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5NI1
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BU of 5ni1 by Molmil
CryoEM structure of haemoglobin at 3.2 A determined with the Volta phase plate
Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE
Authors:Khoshouei, M, Radjainia, M, Bunker, R, Baumeister, W, Danev, R.
Deposit date:2017-03-22
Release date:2017-04-12
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of haemoglobin at 3.2 angstrom determined with the Volta phase plate.
Nat Commun, 8, 2017
5UZ7
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BU of 5uz7 by Molmil
Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex
Descriptor: Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liang, Y.L, Khoshouei, M, Radjainia, M, Zhang, Y, Glukhova, A, Tarrasch, J, Thal, D.M, Furness, S.G.B, Christopoulos, G, Coudrat, T, Danev, R, Baumeister, W, Miller, L.J, Christopoulos, A, Kobilka, B.K, Wootten, D, Skiniotis, G, Sexton, P.M.
Deposit date:2017-02-24
Release date:2017-05-03
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.
Nature, 546, 2017
6D9H
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BU of 6d9h by Molmil
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist
Descriptor: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Draper-Joyce, C.J, Khoshouei, M, Thal, D.M, Liang, Y.-L, Nguyen, A.T.N, Furness, S.G.B, Venugopal, H, Baltos, J, Plitzko, J.M, Danev, R, Baumeister, W, May, L.T, Wootten, D, Sexton, P, Glukhova, A, Christopoulos, A.
Deposit date:2018-04-29
Release date:2018-06-20
Last modified:2018-07-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the adenosine-bound human adenosine A1receptor-Gicomplex.
Nature, 558, 2018
6B3J
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BU of 6b3j by Molmil
3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex
Descriptor: Exendin-P5, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liang, Y.L, Khoshouei, M, Glukhova, A, Furness, S.G.B, Koole, C, Zhao, P, Clydesdale, L, Thal, D.M, Radjainia, M, Danev, R, Baumeister, W, Wang, M.W, Miller, L.J, Christopoulos, A, Sexton, P.M, Wootten, D.
Deposit date:2017-09-22
Release date:2018-02-21
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Nature, 555, 2018
6TEM
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BU of 6tem by Molmil
CENP-A nucleosome core particle with 145 base pairs of the Widom 601 sequence by cryo-EM
Descriptor: Histone H2A, Histone H2B 1.1, Histone H3-like centromeric protein A, ...
Authors:Boopathi, R, Danev, R, Petosa, C, Bednar, J.
Deposit date:2019-11-12
Release date:2020-04-08
Last modified:2020-06-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends.
Nucleic Acids Res., 48, 2020
6X1A
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BU of 6x1a by Molmil
Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Zhang, X, Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
6X19
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BU of 6x19 by Molmil
Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Zhang, X, Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
6X18
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BU of 6x18 by Molmil
GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: Glucagon, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Zhang, X, Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
6WHC
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BU of 6whc by Molmil
CryoEM Structure of the glucagon receptor with a dual-agonist peptide
Descriptor: Dual-agonist peptide, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Sexton, P, Danev, R.
Deposit date:2020-04-07
Release date:2020-05-27
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide.
J.Biol.Chem., 295, 2020
6ORV
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BU of 6orv by Molmil
Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Belousoff, M.J, Liang, Y.L, Danev, R.
Deposit date:2019-05-01
Release date:2020-01-08
Last modified:2020-01-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Activation of the GLP-1 receptor by a non-peptidic agonist.
Nature, 577, 2020
6P9X
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BU of 6p9x by Molmil
CRF1 Receptor Gs GPCR protein complex with CRF1 peptide
Descriptor: Corticoliberin, Corticotropin-releasing factor receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
Deposit date:2019-06-10
Release date:2020-02-05
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Mol.Cell, 77, 2020
6P9Y
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BU of 6p9y by Molmil
PAC1 GPCR Receptor complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
Deposit date:2019-06-10
Release date:2020-02-05
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Mol.Cell, 77, 2020
7VZ4
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BU of 7vz4 by Molmil
Cryo-EM structure of human nucleosome core particle composed of the Widom 601L DNA sequence
Descriptor: DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Takizawa, Y, Ho, C.-H, Sato, S, Danev, R, Kurumizaka, H.
Deposit date:2021-11-15
Release date:2023-05-17
Method:ELECTRON MICROSCOPY (1.89 Å)
Cite:Methods for High Resolution Cryo-EM Analyses of Nucleosomes
To Be Published
8FX5
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BU of 8fx5 by Molmil
Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline
Descriptor: Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Vuckovic, Z, Mobbs, J.I, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M.
Deposit date:2023-01-23
Release date:2023-09-13
Method:ELECTRON MICROSCOPY (2.45 Å)
Cite:Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR.
Nat Commun, 14, 2023
6UUS
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BU of 6uus by Molmil
CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide
Descriptor: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
Deposit date:2019-10-31
Release date:2020-04-01
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
6UVA
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BU of 6uva by Molmil
CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin 2 peptide
Descriptor: Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
Deposit date:2019-11-01
Release date:2020-04-01
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
6UUN
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BU of 6uun by Molmil
CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide
Descriptor: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
Deposit date:2019-10-30
Release date:2020-03-25
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
6WZG
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BU of 6wzg by Molmil
Human secretin receptor Gs complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Piper, S.J, Belousoff, M.J, Danev, R.
Deposit date:2020-05-13
Release date:2020-08-12
Last modified:2020-09-02
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structure and dynamics of the active Gs-coupled human secretin receptor.
Nat Commun, 11, 2020
7MBX
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BU of 7mbx by Molmil
Human Cholecystokinin 1 receptor (CCK1R) Gs complex
Descriptor: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M.
Deposit date:2021-04-01
Release date:2021-05-26
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (1.95 Å)
Cite:Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Plos Biol., 19, 2021
7MBY
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BU of 7mby by Molmil
Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex
Descriptor: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M.
Deposit date:2021-04-01
Release date:2021-05-26
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Plos Biol., 19, 2021
8E3Y
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BU of 8e3y by Molmil
Cryo-EM structure of the VPAC1R-PACAP27-Gs complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Piper, S.J, Danev, R, Sexton, P, Wootten, D.
Deposit date:2022-08-17
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Understanding VPAC receptor family peptide binding and selectivity
Nat Commun, 13, 2022
8E3X
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BU of 8e3x by Molmil
Cryo-EM structure of the PAC1R-PACAP27-Gs complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Piper, S.J, Danev, R, Sexton, P, Wootten, D.
Deposit date:2022-08-17
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Understanding VPAC receptor family peptide binding and selectivity
Nat Commun, 13, 2022
8E3Z
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BU of 8e3z by Molmil
Cryo-EM structure of the VPAC1R-VIP-Gs complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Piper, S.J, Danev, R, Sexton, P, Wootten, D.
Deposit date:2022-08-17
Release date:2022-11-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Understanding VPAC receptor family peptide binding and selectivity
Nat Commun, 13, 2022
7LD3
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BU of 7ld3 by Molmil
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand
Descriptor: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A.
Deposit date:2021-01-12
Release date:2021-09-08
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.
Nature, 597, 2021
7LD4
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BU of 7ld4 by Molmil
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist
Descriptor: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A.
Deposit date:2021-01-12
Release date:2021-09-08
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.
Nature, 597, 2021

 

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