Author results

4BUL
  • Download 4bul
  • View 4bul
Molmil generated image of 4bul
NOVEL HYDROXYL TRICYCLICS (E.G. GSK966587) AS POTENT INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES
Descriptor:DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP *AP*CP*GP*GP*CP*T)-3', ...
Authors:Miles, T.J., Hennessy, A.J., Bax, B., Brooks, G., Brown, B.S., Brown, P., Cailleau, N., Chen, D., Dabbs, S., Davies, D.T., Esken, J.M., Giordano, I., Hoover, J.L., Huang, J., Jones, G.E., Sukmar, S.K.K., Spitzfaden, C., Markwell, R.E., Minthorn, E.A., Rittenhouse, S., Gwynn, M.N., Pearson, N.D.
Deposit date:2013-06-20
Release date:2013-08-07
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases.
Bioorg.Med.Chem.Lett., 23, 2013
5IWI
  • Download 5iwi
  • View 5iwi
Molmil generated image of 5iwi
1.98A STRUCTURE OF GSK945237 WITH S.AUREUS DNA GYRASE AND SINGLY NICKED DNA
Descriptor:DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), ...
Authors:Bax, B.D., Miles, T.J.
Deposit date:2016-03-22
Release date:2016-05-25
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg.Med.Chem.Lett., 26, 2016
5IWM
  • Download 5iwm
  • View 5iwm
Molmil generated image of 5iwm
2.5A STRUCTURE OF GSK945237 WITH S.AUREUS DNA GYRASE AND DNA.
Descriptor:DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*TP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), ...
Authors:Bax, B.D., Miles, T.J.
Deposit date:2016-03-22
Release date:2016-05-25
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg.Med.Chem.Lett., 26, 2016