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3KTM
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STRUCTURE OF THE HEPARIN-INDUCED E1-DIMER OF THE AMYLOID PRECURSOR PROTEIN (APP)
Descriptor:Amyloid beta A4 protein, (3R)-butane-1,3-diol, SULFATE ION, ...
Authors:Dahms, S.O., Hoefgen, S., Roeser, D., Schlott, B., Guhrs, K.H., Than, M.E.
Deposit date:2009-11-25
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
3QO4
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THE CRYSTAL STRUCTURE OF DEATH RECEPTOR 6
Descriptor:Tumor necrosis factor receptor superfamily member 21, ACETATE ION, SULFATE ION
Authors:Kuester, M., Kemmerzehl, S., Dahms, S.O., Roeser, D., Than, M.E.
Deposit date:2011-02-09
Release date:2011-05-18
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of death receptor 6 (DR6): a potential receptor of the amyloid precursor protein (APP).
J.Mol.Biol., 409, 2011
3UMH
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X-RAY STRUCTURE OF THE E2 DOMAIN OF THE HUMAN AMYLOID PRECURSOR PROTEIN (APP) IN COMPLEX WITH CADMIUM
Descriptor:Amyloid beta A4 protein, ACETATE ION, CADMIUM ION
Authors:Dahms, S.O., Konnig, I., Roeser, D., Guhrs, K.H., Than, M.E.
Deposit date:2011-11-13
Release date:2012-01-25
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
3UMI
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X-RAY STRUCTURE OF THE E2 DOMAIN OF THE HUMAN AMYLOID PRECURSOR PROTEIN (APP) IN COMPLEX WITH ZINC
Descriptor:Amyloid beta A4 protein, ACETATE ION, ZINC ION, ...
Authors:Dahms, S.O., Konnig, I., Roeser, D., Guhrs, K.H., Than, M.E.
Deposit date:2011-11-13
Release date:2012-01-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
3UMK
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X-RAY STRUCTURE OF THE E2 DOMAIN OF THE HUMAN AMYLOID PRECURSOR PROTEIN (APP) IN COMPLEX WITH COPPER
Descriptor:Amyloid beta A4 protein, ACETATE ION, COPPER (II) ION, ...
Authors:Dahms, S.O., Konnig, I., Roeser, D., Guhrs, K.H., Than, M.E.
Deposit date:2011-11-13
Release date:2012-01-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
4OMC
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X-RAY STRUCTURE OF HUMAN FURIN IN COMPLEX WITH THE COMPETITIVE INHIBITOR META-GUANIDINOMETHYL-PHAC-RVR-AMBA
Descriptor:Furin, meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2014-01-27
Release date:2014-04-09
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9, 2014
4OMD
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X-RAY STRUCTURE OF HUMAN FURIN IN COMPLEX WITH THE COMPETITIVE INHIBITOR PHAC-RVR-AMBA
Descriptor:Furin, phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2014-01-27
Release date:2014-04-09
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9, 2014
4LXC
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THE ANTIMICROBIAL PEPTIDASE LYSOSTAPHIN FROM STAPHYLOCOCCUS SIMULANS
Descriptor:Lysostaphin, ZINC ION, SULFATE ION
Authors:Sabala, I., Jagielska, E., Bardelang, P.T., Czapinska, H., Dahms, S.O., Sharpe, J.A., James, R., Than, M.E., Thomas, N.R., Bochtler, M.
Deposit date:2013-07-29
Release date:2014-07-09
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.
Febs J., 281, 2014
4QPB
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CATALYTIC DOMAIN OF THE ANTIMICROBIAL PEPTIDASE LYSOSTAPHIN FROM STAPHYLOCOCCUS SIMULANS CRYSTALLIZED IN THE ABSENCE OF PHOSPHATE
Descriptor:Lysostaphin, ZINC ION, 1,2-ETHANEDIOL
Authors:Sabala, I., Jagielska, E., Bardelang, P.T., Czapinska, H., Dahms, S.O., Sharpe, J.A., James, R., Than, M.E., Thomas, N.R., Bochtler, M.
Deposit date:2014-06-22
Release date:2014-07-09
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.
Febs J., 281, 2014
4QP5
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CATALYTIC DOMAIN OF THE ANTIMICROBIAL PEPTIDASE LYSOSTAPHIN FROM STAPHYLOCOCCUS SIMULANS CRYSTALLIZED IN THE PRESENCE OF PHOSPHATE
Descriptor:Lysostaphin, ZINC ION, PHOSPHATE ION, ...
