Author results

1TMW
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SOLUTION STRUCTURE OF HUMAN COACTOSIN LIKE PROTEIN D123N
Descriptor:Coactosin-like protein
Authors:Dai, H., Wu, J., Xu, Y., Tang, Y., Ding, H., Shi, Y.
Deposit date:2004-06-11
Release date:2005-06-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Study on Solution Structure and Its binding function to F-actin
To be Published
4ZZH
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SIRT1/ACTIVATOR COMPLEX
Descriptor:NAD-dependent protein deacetylase sirtuin-1, ZINC ION, (4S)-N-[3-(1,3-oxazol-5-yl)phenyl]-7-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1,4-methanopyrido[2,3-b][1,4]diazepine-5(2H)-carboxamide
Authors:Dai, H.
Deposit date:2015-05-22
Release date:2015-07-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.1001 Å)
Cite:Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Nat Commun, 6, 2015
4ZZI
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SIRT1/ACTIVATOR/INHIBITOR COMPLEX
Descriptor:NAD-dependent protein deacetylase sirtuin-1, (3S)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide, 4-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide, ...
Authors:Dai, H.
Deposit date:2015-05-22
Release date:2015-07-15
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.7346 Å)
Cite:Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Nat Commun, 6, 2015
4ZZJ
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SIRT1/ACTIVATOR/SUBSTRATE COMPLEX
Descriptor:NAD-dependent protein deacetylase sirtuin-1, Ac-p53, ZINC ION, ...
Authors:Dai, H.
Deposit date:2015-05-22
Release date:2015-07-15
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.7403 Å)
Cite:Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Nat Commun, 6, 2015
1W15
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RAT SYNAPTOTAGMIN 4 C2B DOMAIN IN THE PRESENCE OF CALCIUM
Descriptor:SYNAPTOTAGMIN IV, CALCIUM ION, SODIUM ION, ...
Authors:Dai, H., Shin, O.-H., Machius, M., Tomchick, D.R., Sudhof, T.C., Rizo, J.
Deposit date:2004-06-16
Release date:2004-08-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Basis for the Evolutionary Inactivation of Ca2+ Binding to Synaptotagmin 4
Nat.Struct.Mol.Biol., 11, 2004
1W16
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RAT SYNAPTOTAGMIN 4 C2B DOMAIN IN THE ABSENCE OF CALCIUM
Descriptor:SYNAPTOTAGMIN IV, SODIUM ION, CHLORIDE ION
Authors:Dai, H., Shin, O.-H., Machius, M., Tomchick, D.R., Sudhof, T.C., Rizo, J.
Deposit date:2004-06-16
Release date:2004-08-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Evolutionary Inactivation of Ca2+ Binding to Synaptotagmin 4
Nat.Struct.Mol.Biol., 11, 2004
2BWQ
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CRYSTAL STRUCTURE OF THE RIM2 C2A-DOMAIN AT 1.4 ANGSTROM RESOLUTION
Descriptor:REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2, SULFATE ION
Authors:Dai, H., Tomchick, D.R., Garcia, J., Sudhof, T.C., Machius, M., Rizo, J.
Deposit date:2005-07-15
Release date:2005-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystal Structure of the Rim2 C(2)A-Domain at 1.4 A Resolution.
Biochemistry, 44, 2005
2KHA
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SOLUTION STRUCTURE OF A PATHOGEN RECOGNITION DOMAIN FROM A LEPIDOPTERAN INSECT, PLODIA INTERPUNCTELLA
Descriptor:Beta-1,3-glucan-binding protein
Authors:Dai, H., Hiromasa, Y., Fabrick, J., Vandervelde, D., Kanost, M., Krishnamoorthi, R.
Deposit date:2009-03-29
Release date:2010-03-16
Last modified:2013-06-19
Method:SOLUTION NMR
Cite:An initial event in the insect innate immune response: structural and biological studies of interactions between beta-1,3-glucan and the N-terminal domain of beta-1,3-glucan recognition protein
Biochemistry, 52, 2013
2JR8
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SOLUTION STRUCTURE OF MANDUCA SEXTA MORICIN
Descriptor:Antimicrobial peptide moricin
Authors:Gong, Y., Dai, H., Rayaprolu, S., Huang, R., Prakash, O., Jiang, H.
Deposit date:2007-06-21
Release date:2008-03-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure, antibacterial activity, and expression profile of Manduca sexta moricin.
J.Pept.Sci., 14, 2008
4FVT
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HUMAN SIRT3 BOUND TO AC-ACS PEPTIDE AND CARBA-NAD
Descriptor:NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Acetylated ACS2 peptide, ...
Authors:Dai, H.
Deposit date:2012-06-29
Release date:2012-08-15
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.
J.Org.Chem., 77, 2012
4G1C
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HUMAN SIRT5 BOUND TO SUCC-IDH2 AND CARBA-NAD
Descriptor:NAD-dependent protein deacylase sirtuin-5, mitochondrial, Succinylated IDH2 peptide, ...
Authors:Dai, H.
Deposit date:2012-07-10
Release date:2012-08-15
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.944 Å)
Cite:Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.
