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2XE0
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BU of 2xe0 by Molmil
Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus
Descriptor: 24MER DNA, ACETATE ION, I-CREI V2V3 VARIANT, ...
Authors:Munoz, I.G, Prieto, J, Subramanian, S, Coloma, J, Redondo, P, Villate, M, Merino, N, Marenchino, M, D'Abramo, M, Gervasio, F.L, Grizot, S, Daboussi, F, Smith, J, Chion-Sotine, I, Paques, F, Duchateau, P, Alibes, A, Stricher, F, Serrano, L, Blanco, F.J, Montoya, G.
Deposit date:2010-05-10
Release date:2010-09-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus
Nucleic Acids Res., 39, 2011
5AKF
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BU of 5akf by Molmil
THE CRYSTAL STRUCTURE OF I-DMOI Q42AK120M IN COMPLEX WITH ITS TARGET DNA NICKED IN THE CODING STRAND A AND IN THE PRESENCE OF 2MM MN
Descriptor: 25MER, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', 5'-D(*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*GP)-3', ...
Authors:Molina, R, Marcaida, M.J, Redondo, P, Marenchino, M, D'Abramo, M, Montoya, G, Prieto, J.
Deposit date:2015-03-03
Release date:2015-06-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
J.Biol.Chem., 290, 2015
5AKM
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BU of 5akm by Molmil
THE CRYSTAL STRUCTURE OF I-DMOI G20S IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF 2MM MG
Descriptor: 5'-D(*CP*CP*GP*GP*CP*AP*AP*GP*GP*CP)-3', 5'-D(*CP*GP*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*AP*CP)-3', 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', ...
Authors:Molina, R, Marcaida, M.J, Redondo, P, Marenchino, M, D'Abramo, M, Montoya, G, Prieto, J.
Deposit date:2015-03-04
Release date:2015-06-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
J.Biol.Chem., 290, 2015
5AK9
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BU of 5ak9 by Molmil
THE CRYSTAL STRUCTURE OF I-DMOI Q42AK120M IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF 2MM MN
Descriptor: 25MER, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', 5'-D(*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*GP)-3, ...
Authors:Molina, R, Marcaida, M.J, Redondo, P, Marenchino, M, D'Abramo, M, Montoya, G, Prieto, J.
Deposit date:2015-03-02
Release date:2015-06-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
J.Biol.Chem., 290, 2015
5AKN
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BU of 5akn by Molmil
THE CRYSTAL STRUCTURE OF I-DMOI Q42AK120M IN COMPLEX WITH ITS TARGET DNA NICKED IN THE non-CODING STRAND B AND IN THE PRESENCE OF 2MM MN
Descriptor: 5'-D(*CP*CP*GP*GP*CP*AP*AP*GP*GP*CP)-3', 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP *CP*GP*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*AP*C)-3', 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP*GP*TP*AP*AP)-3', ...
Authors:Molina, R, Marcaida, M.J, Redondo, P, Marenchino, M, D'Abramo, M, Montoya, G, Prieto, J.
Deposit date:2015-03-04
Release date:2015-06-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
J.Biol.Chem., 290, 2015
5A0W
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BU of 5a0w by Molmil
THE CRYSTAL STRUCTURE OF I-DMOI E117A IN COMPLEX WITH ITS TARGET DNA AND IN THE PRESENCE OF 2MM MN
Descriptor: 25MER, ACETATE ION, CHLORIDE ION, ...
Authors:Molina, R, Besker, N, Prieto, J, Montoya, G, D'Abramo, M.
Deposit date:2015-04-23
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Dynamical Characterization of the I- Dmo Catalytic Activity
To be Published
4AAB
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BU of 4aab by Molmil
Crystal structure of the mutant D75N I-CreI in complex with its wild- type target (The four central bases, 2NN region, are composed by GTAC from 5' to 3')
Descriptor: 10MER DNA 5'-D(*GP*AP*CP*GP*TP*TP*TP*TP*GP*AP)-3', 14MER DNA 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP)-3', DNA ENDONUCLEASE I-CREI, ...
Authors:Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
4AAG
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BU of 4aag by Molmil
Crystal structure of the mutant D75N I-CreI in complex with its wild- type target in presence of Ca at the active site (The four central bases, 2NN region, are composed by GTAC from 5' to 3')
Descriptor: 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP *GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', CALCIUM ION, DNA ENDONUCLEASE I-CREI
Authors:Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
4AAF
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BU of 4aaf by Molmil
Crystal structure of the mutant D75N I-CreI in complex with an altered target (The four central bases, 2NN region, are composed by TGCA from 5' to 3')
Descriptor: 1,2-ETHANEDIOL, 24MER DNA, DNA ENDONUCLEASE I-CREI
Authors:Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
4AAE
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BU of 4aae by Molmil
Crystal structure of the mutant D75N I-CreI in complex with an altered target (The four central bases, 2NN region, are composed by AGCG from 5' to 3')
Descriptor: 24MER DNA, DNA ENDONUCLEASE I-CREI
Authors:Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
4AAD
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BU of 4aad by Molmil
Crystal structure of the mutant D75N I-CreI in complex with its wild- type target in absence of metal ions at the active site (The four central bases, 2NN region, are composed by GTAC from 5' to 3')
Descriptor: 24MER DNA, DNA ENDONUCLEASE I-CREI, GLYCEROL
Authors:Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G.
