Author results

6JPJ
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CRYSTAL STRUCTURE OF FGF401 IN COMPLEX OF FGFR4
分子名称:Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION
著者Zhou, Z., Chen, X., Chen, Y.
登録日2019-03-27
公開日2019-05-15
最終更新日2019-06-05
実験手法X-RAY DIFFRACTION (2.638 Å)
主引用文献Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.
Chem.Commun.(Camb.), 55, 2019
6AKO
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CRYSTAL STRUCTURE OF FOXC2 DBD BOUND TO DBE2 DNA
分子名称:DNA (5'-D(CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Forkhead box protein C2, ...
著者Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
登録日2018-09-03
公開日2019-02-06
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.396 Å)
主引用文献Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 47, 2019
6AKP
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CRYSTAL STRUCTURAL OF FOXC2 DNA BINDING DOMAIN BOUND TO PC PROMOTER
分子名称:DNA (5'-D(AP*CP*AP*CP*AP*AP*AP*TP*AP*TP*TP*TP*GP*TP*GP*T)-3'), Forkhead box protein C2, MAGNESIUM ION
著者Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
登録日2018-09-03
公開日2019-02-06
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.323 Å)
主引用文献Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 47, 2019
6MBJ
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SETD3, A HISTIDINE METHYLTRANSFERASE, IN COMPLEX WITH AN ACTIN PEPTIDE AND SAH, P21 CRYSTAL FORM
分子名称:Actin Peptide, Histone-lysine N-methyltransferase setd3, 1,2-ETHANEDIOL, ...
著者Horton, J.R., Dai, S., Cheng, X.
登録日2018-08-30
公開日2018-12-19
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献SETD3 is an actin histidine methyltransferase that prevents primary dystocia
Nature, 565, 2018
6MBK
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SETD3, A HISTIDINE METHYLTRANSFERASE, IN COMPLEX WITH AN ACTIN PEPTIDE AND SAH, FIRST P212121 CRYSTAL FORM
分子名称:Actin peptide, Histone-lysine N-methyltransferase setd3, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Horton, J.R., Dai, S., Cheng, X.
登録日2018-08-30
公開日2018-12-19
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献SETD3 is an actin histidine methyltransferase that prevents primary dystocia
Nature, 565, 2018
6MBL
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SETD3, A HISTIDINE METHYLTRANSFERASE, IN COMPLEX WITH AN ACTIN PEPTIDE AND SAH, SECOND P212121 CRYSTAL FORM
分子名称:Actin Peptide, Histone-lysine N-methyltransferase setd3, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Horton, J.R., Dai, S., Cheng, X.
登録日2018-08-30
公開日2018-12-19
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (2.197 Å)
主引用文献SETD3 is an actin histidine methyltransferase that prevents primary dystocia
Nature, 565, 2018
6DFQ
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MOUSE DIABETOGENIC TCR I.29
分子名称:TCR alpha chain, TCR beta chain, CALCIUM ION, ...
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
6DFS
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MOUSE TCR I.29 IN COMPLEX WITH IAG7-P8E9E6SS
分子名称:mouse TCR alpha chain, mouse TCR beta chain, H-2 class II histocompatibility antigen, ...
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
6DFV
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MOUSE DIABETOGENIC TCR 8F10
分子名称:TCR alpha chain, TCR beta chain, 1,2-ETHANEDIOL
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
6DFW
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TCR 8F10 IN COMPLEX WITH IAG7-P8G9E
分子名称:H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, ...
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
6DFX
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HUMAN DIABETOGENIC TCR T1D3 IN COMPLEX WITH DQ8-P8E9E PEPTIDE
分子名称:MHC class II HLA-DQ-alpha chain, MHC class II antigen, T1D3 alpha chain, ...
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
5ZOV
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INWARD-FACING CONFORMATION OF L-ASCORBATE TRANSPORTER ULAA
分子名称:PTS ascorbate-specific subunit IIBC, ASCORBIC ACID, CALCIUM ION
著者Wang, J.W.
登録日2018-04-16
公開日2018-08-01
最終更新日2018-09-19
実験手法X-RAY DIFFRACTION (3.333 Å)
主引用文献Inward-facing conformation of l-ascorbate transporter suggests an elevator mechanism
Cell Discov, 4, 2018
6BLQ
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH INSULIN MIMOTOPE P8E9E
分子名称:H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, ...
