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1F63
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CRYSTAL STRUCTURE OF DEOXY SPERM WHALE MYOGLOBIN MUTANT Y(B10)Q(E7)R(E10)
Descriptor:MYOGLOBIN, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE
Authors:Brunori, M., Cutruzzola, F., Savino, C., Travaglini-Allocatelli, C., Vallone, B., Gibson, Q.H.
Deposit date:2000-06-20
Release date:2000-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural dynamics of ligand diffusion in the protein matrix: A study on a new myoglobin mutant Y(B10) Q(E7) R(E10).
Biophys.J., 76, 1999
1F65
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CRYSTAL STRUCTURE OF OXY SPERM WHALE MYOGLOBIN MUTANT Y(B10)Q(E7)R(E10)
Descriptor:MYOGLOBIN, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Brunori, M., Cutruzzola, F., Savino, C., Travaglini-Allocatelli, C., Vallone, B., Gibson, Q.H.
Deposit date:2000-06-20
Release date:2000-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural dynamics of ligand diffusion in the protein matrix: A study on a new myoglobin mutant Y(B10) Q(E7) R(E10).
Biophys.J., 76, 1999
1DXC
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CO COMPLEX OF MYOGLOBIN MB-YQR AT 100K
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Brunori, M., Vallone, B., Cutruzzola, F., Travaglini-Allocatelli, C., Berendzen, J., Chu, K., Sweet, R.M., Schlichting, I.
Deposit date:2000-01-03
Release date:2000-04-02
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Role of Cavities in Protein Dynamics: Crystal Structure of a Novel Photolytic Intermediate of Myoglobin
Proc.Natl.Acad.Sci.USA, 97, 2000
1DXD
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PHOTOLYZED CO COMPLEX OF MYOGLOBIN MB-YQR AT 20K
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Brunori, M., Vallone, B., Cutruzzola, F., Travaglini-Allocatelli, C., Berendzen, J., Chu, K., Sweet, R.M., Schlichting, I.
Deposit date:2000-01-03
Release date:2000-03-27
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Role of Cavities in Protein Dynamics: Crystal Structure of a Photolytic Intermediate of a Mutant Myoglobin.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FCS
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CRYSTAL STRUCTURE OF A DISTAL SITE DOUBLE MUTANT OF SPERM WHALE MYOGLOBIN AT 1.6 ANGSTROMS RESOLUTION
Descriptor:MYOGLOBIN, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE
Authors:Rizzi, M., Bolognesi, M., Coda, A., Cutruzzola, F., Travaglini Allocatelli, C., Brancaccio, A., Brunori, M.
Deposit date:1993-04-20
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of a distal site double mutant of sperm whale myoglobin at 1.6 A resolution.
FEBS Lett., 320, 1993
1HZU
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DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA
Descriptor:NITRITE REDUCTASE, HEME C, HEME D
Authors:Brown, K., Cutruzzola, F., Brunori, M., Tegoni, M., Cambillau, C.
Deposit date:2001-01-26
Release date:2001-09-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa.
J.Mol.Biol., 312, 2001
5M3C
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STRUCTURE OF THE HYBRID DOMAIN (GGDEF-EAL) OF PA0575 FROM PSEUDOMONAS AERUGINOSA PAO1 AT 2.8 ANG. WITH GTP AND CA2+ BOUND TO THE ACTIVE SITE OF THE GGDEF DOMAIN
Descriptor:Diguanylate cyclase, CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Giardina, G., Brunotti, P., Cutruzzola, F., Rinaldo, S.
Deposit date:2016-10-14
Release date:2017-12-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.
FEBS J., 285, 2018
1DM1
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2.0 A CRYSTAL STRUCTURE OF THE DOUBLE MUTANT H(E7)V, T(E10)R OF MYOGLOBIN FROM APLYSIA LIMACINA
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Federici, L., Savino, C., Musto, R., Travaglini-Allocatelli, C., Cutruzzola, F., Brunori, M.
Deposit date:1999-12-13
Release date:2000-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Engineering His(E7) affects the control of heme reactivity in Aplysia limacina myoglobin.
Biochem.Biophys.Res.Commun., 269, 2000
1YNR
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CRYSTAL STRUCTURE OF THE CYTOCHROME C-552 FROM HYDROGENOBACTER THERMOPHILUS AT 2.0 RESOLUTION
Descriptor:Cytochrome c-552, SULFATE ION, HEME C, ...
