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5OO1
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BU of 5oo1 by Molmil
Cdk2(F80C, C177A) covalent adduct with C37 at F80C
Descriptor: Cyclin-dependent kinase 2, ~{N}-(4-pyrimidin-2-ylphenyl)propanamide
Authors:Craven, G, Morgan, R.M.L, Mann, D.J.
Deposit date:2017-08-04
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-throughput kinetic analysis for target-directed covalent ligand discovery
To be published
5OO3
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BU of 5oo3 by Molmil
Cdk2(F80C, C177A) with covalent ligand at F80C
Descriptor: 1-(4-ethyl-2,3-dihydroquinoxalin-1-yl)propan-1-one, Cyclin-dependent kinase 2
Authors:Craven, G, Morgan, R.M.L, Mann, D.J.
Deposit date:2017-08-05
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:High-throughput kinetic analysis for target-directed covalent ligand discovery
To Be Published
5I6C
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BU of 5i6c by Molmil
The structure of the eukaryotic purine/H+ symporter, UapA, in complex with Xanthine
Descriptor: DODECYL-BETA-D-MALTOSIDE, Uric acid-xanthine permease, XANTHINE
Authors:Alguel, Y, Amillis, S, Leung, J, Lambrinidis, G, Capaldi, S, Scull, N.J, Craven, G, Iwata, S, Armstrong, A, Mikros, E, Diallinas, G, Cameron, A.D, Byrne, B.
Deposit date:2016-02-16
Release date:2016-04-27
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.
Nat Commun, 7, 2016
5OO0
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BU of 5oo0 by Molmil
Cdk2(WT) covalent adduct with D28 at C177
Descriptor: Cyclin-dependent kinase 2, methyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate
Authors:Craven, G, Morgan, R.M.L, Mann, D.J.
Deposit date:2017-08-04
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Angew. Chem. Int. Ed. Engl., 57, 2018
5OSJ
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BU of 5osj by Molmil
Cdk2(WT) with covalent adduct at C177
Descriptor: Cyclin-dependent kinase 2, ~{tert}-butyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate
Authors:Craven, G, Morgan, R.M.L, Mann, D.J.
Deposit date:2017-08-17
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Angew. Chem. Int. Ed. Engl., 57, 2018
5OSM
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BU of 5osm by Molmil
Cdk2(F80C, C177A) with covalent adduct at C80
Descriptor: Cyclin-dependent kinase 2, methyl 1-propanoyl-3,4-dihydro-2~{H}-quinoline-6-carboxylate
Authors:Craven, G, Morgan, R.M.L, Mann, D.J.
Deposit date:2017-08-17
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Angew. Chem. Int. Ed. Engl., 57, 2018
6YL1
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BU of 6yl1 by Molmil
Cdk2(F80C) with Covalent Adduct TK37 at F80C
Descriptor: Cyclin-dependent kinase 2, methyl 4-(cyclopropylmethyl)-1-prop-2-enoyl-2,3-dihydroquinoxaline-6-carboxylate
Authors:Craven, G, Morgan, R.M.L, Mann, D.J.
Deposit date:2020-04-06
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT).
Chembiochem, 21, 2020
6YL6
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BU of 6yl6 by Molmil
Cdk2(F80C)
Descriptor: Cyclin-dependent kinase 2
Authors:Craven, G, Morgan, R.M.L, Mann, D.J.
Deposit date:2020-04-06
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT).
Chembiochem, 21, 2020
6YLK
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BU of 6ylk by Molmil
Cdk2(F80C) with Covalent Adduct TK22 at F80C
Descriptor: Cyclin-dependent kinase 2, methyl 4-ethyl-1-propanoyl-2,3-dihydroquinoxaline-6-carboxylate
Authors:Craven, G, Morgan, R.M.L, Mann, D.J.
Deposit date:2020-04-07
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT).
Chembiochem, 21, 2020

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PDB entries from 2024-03-27

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