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6MPV
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BU of 6mpv by Molmil
Cryo-electron microscopy structure of Plasmodium falciparum Rh5/CyRPA/Ripr invasion complex
Descriptor: Cysteine-rich protective antigen, PfRipr, Reticulocyte binding protein 5
Authors:Wilson, W, Zhiheng, Y, Cowman, A.F.
Deposit date:2018-10-08
Release date:2018-12-12
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (7.17 Å)
Cite:Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.
Nature, 565, 2019
4ZL4
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BU of 4zl4 by Molmil
Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)
Descriptor: (2R)-1-[(2R)-2-(2-methoxyethoxy)propoxy]propan-2-amine, 1,2-ETHANEDIOL, Aspartic protease PM5, ...
Authors:Czabotar, P.E, Hodder, A.N, Smith, B.J, Sleebs, B.E, Gazdic, M, Boddey, J.A, Cowman, A.F.
Deposit date:2015-05-01
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Nat.Struct.Mol.Biol., 22, 2015
7TBB
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BU of 7tbb by Molmil
Crystal structure of Plasmepsin X from Plasmodium falciparum
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, GLYCEROL, ...
Authors:Christensen, J.B, Hodder, A.N, Dietrich, M.H, Scally, S.W, Cowman, A.F.
Deposit date:2021-12-21
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.
Structure, 30, 2022
7TBD
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BU of 7tbd by Molmil
Crystal structure of Plasmepsin X from Plasmodium vivax in complex with WM382
Descriptor: (4R)-4-[(2E)-4,4-diethyl-2-imino-6-oxo-1,3-diazinan-1-yl]-N-[(4S)-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3,4-dihydro-2H-1-benzopyran-6-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Hodder, A.N, Christensen, J.B, Scally, S.W, Cowman, A.F.
Deposit date:2021-12-21
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.
Structure, 30, 2022
7TBC
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BU of 7tbc by Molmil
Crystal structure of Plasmepsin X from Plasmodium falciparum in complex with WM382
Descriptor: (4R)-4-[(2E)-4,4-diethyl-2-imino-6-oxo-1,3-diazinan-1-yl]-N-[(4S)-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-3,4-dihydro-2H-1-benzopyran-6-carboxamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Christensen, J.B, Hodder, A.N, Scally, S.W, Cowman, A.F.
Deposit date:2021-12-21
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.
Structure, 30, 2022
7TBE
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BU of 7tbe by Molmil
Crystal structure of Plasmepsin X from Plasmodium vivax in complex with WM4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(R)-[(2E,4S)-2-imino-4-methyl-6-oxo-4-(propan-2-yl)-1,3-diazinan-1-yl](phenyl)methyl]-N-[(1S)-1-phenylethyl]benzamide, Plasmepsin X, ...
Authors:Hodder, A.N, Christensen, J.B, Scally, S.W, Cowman, A.F.
Deposit date:2021-12-21
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.
Structure, 30, 2022
7UNY
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BU of 7uny by Molmil
Crystal structure of D2 nanobody in complex with PfCSS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cysteine-rich small secreted protein CSS, ...
Authors:Scally, S.W, Lim, P.S, Cowman, A.F.
Deposit date:2022-04-12
Release date:2022-11-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (4.13 Å)
Cite:PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum.
Nat Microbiol, 7, 2022
7UNZ
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BU of 7unz by Molmil
Crystal structure of H2 nanobody in complex with PfCSS
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Scally, S.W, Cowman, A.F.
Deposit date:2022-04-12
Release date:2022-11-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum.
Nat Microbiol, 7, 2022
2MCZ
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BU of 2mcz by Molmil
CR1 Sushi domains 1 and 2
Descriptor: Complement receptor type 1
Authors:Park, H.J, Guariento, M.J, Maciejewski, M, Hauart, R, Tham, W, Cowman, A.F, Schmidt, C.Q, Martens, H, Liszewski, K.M, Hourcade, D, Barlow, P.N, Atkinson, J.P.
Deposit date:2013-08-27
Release date:2013-11-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor.
J.Biol.Chem., 289, 2014
2MCY
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BU of 2mcy by Molmil
CR1 Sushi domains 2 and 3
Descriptor: Complement receptor type 1
Authors:Park, H.J, Guariento, M.J, Maciejewski, M, Hauart, R, Tham, W, Cowman, A.F, Schmidt, C.Q, Martens, H, Liszewski, K.M, Hourcade, D, Barlow, P.N, Atkinson, J.P.
Deposit date:2013-08-27
Release date:2013-11-13
Last modified:2014-01-22
Method:SOLUTION NMR
Cite:Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor.
J.Biol.Chem., 289, 2014
3VUV
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BU of 3vuv by Molmil
Crystal structure of the merozoite surface protein MSPDBL2 from P. falciparum bound to zinc
Descriptor: Erythrocyte membrane protein, putative, ZINC ION
Authors:Czabotar, P.E, Hodder, A.N, Clarke, O.B, Lin, C.S, Smith, B.J, Cowman, A.F.
