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2JM6
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BU of 2jm6 by Molmil
Solution structure of MCL-1 complexed with NOXAB
Descriptor: Myeloid cell leukemia-1 protein Mcl-1 homolog, Noxa
Authors:Czabotar, P.E, Lee, E.F, van Delft, M.F, Day, C.L, Smith, B.J, Huang, D.C.S, Fairlie, W.D, Hinds, M.G, Colman, P.M.
Deposit date:2006-10-17
Release date:2007-03-20
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
2NLA
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BU of 2nla by Molmil
Crystal structure of the Mcl-1:mNoxaB BH3 complex
Descriptor: FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Phorbol-12-myristate-13-acetate-induced protein 1
Authors:Czabotar, P.E, Colman, P.M.
Deposit date:2006-10-19
Release date:2007-03-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
2NL9
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BU of 2nl9 by Molmil
Crystal structure of the Mcl-1:Bim BH3 complex
Descriptor: Bcl-2-like protein 11, CHLORIDE ION, FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, ...
Authors:Czabotar, P.E, Colman, P.M.
Deposit date:2006-10-19
Release date:2007-03-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
3PL7
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BU of 3pl7 by Molmil
Crystal structure of Bcl-xL in complex with the BaxBH3 domain
Descriptor: Apoptosis regulator BAX, Bcl-2-like protein 1
Authors:Czabotar, P.E, Colman, P.M.
Deposit date:2010-11-14
Release date:2010-12-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.613 Å)
Cite:Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
3PK1
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BU of 3pk1 by Molmil
Crystal structure of Mcl-1 in complex with the BaxBH3 domain
Descriptor: Apoptosis regulator BAX, CADMIUM ION, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Czabotar, P.E, Colman, P.M.
Deposit date:2010-11-11
Release date:2010-12-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
4BDU
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BU of 4bdu by Molmil
Bax BH3-in-Groove dimer (GFP)
Descriptor: GREEN FLUORESCENT PROTEIN, APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E, Colman, P.M.
Deposit date:2012-10-08
Release date:2013-02-13
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.998 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD7
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BU of 4bd7 by Molmil
Bax domain swapped dimer induced by octylmaltoside
Descriptor: APOPTOSIS REGULATOR BAX, CHLORIDE ION, PRASEODYMIUM ION
Authors:Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD2
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BU of 4bd2 by Molmil
Bax domain swapped dimer in complex with BidBH3
Descriptor: APOPTOSIS REGULATOR BAX, BH3-INTERACTING DOMAIN DEATH AGONIST
Authors:Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M.
Deposit date:2012-10-04
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD8
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BU of 4bd8 by Molmil
Bax domain swapped dimer induced by BimBH3 with CHAPS
Descriptor: 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BAX, PRASEODYMIUM ION
Authors:Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD6
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BU of 4bd6 by Molmil
Bax domain swapped dimer in complex with BaxBH3
Descriptor: APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4MWI
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BU of 4mwi by Molmil
Crystal structure of the human MLKL pseudokinase domain
Descriptor: (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, GLYCEROL, Mixed lineage kinase domain-like protein
Authors:Czabotar, P.E, Murphy, J.M.
Deposit date:2013-09-25
Release date:2013-12-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.
Biochem.J., 457, 2014
4TUH
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BU of 4tuh by Molmil
Bcl-xL in complex with inhibitor (Compound 10)
Descriptor: 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-{3-[4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy]propyl}-1,3-thiazole-4-carboxylic acid, ACETATE ION, ...
Authors:Czabotar, P.E, Lessense, G, Smith, B.J, Colman, P.M.
Deposit date:2014-06-24
Release date:2014-10-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
Acs Med.Chem.Lett., 5, 2014
6C4G
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BU of 6c4g by Molmil
Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-601)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Czabotar, P.E, Hodder, A.N, Nguyen, W, Sleebs, B.E, Boddey, J.A, Cowman, A.F.
Deposit date:2018-01-11
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2position of PEXEL peptidomimetics.
Eur J Med Chem, 154, 2018
3VPP
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BU of 3vpp by Molmil
Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain
Descriptor: C-type lectin domain family 9 member A, CALCIUM ION
Authors:Czabotar, P.E, Zhang, J.G, Policheni, A.N, Shortman, K, Lahoud, M.H, Colman, P.M.
