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1ZKK
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BU of 1zkk by Molmil
Crystal structure of hSET8 in ternary complex with H4 peptide (16-24) and AdoHcy
Descriptor: Histone-lysine N-methyltransferase, H4 lysine-20 specific, Peptide corresponding to residues 15-24 of histone H4, ...
Authors:Couture, J.-F, Collazo, E, Brunzelle, J.S, Trievel, R.C.
Deposit date:2005-05-03
Release date:2005-06-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase
Genes Dev., 19, 2005
2F69
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BU of 2f69 by Molmil
Ternary complex of SET7/9 bound to AdoHcy and a TAF10 peptide
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Couture, J.-F, Collazo, E, Hauk, G, Trievel, R.C.
Deposit date:2005-11-28
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis for the methylation site specificity of SET7/9
Nat.Struct.Mol.Biol., 13, 2006
1XJB
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BU of 1xjb by Molmil
Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H), citrate and acetate molecules
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Aldo-keto reductase family 1 member C2, ...
Authors:Couture, J.-F, Pereira de Jesus-Tran, K, Roy, A.-M, Legrand, P, Cantin, L, Cote, P.-L, Luu-The, V, Labrie, F, Breton, R.
Deposit date:2004-09-23
Release date:2005-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen
Protein Sci., 14, 2005
3P4F
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BU of 3p4f by Molmil
Structural and biochemical insights into MLL1 core complex assembly and regulation.
Descriptor: Histone-lysine N-methyltransferase MLL, Retinoblastoma-binding protein 5, WD repeat-containing protein 5
Authors:Avdic, V, Zhang, P, Lanouette, S, Groulx, A, Tremblay, V, Brunzelle, J.B, Couture, J.-F.
Deposit date:2010-10-06
Release date:2010-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and biochemical insights into MLL1 core complex assembly.
Structure, 19, 2011
5EJ3
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BU of 5ej3 by Molmil
Crystal structure of XlnB2
Descriptor: Endo-1,4-beta-xylanase B
Authors:Couture, J.-F.
Deposit date:2015-11-01
Release date:2016-09-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.314 Å)
Cite:Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans.
Biochemistry, 55, 2016
6MV6
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BU of 6mv6 by Molmil
Crystal structure of RNAse 6
Descriptor: PHOSPHATE ION, Ribonuclease K6
Authors:Couture, J.-F, Doucet, N.
Deposit date:2018-10-24
Release date:2019-11-13
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding.
Biochemistry, 59, 2020
6MV7
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BU of 6mv7 by Molmil
Crystal structure of RNAse 6
Descriptor: ADENOSINE MONOPHOSPHATE, Ribonuclease K6
Authors:Couture, J.-F, Doucet, N.
Deposit date:2018-10-24
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding.
Biochemistry, 59, 2020
3F9Y
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BU of 3f9y by Molmil
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me1 / AdoHcy
Descriptor: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F9W
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BU of 3f9w by Molmil
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20 / AdoHcy
Descriptor: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F9Z
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BU of 3f9z by Molmil
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y245F / H4-Lys20 / AdoHcy
Descriptor: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F9X
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BU of 3f9x by Molmil
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me2 / AdoHcy
Descriptor: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2Q8C
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BU of 2q8c by Molmil
Crystal structure of JMJD2A in ternary complex with an histone H3K9me3 peptide and 2-oxoglutarate
Descriptor: 2-OXOGLUTARIC ACID, HISTONE 3 PEPTIDE, JmjC domain-containing histone demethylation protein 3A, ...
Authors:Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2Q8D
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BU of 2q8d by Molmil
Crystal structure of JMJ2D2A in ternary complex with histone H3-K36me2 and succinate
Descriptor: HISTONE 3 peptide, JmjC domain-containing histone demethylation protein 3A, NICKEL (II) ION, ...
Authors:Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2Q8E
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BU of 2q8e by Molmil
Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase
Descriptor: JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
1Q13
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BU of 1q13 by Molmil
Crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with NADP and testosterone
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin-E2 9-reductase, SULFATE ION, ...
Authors:Couture, J.-F, Cantin, L, Legrand, P, Luu-The, V, Labrie, F, Breton, R.