Authors:Travaglini-Allocatelli, C., Gianni, S., Dubey, V.K., Borgia, A., Di Matteo, A., Bonivento, D., Cutruzzola, F., Bren, K.L., Brunori, M.
Deposit date:2005-01-25
Release date:2005-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Obligatory Intermediate in the Folding Pathway of Cytochrome c552 from Hydrogenobacter thermophilus
J.Biol.Chem., 280, 2005
3RBF
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CRYSTAL STRUCTURE OF HUMAN AROMATIC L-AMINO ACID DECARBOXYLASE (AADC) IN THE APO FORM
Descriptor:Aromatic-L-amino-acid decarboxylase, PYRIDOXAL-5'-PHOSPHATE, CHLORIDE ION
Authors:Giardina, G., Montioli, R., Gianni, S., Cellini, B., Paiardini, A., Borri Voltattorni, C., Cutruzzola, F.
Deposit date:2011-03-29
Release date:2011-10-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RBL
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CRYSTAL STRUCTURE OF HUMAN AROMATIC L-AMINO ACID DECARBOXYLASE (AADC) IN THE APO FORM
Descriptor:aromatic L-amino acid decarboxylase, CHLORIDE ION
Authors:Giardina, G., Montioli, R., Gianni, S., Cellini, B., Paiardini, A., Borri Voltattorni, C., Cutruzzola, F.
Deposit date:2011-03-29
Release date:2011-10-19
Last modified:2012-01-04
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RCH
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CRYSTAL STRUCTURE OF HUMAN AROMATIC L-AMINO ACID DECARBOXYLASE (AADC) IN THE OPEN CONFORMATION WITH LLP AND PLP BOUND TO CHAIN-A AND CHAIN-B RESPECTIVELY
Descriptor:aromatic L-amino acid decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Giardina, G., Montioli, R., Gianni, S., Cellini, B., Paiardini, A., Borri Voltattorni, C., Cutruzzola, F.
Deposit date:2011-03-31
Release date:2011-10-19
Last modified:2012-01-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
4IOB
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CRYSTAL STRUCTURE OF THE GGDEF DOMAIN OF PA1120 (YFIN OR TPBB) FROM PSEUDOMONAS AERUGINOSA AT 2.7 ANG.
Descriptor:Diguanylate cyclase TpbB, TERTIARY-BUTYL ALCOHOL, GLYCEROL
Authors:Giardina, G., Cutruzzola, F.
Deposit date:2013-01-07
Release date:2013-12-04
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Investigating the Allosteric Regulation of YfiN from Pseudomonas aeruginosa: Clues from the Structure of the Catalytic Domain.
Plos One, 8, 2013
4PVF
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CRYSTAL STRUCTURE OF HOMO SAPIENS HOLO SERINE HYDROXYMETHYLTRANSFERASE 2 (MITOCHONDRIAL) (SHMT2), ISOFORM 3, TRANSCRIPT VARIANT 5, 483 AA, AT 2.6 ANG. RESOLUTION
Descriptor:Serine hydroxymethyltransferase, mitochondrial, GLYCEROL, ...
Authors:Giardina, G., Brunotti, P., Fiascarelli, A., Contestabile, R., Cutruzzola, F.
Deposit date:2014-03-17
Release date:2015-01-28
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Febs J., 282, 2015
5F9S
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CRYSTAL STRUCTURE OF HUMAN ALANINE:GLYOXYLATE AMINOTRANSFERASE MAJOR ALLELE (AGT-MA) AT 1.7 ANGSTROM; INTERNAL ALDIMINE WITH PLP IN THE ACTIVE SITE
Descriptor:Serine--pyruvate aminotransferase, PYRIDOXAL-5'-PHOSPHATE
Authors:Giardina, G., Cutruzzola, F., Borri Voltattorni, C., Cellini, B., Montioli, R.
Deposit date:2015-12-10
Release date:2016-12-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
5HHY
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STRUCTURE OF HUMAN ALANINE:GLYOXYLATE AMINOTRANSFERASE MAJOR ALLELE (AGT-MA) SHOWING X-RAY INDUCED REDUCTION OF PLP INTERNAL ALDIMINE TO 4'-DEOXY-PIRIDOXINE-PHOSPHATE (PLR)
Descriptor:Serine--pyruvate aminotransferase, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE
Authors:Giardina, G., Cutruzzola, F., Borri Voltattorni, C., Cellini, B., Montioli, R.