著者Wang, Y., Dai, S.
登録日2017-11-11
公開日2017-12-20
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLR
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH INSULIN MIMOTOPE P8E9E6SS
分子名称:IAg7 alpha chain, H2-Ab1 protein, 1,2-ETHANEDIOL
著者Wang, Y., Dai, S.
登録日2017-11-11
公開日2017-12-20
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLX
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH INSULIN MIMOTOPE P8G9E
分子名称:H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, ...
著者Wang, Y., Dai, S.
登録日2017-11-11
公開日2017-12-20
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (2.323 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AX3
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COMPLEX STRUCTURE OF JMJD5 AND SYMMETRIC DIMETHYL-ARGININE (SDMA)
分子名称:Lysine-specific demethylase 8, N3, N4-DIMETHYLARGININE, ...
著者Lee, S., Liu, H., Wang, Y., Dai, S., Zhang, G.
登録日2017-09-06
公開日2018-02-28
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.
Sci Rep, 8, 2018
6AVS
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COMPLEX STRUCTURE OF JMJD5 AND SYMMETRIC MONOMETHYL-ARGININE (MMA)
分子名称:Lysine-specific demethylase 8, ZINC ION, (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid
著者Lee, S., Liu, H., Wang, Y., Dai, S., Zhang, G.
登録日2017-09-04
公開日2018-02-28
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.
Sci Rep, 8, 2018
5W1J
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ECHINOCOCCUS GRANULOSUS THIOREDOXIN GLUTATHIONE REDUCTAS (EGTGR)
分子名称:Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE
著者Gao, W., Wang, Y., Dai, S.
登録日2017-06-03
公開日2017-11-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).
Antioxid. Redox Signal., 27, 2017
5W1L
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ECHINOCOCCUS GRANULOSUS THIOREDOXIN GLUTATHIONE REDUCTAS (EGTGR) WITH GOLD
分子名称:Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE, GOLD ION
著者Gao, W., Wang, Y., Dai, S.
登録日2017-06-03
公開日2017-11-22
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).
Antioxid. Redox Signal., 27, 2017
5XP5
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C-SRC IN COMPLEX WITH ATP-CHF
分子名称:Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid, MAGNESIUM ION
著者Duan, Y., Guo, M., Dai, S., Chen, L., Chen, Y.
登録日2017-06-01
公開日2018-02-07
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
5XP7
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C-SRC IN COMPLEX WITH ATP-CHCL
分子名称:Proto-oncogene tyrosine-protein kinase Src, [(R)-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]-chloranyl-methyl]phosphonic acid, MAGNESIUM ION, ...
著者Guo, M., Dai, S., Duan, Y., Chen, L., Chen, Y.
登録日2017-06-01
公開日2017-09-06
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.012 Å)
主引用文献Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
5XFF
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CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550L)
分子名称:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
著者Wu, D., Chen, Y.
登録日2017-04-10
公開日2018-09-05
最終更新日2019-03-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
5XFJ
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CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550M)
分子名称:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
著者Wu, D., Chen, Y.
登録日2017-04-10
公開日2018-08-08
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
5UJT
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CRYSTAL STRUCTURE OF HUMAN HLA-DQ8 IN COMPLEX WITH INSULIN MIMOTOPE BINDING IN REGISTER 3
分子名称:MHC class II antigen, MHC class II HLA-DQ-beta-1, insulin mimotope, ...
著者Wang, Y., Dai, S.
登録日2017-01-18
公開日2017-12-20
最終更新日2018-01-10
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5WTL
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CRYSTAL STRUCTURE OF THE PERIPLASMIC PORTION OF OUTER MEMBRANE PROTEIN A (OMPA) FROM CAPNOCYTOPHAGA GINGIVALIS
分子名称:OmpA family protein, CALCIUM ION, SULFATE ION, ...
著者Dai, S., Tan, K., Ye, S., Zhang, R.
登録日2016-12-13
公開日2017-12-13
最終更新日2018-09-12
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献Structure of thrombospondin type 3 repeats in bacterial outer membrane protein A reveals its intra-repeat disulfide bond-dependent calcium-binding capability.
Cell Calcium, 66, 2017
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