Deposit date:2012-07-09
Release date:2012-08-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.114 Å)
Cite:Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
J.Biol.Chem., 287, 2012
3VUU
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BU of 3vuu by Molmil
Crystal structure of the merozoite surface protein MSPDBL2 from P. falciparum
Descriptor: CHLORIDE ION, Erythrocyte membrane protein, putative
Authors:Czabotar, P.E, Hodder, A.N, Clarke, O.B, Lin, C.S, Smith, B.J, Cowman, A.F.
Deposit date:2012-07-09
Release date:2012-08-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
J.Biol.Chem., 287, 2012
6C4G
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BU of 6c4g by Molmil
Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-601)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Czabotar, P.E, Hodder, A.N, Nguyen, W, Sleebs, B.E, Boddey, J.A, Cowman, A.F.
Deposit date:2018-01-11
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2position of PEXEL peptidomimetics.
Eur J Med Chem, 154, 2018
5TIH
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BU of 5tih by Molmil
Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA
Descriptor: ACETATE ION, CyRPA antibody Fab Heavy Chain, CyRPA antibody Fab Light Chain, ...
Authors:Chen, L, Xu, Y, Wang, W, Thompson, J.K, Goddard-Borger, E, Lawrence, M.C, Cowman, A.F.
Deposit date:2016-10-03
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural basis for inhibition of erythrocyte invasion by antibodies toPlasmodium falciparumprotein CyRPA.
Elife, 6, 2017
5TIK
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BU of 5tik by Molmil
Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA
Descriptor: Cysteine-rich protective antigen
Authors:Chen, L, Xu, Y, Wang, W, Thompson, J.K, Goddard-Borger, E, Lawrence, M.C, Cowman, A.F.
Deposit date:2016-10-03
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structural basis for inhibition of erythrocyte invasion by antibodies toPlasmodium falciparumprotein CyRPA.
Elife, 6, 2017
4WAT
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BU of 4wat by Molmil
Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, IMIDAZOLE, PfRh5
Authors:Chen, L.
Deposit date:2014-09-01
Release date:2014-10-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes.
Elife, 3, 2014
8DSR
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BU of 8dsr by Molmil
Structure of Plasmepsin X (PM10, PMX) from Plasmodium falciparum 3D7 in complex with UCB7362
Descriptor: (2E,6S)-6-{2-chloro-3-[(2-cyclopropylpyrimidin-5-yl)amino]phenyl}-2-imino-6-methyl-3-[(2S,4S)-2-methyloxan-4-yl]-1,3-diazinan-4-one, Plasmepsin X
Authors:Abendroth, J, Lorimer, D.D.
Deposit date:2022-07-22
Release date:2022-10-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 .
J.Med.Chem., 65, 2022
6BPD
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BU of 6bpd by Molmil
Plasmodium vivax invasion blocking monoclonal antibody 10B12
Descriptor: Monoclonal antibody 10B12 Fab heavy chain, Monoclonal antibody 10B12 Fab light chain
Authors:Gruszczyk, J, Chan, L.J, Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6BPB
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BU of 6bpb by Molmil
Plasmodium vivax invasion blocking monoclonal antibody 4F7
Descriptor: Monoclonal antibody 4F7 Fab heavy chain, Monoclonal antibody 4F7 Fab light chain
Authors:Gruszczyk, J, Chan, L.J, Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6BPC
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BU of 6bpc by Molmil
Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 4F7
Descriptor: Monoclonal antibody 4F7 Fab heavy chain, Monoclonal antibody 4F7 Fab light chain, Reticulocyte binding protein 2, ...
Authors:Gruszczyk, J, Chan, L.J, Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6BPA
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BU of 6bpa by Molmil
Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to monoclonal antibody 3E9
Descriptor: BROMIDE ION, Monoclonal antibody 3E9 Fab heavy chain, Monoclonal antibody 3E9 Fab light chain, ...
Authors:Gruszczyk, J, Chan, L.J, Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
7USV
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BU of 7usv by Molmil
Plasmodium falciparum protein Pfs230 D1 in complex with nanobody F10
Descriptor: Gametocyte surface protein P230, Nanobody F10, SULFATE ION
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2022-04-25
Release date:2022-12-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Nanobodies against Pfs230 block Plasmodium falciparum transmission.
Biochem.J., 479, 2022
7USS
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BU of 7uss by Molmil
Plasmodium falciparum protein Pfs230 Pro-D1D2 - Structure of the first two 6-cysteine domains with N-terminal extension
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Gametocyte surface protein P230, ...
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2022-04-25
Release date:2022-12-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nanobodies against Pfs230 block Plasmodium falciparum transmission.
Biochem.J., 479, 2022
7USR
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BU of 7usr by Molmil
Plasmodium falciparum protein Pfs230 D1D2 - Structure of the first two 6-cysteine domains
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Gametocyte surface protein P230
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2022-04-25
Release date:2022-12-28
Last modified:2023-07-12
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Nanobodies against Pfs230 block Plasmodium falciparum transmission.
Biochem.J., 479, 2022
7UST
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BU of 7ust by Molmil
Plasmodium falciparum protein Pfs230 D1 in complex with nanobody F5
Descriptor: Gametocyte surface protein P230, Nanobody F5, SULFATE ION
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2022-04-25
Release date:2022-12-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nanobodies against Pfs230 block Plasmodium falciparum transmission.
Biochem.J., 479, 2022

 

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