3HPL
| KcsA E71H-F103A mutant in the closed state | Descriptor: | Antibody Fab heavy chain, Antibody fab light chain, POTASSIUM ION, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2009-06-04 | Release date: | 2010-06-23 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature, 466, 2010
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5VKH
| Closed conformation of KcsA Y82A-F103A mutant | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... | Authors: | Cuello, L.G, Perozo, E, Cortes, D.M. | Deposit date: | 2017-04-21 | Release date: | 2017-12-06 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The gating cycle of a K+ channel at atomic resolution. Elife, 6, 2017
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5VK6
| Open conformation of KcsA non-inactivating E71A mutant | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... | Authors: | Cuello, L.G, Perozo, E. | Deposit date: | 2017-04-21 | Release date: | 2017-12-06 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The gating cycle of a K+ channel at atomic resolution. Elife, 6, 2017
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5VKE
| Open conformation of KcsA deep-inactivated | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... | Authors: | Cuello, L.G, Perozo, E, Cortes, D.M. | Deposit date: | 2017-04-21 | Release date: | 2017-12-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | The gating cycle of a K+ channel at atomic resolution. Elife, 6, 2017
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3FB5
| KcsA potassium channel in the partially open state with 14.5 A opening at T112 | Descriptor: | POTASSIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-18 | Release date: | 2010-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | KcsA potassium channel in the partially open state with 14.5 A opening at T112 TO BE PUBLISHED
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3FB6
| KcsA Potassium channel in the partially open state with 16 A opening at T112 | Descriptor: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-18 | Release date: | 2010-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | KcsA Potassium channel in the partially open state with 16 A opening at T112 TO BE PUBLISHED
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3FB7
| Open KcsA potassium channel in the presence of Rb+ ion | Descriptor: | RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Pan, A.C, Gagnon, D.H, Cordero-Morales, J.F, Chakrapani, S, Roux, B, Perozo, E. | Deposit date: | 2008-11-18 | Release date: | 2010-07-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Open KcsA potassium channel in the presence of Rb+ ion TO BE PUBLISHED
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3F7Y
| KcsA Potassium channel in the partially open state with 17 A opening at T112 | Descriptor: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-10 | Release date: | 2010-05-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | KcsA Potassium channel in the partially open state with 17 A opening at T112 TO BE PUBLISHED
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3F5W
| KcsA Potassium channel in the open-inactivated state with 32 A opening at T112 | Descriptor: | Antibody heavy chain, Antibody light chain, POTASSIUM ION, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-04 | Release date: | 2010-05-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | KcsA Potassium channel in the open-inactivated state with 32 A opening at T112 TO BE PUBLISHED
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3FB8
| KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion | Descriptor: | RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-18 | Release date: | 2010-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | KcsA Potassium channel in the open-conductive state
with 20 A opening at T112 in the presence of Rb+ ion TO BE PUBLISHED
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3F7V
| KcsA Potassium channel in the open-inactivated state with 23 A opening at T112 | Descriptor: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment Heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-10 | Release date: | 2010-05-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | KcsA Potassium channel in the open-inactivated state with 23 A opening at T112 TO BE PUBLISHED
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7SQW
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6PA0
| Structure of the G77A mutant in Sodium Chloride | Descriptor: | Antibody HEAVY fragment, Antibody LIGHT fragment, DIACYL GLYCEROL, ... | Authors: | Cuello, L.G, Guan, L. | Deposit date: | 2019-06-11 | Release date: | 2019-08-07 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
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1ZWI
| Structure of mutant KcsA potassium channel | Descriptor: | DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Cordero-Morales, J.F, Cuello, L.G, Zhao, Y, Jogini, V, Cortes, D.M, Roux, B, Perozo, E. | Deposit date: | 2005-06-03 | Release date: | 2006-03-07 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular determinants of gating at the potassium-channel selectivity filter. Nat.Struct.Mol.Biol., 13, 2006
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2ATK
| Structure of a mutant KcsA K+ channel | Descriptor: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, NONAN-1-OL, ... | Authors: | Cordero-Morales, J.F, Cuello, L.G, Zhao, Y, Jogini, V, Chakrapani, S, Roux, B, Perozo, E. | Deposit date: | 2005-08-25 | Release date: | 2006-03-07 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular determinants of gating at the potassium-channel selectivity filter. Nat.Struct.Mol.Biol., 13, 2006
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3PJS
| Mechanism of Activation Gating in the Full-Length KcsA K+ Channel | Descriptor: | FAB heavy chain, FAB light chain, Voltage-gated potassium channel | Authors: | Uysal, S, Cuello, L.G, Kossiakoff, A, Perozo, E. | Deposit date: | 2010-11-10 | Release date: | 2011-07-06 | Last modified: | 2011-08-03 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Mechanism of activation gating in the full-length KcsA K+ channel. Proc.Natl.Acad.Sci.USA, 108, 2011
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6NFV
| Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G. | Deposit date: | 2018-12-20 | Release date: | 2019-08-07 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
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6NFU
| Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G. | Deposit date: | 2018-12-20 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
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6BY3
| Open and conductive conformation of KcsA-T75A mutant | Descriptor: | Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ... | Authors: | Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G. | Deposit date: | 2017-12-19 | Release date: | 2018-05-09 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Inverted allosteric coupling between activation and inactivation gates in K+channels. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BY2
| Closed and deep-inactivated conformation of KcsA-T75A mutant | Descriptor: | Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ... | Authors: | Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G. | Deposit date: | 2017-12-19 | Release date: | 2018-05-09 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Inverted allosteric coupling between activation and inactivation gates in K+channels. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HJY
| X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) Delta8 truncation mutant in complex with nanobody 72 | Descriptor: | Cys-loop ligand-gated ion channel, nanobody 72 | Authors: | Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C. | Deposit date: | 2018-09-04 | Release date: | 2019-10-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Nat.Chem.Biol., 15, 2019
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1F6G
| POTASSIUM CHANNEL (KCSA) FULL-LENGTH FOLD | Descriptor: | VOLTAGE-GATED POTASSIUM CHANNEL | Authors: | Cortes, D.M, Perozo, E. | Deposit date: | 2000-06-21 | Release date: | 2001-02-21 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating. J.Gen.Physiol., 117, 2001
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6HK0
| X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) F16'S pore mutant (F247S) with alternate M4 conformation. | Descriptor: | Cys-loop ligand-gated ion channel, DODECYL-BETA-D-MALTOSIDE | Authors: | Nury, H, Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C. | Deposit date: | 2018-09-04 | Release date: | 2019-10-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Nat.Chem.Biol., 15, 2019
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6HJX
| X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) 7'C pore mutant (L238C) in complex with nanobody 72 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cys-loop ligand-gated ion channel, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C. | Deposit date: | 2018-09-04 | Release date: | 2019-10-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Nat.Chem.Biol., 15, 2019
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2KIR
| Solution structure of a designer toxin, mokatoxin-1 | Descriptor: | Designer toxin | Authors: | Biancalana, M, Koide, A, Takacs, Z, Goldstein, S, Koide, S. | Deposit date: | 2009-05-07 | Release date: | 2009-12-29 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proc.Natl.Acad.Sci.USA, 106, 2009
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