Author results

1XJB
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CRYSTAL STRUCTURE OF HUMAN TYPE 3 3ALPHA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP(H), CITRATE AND ACETATE MOLECULES
Descriptor:Aldo-keto reductase family 1 member C2, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Couture, J.-F., Pereira de Jesus-Tran, K., Roy, A.-M., Legrand, P., Cantin, L., Cote, P.-L., Luu-The, V., Labrie, F., Breton, R.
Deposit date:2004-09-23
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen
Protein Sci., 14, 2005
1ZKK
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CRYSTAL STRUCTURE OF HSET8 IN TERNARY COMPLEX WITH H4 PEPTIDE (16-24) AND ADOHCY
Descriptor:Histone-lysine N-methyltransferase, H4 lysine-20 specific, Peptide corresponding to residues 15-24 of histone H4, ...
Authors:Couture, J.-F., Collazo, E., Brunzelle, J.S., Trievel, R.C.
Deposit date:2005-05-03
Release date:2005-06-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase
Genes Dev., 19, 2005
2F69
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TERNARY COMPLEX OF SET7/9 BOUND TO ADOHCY AND A TAF10 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7, TAF10 peptide, ...
Authors:Couture, J.-F., Collazo, E., Hauk, G., Trievel, R.C.
Deposit date:2005-11-28
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis for the methylation site specificity of SET7/9
Nat.Struct.Mol.Biol., 13, 2006
3P4F
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STRUCTURAL AND BIOCHEMICAL INSIGHTS INTO MLL1 CORE COMPLEX ASSEMBLY AND REGULATION.
Descriptor:WD repeat-containing protein 5, Retinoblastoma-binding protein 5, Histone-lysine N-methyltransferase MLL
Authors:Avdic, V., Zhang, P., Lanouette, S., Groulx, A., Tremblay, V., Brunzelle, J.B., Couture, J.-F.
Deposit date:2010-10-06
Release date:2010-12-08
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and biochemical insights into MLL1 core complex assembly.
Structure, 19, 2011
1Q13
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CRYSTAL STRUCTURE OF RABBIT 20ALPHA HYROXYSTEROID DEHYDROGENASE IN TERNARY COMPLEX WITH NADP AND TESTOSTERONE
Descriptor:Prostaglandin-E2 9-reductase, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Couture, J.-F., Cantin, L., Legrand, P., Luu-The, V., Labrie, F., Breton, R.
Deposit date:2003-07-18
Release date:2004-11-16
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.
J. Mol. Biol., 339, 2004
2Q8C
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CRYSTAL STRUCTURE OF JMJD2A IN TERNARY COMPLEX WITH AN HISTONE H3K9ME3 PEPTIDE AND 2-OXOGLUTARATE
Descriptor:JmjC domain-containing histone demethylation protein 3A, HISTONE 3 PEPTIDE, NICKEL (II) ION, ...
Authors:Couture, J.-F., Collazo, E., Ortiz-Tello, P., Brunzelle, J.S., Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2Q8D
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CRYSTAL STRUCTURE OF JMJ2D2A IN TERNARY COMPLEX WITH HISTONE H3-K36ME2 AND SUCCINATE
Descriptor:JmjC domain-containing histone demethylation protein 3A, HISTONE 3 peptide, NICKEL (II) ION, ...
Authors:Couture, J.-F., Collazo, E., Ortiz-Tello, P., Brunzelle, J.S., Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2Q8E
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SPECIFICITY AND MECHANISM OF JMJD2A, A TRIMETHYLLYSINE-SPECIFIC HISTONE DEMETHYLASE
Descriptor:JmjC domain-containing histone demethylation protein 3A, histone 3 peptide, NICKEL (II) ION, ...
Authors:Couture, J.-F., Collazo, E., Ortiz-Tello, P., Brunzelle, J.S., Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
3F9W
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STRUCTURAL INSIGHTS INTO LYSINE MULTIPLE METHYLATION BY SET DOMAIN METHYLTRANSFERASES, SET8-Y334F / H4-LYS20 / ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD8, Histone H4, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F., Dirk, L.M.A., Brunzelle, J.S., Houtz, R.L., Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F9X
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STRUCTURAL INSIGHTS INTO LYSINE MULTIPLE METHYLATION BY SET DOMAIN METHYLTRANSFERASES, SET8-Y334F / H4-LYS20ME2 / ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD8, Histone H4, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F., Dirk, L.M.A., Brunzelle, J.S., Houtz, R.L., Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F9Y
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STRUCTURAL INSIGHTS INTO LYSINE MULTIPLE METHYLATION BY SET DOMAIN METHYLTRANSFERASES, SET8-Y334F / H4-LYS20ME1 / ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD8, Histone H4, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F., Dirk, L.M.A., Brunzelle, J.S., Houtz, R.L., Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F9Z
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STRUCTURAL INSIGHTS INTO LYSINE MULTIPLE METHYLATION BY SET DOMAIN METHYLTRANSFERASES, SET8-Y245F / H4-LYS20 / ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD8, Histone H4, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F., Dirk, L.M.A., Brunzelle, J.S., Houtz, R.L., Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
5EJ3
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CRYSTAL STRUCTURE OF XLNB2
Descriptor:Endo-1,4-beta-xylanase B
Authors:Couture, J.-F.
