMAIN OF TRANSCRIPTION FACTOR IIB FROM TRYPANOSOMA BRUCEI
Descriptor:Transcription factor TFIIB-like, 1,2-ETHANEDIOL
Authors:Syed Ibrahim, B., Kanneganti, N., Rieckhof, G.E., Das, A., Laurents, D.V., Palenchar, J.B., Bellofatto, V., Wah, D.A.
Deposit date:2009-04-18
Release date:2009-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei.
Proc.Natl.Acad.Sci.USA, 106, 2009
3KT2
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CRYSTAL STRUCTURE OF N88D MUTANT HIV-1 PROTEASE
Descriptor:Protease
Authors:Bihani, S.C., Das, A., Prashar, V., Ferrer, J.L., Hosur, M.V.
Deposit date:2009-11-24
Release date:2010-02-16
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.651 Å)
Cite:Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S.
Biochem.Biophys.Res.Commun., 389, 2009
3KT5
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CRYSTAL STRUCTURE OF N88S MUTANT HIV-1 PROTEASE
Descriptor:Protease
Authors:Bihani, S.C., Das, A., Prashar, V., Ferrer, J.L., Hosur, M.V.
Deposit date:2009-11-24
Release date:2010-02-16
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S.
Biochem.Biophys.Res.Commun., 389, 2009
3N3I
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CRYSTAL STRUCTURE OF G48V/C95F TETHERED HIV-1 PROTEASE/SAQUINAVIR COMPLEX
Descriptor:Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide
Authors:Prashar, V., Bihani, S.C., Das, A., Rao, D.R., Hosur, M.V.
Deposit date:2010-05-20
Release date:2010-06-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Insights into the mechanism of drug resistance: X-ray structure analysis of G48V/C95F tethered HIV-1 protease dimer/saquinavir complex
Biochem.Biophys.Res.Commun., 396, 2010
4QLH
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CRYSTAL STRUCTURE OF DRUG RESISTANT V82S/V1082S HIV-1 PROTEASE
Descriptor:Protease, linker
Authors:Das, A., Raskar, T., Hosur, M.V.
Deposit date:2014-06-12
Release date:2014-08-06
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of drug resistant V82S/V1082S HIV-1 Protease
To be Published
4IB0
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X-RAY STRUCTURE OF CAMP DEPENDENT PROTEIN KINASE A IN COMPLEX WITH HIGH NA+ CONCENTRATION, ADP AND PHOSPHORYLATED PEPTIDE PSP20
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, phosphorylated pseudo-substrate peptide pSP20, SODIUM ION, ...
Authors:Gerlits, O., Kovalevsky, A.
Deposit date:2012-12-07
Release date:2013-12-11
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer.
Biochemistry, 53, 2014
4IB1
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STRUCTURE OF CAMP DEPENDENT PROTEIN KINASE A IN COMPLEX WITH HIGH K+ CONCENTRATION, ADP AND PHOSPHORYLATED PEPTIDE PSP20
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, phosphorylated pseudo-substrate peptide pSP20, POTASSIUM ION, ...
Authors:Gerlits, O., Kovalevsky, A.
Deposit date:2012-12-07
Release date:2013-12-11
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer.
Biochemistry, 53, 2014
4IB3
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STRUCTURE OF CAMP DEPENDENT PROTEIN KINASE A IN COMPLEX WITH ADP, PHOSPHORYLATED PEPTIDE PSP20, AND NO METAL
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, phosphorylated pseudo-substrate peptide pSP20, ADENOSINE-5'-DIPHOSPHATE
Authors:Gerlits, O., Kovalevsky, A.
Deposit date:2012-12-07
Release date:2013-12-11
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer.
Biochemistry, 53, 2014
4Z7X
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MDBA PROTEIN, A THIOL-DISULFIDE OXIDOREDUCTASE FROM ACTINOMYCES ORIS.
Descriptor:MdbA, (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid
Authors:OSIPIUK, J., Reardon-Robinson, M.E., Ton-That, H., JOACHIMIAK, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-04-08
Release date:2015-04-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway in the Gram-positive Bacterium Actinomyces oris.
J.Biol.Chem., 290, 2015
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