Authors:Sabala, I., Jagielska, E., Bardelang, P.T., Czapinska, H., Dahms, S.O., Sharpe, J.A., James, R., Than, M.E., Thomas, N.R., Bochtler, M.
Deposit date:2014-06-22
Release date:2014-07-16
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.
Febs J., 281, 2014
4PWQ
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HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE E1-DOMAIN OF THE AMYLOID PRECURSOR PROTEIN
Descriptor:Amyloid beta A4 protein
Authors:Hoefgen, S., Dahms, S.O., Than, M.E.
Deposit date:2014-03-21
Release date:2015-02-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain.
J.Mol.Biol., 427, 2015
4RD9
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X-RAY STRUCTURE OF THE APO FORM OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN
Descriptor:Amyloid-like protein 1
Authors:Dahms, S.O., Than, M.E.
Deposit date:2014-09-18
Release date:2015-03-11
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
Acta Crystallogr.,Sect.D, 71, 2015
4RDA
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X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE
Descriptor:Amyloid-like protein 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2014-09-18
Release date:2015-03-11
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
Acta Crystallogr.,Sect.D, 71, 2015
4RYD
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X-RAY STRUCTURE OF HUMAN FURIN IN COMPLEX WITH THE COMPETITIVE INHIBITOR PARA-GUANIDINOMETHYL-PHAC-R-TLE-R-AMBA
Descriptor:Furin, para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine, FORMIC ACID, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2014-12-15
Release date:2015-05-27
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Novel Furin Inhibitors with Potent Anti-infectious Activity.
Chemmedchem, 10, 2015
5JXG
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STRUCTURE OF THE UNLIGANDED FORM OF THE PROPROTEIN CONVERTASE FURIN.
Descriptor:Furin, CALCIUM ION, SODIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXH
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STRUCTURE THE PROPROTEIN CONVERTASE FURIN IN COMPLEX WITH META-GUANIDINOMETHYL-PHAC-RVR-AMBA AT 2.0 ANGSTROM RESOLUTION.
Descriptor:Furin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXI
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STRUCTURE OF THE UNLIGANDED FORM OF THE PROPROTEIN CONVERTASE FURIN IN PRESENCE OF EDTA.
Descriptor:Furin, CALCIUM ION, SODIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXJ
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STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN COMPLEXED TO META-GUANIDINOMETHYL-PHAC-RVR-AMBA IN PRESENCE OF EDTA
Descriptor:Furin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JMO
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X-RAY STRUCTURE OF FURIN IN COMPLEX WITH THE INHIBITORY ANTIBODY NB14
Descriptor:Furin, camelid VHH fragment, CMK-inhibitor, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2016-04-29
Release date:2016-12-07
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Sci Rep, 6, 2016
5JMR
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X-RAY STRUCTURE OF THE FURIN INHIBITORY ANTIBODY NB14
Descriptor:camelid VHH fragment, CHLORIDE ION
Authors:Dahms, S.O., Than, M.E.
Deposit date:2016-04-29
Release date:2016-12-07
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Sci Rep, 6, 2016
5MIM
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XRAY STRUCTURE OF HUMAN FURIN BOUND WITH THE 2,5-DIDEOXYSTREPTAMINE DERIVED SMALL MOLECULE INHIBITOR 1N
Descriptor:Furin, CALCIUM ION, SODIUM ION, ...
Authors:Dahms, S.O., Guan-Sheng, J., Than, M.E.
Deposit date:2016-11-28
Release date:2017-05-10
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
ACS Chem. Biol., 12, 2017
6EQV
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X-RAY STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN BOUND WITH THE COMPETITIVE INHIBITOR PHAC-CIT-VAL-ARG-AMBA
Descriptor:Furin, HY1-LLI-VAL-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2017-10-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
6EQW
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X-RAY STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN BOUND WITH THE COMPETITIVE INHIBITOR 4-AMINOMETHYL-PHENYLACETYL-ARG-VAL-ARG-AMBA
Descriptor:Furin, AMA-ARG-TBG-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2017-10-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
6EQX
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X-RAY STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN BOUND WITH THE COMPETITIVE INHIBITOR ARG-ARG-ARG-VAL-ARG-AMBA
Descriptor:Furin, Arg-Arg-Arg-Val-Arg-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2017-10-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
6FK0
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XRAY STRUCTURE OF DOMAIN-SWAPPED CYSTATIN E DIMER
Descriptor:Cystatin-M
Authors:Dall, E., Brandstetter, H.
Deposit date:2018-01-23
Release date:2018-07-11
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states.
J. Biol. Chem., 293, 2018
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