Deposit date:2015-11-01
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.314 Å)
Cite:Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans.
Biochemistry, 55, 2016
5VBC
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CRYSTAL STRUCTURE OF ATXR5 IN COMPLEX WITH HISTONE H3.1
Descriptor:Probable Histone-lysine N-methyltransferase ATXR5, Histone H3.1 peptide, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Couture, J.-F., Bergamin, E.
Deposit date:2017-03-29
Release date:2017-04-19
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular basis for the methylation specificity of ATXR5 for histone H3.
Nucleic Acids Res., 45, 2017
3IVS
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HOMOCITRATE SYNTHASE LYS4
Descriptor:Homocitrate synthase, mitochondrial, COBALT (II) ION, ...
Authors:Bulfer, S.L., Scott, E.M., Couture, J.-F., Pillus, L., Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVT
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HOMOCITRATE SYNTHASE LYS4 BOUND TO 2-OG
Descriptor:Homocitrate synthase, mitochondrial, ZINC ION, ...
Authors:Bulfer, S.L., Scott, E.M., Couture, J.-F., Pillus, L., Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3IVU
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HOMOCITRATE SYNTHASE LYS4 BOUND TO 2-OG
Descriptor:Homocitrate synthase, mitochondrial, COBALT (II) ION, ...
Authors:Bulfer, S.L., Scott, E.M., Couture, J.-F., Pillus, L., Trievel, R.C.
Deposit date:2009-09-01
Release date:2009-09-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
3M53
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SET7/9 IN COMPLEX WITH TAF10 PEPTIDE AND ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD7, TAF10 peptide, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Del Rizzo, P.A., Couture, J.-F., Roiko, M.S., Strunk, B.S., Brunzelle, J.S., Dirk, L.M., Houtz, R.L., Trievel, R.C.
Deposit date:2010-03-12
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
3M54
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SET7/9 Y305F IN COMPLEX WITH TAF10 PEPTIDE AND ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD7, TAF10 peptide, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Del Rizzo, P.A., Couture, J.-F., Roiko, M.S., Strunk, B.S., Brunzelle, J.S., Dirk, L.M., Houtz, R.L., Trievel, R.C.
Deposit date:2010-03-12
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
3M55
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SET7/9 Y305F IN COMPLEX WITH TAF10-K189ME1 PEPTIDE AND ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD7, TAF10 peptide, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Del Rizzo, P.A., Couture, J.-F., Roiko, M.S., Strunk, B.S., Brunzelle, J.S., Dirk, L.M., Houtz, R.L., Trievel, R.C.
Deposit date:2010-03-12
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
3M56
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SET7/9 Y305F IN COMPLEX WITH TAF10-K189ME2 PEPTIDE AND ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD7, TAF10-K189me2 PEPTIDE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Del Rizzo, P.A., Couture, J.-F., Roiko, M.S., Strunk, B.S., Brunzelle, J.S., Dirk, L.M., Houtz, R.L., Trievel, R.C.
Deposit date:2010-03-12
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
3M57
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SET7/9 Y245A IN COMPLEX WITH TAF10 PEPTIDE AND ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD7, TAF10 peptide, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Del Rizzo, P.A., Couture, J.-F., Roiko, M.S., Strunk, B.S., Brunzelle, J.S., Dirk, L.M., Houtz, R.L., Trievel, R.C.
Deposit date:2010-03-12
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
3M58
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SET7/9 Y245A IN COMPLEX WITH TAF10-K189ME1 PEPTIDE AND ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD7, TAF10-K189me1 Peptide, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Del Rizzo, P.A., Couture, J.-F., Roiko, M.S., Strunk, B.S., Brunzelle, J.S., Dirk, L.M., Houtz, R.L., Trievel, R.C.
Deposit date:2010-03-12
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
3M59
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SET7/9 Y245A IN COMPLEX WITH TAF10-K189ME2 PEPTIDE AND ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD7, TAF10-K189me2 Peptide, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Del Rizzo, P.A., Couture, J.-F., Roiko, M.S., Strunk, B.S., Brunzelle, J.S., Dirk, L.M., Houtz, R.L., Trievel, R.C.
Deposit date:2010-03-12
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
3M5A
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SET7/9 Y245A IN COMPLEX WITH TAF10-K189ME3 PEPTIDE AND ADOHCY
Descriptor:Histone-lysine N-methyltransferase SETD7, TAF10-K189me3 Peptide, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Del Rizzo, P.A., Couture, J.-F., Roiko, M.S., Strunk, B.S., Brunzelle, J.S., Dirk, L.M., Houtz, R.L., Trievel, R.C.
Deposit date:2010-03-12
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
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