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1PWL
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH NADP AND MINALRESTAT
Descriptor:aldose reductase, 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:El-Kabbani, O., Darmanin, C., Schneider, T.R., Hazemann, I., Ruiz, F., Oka, M., Joachimiak, A., Schulze-Briese, C., Tomizaki, T., Mitschler, A., Podjarny, A.
Deposit date:2003-07-02
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors
PROTEINS, 55, 2004
1PWM
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH NADP AND FIDARESTAT
Descriptor:aldose reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Darmanin, C., Schneider, T.R., Hazemann, I., Ruiz, F., Oka, M., Joachimiak, A., Schulze-Briese, C., Tomizaki, T., Mitschler, A., Podjarny, A.
Deposit date:2003-07-02
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (0.92 Å)
Cite:Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors
PROTEINS, 55, 2004
1X96
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE WITH CITRATES BOUND IN THE ACTIVE SITE
Descriptor:aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID
Authors:El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., Podjarny, A.
Deposit date:2004-08-19
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47, 2004
1X97
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH 2R4S (STEREOISOMER OF FIDARESTAT, 2S4S)
Descriptor:Aldose Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE
Authors:El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., Podjarny, A.
Deposit date:2004-08-19
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47, 2004
1X98
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH 2S4R (STEREOISOMER OF FIDARESTAT, 2S4S)
Descriptor:Aldose Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ...
Authors:El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., Podjarny, A.
Deposit date:2004-08-19
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47, 2004
1PR9
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HUMAN L-XYLULOSE REDUCTASE HOLOENZYME
Descriptor:L-XYLULOSE REDUCTASE, POTASSIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Ishikura, S., Darmanin, C., Carbone, V., Chung, R.P.-T., Usami, N., Hara, A.
Deposit date:2003-06-20
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis
Proteins, 55, 2004
1WNT
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STRUCUTRE OF THE TETRAMERIC FORM OF HUMAN L-XYLULOSE REDUCTASE
Descriptor:L-xylulose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:El-Kabbani, O., Carbone, V., Darmanin, C., Ishikura, S., Hara, A.
Deposit date:2004-08-09
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the tetrameric form of human L-Xylulose reductase: Probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis
Proteins, 60, 2005
2PZN
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THE CRYSTALLOGRAPHIC STRUCTURE OF ALDOSE REDUCTASE IDD393 COMPLEX CONFIRMS LEU300 AS A SPECIFICITY DETERMINANT
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID
Authors:Ruiz, F., Hazemann, I., Darmanin, C., Mitschler, A., Van Zandt, M., Joachimiak, A., El-Kabbani, O., Podjarny, A.
Deposit date:2007-05-18
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:The Crystallographic Structure of Alr2-Idd393 Complex Confirms Leu300 as a Specificity Determinant
To be Published
6GTH
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SERIAL FEMTOSECOND CRYSTALLOGRAPHY AT MEGAHERTZ PULSE RATES
Descriptor:Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide
Authors:Wiedorn, M., Oberthuer, D., Werner, N., Schubert, R., White, T.A., Mancuso, A., Perbandt, M., Betzel, C., Barty, A., Chapman, H.
Deposit date:2018-06-18
Release date:2018-10-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Megahertz serial crystallography.
Nat Commun, 9, 2018
6FTR
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SERIAL FEMTOSECOND CRYSTALLOGRAPHY AT MEGAHERTZ PULSE RATES
Descriptor:Lysozyme C, CHLORIDE ION, SODIUM ION, ...
Authors:Wiedorn, M.O., Oberthuer, D., Barty, A., Chapman, H.N.
Deposit date:2018-02-23
Release date:2018-10-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.760001 Å)
Cite:Megahertz serial crystallography.
Nat Commun, 9, 2018
3H4G
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STRUCTURE OF ALDEHYDE REDUCTASE HOLOENZYME IN COMPLEX WITH POTENT ALDOSE REDUCTASE INHIBITOR FIDARESTAT: IMPLICATIONS FOR INHIBITOR BINDING AND SELECTIVITY
Descriptor:Alcohol dehydrogenase [NADP+], SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2009-04-20
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
J.Med.Chem., 48, 2005