Author results

1H3N
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE
Descriptor:LEUCYL-TRNA SYNTHETASE, LEUCINE, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE, ...
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2002-09-11
Release date:2002-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2A Structure of Leucyl-tRNA Synthetase and its Complex with a Leucyl-Adenylate Analogue
Embo J., 19, 2000
1SES
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CRYSTAL STRUCTURES AT 2.5 ANGSTROMS RESOLUTION OF SERYL-TRNA SYNTHETASE COMPLEXED WITH TWO DIFFERENT ANALOGUES OF SERYL-ADENYLATE
Descriptor:SERYL-tRNA SYNTHETASE, SERYL-HYDROXAMATE-ADENOSINE MONOPHOSPHATE, ADENOSINE MONOPHOSPHATE
Authors:Cusack, S., Belrhali, H.
Deposit date:1994-02-21
Release date:1994-07-31
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate.
Science, 263, 1994
1SET
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CRYSTAL STRUCTURES AT 2.5 ANGSTROMS RESOLUTION OF SERYL-TRNA SYNTHETASE COMPLEXED WITH TWO DIFFERENT ANALOGUES OF SERYL-ADENYLATE
Descriptor:SERYL-tRNA SYNTHETASE, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
Authors:Cusack, S., Belrhali, H.
Deposit date:1994-02-21
Release date:1994-07-31
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate.
Science, 263, 1994
1OBC
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
Descriptor:LEUCYL-TRNA SYNTHETASE, LEUCINE, ZINC ION, ...
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2003-01-30
Release date:2003-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1OBH
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A PRE-TRANSFER EDITING SUBSTRATE ANALOGUE IN BOTH SYNTHETIC ACTIVE SITE AND EDITING SITE
Descriptor:LEUCYL-TRNA SYNTHETASE, SULFATE ION, MERCURY (II) ION, ...
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2003-01-31
Release date:2003-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1H4V
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HISTIDYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS (LIGAND FREE)
Descriptor:HISTIDYL-TRNA SYNTHETASE, SULFATE ION
Authors:Cusack, S., Yaremchuk, A., Tukalo, M.
Deposit date:2001-05-14
Release date:2001-06-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
6EUW
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CRYSTAL STRUCTURE OF THE CAP-BINDING DOMAIN OF THE PB2 SUBUNIT OF INFLUENZA A/H5N1 POLYMERASE BOUND TO AN AZAINDAZOLE INHIBITOR
Descriptor:Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL
Authors:Cusack, S., Gaudon, S.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUX
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STRUCTURE OF THE MIDLINK AND CAP-BINDING DOMAINS OF INFLUENZA B POLYMERASE PB2 SUBUNIT WITH A BOUND AZAINDAZOLE CAP-BINDING INHIBITOR
Descriptor:Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid
Authors:Cusack, S., Gaudon, S.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUY
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STRUCTURE OF THE MIDLINK AND CAP-BINDING DOMAINS OF INFLUENZA A POLYMERASE PB2 SUBUNIT WITH A BOUND AZAINDAZOLE CAP-BINDING INHIBITOR
Descriptor:Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, SULFATE ION
Authors:Cusack, S., Gaudon, S.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
2BTE
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THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION AND A POST- TRANSFER EDITING SUBSTRATE ANALOGUE
Descriptor:AMINOACYL-TRNA SYNTHETASE, TRNALEU TRANSCRIPT WITH ANTICODON CAG, ZINC ION, ...
Authors:Cusack, S., Tukalo, M., Yaremchuk, A., Fukunaga, R., Yokoyama, S.
Deposit date:2005-05-31
Release date:2005-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer- Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
2BYT
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THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE, TRNALEU TRANSCRIPT WITH ANTICODON CAG, LEUCINE, ...
Authors:Cusack, S., Tukalo, M., Yaremchuk, A., Fukunaga, R., Yokoyama, S.
Deposit date:2005-08-04
Release date:2005-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
3ZJT
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TERNARY COMPLEX OF E.COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU)574 AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJV
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3213 IN THE EDITING CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE, TRNALEU5 UAA ISOACCEPTOR
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
4WSB
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BAT INFLUENZA A POLYMERASE WITH BOUND VRNA PROMOTER
Descriptor:Polymerase PA, RNA-directed RNA polymerase catalytic subunit, Polymerase PB2, ...