Deposit date:2011-12-01
Release date:2012-05-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage.
Nucleic Acids Res., 40, 2012
3MXA
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BU of 3mxa by Molmil
Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus
Descriptor: DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*GP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(P*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G, Prieto, J, Subramanian, S, Coloma, J, Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
3MX9
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BU of 3mx9 by Molmil
Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus
Descriptor: CALCIUM ION, DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*GP*AP*GP*GP*TP*AP*CP*CP*TP*GP*AP*GP*AP*AP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G, Prieto, J, Subramanian, S, Coloma, J, Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
7Q6X
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BU of 7q6x by Molmil
OleP mutant S240Y in complex with 6DEB
Descriptor: 6-DEOXYERYTHRONOLIDE B, Cytochrome P-450, FORMIC ACID, ...
Authors:Savino, C, Montemiglio, L.C, Vallone, B, Exertier, C, Freda, I, Gugole, E.
Deposit date:2021-11-09
Release date:2022-01-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics.
Biomolecules, 12, 2021
7Q89
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BU of 7q89 by Molmil
OleP mutant G92W in complex with 6DEB
Descriptor: 6-DEOXYERYTHRONOLIDE B, Cytochrome P-450, FORMIC ACID, ...
Authors:Savino, C, Montemiglio, L.C, Vallone, B, Exertier, C, Freda, I, Gugole, E.
Deposit date:2021-11-10
Release date:2022-01-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics.
Biomolecules, 12, 2021
7Q6R
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BU of 7q6r by Molmil
OleP mutant E89Y in complex with 6DEB
Descriptor: 6-DEOXYERYTHRONOLIDE B, Cytochrome P-450, FORMIC ACID, ...
Authors:Savino, C, Montemiglio, L.C, Vallone, B, Exertier, C, Freda, I, Gugole, E.
Deposit date:2021-11-09
Release date:2022-01-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics.
Biomolecules, 12, 2021
3MXB
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BU of 3mxb by Molmil
Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus
Descriptor: CALCIUM ION, DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*GP*AP*GP*GP*TP*AP*CP*CP*TP*GP*AP*GP*AP*AP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G, Prieto, J, Subramanian, S, Coloma, J, Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
5O6I
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BU of 5o6i by Molmil
Structures and dynamics of mesophilic variants from the homing endonuclease I-DmoI
Descriptor: CHLORIDE ION, DNA (25-MER), Homing endonuclease I-DmoI, ...
Authors:Molina, R, Marcaida, M.J.
Deposit date:2017-06-06
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI.
J. Comput. Aided Mol. Des., 31, 2017
5O6G
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BU of 5o6g by Molmil
Structures and dynamics of mesophilic variants from the homing endonuclease I-DmoI
Descriptor: CHLORIDE ION, DNA (25-MER), Homing endonuclease I-DmoI, ...
Authors:Molina, R, Marcaida, M.J.
Deposit date:2017-06-06
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI.
J. Comput. Aided Mol. Des., 31, 2017
6FB6
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BU of 6fb6 by Molmil
Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with an altered version of its target DNA (Haemoglobin beta subunit gene) at 5NNN region in the presence of Manganese
Descriptor: DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), DNA (5'-D(P*AP*CP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ...
Authors:Molina, R, Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB5
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BU of 6fb5 by Molmil
Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with an altered version of its target DNA (Haemoglobin beta subunit gene) at 5NNN region in the presence of Magnesium
Descriptor: ACETATE ION, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*GP*AP*CP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ...
Authors:Molina, R, Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB0
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BU of 6fb0 by Molmil
Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with its target DNA (Haemoglobin beta subunit gene) in the presence of Calcium
Descriptor: ACETATE ION, CALCIUM ION, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), ...
Authors:Molina, R, Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB2
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BU of 6fb2 by Molmil
Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with its target DNA (Haemoglobin beta subunit gene) in the presence of Manganese
Descriptor: DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), DNA (5'-D(P*AP*GP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ...
Authors:Molina, R, Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB1
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BU of 6fb1 by Molmil
Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with its target DNA (Haemoglobin beta subunit gene) in the presence of Magnesium
Descriptor: DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), DNA (5'-D(P*AP*GP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ...
Authors:Molina, R, Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.024 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB8
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BU of 6fb8 by Molmil
Crystal Structure of the I-CreI Homing Endonuclease D75N variant in complex with an altered version of its target DNA at 5NNN region in the presence of Magnesium
Descriptor: DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP*GP*CP*AP*GP*TP*TP*TP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*TP*GP*CP*GP*TP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), DNA endonuclease I-CreI, ...
Authors:Molina, R, Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018

 

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