2ETL
| Crystal Structure of Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) | Descriptor: | CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Authors: | Das, C, Hoang, Q.Q, Kreinbring, C.A, Luchansky, S.J, Meray, R.K, Ray, S.S, Lansbury, P.T, Ringe, D, Petsko, G.A. | Deposit date: | 2005-10-27 | Release date: | 2006-03-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1. Proc.Natl.Acad.Sci.USA, 103, 2006
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6MEP
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC3437 | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Tyrosine-protein kinase Mer, ... | Authors: | Da, C, Zhang, D, Stashko, M.A, Cheng, A, Hunter, D, Norris-Drouin, J, Graves, L, Machius, M, Miley, M.J, DeRyckere, D, Earp, H.S, Graham, D.K, Frye, S.V, Wang, X, Kireev, D. | Deposit date: | 2018-09-06 | Release date: | 2019-09-11 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.893 Å) | Cite: | Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology. J.Am.Chem.Soc., 141, 2019
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3RII
| Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Authors: | Das, C. | Deposit date: | 2011-04-13 | Release date: | 2011-11-09 | Last modified: | 2011-12-14 | Method: | X-RAY DIFFRACTION (2.0008 Å) | Cite: | Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme. Febs J., 278, 2011
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3RIS
| Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme | Descriptor: | GLYCEROL, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Authors: | Das, C, Permaul, M, Maiti, T.K. | Deposit date: | 2011-04-14 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.398 Å) | Cite: | Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme. Febs J., 278, 2011
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4IG7
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3IFW
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4OUF
| Crystal Structure of CBP bromodomain | Descriptor: | 1,2-ETHANEDIOL, CREB-binding protein, DI(HYDROXYETHYL)ETHER | Authors: | Roy, S, Das, C, Tyler, J.K, Kutateladze, T.G. | Deposit date: | 2014-02-17 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation. Proc.Natl.Acad.Sci.USA, 111, 2014
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8UX2
| Chromobacterium violaceum mono-ADP-ribosyltransferase CteC in complex with NAD+ | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, NAD(+)--protein-threonine ADP-ribosyltransferase, ... | Authors: | Zhang, Z, Rondon, H, Das, C. | Deposit date: | 2023-11-08 | Release date: | 2024-01-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Crystal structure of bacterial ubiquitin ADP-ribosyltransferase CteC reveals a substrate-recruiting insertion. J.Biol.Chem., 300, 2023
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4Q3Z
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4Q3W
| Crystal structure of C. violaceum phenylalanine hydroxylase D139E mutation | Descriptor: | 1,2-ETHANEDIOL, COBALT (II) ION, Phenylalanine-4-hydroxylase | Authors: | Ronau, J.A, Abu-Omar, M.M, Das, C. | Deposit date: | 2014-04-12 | Release date: | 2015-02-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. Biochemistry, 53, 2014
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4Q3X
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6WTG
| SdeA DUB Domain in complex with Ubiquitin | Descriptor: | Ubiquitin, Ubiquitinating/deubiquitinating enzyme SdeA | Authors: | Kenny, S, Sheedlo, M, Das, C. | Deposit date: | 2020-05-02 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA. Biochemistry, 60, 2021
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8EFW
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8EDE
| Crystal structure of covalent inhibitor 2-chloro-N'-(N-(4-chlorophenyl)-N-methylglycyl)acetohydrazide bound to Ubiquitin C-terminal Hydrolase-L1 | Descriptor: | 2-[(4-chlorophenyl)-methyl-amino]-~{N}'-ethanoyl-ethanehydrazide, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Authors: | Patel, R, Imhoff, R, Flaherty, D, Das, C. | Deposit date: | 2022-09-04 | Release date: | 2023-09-20 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1. J.Med.Chem., 67, 2024
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8EFX
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8FEK
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6OAM
| Crystal Structure of ChlaDUB2 DUB domain | Descriptor: | Deubiquitinase and deneddylase Dub2, Ubiquitin | Authors: | Hausman, J.M, Das, C. | Deposit date: | 2019-03-17 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | The Two Deubiquitinating Enzymes fromChlamydia trachomatisHave Distinct Ubiquitin Recognition Properties. Biochemistry, 59, 2020
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6OV1
| Structure of Staphylococcus aureus RNase P protein mutant with defective mRNA degradation activity | Descriptor: | Ribonuclease P protein component | Authors: | Ha, L, Colquhoun, J, Noinaj, N, Das, C, Dunman, P, Flaherty, D.P. | Deposit date: | 2019-05-06 | Release date: | 2020-12-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Genetic and biochemical characterization of Staphylococcus aureus RnpA To Be Published
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6P5H
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6P5B
| Crystal Structure of MavC in Complex with Ub-UbE2N | Descriptor: | MavC, Ubiquitin, Ubiquitin-conjugating enzyme E2 N | Authors: | Puvar, K, Iyer, S, Negron Teron, K.I, Das, C. | Deposit date: | 2019-05-30 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. Nat Commun, 11, 2020
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8DY8
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8DMU
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7LM3
| Crystal Structure of Thr316Ala mutant of JAMM domain of S. pombe | Descriptor: | AMSH-like protease sst2, PHOSPHATE ION, ZINC ION | Authors: | Shrestha, R, Das, C. | Deposit date: | 2021-02-05 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the Thr316Ala mutant of a yeast JAMM deubiquitinase: implication of active-site loop dynamics in catalysis. Acta Crystallogr.,Sect.F, 77, 2021
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6ULH
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6UMS
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