Deposit date:2016-01-11
Release date:2017-01-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
5LUC
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CRYSTAL STRUCTURE OF THE D183N VARIANT OF HUMAN ALANINE:GLYOXYLATE AMINOTRANSFERASE MAJOR ALLELE (AGT-MA) AT 1.8 ANGSTROM; INTERNAL ALDIMINE WITH PLP IN THE ACTIVE SITE
Descriptor:Serine--pyruvate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Giardina, G., Cutruzzola, F., Cellini, B., Borri Voltattorni, C., Montioli, R.
Deposit date:2016-09-08
Release date:2017-09-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
5OFY
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CRYSTAL STRUCTURE OF THE D183N VARIANT OF HUMAN ALANINE:GLYOXYLATE AMINOTRANSFERASE MAJOR ALLELE (AGT-MA) AT PH 9.0. 2.8 ANG; INTERNAL ALDIMINE WITH PLP IN THE ACTIVE SITE
Descriptor:Serine--pyruvate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 1,4-DIETHYLENE DIOXIDE
Authors:Giardina, G., Cutruzzola, F., Borri Voltattorni, C., Cellini, B., Montioli, R.
Deposit date:2017-07-11
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
5OG0
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CRYSTAL STRUCTURE OF HUMAN ALANINE:GLYOXYLATE AMINOTRANSFERASE MAJOR ALLELE (AGT-MA) AT 2.5 ANGSTROM; INTERNAL ALDIMINE WITH PLP IN THE ACTIVE SITE
Descriptor:Serine--pyruvate aminotransferase, PYRIDOXAL-5'-PHOSPHATE
Authors:Giardina, G., Cutruzzola, F., Borri Voltattorni, C., Cellini, B., Montioli, R.
Deposit date:2017-07-11
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
6FL5
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STRUCTURE OF HUMAN SHMT1-H135N-R137A-E168N MUTANT AT 3.6 ANG. RESOLUTION
Descriptor:Serine hydroxymethyltransferase, cytosolic, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Giardina, G., Cutruzzola, F., Lucchi, R.
Deposit date:2018-01-25
Release date:2018-10-10
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
FEBS J., 285, 2018
6HX7
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CRYSTAL STRUCTURE OF HUMAN R180T VARIANT OF ORNITHINE AMINOTRANSFERASE AT 1.8 ANGSTROM
Descriptor:Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE
Authors:Giardina, G., Montioli, R., Cellini, B., Cutruzzola, F., Borri Voltattorni, C.
Deposit date:2018-10-16
Release date:2019-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:R180T variant of delta-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.
Febs J., 2019
1HZV
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DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA
Descriptor:NITRITE REDUCTASE, HEME C, HEME D, ...
Authors:Brown, K., Tegoni, M., Cambillau, C.
Deposit date:2001-01-26
Release date:2001-09-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa.
J.Mol.Biol., 312, 2001
4R8Z
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CRYSTAL STRUCTURE OF PA4781 HD-GYP DOMAIN FROM PSEUDOMONAS AERUGINOSA AT 2.2A RESOLUTION SHOWING A BI-METALLIC NI ION CENTER
Descriptor:Cyclic di-GMP phosphodiesterase, NICKEL (II) ION, CHLORIDE ION
Authors:Giardina, G., Cutruzzolaa, F., Rinaldo, S., Stelitano, V.
Deposit date:2014-09-03
Release date:2015-03-04
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site.
J.Bacteriol., 197, 2015
1BL9
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CONFORMATIONAL CHANGES OCCURRING UPON REDUCTION IN NITRITE REDUCTASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:NITRITE REDUCTASE, HEME C, HEME D, ...
Authors:Nurizzo, D., Cambillau, C., Tegoni, M.
Deposit date:1998-07-20
Release date:1999-04-27
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Conformational changes occurring upon reduction and NO binding in nitrite reductase from Pseudomonas aeruginosa.
Biochemistry, 37, 1998
1GJQ
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PSEUDOMONAS AERUGINOSA CD1 NITRITE REDUCTASE REDUCED CYANIDE COMPLEX
Descriptor:NITRITE REDUCTASE, HEME C, HEME D, ...
Authors:Nurizzo, D., Brown, K., Tegoni, M., Cambillau, C.
Deposit date:2001-08-01
Release date:2002-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cyanide Binding to Cd(1) Nitrite Reductase from Pseudomonas Aeruginosa: Role of the Active-Site His369 in Ligand Stabilization.
Biochem.Biophys.Res.Commun., 291, 2002
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