J.Org.Chem., 77, 2012
4JSR
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CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ELT INHIBITOR 11C [N-{2-[1-(6-CARBAMOYLTHIENO[3,2-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL]ETHYL}-N'-ETHYLTHIOPHENE-2,5-DICARBOXAMIDE]
Descriptor:NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, ...
Authors:Dai, H.
Deposit date:2013-03-22
Release date:2013-04-24
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3.
J.Med.Chem., 56, 2013
4JT8
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CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ELT INHIBITOR 28 [4-(4-{2-[(2,2-DIMETHYLPROPANOYL)AMINO]ETHYL}PIPERIDIN-1-YL)THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDE[
Descriptor:NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, ...
Authors:Dai, H.
Deposit date:2013-03-22
Release date:2013-04-24
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3.
J.Med.Chem., 56, 2013
4JT9
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CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ELT INHIBITOR 3 [14-(4-{2-[(METHYLSULFONYL)AMINO]ETHYL}PIPERIDIN-1-YL)THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDE]
Descriptor:NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, ...
Authors:Dai, H.
Deposit date:2013-03-22
Release date:2013-04-24
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3.
J.Med.Chem., 56, 2013
2HFR
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SOLUTION STRUCTURE OF ANTIMICROBIAL PEPTIDE FOWLICIDIN 3
Descriptor:Fowlicidin-3
Authors:Bommineni, Y.R., Dai, H., Gong, Y., Prakash, O., Zhang, G.
Deposit date:2006-06-26
Release date:2007-04-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities.
Febs J., 274, 2007
1U4A
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SOLUTION STRUCTURE OF HUMAN SUMO-3 C47S
Descriptor:Ubiquitin-like protein SMT3A
Authors:Ding, H., Xu, Y., Dai, H., Tang, Y., Wu, J., Shi, Y.
Deposit date:2004-07-23
Release date:2005-03-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of Human SUMO-3 C47S and Its Binding Surface for Ubc9
Biochemistry, 44, 2005
2DK9
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SOLUTION STRUCTURE OF CALPONIN HOMOLOGY DOMAIN OF HUMAN MICAL-1
Descriptor:NEDD9-interacting protein with calponin homology and LIM domains
Authors:Sun, H., Dai, H., Zhang, J., Xiong, S., Wu, J., Shi, Y.
Deposit date:2006-04-07
Release date:2006-09-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of calponin homology domain of Human MICAL-1
J.Biomol.Nmr, 36, 2006
3GLR
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CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ACETYL-LYSINE ACECS2 PEPTIDE
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3GLS
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CRYSTAL STRUCTURE OF HUMAN SIRT3
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, ZINC ION, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3GLT
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CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ADPR BOUND TO THE ACECS2 PEPTIDE CONTAINING A THIOACETYL LYSINE
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3GLU
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CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ACECS2 PEPTIDE
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
2AMN
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SOLUTION STRUCTURE OF FOWLICIDIN-1, A NOVEL CATHELICIDIN ANTIMICROBIAL PEPTIDE FROM CHICKEN
Descriptor:cathelicidin
Authors:Xiao, Y., Dai, H., Bommineni, Y.R., Prakash, O., Zhang, G.
Deposit date:2005-08-09
Release date:2006-07-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken.
Febs J., 273, 2006
2CJS
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STRUCTURAL BASIS FOR A MUNC13-1 HOMODIMER - MUNC13-1 - RIM HETERODIMER SWITCH: C2-DOMAINS AS VERSATILE PROTEIN-PROTEIN INTERACTION MODULES
Descriptor:UNC-13 HOMOLOG A, REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2, 1,2-ETHANEDIOL, ...
Authors:Lu, J., Machius, M., Dulubova, I., Dai, H., Sudhof, T.C., Tomchick, D.R., Rizo, J.
Deposit date:2006-04-06
Release date:2006-06-07
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Basis for a Munc13-1 Homodimer to Munc13-1/Rim Heterodimer Switch.
Plos Biol., 4, 2006
2CJT
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STRUCTURAL BASIS FOR A MUNC13-1 HOMODIMER - MUNC13-1 - RIM HETERODIMER SWITCH: C2-DOMAINS AS VERSATILE PROTEIN-PROTEIN INTERACTION MODULES
Descriptor:UNC-13 HOMOLOG A, 1,2-ETHANEDIOL, FORMIC ACID
Authors:Lu, J., Machius, M., Dulubova, I., Dai, H., Sudhof, T.C., Tomchick, D.R., Rizo, J.
Deposit date:2006-04-06
Release date:2006-06-07
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural Basis for a Munc13-1 Dimeric to Munc13-1/Rim Heterodimer Switch
Plos Biol., 4, 2006
2FEI
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SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OF HUMAN CMS PROTEIN
Descriptor:CD2-associated protein
Authors:Yao, B., Dai, H., Jiao, Y., Wu, J., Shi, Y.
Deposit date:2005-12-15
Release date:2006-12-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the second SH3 domain of human CMS and a newly identified binding site at the C-terminus of c-Cbl
Biochim.Biophys.Acta, 1774, 2007
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