Authors:Cusack, S., Pflug, A., Guilligay, D., Reich, S.
Deposit date:2014-10-26
Release date:2014-11-19
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
Nature, 516, 2014
5MSG
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INFLUENZA B POLYMERASE BOUND TO VRNA PROMOTER AND CAPPED RNA PRIMER
Descriptor:Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ...
Authors:Cusack, S., Guilligay, D.
Deposit date:2017-01-04
Release date:2017-02-08
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase.
Nucleic Acids Res., 45, 2017
6EUV
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STRUCTURE OF THE MIDLINK AND CAP-BINDING DOMAINS OF INFLUENZA A POLYMERASE PB2 SUBUNIT WITH A BOUND AZAINDOLE CAP-BINDING INHIBITOR (VX-787)
Descriptor:Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION
Authors:Cusack, S., Lethier, M.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6FS6
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INFLUENZA A/CALIFORNIA/04/2009 (PH1N1) ENDONUCLEASE WITH BOUND INHIBITOR, BALOXAVIR ACID (BXA)
Descriptor:Polymerase acidic protein,Polymerase acidic protein, MANGANESE (II) ION, Baloxavir acid
Authors:Cusack, S., Speranzini, V.
Deposit date:2018-02-19
Release date:2018-07-11
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS7
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INFLUENZA A/CALIFORNIA/04/2009 (PH1N1) ENDONUCLEASE WITH I38T MUTATION WITH BOUND INHIBITOR, BALOXAVIR ACID (BXA)
Descriptor:Polymerase acidic protein,Polymerase acidic protein, MANGANESE (II) ION, Baloxavir acid
Authors:Cusack, S., Speranzini, V.
Deposit date:2018-02-19
Release date:2018-07-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS8
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INFLUENZA B/MEMPHIS/13/03 ENDONUCLEASE WITH BOUND INHIBITOR, BALOXAVIR ACID (BXA)
Descriptor:Polymerase acidic protein, Baloxavir acid, MANGANESE (II) ION
Authors:Cusack, S., Speranzini, V.
Deposit date:2018-02-19
Release date:2018-07-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS9
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INFLUENZA B/MEMPHIS/13/03 ENDONUCLEASE WITH I38T MUTATION WITH BOUND INHIBITOR, BALOXAVIR ACID (BXA)
Descriptor:Polymerase acidic protein, MANGANESE (II) ION, Baloxavir acid, ...
Authors:Cusack, S., Speranzini, V.
Deposit date:2018-02-19
Release date:2018-07-11
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FSB
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INFLUENZA B/MEMPHIS/13/03 ENDONUCLEASE WITH I38T MUTATION
Descriptor:Polymerase acidic protein, MANGANESE (II) ION, MAGNESIUM ION
Authors:Cusack, S., Speranzini, V.
Deposit date:2018-02-19
Release date:2018-07-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
1ADJ
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HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDINE
Descriptor:HISTIDYL-TRNA SYNTHETASE, SULFATE ION, HISTIDINE
Authors:Cusack, S., Aberg, A.
Deposit date:1997-02-18
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Biochemistry, 36, 1997
1ADY
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HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDYL-ADENYLATE
Descriptor:HISTIDYL-TRNA SYNTHETASE, SULFATE ION, HISTIDYL-ADENOSINE MONOPHOSPHATE
Authors:Cusack, S., Aberg, A.
Deposit date:1997-02-19
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Biochemistry, 36, 1997
1H3E
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TYROSYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH WILD-TYPE TRNATYR(GUA) AND WITH ATP AND TYROSINOL
Descriptor:TYROSYL-TRNA SYNTHETASE, WILD-TYPE TRNATYR(GUA), ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Cusack, S., Yaremchuk, A., Kriklivyi, I., Tukalo, M.
Deposit date:2002-08-28
Release date:2002-10-27
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Class I Tyrosyl-tRNA Synthetase Has a Class II Mode or tRNA Recognition
Embo J., 21, 2002