Author results

6AKO
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CRYSTAL STRUCTURE OF FOXC2 DBD BOUND TO DBE2 DNA
Descriptor:DNA (5'-D(CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Forkhead box protein C2, ...
Authors:Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
Deposit date:2018-09-03
Release date:2019-02-06
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 2019
6AKP
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CRYSTAL STRUCTURAL OF FOXC2 DNA BINDING DOMAIN BOUND TO PC PROMOTER
Descriptor:DNA (5'-D(AP*CP*AP*CP*AP*AP*AP*TP*AP*TP*TP*TP*GP*TP*GP*T)-3'), Forkhead box protein C2, MAGNESIUM ION
Authors:Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
Deposit date:2018-09-03
Release date:2019-02-06
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 2019
6MBJ
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SETD3, A HISTIDINE METHYLTRANSFERASE, IN COMPLEX WITH AN ACTIN PEPTIDE AND SAH, P21 CRYSTAL FORM
Descriptor:Actin Peptide, Histone-lysine N-methyltransferase setd3, 1,2-ETHANEDIOL, ...
Authors:Horton, J.R., Dai, S., Cheng, X.
Deposit date:2018-08-30
Release date:2018-12-19
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:SETD3 is an actin histidine methyltransferase that prevents primary dystocia
Nature, 565, 2018
6MBK
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SETD3, A HISTIDINE METHYLTRANSFERASE, IN COMPLEX WITH AN ACTIN PEPTIDE AND SAH, FIRST P212121 CRYSTAL FORM
Descriptor:Actin peptide, Histone-lysine N-methyltransferase setd3, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Horton, J.R., Dai, S., Cheng, X.
Deposit date:2018-08-30
Release date:2018-12-19
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:SETD3 is an actin histidine methyltransferase that prevents primary dystocia
Nature, 565, 2018
6MBL
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SETD3, A HISTIDINE METHYLTRANSFERASE, IN COMPLEX WITH AN ACTIN PEPTIDE AND SAH, SECOND P212121 CRYSTAL FORM
Descriptor:Actin Peptide, Histone-lysine N-methyltransferase setd3, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Horton, J.R., Dai, S., Cheng, X.
Deposit date:2018-08-30
Release date:2018-12-19
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:SETD3 is an actin histidine methyltransferase that prevents primary dystocia
Nature, 565, 2018
5ZOV
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INWARD-FACING CONFORMATION OF L-ASCORBATE TRANSPORTER ULAA
Descriptor:PTS ascorbate-specific subunit IIBC, ASCORBIC ACID, CALCIUM ION
Authors:Wang, J.W.
Deposit date:2018-04-16
Release date:2018-08-01
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.333 Å)
Cite:Inward-facing conformation of l-ascorbate transporter suggests an elevator mechanism
Cell Discov, 4, 2018
6BLQ
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH INSULIN MIMOTOPE P8E9E
Descriptor:H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, ...
Authors:Wang, Y., Dai, S.
Deposit date:2017-11-11
Release date:2017-12-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLR
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH INSULIN MIMOTOPE P8E9E6SS
Descriptor:IAg7 alpha chain, H2-Ab1 protein, 1,2-ETHANEDIOL
Authors:Wang, Y., Dai, S.
Deposit date:2017-11-11
Release date:2017-12-20
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLX
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH INSULIN MIMOTOPE P8G9E
Descriptor:H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, ...
Authors:Wang, Y., Dai, S.
Deposit date:2017-11-11
Release date:2017-12-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AX3
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COMPLEX STRUCTURE OF JMJD5 AND SYMMETRIC DIMETHYL-ARGININE (SDMA)
Descriptor:Lysine-specific demethylase 8, N3, N4-DIMETHYLARGININE, ...
Authors:Lee, S., Liu, H., Wang, Y., Dai, S., Zhang, G.
Deposit date:2017-09-06
Release date:2018-02-28
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.
Sci Rep, 8, 2018
6AVS
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COMPLEX STRUCTURE OF JMJD5 AND SYMMETRIC MONOMETHYL-ARGININE (MMA)
Descriptor:Lysine-specific demethylase 8, ZINC ION, (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid
Authors:Lee, S., Liu, H., Wang, Y., Dai, S., Zhang, G.
Deposit date:2017-09-04
Release date:2018-02-28
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.
Sci Rep, 8, 2018
5W1J
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ECHINOCOCCUS GRANULOSUS THIOREDOXIN GLUTATHIONE REDUCTAS (EGTGR)
Descriptor:Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Gao, W., Wang, Y., Dai, S.
Deposit date:2017-06-03
Release date:2017-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).
Antioxid. Redox Signal., 27, 2017
5W1L
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ECHINOCOCCUS GRANULOSUS THIOREDOXIN GLUTATHIONE REDUCTAS (EGTGR) WITH GOLD
Descriptor:Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE, GOLD ION
Authors:Gao, W., Wang, Y., Dai, S.
Deposit date:2017-06-03
Release date:2017-11-22
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).