Deposit date:2012-03-07
Release date:2012-04-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.642 Å)
Cite:The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity, 36, 2012
3VUV
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BU of 3vuv by Molmil
Crystal structure of the merozoite surface protein MSPDBL2 from P. falciparum bound to zinc
Descriptor: Erythrocyte membrane protein, putative, ZINC ION
Authors:Czabotar, P.E, Hodder, A.N, Clarke, O.B, Lin, C.S, Smith, B.J, Cowman, A.F.
Deposit date:2012-07-09
Release date:2012-08-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.114 Å)
Cite:Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
J.Biol.Chem., 287, 2012
3VUU
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BU of 3vuu by Molmil
Crystal structure of the merozoite surface protein MSPDBL2 from P. falciparum
Descriptor: CHLORIDE ION, Erythrocyte membrane protein, putative
Authors:Czabotar, P.E, Hodder, A.N, Clarke, O.B, Lin, C.S, Smith, B.J, Cowman, A.F.
Deposit date:2012-07-09
Release date:2012-08-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
J.Biol.Chem., 287, 2012
3IO9
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BU of 3io9 by Molmil
BimL12Y in complex with Mcl-1
Descriptor: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Czabotar, P.E, Lee, E.F, Yang, H, Sleebs, B.E, Lessene, G, Colman, P.M, Smith, B.J, Fairlie, W.D.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
3QKD
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BU of 3qkd by Molmil
Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor
Descriptor: (R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4-yl)-4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide, Bcl-2-like protein 1, CHLORIDE ION, ...
Authors:Czabotar, P.E, Smith, B.J.
Deposit date:2011-01-31
Release date:2011-04-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
J.Med.Chem., 54, 2011
2YXJ
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BU of 2yxj by Molmil
Crystal structure of Bcl-xL in complex with ABT-737
Descriptor: 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, Apoptosis regulator Bcl-X, CHLORIDE ION, ...
Authors:Czabotar, P.E, Lee, E.F, Smith, B.J, Deshayes, K, Zobel, K, Fairlie, W.D, Colman, P.M.
Deposit date:2007-04-26
Release date:2007-05-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family
Cell Death Differ., 14, 2007
4ZL4
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BU of 4zl4 by Molmil
Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)
Descriptor: (2R)-1-[(2R)-2-(2-methoxyethoxy)propoxy]propan-2-amine, 1,2-ETHANEDIOL, Aspartic protease PM5, ...
Authors:Czabotar, P.E, Hodder, A.N, Smith, B.J, Sleebs, B.E, Gazdic, M, Boddey, J.A, Cowman, A.F.
Deposit date:2015-05-01
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Nat.Struct.Mol.Biol., 22, 2015
4ZII
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BU of 4zii by Molmil
Crystal Structure of core/latch dimer of BaxI66A in complex with BidBH3
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator BAX, BH3-interacting domain death agonist
Authors:Czabotar, P.E, Robin, A.Y, Krishna Kumar, K, Westphal, D, Wardak, A.Z, Thompson, G.V, Dewson, G, Colman, P.M.
Deposit date:2015-04-28
Release date:2015-07-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.191 Å)
Cite:Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction.
Cell Death Dis, 6, 2015
3ZLR
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BU of 3zlr by Molmil
Crystal structure of BCL-XL in complex with inhibitor (WEHI-539)
Descriptor: 1,2-ETHANEDIOL, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1, ...
Authors:Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.026 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLO
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BU of 3zlo by Molmil
Crystal structure of BCL-XL in complex with inhibitor (Compound 6)
Descriptor: 2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-5-(4-phenylbutyl)-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1
Authors:Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZK6
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BU of 3zk6 by Molmil
Crystal structure of Bcl-xL in complex with inhibitor (Compound 2).
Descriptor: BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide
Authors:Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
Deposit date:2013-01-22
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLN
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BU of 3zln by Molmil
Crystal structure of BCL-XL in complex with inhibitor (Compound 3)
Descriptor: 1,2-ETHANEDIOL, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, BCL-2-LIKE PROTEIN 1, ...
Authors:Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.288 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013

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