Deposit date:2003-07-18
Release date:2004-11-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.
J. Mol. Biol., 339, 2004
5VBC
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BU of 5vbc by Molmil
Crystal structure of ATXR5 in complex with histone H3.1
Descriptor: DIMETHYL SULFOXIDE, Histone H3.1 peptide, Probable Histone-lysine N-methyltransferase ATXR5, ...
Authors:Couture, J.-F, Bergamin, E.
Deposit date:2017-03-29
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular basis for the methylation specificity of ATXR5 for histone H3.
Nucleic Acids Res., 45, 2017
4ETS
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BU of 4ets by Molmil
Crystal structure of Campylobacter jejuni ferric uptake regulator
Descriptor: CHLORIDE ION, Ferric uptake regulation protein, ZINC ION
Authors:Sarvan, S, Brunzelle, J.B, Couture, J.-F.
Deposit date:2012-04-24
Release date:2012-06-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and regulon of Campylobacter jejuni ferric uptake regulator Fur define apo-Fur regulation.
Proc.Natl.Acad.Sci.USA, 109, 2012
4RIQ
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BU of 4riq by Molmil
Crystal structure of DPY-30 dimerization/docking domain in complex with Ash2L Sdc1-DPY-30 Interacting region (SDI)
Descriptor: Protein dpy-30 homolog, SULFATE ION, Set1/Ash2 histone methyltransferase complex subunit ASH2
Authors:Tremblay, V, Couture, J.-F.
Deposit date:2014-10-07
Release date:2014-12-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.231 Å)
Cite:Molecular Basis for DPY-30 Association to COMPASS-like and NURF Complexes.
Structure, 22, 2014
3IVS
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BU of 3ivs by Molmil
Homocitrate Synthase Lys4
Descriptor: COBALT (II) ION, Homocitrate synthase, mitochondrial, ...
Authors:Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVU
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BU of 3ivu by Molmil
Homocitrate Synthase Lys4 bound to 2-OG
Descriptor: 2-OXOGLUTARIC ACID, COBALT (II) ION, Homocitrate synthase, ...
Authors:Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVT
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BU of 3ivt by Molmil
Homocitrate Synthase Lys4 bound to 2-OG
Descriptor: 2-OXOGLUTARIC ACID, Homocitrate synthase, mitochondrial, ...
Authors:Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
4X8P
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BU of 4x8p by Molmil
Crystal structure of Ash2L SPRY domain in complex with RbBP5
Descriptor: GLYCEROL, Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2
Authors:Zhang, P, Chaturvedi, C.P, Brunzelle, J.S, Skiniotis, G, Brand, M, Shilatifard, A, Couture, J.-F.
Deposit date:2014-12-10
Release date:2015-01-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.
Genes Dev., 29, 2015
4X8N
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BU of 4x8n by Molmil
Crystal structure of Ash2L SPRY domain in complex with phosphorylated RbBP5
Descriptor: Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2
Authors:Zhang, P, Chaturvedi, C.P, Brunzelle, J.S, Skiniotis, G, Brand, M, Shilatifard, A, Couture, J.-F.
Deposit date:2014-12-10
Release date:2015-01-28
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.
Genes Dev., 29, 2015
5H88
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BU of 5h88 by Molmil
Crystal structure of mRojoA mutant - T16V -P63F - W143A - L163V
Descriptor: mRojoA fluorescent protein
Authors:Pandelieva, A.T, Tremblay, V, Sarvan, S, Chica, R.A, Couture, J.-F.
Deposit date:2015-12-23
Release date:2016-01-27
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Brighter Red Fluorescent Proteins by Rational Design of Triple-Decker Motif.
Acs Chem.Biol., 11, 2016
5H89
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BU of 5h89 by Molmil
Crystal structure of mRojoA mutant - T16V - P63Y - W143G - L163V
Descriptor: mRojoA fluorescent protein
Authors:Pandelieva, A.T, Tremblay, V, Sarvan, S, Chica, R.A, Couture, J.-F.
Deposit date:2015-12-23
Release date:2016-01-27
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Brighter Red Fluorescent Proteins by Rational Design of Triple-Decker Motif.
Acs Chem.Biol., 11, 2016

 

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