Antioxid. Redox Signal., 27, 2017
5XP5
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C-SRC IN COMPLEX WITH ATP-CHF
Descriptor:Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid, MAGNESIUM ION
Authors:Duan, Y., Guo, M., Dai, S., Chen, L., Chen, Y.
Deposit date:2017-06-01
Release date:2018-02-07
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
5XP7
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C-SRC IN COMPLEX WITH ATP-CHCL
Descriptor:Proto-oncogene tyrosine-protein kinase Src, [(R)-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]-chloranyl-methyl]phosphonic acid, MAGNESIUM ION, ...
Authors:Guo, M., Dai, S., Duan, Y., Chen, L., Chen, Y.
Deposit date:2017-06-01
Release date:2017-09-06
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.012 Å)
Cite:Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
5XFJ
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CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550M)
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, Y.
Deposit date:2017-04-10
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
5UJT
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CRYSTAL STRUCTURE OF HUMAN HLA-DQ8 IN COMPLEX WITH INSULIN MIMOTOPE BINDING IN REGISTER 3
Descriptor:MHC class II antigen, MHC class II HLA-DQ-beta-1, insulin mimotope, ...
Authors:Wang, Y., Dai, S.
Deposit date:2017-01-18
Release date:2017-12-20
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5WTL
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CRYSTAL STRUCTURE OF THE PERIPLASMIC PORTION OF OUTER MEMBRANE PROTEIN A (OMPA) FROM CAPNOCYTOPHAGA GINGIVALIS
Descriptor:OmpA family protein, CALCIUM ION, SULFATE ION, ...
Authors:Dai, S., Tan, K., Ye, S., Zhang, R.
Deposit date:2016-12-13
Release date:2017-12-13
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structure of thrombospondin type 3 repeats in bacterial outer membrane protein A reveals its intra-repeat disulfide bond-dependent calcium-binding capability.
Cell Calcium, 66, 2017
5WTP
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF OUTER MEMBRANE PROTEIN A (OMPA) FROM CAPNOCYTOPHAGA GINGIVALIS
Descriptor:OmpA family protein, SULFATE ION
Authors:Dai, S., Tan, K., Ye, S., Zhang, R.
Deposit date:2016-12-13
Release date:2017-12-13
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of thrombospondin type 3 repeats in bacterial outer membrane protein A reveals its intra-repeat disulfide bond-dependent calcium-binding capability.
Cell Calcium, 66, 2017
5HHT
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CRYSTAL STRUCTURE OF E. COLI TRANSKETOLASE TRIPLE VARIANT SER385TYR/ASP469THR/ARG520GLN
Descriptor:Transketolase 1, 1,2-ETHANEDIOL, CALCIUM ION, ...
Authors:Dai, S., Tittmann, K.
Deposit date:2016-01-11
Release date:2016-11-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.
Sci Rep, 6, 2016
5DMK
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH RLGL-WE14
Descriptor:H-2 class II histocompatibility antigen, A-D alpha chain, beta chain of Major Histocompatibility Complex Class II, ...
Authors:Wang, Y., Jin, N., Dai, S., Kappler, J.W.
Deposit date:2015-09-08
Release date:2015-10-28
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YK9
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COMPLEX STRUCTURE OF BCL-XL AND MUTATED BIM BH3 DOMAIN
Descriptor:Bcl-2-like protein 1, BH3BIM, ACETATE ION, ...
Authors:Ha, N.C., Kim, J.S.
Deposit date:2015-03-04
Release date:2016-04-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Complex structure of BCL-XL and mutated BIM BH3 domain
To be published
4P5M
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STRUCTURAL BASIS OF CHRONIC BERYLLIUM DISEASE: BRIDGING THE GAP BETWEEN ALLERGIC HYPERSENSITIVITY AND AUTOIMMUNITY
Descriptor:HLA class II histocompatibility antigen, DP alpha 1 chain, peptide,HLA class II histocompatibility antigen, ...
Authors:Wang, Y., Dai, S., Kappler, J.
Deposit date:2014-03-18
Release date:2014-08-27
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.
Cell, 158, 2014
4P5K
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STRUCTURAL BASIS OF CHRONIC BERYLLIUM DISEASE: BRIDGING THE GAP BETWEEN ALLERGY AND AUTOIMMUNITY
Descriptor:HLA class II histocompatibility antigen, DP alpha 1 chain, RAS peptide,HLA class II histocompatibility antigen, ...
Authors:Clayton, G.M., Wang, Y., Crawford, F., Novikov, A., Wimberly, B.T., Kieft, J.S., Falta, M.T., Bowerman, N.A., Marrack, P., Fontenot, A.P., Dai, S., Kappler, J.W.
Deposit date:2014-03-17
Release date:2015-01-21
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.
Cell, 158, 2014
4P57
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MHC TCR PEPTIDE COMPLEX
Descriptor:HLA class II histocompatibility antigen, DP alpha 1 chain, mim2 peptide,HLA class II histocompatibility antigen, ...
Authors:Clayton, G.M., Crawford, F., Kappler, J.W.
Deposit date:2014-03-14
Release date:2014-07-16
Last modified:2015-01-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.
Cell, 158, 2014
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